GREMLIN Database
CSGA - Major curlin subunit
UniProt: P28307 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11489
Length: 151 (118)
Sequences: 570 (506)
Seq/√Len: 46.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
105_Q128_Q2.8941.00
47_I70_I2.6191.00
103_L126_V2.5991.00
115_V137_V2.4211.00
101_A124_A2.3981.00
99_N122_N2.3301.00
111_S133_S2.3041.00
43_S66_S2.2951.00
83_Q105_Q2.2921.00
60_Q83_Q2.2851.00
113_M135_V2.2001.00
124_A146_A2.1711.00
92_L115_V2.1601.00
79_A101_A2.0891.00
90_I113_M2.0470.99
108_G111_S1.9770.99
117_Q139_Q1.9180.99
83_Q128_Q1.9150.99
79_A124_A1.8850.99
58_A81_V1.8150.99
70_I92_L1.8080.99
77_N99_N1.7780.99
126_V148_A1.7690.98
94_Q117_Q1.6940.98
72_Q117_Q1.6840.98
56_A79_A1.6450.98
72_Q94_Q1.6220.97
88_S111_S1.6100.97
54_N77_N1.5980.97
85_S108_G1.5400.96
77_N122_N1.4850.96
126_V137_V1.4530.95
101_A146_A1.4230.94
60_Q105_Q1.4190.94
120_G142_F1.3700.93
60_Q128_Q1.3610.93
70_I115_V1.3470.92
97_F120_G1.3190.92
92_L137_V1.3110.91
45_L68_L1.2890.91
68_L90_I1.2150.88
128_Q150_Q1.1600.85
105_Q150_Q1.1470.85
66_S88_S1.1380.84
119_G141_G1.1340.84
45_L58_A1.1140.83
103_L113_M1.1110.83
114_T136_N1.1050.83
58_A68_L1.1010.82
118_F140_V1.0930.82
94_Q139_Q1.0880.82
47_I56_A1.0760.81
32_H40_G1.0720.81
63_A66_S1.0610.80
116_K138_T1.0560.80
81_V92_L1.0410.79
45_L90_I1.0220.77
97_F142_F1.0080.76
81_V103_L0.9810.74
34_G56_A0.9800.74
128_Q135_V0.9770.74
56_A70_I0.9770.74
90_I101_A0.9760.74
101_A115_V0.9580.73
122_N144_N0.9580.73
78_G123_G0.9530.72
54_N99_N0.9480.72
113_M126_V0.9440.71
90_I103_L0.9440.71
70_I137_V0.9320.70
83_Q90_I0.9190.69
66_S133_S0.9190.69
92_L101_A0.8930.67
74_G119_G0.8920.67
62_D108_G0.8860.66
115_V126_V0.8830.66
72_Q139_Q0.8810.66
141_G144_N0.8750.66
85_S88_S0.8710.65
66_S111_S0.8590.64
79_A92_L0.8570.64
44_E95_R0.8550.64
56_A101_A0.8430.63
72_Q79_A0.8210.61
101_A117_Q0.8140.60
89_S112_E0.8080.59
36_G58_A0.8010.59
70_I81_V0.8010.59
48_Y93_T0.7980.58
124_A137_V0.7950.58
92_L103_L0.7820.57
108_G130_A0.7660.55
90_I135_V0.7610.55
43_S88_S0.7600.55
68_L81_V0.7590.55
52_G75_G0.7550.54
82_G104_D0.7470.53
37_N59_L0.7450.53
77_N80_D0.7420.53
67_D89_S0.7360.52
135_V148_A0.7300.52
34_G38_N0.7280.51
36_G47_I0.7270.51
47_I115_V0.7230.51
36_G81_V0.7210.51
96_G141_G0.7200.51
75_G97_F0.7150.50
96_G99_N0.7140.50
118_F146_A0.7060.49
50_Y95_R0.7060.49
87_D109_K0.7040.49
85_S130_A0.6920.48
88_S130_A0.6710.46
91_D124_A0.6650.45
130_A148_A0.6650.45
32_H36_G0.6580.45
49_Q56_A0.6550.44
71_T91_D0.6530.44
46_N67_D0.6480.44
81_V90_I0.6470.44
38_N51_G0.6460.43
139_Q146_A0.6410.43
50_Y73_H0.6400.43
123_G147_T0.6370.43
88_S133_S0.6350.42
83_Q150_Q0.6330.42
70_I103_L0.6280.42
65_N87_D0.6170.41
130_A133_S0.6120.40
121_G143_G0.6040.39
98_G143_G0.6000.39
60_Q101_A0.5960.39
113_M128_Q0.5950.39
77_N144_N0.5940.38
67_D91_D0.5910.38
123_G130_A0.5900.38
43_S62_D0.5870.38
32_H38_N0.5860.38
137_V148_A0.5820.37
87_D110_N0.5800.37
126_V135_V0.5780.37
102_T138_T0.5770.37
68_L113_M0.5690.36
70_I78_G0.5680.36
70_I79_A0.5650.36
57_L80_D0.5590.35
49_Q72_Q0.5590.35
102_T125_A0.5570.35
96_G119_G0.5570.35
96_G130_A0.5560.35
77_N96_G0.5550.35
127_D149_H0.5500.34
115_V124_A0.5480.34
118_F142_F0.5460.34
112_E134_S0.5440.34
31_N143_G0.5440.34
92_L106_W0.5410.34
134_S138_T0.5400.34
74_G90_I0.5390.33
33_G57_L0.5380.33
90_I148_A0.5350.33
37_N57_L0.5340.33
94_Q106_W0.5320.33
85_S120_G0.5310.33
76_G98_G0.5270.32
98_G121_G0.5260.32
69_T135_V0.5250.32
36_G68_L0.5230.32
89_S110_N0.5200.32
36_G43_S0.5180.32
38_N58_A0.5170.32
104_D127_D0.5160.31
47_I92_L0.5110.31
55_S76_G0.5090.31
125_A145_N0.5070.31
125_A147_T0.5030.30
129_T149_H0.5000.30
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2jnaA 2 0.6291 8.6 0.92 Contact Map
3zbiC 1 0.1854 8.3 0.92 Contact Map
2vdaB 1 0.1325 3.1 0.935 Contact Map
1qleD 1 0.1325 2.7 0.937 Contact Map
1m56D 1 0.1325 2.6 0.938 Contact Map
2akhX 1 0.1722 2.1 0.94 Contact Map
3j45G 1 0.1457 2.1 0.94 Contact Map
2nocA 1 0.596 2.1 0.94 Contact Map
4n7wA 2 0.3377 2 0.941 Contact Map
1z65A 1 0.1722 1.9 0.942 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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