GREMLIN Database
YCEG - UPF0755 protein YceG
UniProt: P28306 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11494
Length: 340 (323)
Sequences: 3868 (3083)
Seq/√Len: 171.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
320_L324_N5.0991.00
302_P318_T3.9691.00
317_N326_S3.9541.00
230_S301_T3.8221.00
232_F244_T3.3051.00
319_N322_S3.2921.00
45_K48_T3.1221.00
58_Y66_P2.6921.00
202_Y211_M2.5621.00
225_R291_S2.4961.00
268_P276_I2.4631.00
214_I244_T2.4611.00
241_R277_T2.4421.00
227_K299_A2.4371.00
45_K56_Q2.3841.00
211_M232_F2.3371.00
48_T56_Q2.2981.00
215_I295_A2.2881.00
208_L296_A2.2851.00
226_D299_A2.2411.00
224_E314_H2.2101.00
219_T228_V2.2001.00
231_V306_F2.1831.00
20_G24_W2.1321.00
160_W206_N2.1221.00
188_A289_A2.1001.00
251_G269_T2.0931.00
142_Y145_V2.0711.00
215_I229_A2.0601.00
118_M126_Q2.0591.00
268_P275_T2.0321.00
184_K188_A2.0291.00
39_E88_R2.0241.00
289_A293_K2.0211.00
209_V292_L2.0151.00
222_A290_D1.9791.00
318_T322_S1.9701.00
292_L296_A1.9671.00
232_F306_F1.9171.00
243_Q305_Y1.9021.00
164_D184_K1.8911.00
230_S303_Y1.8661.00
233_I295_A1.8571.00
309_D313_G1.8511.00
229_A233_I1.8441.00
230_S299_A1.8431.00
328_Q332_K1.8401.00
227_K303_Y1.8351.00
173_T176_A1.7901.00
216_E225_R1.7741.00
315_T329_D1.7661.00
50_R73_L1.7441.00
244_T306_F1.7211.00
243_Q274_Y1.7151.00
204_D207_Q1.7061.00
240_M304_L1.6971.00
42_F56_Q1.6551.00
54_G69_F1.6011.00
221_V313_G1.5981.00
141_K145_V1.5681.00
323_H327_V1.5371.00
229_A295_A1.5321.00
125_K135_H1.5281.00
214_I247_T1.5271.00
248_V265_L1.5261.00
238_I304_L1.5211.00
315_T326_S1.5181.00
43_T86_T1.5171.00
211_M233_I1.5051.00
227_K301_T1.4971.00
262_R265_L1.4921.00
115_V118_M1.4861.00
217_K285_A1.4821.00
184_K187_K1.4791.00
115_V126_Q1.4771.00
56_Q60_D1.4491.00
247_T273_T1.4451.00
206_N210_T1.4301.00
87_Y105_G1.4151.00
125_K129_E1.4111.00
111_P167_M1.4101.00
90_T93_M1.4091.00
101_L106_K1.4081.00
211_M244_T1.4061.00
142_Y146_A1.3851.00
51_L70_Q1.3821.00
19_A23_V1.3771.00
48_T52_A1.3731.00
210_T282_G1.3691.00
246_P306_F1.3661.00
262_R266_E1.3561.00
119_R122_D1.3551.00
130_A168_Y1.3491.00
185_M209_V1.3471.00
89_F98_M1.3431.00
48_T53_L1.3411.00
211_M295_A1.3161.00
197_A200_L1.3141.00
114_L123_Y1.3041.00
182_H186_V1.2851.00
89_F93_M1.2811.00
192_A296_A1.2691.00
141_K144_T1.2661.00
260_L265_L1.2501.00
137_L174_D1.2491.00
96_R100_K1.2481.00
134_K137_L1.2391.00
206_N282_G1.2321.00
323_H326_S1.2291.00
54_G70_Q1.2221.00
327_V331_L1.2191.00
249_I260_L1.2191.00
188_A191_S1.2171.00
234_N301_T1.2131.00
128_R135_H1.2081.00
179_K183_K1.2061.00
94_T97_E1.2041.00
55_E59_A1.1931.00
325_K329_D1.1921.00
185_M287_P1.1801.00
168_Y177_L1.1751.00
123_Y286_T1.1671.00
133_I174_D1.1581.00
86_T110_F1.1541.00
321_A324_N1.1541.00
113_R165_T1.1521.00
192_A293_K1.1461.00
321_A325_K1.1361.00
251_G267_T1.1361.00
109_Q167_M1.1241.00
326_S329_D1.1211.00
163_P287_P1.1191.00
233_I298_P1.1171.00
21_V24_W1.1091.00
196_R297_H1.1041.00
290_D293_K1.1031.00
196_R199_G1.0941.00
44_L56_Q1.0821.00
271_Y282_G1.0781.00
266_E275_T1.0771.00
241_R276_I1.0681.00
252_M264_D1.0681.00
191_S289_A1.0540.99
93_M98_M1.0530.99
118_M122_D1.0500.99
22_G26_V1.0500.99
293_K297_H1.0500.99
263_A266_E1.0430.99
190_D205_K1.0430.99
120_L286_T1.0410.99
261_S264_D1.0400.99
271_Y281_P1.0390.99
239_G277_T1.0380.99
325_K328_Q1.0340.99
112_L127_L1.0290.99
124_L139_D1.0280.99
137_L140_D1.0220.99
217_K249_I1.0200.99
116_E288_G1.0180.99
252_M267_T1.0170.99
295_A298_P1.0090.99
303_Y318_T1.0070.99
162_W184_K1.0030.99
202_Y233_I1.0010.99
322_S325_K1.0000.99
93_M101_L0.9960.99
264_D267_T0.9940.99
208_L292_L0.9820.99
40_T60_D0.9810.99
52_A56_Q0.9760.99
62_I98_M0.9730.99
201_P233_I0.9710.99
162_W185_M0.9700.99
124_L128_R0.9680.99
127_L138_S0.9680.99
269_T276_I0.9610.99
232_F246_P0.9570.99
73_L99_L0.9560.99
42_F62_I0.9530.99
111_P165_T0.9510.99
240_M243_Q0.9510.99
172_T176_A0.9490.99
308_A313_G0.9470.99
196_R200_L0.9460.99
307_V327_V0.9450.99
216_E291_S0.9430.99
57_L62_I0.9380.99
274_Y323_H0.9370.99
238_I241_R0.9310.99
49_G52_A0.9300.99
54_G66_P0.9250.99
175_V179_K0.9230.99
241_R275_T0.9220.99
329_D332_K0.9190.99
246_P308_A0.9180.99
41_I86_T0.9170.99
190_D194_E0.9170.99
9_L16_G0.9140.99
324_N327_V0.9130.99
259_K331_L0.9120.99
214_I306_F0.9080.98
183_K187_K0.9080.98
40_T62_I0.9030.98
22_G25_K0.8960.98
185_M189_V0.8910.98
168_Y180_R0.8900.98
225_R290_D0.8890.98
252_M260_L0.8870.98
308_A314_H0.8870.98
138_S142_Y0.8830.98
248_V274_Y0.8750.98
116_E162_W0.8640.98
38_E91_P0.8640.98
224_E316_F0.8630.98
315_T322_S0.8630.98
120_L124_L0.8600.98
67_R70_Q0.8600.98
200_L233_I0.8500.98
126_Q129_E0.8490.98
219_T225_R0.8490.98
67_R71_W0.8480.98
267_T276_I0.8460.98
202_Y208_L0.8430.98
234_N237_R0.8410.98
222_A225_R0.8380.97
125_K128_R0.8360.97
101_L104_S0.8300.97
41_I88_R0.8300.97
191_S195_G0.8230.97
76_E96_R0.8230.97
317_N322_S0.8220.97
161_F178_L0.8210.97
162_W288_G0.8200.97
86_T170_A0.8190.97
163_P166_W0.8190.97
48_T84_A0.8150.97
121_S254_E0.8130.97
90_T101_L0.8110.97
21_V25_K0.8100.97
65_R68_V0.8090.97
50_R54_G0.8070.97
294_A298_P0.8020.97
263_A267_T0.7970.97
55_E66_P0.7940.97
192_A292_L0.7910.96
118_M123_Y0.7900.96
24_W28_H0.7890.96
23_V27_R0.7880.96
180_R184_K0.7840.96
172_T177_L0.7810.96
136_T174_D0.7750.96
168_Y172_T0.7750.96
248_V260_L0.7710.96
233_I237_R0.7710.96
188_A192_A0.7670.96
25_K28_H0.7610.96
189_V209_V0.7590.95
249_I258_G0.7520.95
236_L279_L0.7510.95
126_Q130_A0.7510.95
176_A179_K0.7500.95
309_D315_T0.7490.95
54_G58_Y0.7450.95
227_K230_S0.7430.95
114_L181_A0.7410.95
93_M97_E0.7410.95
210_T279_L0.7380.95
44_L53_L0.7350.95
68_V95_V0.7340.95
202_Y207_Q0.7330.95
328_Q331_L0.7330.95
112_L130_A0.7290.94
127_L177_L0.7270.94
128_R134_K0.7270.94
164_D167_M0.7260.94
31_D34_L0.7250.94
50_R53_L0.7250.94
248_V272_N0.7240.94
186_V190_D0.7230.94
248_V251_G0.7230.94
152_E155_E0.7220.94
197_A297_H0.7220.94
248_V269_T0.7200.94
88_R108_A0.7180.94
160_W282_G0.7160.94
247_T280_P0.7140.94
230_S234_N0.7130.94
143_A155_E0.7120.94
56_Q59_A0.7120.94
163_P185_M0.7100.94
124_L142_Y0.7100.94
61_K92_Q0.7070.93
119_R217_K0.7060.93
188_A292_L0.7050.93
261_S266_E0.7040.93
307_V314_H0.7040.93
246_P249_I0.7030.93
70_Q74_R0.7010.93
269_T275_T0.7010.93
224_E227_K0.6990.93
210_T213_S0.6960.93
273_T280_P0.6940.93
25_K29_L0.6940.93
214_I281_P0.6920.93
71_W75_I0.6910.93
197_A208_L0.6900.93
37_K92_Q0.6870.92
162_W188_A0.6860.92
72_L76_E0.6840.92
69_F73_L0.6840.92
164_D289_A0.6830.92
219_T249_I0.6820.92
113_R116_E0.6810.92
270_A281_P0.6800.92
248_V267_T0.6790.92
121_S253_G0.6790.92
114_L118_M0.6780.92
143_A146_A0.6770.92
16_G20_G0.6760.92
221_V224_E0.6760.92
249_I257_N0.6750.92
72_L99_L0.6740.92
159_G209_V0.6740.92
42_F102_L0.6710.92
305_Y320_L0.6690.91
162_W289_A0.6670.91
160_W185_M0.6670.91
309_D330_Y0.6650.91
17_I20_G0.6640.91
319_N323_H0.6640.91
266_E277_T0.6560.91
97_E100_K0.6560.91
33_K36_I0.6540.91
113_R164_D0.6540.91
157_I182_H0.6540.91
315_T330_Y0.6500.90
322_S326_S0.6490.90
55_E58_Y0.6480.90
150_E153_N0.6480.90
135_H139_D0.6470.90
254_E264_D0.6470.90
141_K146_A0.6440.90
136_T139_D0.6390.89
231_V316_F0.6390.89
206_N283_A0.6370.89
257_N260_L0.6340.89
320_L327_V0.6320.89
222_A291_S0.6310.89
164_D188_A0.6290.89
72_L75_I0.6290.89
87_Y101_L0.6290.89
267_T275_T0.6270.89
52_A55_E0.6240.88
178_L182_H0.6190.88
226_D293_K0.6180.88
216_E288_G0.6180.88
248_V252_M0.6170.88
124_L135_H0.6170.88
138_S178_L0.6160.88
223_S313_G0.6160.88
276_I281_P0.6150.88
252_M255_R0.6140.88
124_L138_S0.6130.87
17_I21_V0.6130.87
116_E164_D0.6130.87
35_L97_E0.6130.87
257_N261_S0.6120.87
39_E90_T0.6120.87
11_L15_L0.6100.87
43_T170_A0.6090.87
211_M306_F0.6080.87
327_V330_Y0.6060.87
200_L298_P0.6060.87
287_P290_D0.6050.87
62_I89_F0.6050.87
50_R79_L0.6050.87
226_D297_H0.6040.87
133_I177_L0.6020.87
259_K262_R0.6000.86
53_L82_F0.6000.86
18_A22_G0.5990.86
100_K104_S0.5970.86
324_N328_Q0.5960.86
258_G265_L0.5950.86
32_S61_K0.5940.86
81_H103_E0.5940.86
73_L78_D0.5860.85
153_N206_N0.5850.85
243_Q275_T0.5850.85
161_F181_A0.5830.85
82_F103_E0.5830.85
287_P292_L0.5830.85
39_E91_P0.5820.85
192_A196_R0.5810.85
29_L32_S0.5790.84
122_D125_K0.5790.84
161_F182_H0.5780.84
140_D144_T0.5770.84
299_A303_Y0.5760.84
182_H185_M0.5750.84
193_W196_R0.5720.84
216_E222_A0.5700.83
189_V208_L0.5700.83
317_N323_H0.5680.83
189_V192_A0.5670.83
252_M257_N0.5660.83
169_T180_R0.5660.83
153_N156_W0.5640.83
24_W27_R0.5640.83
245_D267_T0.5630.83
320_L323_H0.5630.83
225_R229_A0.5610.82
313_G331_L0.5590.82
138_S141_K0.5590.82
280_P284_I0.5590.82
309_D331_L0.5580.82
110_F170_A0.5570.82
158_E250_Y0.5560.82
116_E165_T0.5560.82
249_I255_R0.5530.82
63_I99_L0.5520.81
245_D251_G0.5510.81
78_D81_H0.5500.81
293_K296_A0.5490.81
87_Y107_E0.5490.81
172_T180_R0.5480.81
36_I40_T0.5480.81
307_V326_S0.5470.81
42_F45_K0.5460.81
254_E257_N0.5460.81
146_A157_I0.5460.81
189_V193_W0.5440.81
140_D148_A0.5430.80
258_G330_Y0.5430.80
226_D295_A0.5420.80
151_L160_W0.5410.80
193_W207_Q0.5410.80
123_Y177_L0.5390.80
142_Y178_L0.5390.80
228_V311_K0.5370.80
192_A289_A0.5370.80
185_M286_T0.5370.80
230_S300_K0.5360.80
136_T140_D0.5320.79
128_R138_S0.5320.79
231_V304_L0.5320.79
309_D326_S0.5310.79
248_V264_D0.5300.79
50_R82_F0.5300.79
10_L17_I0.5300.79
184_K289_A0.5280.79
72_L96_R0.5270.78
304_L318_T0.5270.78
86_T108_A0.5270.78
157_I161_F0.5260.78
57_L63_I0.5260.78
246_P284_I0.5260.78
13_V16_G0.5250.78
44_L48_T0.5250.78
159_G206_N0.5230.78
69_F72_L0.5220.78
7_I10_L0.5210.78
195_G199_G0.5200.77
297_H300_K0.5200.77
255_R267_T0.5190.77
82_F102_L0.5160.77
311_K330_Y0.5150.77
97_E101_L0.5150.77
76_E100_K0.5150.77
72_L95_V0.5120.76
120_L157_I0.5120.76
77_P80_S0.5110.76
206_N209_V0.5110.76
120_L156_W0.5100.76
128_R131_P0.5090.76
238_I302_P0.5090.76
49_G82_F0.5090.76
169_T172_T0.5080.76
249_I252_M0.5070.76
98_M102_L0.5070.76
247_T284_I0.5020.75
144_T147_Q0.5010.75
250_Y282_G0.5000.75
32_S36_I0.5000.75
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4iiwA 4 0.85 100 0.114 Contact Map
2r1fA 4 0.7647 100 0.186 Contact Map
4f55A 1 0.3118 91.8 0.95 Contact Map
4b8vA 2 0.4941 71.2 0.961 Contact Map
4fetB 1 0.2882 69.6 0.962 Contact Map
4uz3A 1 0.2882 37.6 0.969 Contact Map
4m1bA 1 0.5588 36.6 0.969 Contact Map
4mxgA 1 0.7206 34.5 0.969 Contact Map
4zj1A 1 0.6706 21 0.972 Contact Map
2v3sA 1 0.2647 20 0.973 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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