GREMLIN Database
PABC - Aminodeoxychorismate lyase
UniProt: P28305 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11493
Length: 269 (255)
Sequences: 9067 (6033)
Seq/√Len: 377.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
186_V217_V4.4061.00
122_T246_A4.2291.00
186_V215_Q3.0481.00
219_V225_E2.9991.00
187_V209_L2.9971.00
24_G142_L2.9861.00
198_N203_Q2.5791.00
170_W220_Q2.4211.00
41_A203_Q2.3591.00
188_Y219_V2.3581.00
174_C177_A2.1771.00
54_M156_Q2.1401.00
124_A159_A2.1211.00
183_K230_D2.0751.00
125_L248_G2.0491.00
124_A157_T2.0201.00
65_Q69_T1.9751.00
232_M244_V1.9731.00
178_N199_G1.9711.00
206_I216_L1.9571.00
25_C49_A1.9401.00
212_S264_L1.9321.00
38_L204_F1.8861.00
69_T72_A1.8381.00
74_Q77_G1.7591.00
259_E263_P1.7581.00
125_L223_L1.7491.00
203_Q207_R1.7391.00
40_S64_E1.7381.00
46_L83_I1.7341.00
23_D85_R1.7291.00
123_L244_V1.6851.00
181_W221_A1.6821.00
50_C83_I1.6751.00
51_Q57_C1.6681.00
32_I240_P1.6671.00
153_H157_T1.6511.00
123_L174_C1.6471.00
180_F235_C1.6241.00
212_S260_Y1.6181.00
260_Y264_L1.5601.00
166_D170_W1.5511.00
25_C50_C1.5311.00
69_T73_E1.5171.00
246_A249_D1.5151.00
29_A36_V1.5111.00
179_L232_M1.4991.00
44_Q48_D1.4981.00
232_M247_C1.4931.00
41_A207_R1.4891.00
205_C235_C1.4861.00
191_R220_Q1.4851.00
47_Q57_C1.4811.00
39_L43_I1.4771.00
181_W229_A1.4671.00
64_E68_K1.4611.00
122_T245_C1.4551.00
66_E102_R1.4541.00
121_I160_D1.4541.00
55_I83_I1.4511.00
182_R257_L1.4431.00
55_I100_A1.4431.00
170_W222_S1.4421.00
31_V71_A1.4321.00
174_C234_I1.4301.00
123_L163_L1.4221.00
122_T160_D1.3981.00
181_W188_Y1.3921.00
73_E77_G1.3901.00
48_D51_Q1.3881.00
194_Q220_Q1.3791.00
40_S44_Q1.3781.00
39_L64_E1.3751.00
187_V214_Y1.3661.00
182_R187_V1.3521.00
65_Q68_K1.3321.00
180_F233_V1.3181.00
207_R211_Q1.3171.00
49_A139_I1.3131.00
246_A251_S1.3121.00
181_W232_M1.3061.00
183_K228_Q1.3061.00
38_L41_A1.3031.00
202_R218_E1.2971.00
260_Y263_P1.2961.00
209_L214_Y1.2731.00
48_D198_N1.2661.00
132_R167_S1.2611.00
36_V39_L1.2491.00
222_S225_E1.2431.00
70_L104_L1.2381.00
163_L179_L1.2301.00
152_S156_Q1.2271.00
236_N239_M1.2251.00
41_A44_Q1.2231.00
36_V67_M1.2211.00
20_Q80_K1.1911.00
44_Q60_W1.1861.00
189_T202_R1.1851.00
68_K72_A1.1811.00
33_D75_Q1.1741.00
188_Y217_V1.1691.00
18_A84_S1.1621.00
231_E258_Y1.1611.00
47_Q60_W1.1431.00
251_S254_S1.1371.00
16_D84_S1.1311.00
67_M79_L1.1301.00
52_R139_I1.1281.00
150_I164_V1.1231.00
221_A225_E1.1191.00
227_L250_V1.1171.00
62_Q65_Q1.1151.00
18_A24_G1.1081.00
224_E228_Q1.1071.00
151_R155_E1.1061.00
61_P65_Q1.0911.00
25_C46_L1.0781.00
66_E104_L1.0781.00
191_R219_V1.0731.00
126_S162_A1.0721.00
182_R231_E1.0701.00
202_R206_I1.0681.00
183_K225_E1.0671.00
183_K188_Y1.0591.00
31_V77_G1.0541.00
180_F202_R1.0521.00
234_I244_V1.0521.00
123_L234_I1.0501.00
67_M104_L1.0421.00
127_P153_H1.0281.00
188_Y221_A1.0261.00
191_R218_E1.0251.00
153_H156_Q1.0231.00
41_A204_F1.0201.00
43_I64_E1.0181.00
192_L202_R1.0101.00
82_V103_I1.0001.00
214_Y257_L0.9941.00
70_L106_V0.9931.00
47_Q51_Q0.9881.00
169_G224_E0.9821.00
44_Q47_Q0.9811.00
192_L198_N0.9781.00
52_R138_G0.9741.00
245_C255_A0.9731.00
180_F206_I0.9721.00
161_E175_C0.9601.00
26_F144_R0.9581.00
256_T259_E0.9561.00
163_L226_S0.9521.00
171_V179_L0.9511.00
93_S96_N0.9501.00
86_G101_T0.9441.00
9_Q13_A0.9381.00
165_L223_L0.9381.00
190_P221_A0.9351.00
166_D195_A0.9341.00
178_N235_C0.9311.00
48_D138_G0.9281.00
7_H11_S0.9271.00
83_I102_R0.9221.00
19_T84_S0.9221.00
120_G245_C0.9211.00
25_C83_I0.9201.00
171_V181_W0.9171.00
82_V142_L0.9111.00
73_E76_N0.9111.00
209_L261_L0.9071.00
259_E262_A0.9071.00
43_I47_Q0.9011.00
16_D86_G0.8991.00
209_L216_L0.8951.00
57_C83_I0.8921.00
48_D52_R0.8871.00
199_G235_C0.8851.00
121_I242_M0.8791.00
209_L212_S0.8781.00
210_A218_E0.8771.00
157_T248_G0.8741.00
59_F62_Q0.8621.00
66_E69_T0.8561.00
54_M152_S0.8551.00
161_E177_A0.8531.00
187_V233_V0.8511.00
150_I162_A0.8511.00
14_V103_I0.8471.00
161_E174_C0.8471.00
43_I67_M0.8381.00
124_A248_G0.8291.00
184_G230_D0.8291.00
123_L161_E0.8271.00
185_N215_Q0.8271.00
16_D88_G0.8211.00
20_Q82_V0.8201.00
12_L19_T0.8141.00
229_A232_M0.8131.00
50_C57_C0.8121.00
210_A215_Q0.8121.00
47_Q63_L0.8091.00
126_S153_H0.8071.00
117_R262_A0.8071.00
168_E220_Q0.8071.00
39_L67_M0.8051.00
31_V36_V0.8041.00
32_I37_S0.8031.00
207_R210_A0.8021.00
193_D220_Q0.7961.00
231_E255_A0.7941.00
116_L160_D0.7871.00
188_Y225_E0.7841.00
41_A200_I0.7831.00
20_Q105_S0.7821.00
37_S204_F0.7811.00
94_T152_S0.7771.00
173_E197_V0.7761.00
150_I175_C0.7731.00
10_E14_V0.7681.00
43_I63_L0.7671.00
117_R120_G0.7661.00
172_T196_G0.7661.00
165_L171_V0.7601.00
257_L260_Y0.7581.00
50_C55_I0.7541.00
62_Q66_E0.7531.00
31_V79_L0.7531.00
151_R176_A0.7521.00
206_I218_E0.7521.00
151_R161_E0.7511.00
71_A77_G0.7501.00
11_S14_V0.7451.00
180_F189_T0.7441.00
211_Q264_L0.7441.00
29_A67_M0.7441.00
204_F207_R0.7401.00
182_R233_V0.7381.00
30_R76_N0.7341.00
17_R23_D0.7341.00
29_A81_V0.7281.00
252_F255_A0.7241.00
87_S101_T0.7241.00
93_S155_E0.7221.00
30_R237_A0.7211.00
18_A142_L0.7181.00
53_L141_H0.7171.00
129_R134_P0.7171.00
152_S155_E0.7171.00
22_G143_N0.7171.00
28_T78_V0.7161.00
206_I210_A0.7151.00
154_L158_N0.7091.00
225_E228_Q0.7091.00
53_L145_L0.7071.00
28_T238_L0.7051.00
10_E103_I0.7040.99
185_N230_D0.7030.99
119_E160_D0.7030.99
27_T49_A0.7020.99
224_E227_L0.7010.99
61_P64_E0.7000.99
179_L190_P0.7000.99
159_A248_G0.6940.99
118_N259_E0.6940.99
33_D76_N0.6920.99
169_G223_L0.6890.99
122_T159_A0.6890.99
58_D62_Q0.6860.99
126_S150_I0.6820.99
90_R93_S0.6790.99
84_S103_I0.6760.99
30_R240_P0.6750.99
78_V107_T0.6740.99
177_A234_I0.6730.99
63_L102_R0.6720.99
36_V79_L0.6710.99
226_S232_M0.6700.99
19_T103_I0.6610.99
239_M242_M0.6600.99
84_S101_T0.6580.99
204_F208_L0.6580.99
23_D148_V0.6560.99
191_R194_Q0.6520.99
208_L212_S0.6510.99
256_T260_Y0.6510.99
201_M265_C0.6490.99
189_T218_E0.6490.99
150_I153_H0.6430.99
223_L227_L0.6430.99
78_V238_L0.6410.99
241_V261_L0.6400.99
38_L200_I0.6370.99
141_H145_L0.6320.99
125_L165_L0.6290.99
232_M252_F0.6260.99
77_G106_V0.6250.99
92_Y147_Q0.6240.99
132_R168_E0.6240.99
226_S247_C0.6230.99
221_A229_A0.6230.99
130_L144_R0.6200.99
44_Q203_Q0.6190.99
140_K197_V0.6170.99
67_M81_V0.6170.99
171_V221_A0.6150.99
144_R147_Q0.6150.99
12_L16_D0.6140.99
59_F63_L0.6080.99
37_S237_A0.6070.99
162_A175_C0.6030.98
125_L247_C0.6020.98
210_A216_L0.6010.98
31_V106_V0.6000.98
163_L232_M0.6000.98
19_T82_V0.5990.98
86_G99_P0.5980.98
113_Y116_L0.5960.98
28_T236_N0.5960.98
60_W64_E0.5950.98
183_K229_A0.5940.98
17_R85_R0.5920.98
128_V153_H0.5900.98
180_F187_V0.5900.98
25_C53_L0.5900.98
51_Q56_S0.5890.98
233_V241_V0.5880.98
185_N214_Y0.5870.98
59_F102_R0.5860.98
132_R135_H0.5850.98
59_F66_E0.5830.98
200_I203_Q0.5820.98
140_K173_E0.5810.98
121_I234_I0.5800.98
123_L247_C0.5780.98
90_R94_T0.5750.98
15_S20_Q0.5720.98
32_I76_N0.5710.98
29_A39_L0.5680.98
200_I204_F0.5670.98
131_G146_E0.5650.98
233_V258_Y0.5600.97
36_V71_A0.5590.97
15_S87_S0.5560.97
170_W194_Q0.5550.97
181_W226_S0.5540.97
39_L68_K0.5510.97
192_L218_E0.5500.97
80_K142_L0.5490.97
30_R37_S0.5480.97
36_V68_K0.5460.97
129_R167_S0.5420.97
180_F205_C0.5420.97
27_T46_L0.5410.97
182_R185_N0.5410.97
120_G242_M0.5410.97
258_Y262_A0.5380.97
46_L81_V0.5360.97
154_L162_A0.5340.97
25_C141_H0.5330.97
116_L242_M0.5330.97
125_L226_S0.5320.97
124_A153_H0.5270.96
25_C139_I0.5260.96
13_A87_S0.5250.96
201_M237_A0.5230.96
151_R175_C0.5230.96
45_R197_V0.5220.96
79_L106_V0.5200.96
189_T196_G0.5200.96
186_V219_V0.5170.96
70_L74_Q0.5160.96
189_T192_L0.5150.96
84_S142_L0.5120.96
55_I85_R0.5110.96
131_G137_A0.5100.96
129_R132_R0.5080.96
235_C241_V0.5070.96
227_L248_G0.5050.95
92_Y144_R0.5040.95
154_L159_A0.5040.95
11_S15_S0.5030.95
240_P265_C0.5020.95
37_S41_A0.5000.95
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1i2kA 2 1 100 0.08 Contact Map
2y4rA 2 0.9963 100 0.098 Contact Map
1iyeA 5 1 100 0.122 Contact Map
3lulA 2 0.9591 100 0.125 Contact Map
2eiyA 5 0.9963 100 0.126 Contact Map
4tm5A 2 0.9851 100 0.13 Contact Map
3u0gA 5 0.9926 100 0.134 Contact Map
3snoA 2 0.8364 100 0.135 Contact Map
4chiA 2 0.9926 100 0.135 Contact Map
3daaA 2 0.9814 100 0.139 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0094 seconds.