GREMLIN Database
QOR1 - Quinone oxidoreductase 1
UniProt: P28304 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11492
Length: 327 (303)
Sequences: 52951 (36422)
Seq/√Len: 2092.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
306_D309_R2.9601.00
36_K115_F2.8711.00
34_E70_S2.8051.00
36_K68_I2.7511.00
8_H19_V2.6701.00
32_Q70_S2.6391.00
31_I106_A2.5591.00
162_K187_W2.5171.00
143_Q167_K2.5161.00
114_S117_Q2.5091.00
84_R109_L2.3841.00
83_D108_I2.3741.00
80_K83_D2.3391.00
200_R203_E2.2941.00
179_Q183_K2.2931.00
302_Y313_I2.2841.00
34_E68_I2.2541.00
23_P98_V2.1831.00
34_E98_V2.1451.00
167_K188_Q2.1401.00
65_A94_A2.1301.00
116_E301_K2.1041.00
178_A182_L2.0881.00
144_F161_A2.0821.00
78_H103_A2.0531.00
285_S289_S2.0511.00
149_A170_G2.0501.00
303_P306_D2.0271.00
300_Q313_I2.0181.00
139_K142_E1.9871.00
28_E74_S1.9861.00
27_A30_E1.9691.00
6_E19_V1.9681.00
29_N75_G1.9671.00
158_C186_A1.9581.00
8_H17_Q1.9481.00
133_R164_L1.9301.00
65_A87_Y1.9091.00
66_A115_F1.9051.00
28_E75_G1.8991.00
112_A288_A1.8931.00
84_R115_F1.8821.00
312_E316_S1.8451.00
25_D71_K1.8341.00
125_G156_I1.8011.00
142_E234_L1.8001.00
70_S98_V1.7821.00
32_Q100_N1.7731.00
133_R282_E1.7551.00
179_Q182_L1.7521.00
145_L171_T1.7511.00
49_S315_E1.7351.00
145_L210_V1.7301.00
309_R312_E1.7271.00
163_A291_V1.7001.00
175_A179_Q1.7001.00
178_A189_V1.6971.00
169_I210_V1.6901.00
211_R230_Q1.6901.00
302_Y310_A1.6821.00
234_L260_Y1.6611.00
109_L115_F1.6611.00
73_G76_V1.6531.00
172_V178_A1.6481.00
313_I318_A1.6371.00
309_R313_I1.6201.00
109_L118_A1.6001.00
229_L235_M1.5801.00
256_K259_L1.5691.00
147_H225_S1.5661.00
175_A191_N1.5521.00
229_L259_L1.5451.00
72_V81_A1.5251.00
188_Q204_I1.5251.00
195_E200_R1.5171.00
79_I108_I1.5151.00
167_K187_W1.5121.00
30_E102_I1.5091.00
191_N194_E1.5051.00
180_S183_K1.5031.00
234_L262_T1.4991.00
175_A194_E1.4991.00
196_D199_E1.4961.00
95_Y311_H1.4781.00
26_P100_N1.4691.00
71_K81_A1.4681.00
136_Y212_V1.4591.00
35_N65_A1.4531.00
32_Q98_V1.4421.00
79_I83_D1.4271.00
229_L233_G1.4141.00
68_I84_R1.4041.00
173_G192_Y1.3961.00
29_N102_I1.3881.00
26_P32_Q1.3791.00
84_R111_A1.3781.00
30_E100_N1.3551.00
37_A116_E1.3541.00
213_V225_S1.3511.00
213_V229_L1.3421.00
158_C170_G1.3371.00
48_R311_H1.3361.00
308_Q312_E1.3291.00
69_V79_I1.3131.00
150_A170_G1.3131.00
199_E203_E1.2981.00
32_Q71_K1.2911.00
299_Q313_I1.2861.00
31_I79_I1.2761.00
143_Q169_I1.2611.00
68_I115_F1.2591.00
147_H171_T1.2441.00
157_A214_Y1.2431.00
163_A286_L1.2221.00
285_S288_A1.2181.00
129_Y133_R1.1881.00
79_I106_A1.1711.00
150_A172_V1.1601.00
138_I166_A1.1601.00
23_P32_Q1.1541.00
36_K84_R1.1381.00
182_L189_V1.1291.00
26_P30_E1.1191.00
143_Q211_R1.1141.00
175_A178_A1.1131.00
159_Q293_K1.1111.00
178_A191_N1.1061.00
101_I106_A1.1051.00
29_N103_A1.0961.00
35_N99_H1.0911.00
70_S81_A1.0861.00
33_V67_G1.0821.00
282_E285_S1.0731.00
200_R204_I1.0691.00
174_T191_N1.0611.00
277_T281_N1.0601.00
117_Q293_K1.0591.00
142_E211_R1.0521.00
136_Y236_V1.0501.00
170_G186_A1.0481.00
48_R315_E1.0451.00
182_L188_Q1.0431.00
18_A305_K1.0411.00
40_I310_A1.0361.00
173_G193_R1.0251.00
130_Y279_A1.0241.00
133_R279_A1.0221.00
37_A115_F1.0051.00
227_D252_I1.0041.00
38_I95_Y1.0041.00
286_L291_V1.0031.00
307_A325_L1.0021.00
128_V160_W1.0011.00
180_S320_Q0.9991.00
217_V221_T0.9941.00
196_D200_R0.9941.00
36_K66_A0.9901.00
128_V157_A0.9881.00
33_V85_V0.9871.00
41_N64_E0.9831.00
41_N63_T0.9711.00
198_V227_D0.9691.00
194_E200_R0.9651.00
95_Y307_A0.9631.00
281_N285_S0.9561.00
135_T260_Y0.9511.00
205_T209_K0.9451.00
138_I142_E0.9341.00
161_A166_A0.9331.00
117_Q295_D0.9321.00
72_V76_V0.9291.00
6_E21_F0.9281.00
169_I188_Q0.9281.00
38_I94_A0.9281.00
23_P71_K0.9241.00
215_D218_G0.9231.00
146_F157_A0.9201.00
113_I118_A0.9181.00
131_L238_F0.9171.00
173_G178_A0.9151.00
293_K296_V0.9131.00
158_C168_L0.9121.00
252_I256_K0.9051.00
125_G283_L0.9031.00
183_K296_V0.9021.00
313_I323_S0.9001.00
312_E315_E0.8951.00
129_Y282_E0.8941.00
201_L210_V0.8921.00
45_T314_L0.8901.00
198_V224_R0.8891.00
34_E97_S0.8881.00
223_E227_D0.8831.00
6_E60_G0.8771.00
25_D32_Q0.8761.00
224_R227_D0.8731.00
76_V103_A0.8721.00
77_K103_A0.8711.00
171_T192_Y0.8701.00
147_H213_V0.8681.00
172_V189_V0.8671.00
160_W283_L0.8631.00
253_L261_V0.8621.00
146_F161_A0.8611.00
80_K108_I0.8601.00
155_L180_S0.8591.00
121_S287_I0.8581.00
145_L228_C0.8521.00
65_A99_H0.8521.00
95_Y325_L0.8461.00
29_N73_G0.8431.00
169_I190_I0.8411.00
176_Q179_Q0.8401.00
23_P70_S0.8401.00
59_S92_L0.8381.00
131_L214_Y0.8301.00
39_G64_E0.8291.00
249_N252_I0.8281.00
232_R258_S0.8261.00
198_V202_K0.8251.00
111_A288_A0.8151.00
143_Q210_V0.8131.00
177_K320_Q0.8131.00
314_L323_S0.8111.00
142_E212_V0.8101.00
160_W286_L0.8031.00
278_E282_E0.8031.00
302_Y306_D0.8021.00
174_T177_K0.8011.00
41_N44_D0.7981.00
21_F92_L0.7981.00
40_I314_L0.7951.00
86_V284_F0.7951.00
282_E286_L0.7951.00
170_G181_A0.7941.00
18_A304_L0.7941.00
181_A186_A0.7941.00
37_A324_L0.7911.00
128_V153_V0.7781.00
132_L161_A0.7761.00
29_N74_S0.7701.00
126_L279_A0.7671.00
128_V156_I0.7641.00
131_L157_A0.7641.00
197_L224_R0.7641.00
150_A181_A0.7591.00
198_V228_C0.7581.00
164_L282_E0.7551.00
144_F166_A0.7531.00
40_I95_Y0.7511.00
169_I201_L0.7501.00
130_Y258_S0.7501.00
302_Y325_L0.7491.00
199_E202_K0.7481.00
196_D224_R0.7471.00
225_S235_M0.7461.00
286_L289_S0.7451.00
72_V80_K0.7431.00
27_A100_N0.7421.00
133_R160_W0.7401.00
138_I212_V0.7361.00
149_A158_C0.7361.00
161_A168_L0.7361.00
26_P71_K0.7341.00
14_E312_E0.7331.00
64_E123_L0.7301.00
169_I204_I0.7301.00
85_V106_A0.7301.00
278_E281_N0.7291.00
213_V235_M0.7281.00
87_Y101_I0.7251.00
43_I63_T0.7251.00
286_L290_G0.7241.00
237_S261_V0.7221.00
113_I287_I0.7221.00
168_L187_W0.7221.00
31_I103_A0.7201.00
205_T208_K0.7201.00
88_A92_L0.7171.00
41_N123_L0.7161.00
135_T262_T0.7161.00
146_F170_G0.7121.00
202_K205_T0.7111.00
216_S238_F0.7091.00
26_P73_G0.7091.00
7_F15_V0.7051.00
296_V299_Q0.7041.00
208_K230_Q0.7001.00
210_V213_V0.6991.00
110_P288_A0.6981.00
107_A281_N0.6971.00
21_F60_G0.6961.00
137_E260_Y0.6941.00
300_Q309_R0.6941.00
313_I316_S0.6911.00
86_V109_L0.6911.00
37_A301_K0.6891.00
166_A212_V0.6881.00
137_E234_L0.6801.00
300_Q323_S0.6781.00
201_L228_C0.6781.00
128_V132_L0.6771.00
212_V236_V0.6771.00
244_A247_G0.6761.00
84_R112_A0.6751.00
147_H221_T0.6711.00
107_A280_S0.6701.00
183_K293_K0.6681.00
94_A99_H0.6671.00
66_A119_A0.6621.00
129_Y283_L0.6601.00
124_K152_G0.6581.00
172_V181_A0.6581.00
178_A181_A0.6551.00
31_I69_V0.6551.00
253_L259_L0.6551.00
63_T123_L0.6541.00
127_T153_V0.6531.00
123_L127_T0.6511.00
78_H108_I0.6491.00
8_H15_V0.6481.00
319_T323_S0.6461.00
12_G15_V0.6451.00
33_V87_Y0.6451.00
137_E262_T0.6451.00
42_F46_Y0.6441.00
41_N124_K0.6441.00
284_F288_A0.6441.00
129_Y286_L0.6421.00
66_A109_L0.6401.00
107_A284_F0.6391.00
24_A100_N0.6361.00
253_L263_R0.6361.00
86_V122_F0.6331.00
311_H315_E0.6321.00
222_W235_M0.6291.00
172_V192_Y0.6261.00
29_N104_D0.6251.00
244_A249_N0.6251.00
162_K168_L0.6241.00
78_H277_T0.6221.00
223_E252_I0.6181.00
143_Q208_K0.6151.00
18_A307_A0.6121.00
210_V228_C0.6121.00
215_D235_M0.6111.00
83_D111_A0.6101.00
213_V228_C0.6091.00
35_N38_I0.6091.00
136_Y234_L0.6091.00
37_A66_A0.6081.00
206_G209_K0.6061.00
180_S184_A0.6041.00
78_H81_A0.6031.00
66_A84_R0.6031.00
188_Q200_R0.6021.00
158_C184_A0.5951.00
157_A238_F0.5941.00
302_Y323_S0.5941.00
43_I47_I0.5941.00
180_S295_D0.5911.00
220_D223_E0.5911.00
150_A158_C0.5911.00
212_V234_L0.5901.00
171_T190_I0.5891.00
129_Y279_A0.5881.00
24_A32_Q0.5871.00
127_T238_F0.5871.00
160_W164_L0.5871.00
24_A98_V0.5861.00
178_A192_Y0.5831.00
231_R256_K0.5831.00
221_T225_S0.5831.00
26_P75_G0.5821.00
134_K279_A0.5821.00
114_S118_A0.5801.00
159_Q184_A0.5801.00
87_Y106_A0.5801.00
197_L201_L0.5771.00
120_A324_L0.5751.00
149_A181_A0.5741.00
66_A118_A0.5731.00
202_K209_K0.5731.00
181_A189_V0.5711.00
46_Y51_L0.5711.00
124_K156_I0.5671.00
287_I294_V0.5641.00
144_F212_V0.5631.00
62_G95_Y0.5621.00
77_K80_K0.5621.00
155_L295_D0.5621.00
236_V264_P0.5611.00
131_L264_P0.5611.00
145_L213_V0.5601.00
45_T315_E0.5561.00
215_D239_G0.5551.00
72_V83_D0.5531.00
55_P59_S0.5521.00
172_V177_K0.5511.00
313_I319_T0.5511.00
23_P26_P0.5501.00
33_V106_A0.5501.00
107_A277_T0.5501.00
251_G254_N0.5491.00
190_I204_I0.5471.00
258_S268_G0.5471.00
300_Q306_D0.5441.00
158_C181_A0.5441.00
102_I105_K0.5421.00
43_I46_Y0.5421.00
156_I160_W0.5391.00
172_V191_N0.5391.00
254_N263_R0.5391.00
47_I52_Y0.5381.00
132_L160_W0.5371.00
23_P100_N0.5361.00
42_F151_G0.5351.00
13_P312_E0.5331.00
79_I103_A0.5311.00
290_G293_K0.5311.00
103_A106_A0.5261.00
16_L311_H0.5261.00
115_F118_A0.5261.00
162_K186_A0.5251.00
140_P164_L0.5251.00
56_S59_S0.5241.00
169_I205_T0.5231.00
120_A294_V0.5231.00
35_N94_A0.5221.00
129_Y164_L0.5211.00
147_H197_L0.5211.00
7_F16_L0.5211.00
22_T25_D0.5201.00
41_N322_S0.5201.00
35_N87_Y0.5201.00
143_Q205_T0.5191.00
33_V65_A0.5161.00
223_E247_G0.5161.00
150_A177_K0.5151.00
287_I292_I0.5151.00
122_F280_S0.5141.00
45_T49_S0.5121.00
190_I195_E0.5111.00
114_S301_K0.5101.00
14_E48_R0.5101.00
26_P29_N0.5081.00
39_G119_A0.5061.00
173_G191_N0.5051.00
110_P118_A0.5051.00
7_F48_R0.5021.00
155_L184_A0.5021.00
140_P165_G0.5011.00
302_Y309_R0.5011.00
203_E206_G0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1qorA 2 0.9969 100 0.149 Contact Map
3jynA 2 0.9939 100 0.154 Contact Map
4j6fA 2 0.9572 100 0.169 Contact Map
1wlyA 2 0.9694 100 0.171 Contact Map
4gi2A 2 0.9664 100 0.174 Contact Map
3uogA 4 0.9572 100 0.174 Contact Map
1h2bA 4 0.9419 100 0.178 Contact Map
2eihA 4 0.9633 100 0.179 Contact Map
3qwbA 2 0.9817 100 0.18 Contact Map
4rvuA 2 0.9847 100 0.181 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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