GREMLIN Database
DINF - DNA-damage-inducible protein F
UniProt: P28303 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11491
Length: 459 (424)
Sequences: 18283 (13775)
Seq/√Len: 669.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
99_N102_A4.7621.00
159_A217_Y3.9441.00
148_R206_Q3.3761.00
67_A289_A3.2821.00
92_A314_G3.1551.00
355_I368_A3.1091.00
350_A353_H3.1011.00
130_D147_R3.0331.00
250_R254_A2.9161.00
130_D134_H2.8021.00
175_Y178_A2.8021.00
321_D324_Q2.7911.00
128_I131_L2.7621.00
196_W201_L2.5371.00
87_T110_P2.5281.00
152_I206_Q2.5071.00
189_L218_A2.4801.00
53_V198_V2.4621.00
246_R250_R2.4471.00
147_R151_E2.4261.00
94_A102_A2.3601.00
397_R445_I2.3321.00
61_V141_A2.3261.00
53_V195_V2.2911.00
65_G145_Q2.2861.00
27_K31_H2.2361.00
186_G219_T2.1831.00
309_V332_A2.1491.00
145_Q148_R2.1311.00
182_L222_I2.1211.00
139_S282_S2.0931.00
330_R334_R2.0521.00
152_I209_A2.0301.00
162_A220_L2.0251.00
362_T366_Q2.0201.00
351_G373_I1.9911.00
50_D212_T1.9851.00
423_G426_A1.9701.00
287_V367_L1.9631.00
198_V208_A1.9591.00
58_D62_Y1.9471.00
203_M210_L1.9451.00
156_S213_V1.9371.00
206_Q210_L1.9371.00
363_Q366_Q1.9281.00
370_R425_H1.9191.00
144_E148_R1.9081.00
54_I208_A1.9021.00
37_I304_G1.9001.00
316_A324_Q1.8791.00
352_E369_D1.8591.00
114_A165_V1.8501.00
94_A99_N1.8481.00
53_V194_D1.8331.00
283_D363_Q1.7991.00
196_W200_G1.7981.00
34_L38_F1.7651.00
177_R181_I1.7341.00
94_A97_A1.7321.00
221_L225_L1.6981.00
381_V436_A1.6861.00
155_L158_P1.6821.00
351_G369_D1.6791.00
312_H328_V1.6771.00
152_I210_L1.6661.00
188_I192_V1.6641.00
134_H143_L1.6621.00
129_I147_R1.6461.00
33_A308_A1.6451.00
182_L223_G1.6421.00
159_A220_L1.6371.00
327_D330_R1.6331.00
329_W388_L1.6191.00
348_L373_I1.6181.00
105_R244_A1.6071.00
317_Y395_A1.6071.00
131_L134_H1.6061.00
326_L330_R1.6021.00
327_D331_A1.5891.00
336_S383_V1.5851.00
90_L106_T1.5811.00
317_Y325_L1.5591.00
352_E356_A1.5361.00
49_V191_I1.5331.00
152_I213_V1.5321.00
195_V199_M1.5101.00
344_S348_L1.4981.00
194_D208_A1.4961.00
143_L147_R1.4931.00
195_V201_L1.4931.00
316_A321_D1.4851.00
125_R154_W1.4841.00
140_E144_E1.4711.00
192_V196_W1.4671.00
440_L444_A1.4661.00
69_G150_L1.4591.00
197_L201_L1.4591.00
166_L223_G1.4571.00
129_I151_E1.4561.00
323_S327_D1.4541.00
122_A158_P1.4531.00
422_L426_A1.4481.00
100_P104_A1.4481.00
444_A447_R1.4421.00
353_H356_A1.4411.00
397_R400_E1.4401.00
141_A144_E1.4381.00
130_D144_E1.4351.00
26_D331_A1.4291.00
134_H140_E1.4231.00
193_L211_A1.4211.00
25_S312_H1.4051.00
189_L193_L1.4041.00
131_L135_I1.4041.00
192_V195_V1.4031.00
356_A365_Q1.3971.00
329_W391_M1.3931.00
94_A106_T1.3801.00
133_L143_L1.3771.00
369_D373_I1.3761.00
374_W429_L1.3751.00
50_D190_N1.3681.00
334_R338_I1.3631.00
181_I185_V1.3631.00
102_A105_R1.3591.00
54_I66_V1.3551.00
197_L203_M1.3501.00
443_A447_R1.3461.00
96_G318_G1.3451.00
141_A282_S1.3371.00
101_Q105_R1.3361.00
206_Q209_A1.3301.00
42_T184_V1.3271.00
38_F180_V1.3251.00
417_L421_W1.3161.00
62_Y145_Q1.3051.00
353_H357_L1.3001.00
130_D143_L1.2961.00
95_Y315_Q1.2951.00
93_Q314_G1.2931.00
95_Y103_L1.2901.00
23_T27_K1.2871.00
64_G286_A1.2851.00
322_G326_L1.2811.00
93_Q97_A1.2801.00
193_L214_I1.2761.00
247_G250_R1.2751.00
182_L226_M1.2741.00
336_S387_L1.2691.00
348_L376_V1.2691.00
366_Q370_R1.2671.00
444_A448_R1.2611.00
294_L354_I1.2571.00
400_E445_I1.2481.00
51_T293_T1.2241.00
26_D335_Q1.2211.00
355_I365_Q1.2151.00
102_A248_N1.2131.00
56_H360_S1.2111.00
345_V349_L1.2101.00
51_T63_L1.1981.00
426_A430_A1.1961.00
190_N212_T1.1961.00
57_L199_M1.1921.00
194_D211_A1.1861.00
399_T403_N1.1751.00
61_V145_Q1.1541.00
93_Q396_T1.1511.00
185_V222_I1.1511.00
195_V198_V1.1421.00
65_G142_V1.1391.00
122_A126_T1.1301.00
306_A390_G1.1301.00
126_T151_E1.1241.00
445_I448_R1.1241.00
313_S325_L1.1241.00
197_L214_I1.1231.00
66_V205_V1.1211.00
56_H199_M1.1161.00
422_L429_L1.1101.00
257_R261_L1.1041.00
407_V411_G1.1011.00
24_S27_K1.0991.00
109_Q249_F1.0951.00
91_T172_G1.0911.00
388_L446_W1.0911.00
133_L146_A1.0891.00
113_L249_F1.0891.00
404_S442_L1.0821.00
59_S361_L1.0791.00
107_L169_W1.0791.00
367_L370_R1.0741.00
284_I424_N1.0731.00
175_Y179_P1.0711.00
283_D367_L1.0661.00
329_W446_W1.0601.00
276_L280_L1.0601.00
225_L229_K1.0581.00
291_L371_Y1.0571.00
189_L215_A1.0551.00
29_L332_A1.0551.00
50_D194_D1.0521.00
178_A226_M1.0491.00
365_Q368_A1.0481.00
275_V279_R1.0441.00
338_I342_L1.0411.00
385_C435_L1.0321.00
197_L200_G1.0281.00
403_N407_V1.0281.00
114_A161_L1.0191.00
127_P131_L1.0171.00
96_G319_A1.0171.00
174_Q315_Q1.0161.00
200_G203_M1.0151.00
195_V200_G1.0141.00
210_L213_V1.0141.00
411_G414_L0.9991.00
115_L162_A0.9991.00
151_E155_L0.9981.00
106_T248_N0.9941.00
331_A335_Q0.9941.00
105_R248_N0.9941.00
30_W34_L0.9911.00
110_P252_L0.9881.00
68_V138_G0.9821.00
52_A55_G0.9821.00
61_V282_S0.9801.00
251_R254_A0.9781.00
95_Y173_V0.9761.00
352_E366_Q0.9751.00
392_F445_I0.9721.00
184_V188_I0.9711.00
122_A155_L0.9701.00
108_V241_L0.9611.00
304_G308_A0.9551.00
366_Q369_D0.9521.00
359_T364_I0.9451.00
104_A240_M0.9441.00
194_D212_T0.9411.00
316_A328_V0.9381.00
47_G70_A0.9361.00
126_T130_D0.9351.00
287_V364_I0.9341.00
129_I150_L0.9331.00
341_L345_V0.9311.00
415_T433_V0.9301.00
371_Y424_N0.9301.00
213_V217_Y0.9281.00
294_L347_Y0.9271.00
95_Y100_P0.9211.00
414_L418_T0.9201.00
49_V190_N0.9191.00
290_V358_L0.9151.00
416_L420_P0.9141.00
419_L422_L0.9121.00
333_C384_W0.9101.00
166_L220_L0.9101.00
374_W425_H0.9081.00
239_E242_K0.9071.00
93_Q317_Y0.9061.00
363_Q367_L0.9041.00
175_Y226_M0.9011.00
36_M307_Y0.9011.00
434_F438_R0.9001.00
342_L346_V0.8991.00
80_L161_L0.8991.00
127_P151_E0.8981.00
218_A222_I0.8951.00
193_L197_L0.8931.00
237_S240_M0.8931.00
116_G120_L0.8921.00
170_L227_V0.8911.00
217_Y221_L0.8871.00
241_L244_A0.8861.00
145_Q205_V0.8851.00
412_F437_L0.8851.00
28_A31_H0.8791.00
325_L329_W0.8781.00
148_R151_E0.8741.00
238_G241_L0.8711.00
222_I225_L0.8691.00
265_L406_A0.8691.00
93_Q251_R0.8681.00
348_L352_E0.8681.00
342_L345_V0.8661.00
381_V439_G0.8621.00
155_L213_V0.8601.00
349_L353_H0.8581.00
325_L395_A0.8581.00
313_S391_M0.8521.00
87_T91_T0.8471.00
425_H429_L0.8461.00
53_V199_M0.8461.00
57_L202_H0.8451.00
190_N194_D0.8411.00
73_T153_R0.8411.00
42_T187_N0.8391.00
284_I367_L0.8381.00
351_G372_L0.8361.00
210_L214_I0.8331.00
49_V187_N0.8321.00
254_A399_T0.8301.00
123_L127_P0.8291.00
313_S394_G0.8241.00
32_L176_A0.8241.00
280_L420_P0.8231.00
140_E143_L0.8191.00
288_N428_W0.8181.00
163_N219_T0.8161.00
104_A237_S0.8131.00
181_I184_V0.8121.00
302_L340_A0.8121.00
355_I369_D0.8111.00
29_L331_A0.8101.00
244_A247_G0.8061.00
365_Q369_D0.8041.00
287_V368_A0.8041.00
261_L402_R0.8021.00
129_I154_W0.8001.00
277_G424_N0.7981.00
305_F332_A0.7951.00
324_Q327_D0.7941.00
287_V371_Y0.7941.00
430_A434_F0.7941.00
26_D334_R0.7941.00
55_G63_L0.7941.00
424_N428_W0.7941.00
61_V142_V0.7941.00
338_I341_L0.7901.00
120_L124_L0.7891.00
316_A319_A0.7871.00
293_T358_L0.7831.00
64_G142_V0.7811.00
327_D334_R0.7811.00
185_V189_L0.7801.00
180_V184_V0.7801.00
54_I198_V0.7801.00
170_L223_G0.7801.00
142_V285_I0.7781.00
166_L227_V0.7751.00
229_K232_K0.7751.00
152_I155_L0.7741.00
290_V368_A0.7731.00
429_L432_T0.7711.00
124_L128_I0.7681.00
90_L255_L0.7681.00
110_P165_V0.7681.00
276_L279_R0.7671.00
144_E147_R0.7661.00
362_T365_Q0.7631.00
436_A440_L0.7601.00
61_V64_G0.7591.00
332_A387_L0.7591.00
92_A172_G0.7571.00
171_L179_P0.7561.00
46_L212_T0.7551.00
101_Q240_M0.7551.00
337_G341_L0.7551.00
408_A438_R0.7541.00
112_L116_G0.7531.00
348_L351_G0.7521.00
374_W432_T0.7511.00
170_L178_A0.7511.00
202_H206_Q0.7501.00
28_A312_H0.7491.00
361_L365_Q0.7491.00
48_L297_F0.7481.00
323_S330_R0.7481.00
91_T169_W0.7481.00
89_G93_Q0.7461.00
384_W439_G0.7461.00
194_D198_V0.7451.00
59_S62_Y0.7431.00
28_A315_Q0.7421.00
90_L94_A0.7401.00
148_R205_V0.7401.00
175_Y230_I0.7391.00
65_G205_V0.7341.00
341_L380_V0.7341.00
313_S329_W0.7341.00
419_L426_A0.7331.00
97_A318_G0.7331.00
190_N215_A0.7311.00
133_L150_L0.7291.00
388_L442_L0.7261.00
280_L284_I0.7261.00
390_G394_G0.7261.00
331_A334_R0.7261.00
42_T45_L0.7261.00
39_S183_L0.7241.00
126_T129_I0.7201.00
52_A357_L0.7161.00
251_R396_T0.7121.00
228_R231_L0.7121.00
334_R337_G0.7101.00
340_A383_V0.7101.00
128_I132_A0.7061.00
108_V240_M0.7051.00
248_N251_R0.7051.00
316_A325_L0.7021.00
33_A304_G0.7021.00
256_N260_M0.7021.00
79_L260_M0.7011.00
149_F194_D0.7011.00
49_V53_V0.7001.00
350_A354_I0.7001.00
264_L268_L0.6991.00
112_L241_L0.6971.00
65_G146_A0.6961.00
26_D30_W0.6951.00
89_G255_L0.6941.00
364_I368_A0.6941.00
45_L49_V0.6941.00
150_L154_W0.6931.00
225_L228_R0.6921.00
337_G383_V0.6921.00
377_I380_V0.6911.00
209_A213_V0.6911.00
120_L123_L0.6901.00
323_S326_L0.6901.00
426_A429_L0.6901.00
400_E404_S0.6881.00
185_V218_A0.6851.00
102_A106_T0.6841.00
305_F336_S0.6841.00
154_W157_A0.6821.00
276_L417_L0.6801.00
305_F339_V0.6791.00
141_A145_Q0.6781.00
214_I217_Y0.6751.00
276_L416_L0.6751.00
203_M206_Q0.6721.00
41_I45_L0.6711.00
420_P426_A0.6681.00
359_T362_T0.6661.00
91_T103_L0.6661.00
54_I205_V0.6641.00
352_E365_Q0.6641.00
277_G288_N0.6641.00
156_S216_E0.6631.00
54_I62_Y0.6631.00
253_L257_R0.6631.00
224_L228_R0.6621.00
29_L308_A0.6601.00
244_A248_N0.6581.00
52_A56_H0.6571.00
155_L159_A0.6561.00
97_A320_R0.6561.00
101_Q104_A0.6551.00
138_G278_A0.6511.00
178_A222_I0.6501.00
62_Y204_N0.6501.00
258_D402_R0.6501.00
441_S444_A0.6481.00
151_E206_Q0.6461.00
295_L379_P0.6451.00
351_G355_I0.6451.00
283_D286_A0.6431.00
133_L138_G0.6421.00
166_L224_L0.6421.00
130_D151_E0.6411.00
349_L352_E0.6411.00
109_Q243_T0.6411.00
123_L126_T0.6401.00
257_R260_M0.6391.00
231_L234_R0.6391.00
189_L214_I0.6391.00
298_T343_F0.6371.00
415_T419_L0.6371.00
417_L420_P0.6361.00
142_V145_Q0.6351.00
309_V313_S0.6351.00
105_R108_V0.6351.00
215_A218_A0.6351.00
156_S159_A0.6341.00
322_G325_L0.6321.00
373_I377_I0.6311.00
228_R232_K0.6271.00
278_A285_I0.6271.00
57_L62_Y0.6251.00
301_A339_V0.6251.00
63_L359_T0.6221.00
243_T249_F0.6201.00
46_L216_E0.6201.00
126_T155_L0.6191.00
115_L119_A0.6191.00
317_Y322_G0.6161.00
154_W158_P0.6141.00
339_V343_F0.6131.00
310_E393_I0.6131.00
299_A382_G0.6121.00
28_A324_Q0.6091.00
99_N105_R0.6051.00
255_L398_A0.6051.00
46_L186_G0.6041.00
197_L208_A0.6031.00
346_V350_A0.6031.00
184_V187_N0.6021.00
105_R109_Q0.6021.00
59_S283_D0.6021.00
163_N220_L0.6011.00
243_T246_R0.6011.00
284_I287_V0.6001.00
118_G154_W0.5981.00
25_S331_A0.5981.00
335_Q338_I0.5971.00
337_G380_V0.5961.00
119_A123_L0.5951.00
279_R421_W0.5951.00
283_D364_I0.5941.00
277_G427_L0.5941.00
273_I427_L0.5941.00
429_L433_V0.5931.00
82_F260_M0.5921.00
133_L147_R0.5911.00
64_G67_A0.5911.00
199_M203_M0.5911.00
118_G158_P0.5891.00
391_M395_A0.5881.00
62_Y65_G0.5871.00
333_C337_G0.5851.00
189_L192_V0.5851.00
167_L171_L0.5841.00
230_I233_L0.5831.00
89_G314_G0.5831.00
88_T168_G0.5831.00
143_L146_A0.5821.00
45_L187_N0.5791.00
63_L290_V0.5791.00
203_M207_G0.5781.00
272_A413_A0.5771.00
190_N211_A0.5771.00
359_T365_Q0.5741.00
388_L443_A0.5741.00
185_V188_I0.5741.00
269_C409_A0.5731.00
159_A213_V0.5701.00
91_T106_T0.5691.00
82_F310_E0.5681.00
247_G251_R0.5681.00
274_T278_A0.5671.00
204_N207_G0.5671.00
315_Q319_A0.5671.00
392_F397_R0.5661.00
376_V380_V0.5651.00
122_A127_P0.5631.00
296_T299_A0.5621.00
287_V428_W0.5611.00
418_T421_W0.5611.00
347_Y354_I0.5601.00
423_G430_A0.5601.00
129_I133_L0.5601.00
149_F208_A0.5581.00
416_L419_L0.5581.00
24_S28_A0.5581.00
398_A402_R0.5551.00
118_G122_A0.5551.00
142_V146_A0.5551.00
108_V112_L0.5551.00
230_I234_R0.5541.00
112_L243_T0.5531.00
54_I58_D0.5521.00
158_P217_Y0.5521.00
222_I226_M0.5511.00
388_L439_G0.5511.00
29_L335_Q0.5511.00
70_A74_S0.5501.00
415_T418_T0.5491.00
416_L427_L0.5491.00
148_R152_I0.5491.00
168_G171_L0.5481.00
163_N167_L0.5461.00
412_F434_F0.5461.00
211_A215_A0.5461.00
309_V387_L0.5441.00
86_S256_N0.5441.00
344_S380_V0.5431.00
295_L375_Q0.5431.00
83_L260_M0.5431.00
25_S327_D0.5411.00
337_G384_W0.5411.00
267_Q271_G0.5381.00
85_M307_Y0.5381.00
232_K235_G0.5381.00
197_L210_L0.5371.00
333_C388_L0.5371.00
76_L157_A0.5361.00
290_V364_I0.5361.00
68_V146_A0.5351.00
302_L383_V0.5351.00
119_A122_A0.5341.00
207_G211_A0.5341.00
122_A154_W0.5331.00
340_A376_V0.5321.00
114_A118_G0.5321.00
404_S441_S0.5311.00
370_R373_I0.5291.00
310_E390_G0.5281.00
408_A441_S0.5281.00
312_H316_A0.5250.99
249_F253_L0.5240.99
220_L224_L0.5240.99
137_G140_E0.5230.99
191_I195_V0.5230.99
439_G443_A0.5210.99
109_Q248_N0.5200.99
437_L441_S0.5200.99
171_L176_A0.5200.99
98_K319_A0.5200.99
382_G435_L0.5200.99
25_S328_V0.5190.99
170_L173_V0.5180.99
30_W335_Q0.5160.99
56_H359_T0.5160.99
330_R446_W0.5150.99
49_V52_A0.5140.99
337_G340_A0.5140.99
291_L372_L0.5130.99
226_M230_I0.5120.99
329_W333_C0.5110.99
29_L33_A0.5110.99
36_M304_G0.5110.99
103_L107_L0.5100.99
281_G284_I0.5090.99
384_W443_A0.5090.99
232_K236_I0.5090.99
147_R150_L0.5080.99
83_L117_A0.5070.99
414_L417_L0.5070.99
413_A417_L0.5060.99
351_G376_V0.5060.99
272_A275_V0.5060.99
405_M408_A0.5040.99
385_C438_R0.5040.99
182_L219_T0.5000.99
407_V441_S0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3mktA 1 0.963 100 0.313 Contact Map
4lz6A 1 0.9651 100 0.313 Contact Map
4humA 1 0.9695 100 0.316 Contact Map
3w4tA 1 0.9542 100 0.372 Contact Map
1pw4A 1 0.8932 85.4 0.939 Contact Map
4ikvA 1 0.8911 81.7 0.941 Contact Map
3wdoA 1 0.8431 80.7 0.942 Contact Map
4tphA 2 0.8017 68.7 0.947 Contact Map
2cfqA 1 0.8627 67.4 0.948 Contact Map
4xnjA 1 0.8627 57.8 0.951 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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