GREMLIN Database
DCD - Deoxycytidine triphosphate deaminase
UniProt: P28248 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11418
Length: 193 (174)
Sequences: 1768 (757)
Seq/√Len: 57.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
98_T132_S5.0731.00
45_R71_D4.5041.00
35_V156_G3.8041.00
10_A14_E3.7731.00
127_I135_I3.5141.00
36_R94_L3.3261.00
19_I33_V3.1561.00
40_K72_E3.0491.00
102_D162_P2.7811.00
11_W16_R2.5881.00
94_L152_G2.2931.00
111_S115_R2.2651.00
38_G92_V2.1131.00
118_L147_L2.1071.00
39_N74_V2.0511.00
27_R36_R2.0311.00
105_G160_F1.9801.00
7_D165_G1.9391.00
96_S132_S1.9011.00
44_F90_L1.7960.99
15_G18_S1.7770.99
106_W161_E1.7410.99
22_R33_V1.7310.99
55_S150_R1.7080.99
9_E24_P1.6700.99
12_L22_R1.6490.99
92_V134_C1.6370.99
125_H128_D1.6350.99
7_D164_S1.6290.99
23_P26_E1.6210.99
53_D150_R1.6120.99
31_A129_P1.5790.98
94_L151_P1.5570.98
11_W103_L1.5010.98
3_L7_D1.5000.98
99_L105_G1.4830.98
7_D10_A1.4700.97
84_H87_E1.4620.97
22_R28_I1.4580.97
132_S181_N1.4420.97
172_N177_A1.4260.97
34_D110_R1.4200.97
115_R157_A1.3980.97
112_S188_S1.3870.96
93_T137_L1.3780.96
99_L103_L1.3750.96
29_N157_A1.3640.96
35_V158_L1.3520.96
28_I33_V1.3510.96
23_P36_R1.3500.96
35_V97_V1.3460.96
6_R168_V1.3420.96
38_G152_G1.3240.95
4_C7_D1.3200.95
9_E168_V1.3170.95
89_A141_N1.3150.95
111_S157_A1.2850.94
134_C184_G1.2760.94
127_I158_L1.2650.94
80_A150_R1.2390.93
113_L153_M1.2300.93
80_A148_A1.2080.92
84_H146_P1.2020.92
27_R154_L1.2010.92
120_V156_G1.1970.92
2_R161_E1.1880.92
8_I33_V1.1770.91
122_V146_P1.1740.91
138_E182_Q1.1730.91
131_W182_Q1.1440.90
41_F81_F1.1330.90
11_W100_P1.1150.89
40_K92_V1.1130.89
114_A138_E1.0660.87
110_R133_G1.0600.86
101_A170_P1.0590.86
20_N96_S1.0530.86
29_N34_D1.0450.86
119_M140_Y1.0450.86
73_I81_F1.0370.85
18_S98_T1.0370.85
100_P103_L1.0190.84
39_N76_D1.0010.83
91_A109_G0.9920.83
167_A170_P0.9840.82
53_D146_P0.9790.82
108_D121_H0.9770.82
42_R72_E0.9750.81
10_A18_S0.9750.81
9_E28_I0.9740.81
35_V93_T0.9630.81
109_G114_A0.9600.80
7_D11_W0.9350.79
105_G127_I0.9320.78
8_I16_R0.9310.78
109_G121_H0.9120.77
82_Y158_L0.9110.77
110_R157_A0.8950.76
112_S157_A0.8890.75
8_I160_F0.8820.74
110_R154_L0.8770.74
114_A121_H0.8730.74
4_C164_S0.8710.74
93_T155_I0.8710.74
101_A166_P0.8620.73
109_G182_Q0.8610.73
10_A13_D0.8570.72
23_P27_R0.8550.72
100_P133_G0.8520.72
59_D184_G0.8500.72
114_A124_A0.8490.72
106_W126_R0.8470.71
4_C165_G0.8470.71
85_P118_L0.8440.71
102_D166_P0.8400.71
34_D159_S0.8390.71
118_L139_F0.8270.70
131_W135_I0.8260.70
126_R131_W0.8220.69
128_D131_W0.8190.69
11_W102_D0.8180.69
118_L141_N0.8030.67
28_I172_N0.8010.67
90_L136_V0.7990.67
101_A130_G0.7960.67
54_L153_M0.7960.67
16_R102_D0.7830.65
45_R59_D0.7810.65
107_L127_I0.7790.65
4_C163_L0.7650.64
12_L33_V0.7540.62
32_T124_A0.7510.62
108_D138_E0.7490.62
17_L160_F0.7460.62
128_D179_Y0.7460.62
81_F89_A0.7460.62
125_H131_W0.7400.61
53_D148_A0.7310.60
31_A141_N0.7290.60
100_P160_F0.7250.59
141_N147_L0.7180.59
110_R115_R0.7170.59
24_P158_L0.7120.58
16_R98_T0.7080.58
9_E13_D0.7080.58
122_V158_L0.7060.57
173_R177_A0.7030.57
3_L162_P0.7010.57
11_W160_F0.6960.56
93_T114_A0.6940.56
104_V126_R0.6870.55
41_F91_A0.6830.55
18_S96_S0.6820.55
9_E39_N0.6820.55
101_A160_F0.6810.55
186_V189_R0.6800.55
14_E79_E0.6790.54
37_L149_L0.6780.54
23_P137_L0.6720.54
85_P146_P0.6630.53
91_A139_F0.6620.53
3_L11_W0.6610.52
11_W17_L0.6590.52
59_D71_D0.6580.52
139_F185_A0.6580.52
87_E154_L0.6580.52
40_K74_V0.6580.52
110_R178_K0.6580.52
82_Y148_A0.6570.52
76_D79_E0.6550.52
36_R95_E0.6460.51
118_L140_Y0.6410.50
76_D80_A0.6390.50
37_L91_A0.6390.50
13_D24_P0.6350.50
75_L80_A0.6340.50
9_E183_Q0.6330.49
78_G169_R0.6320.49
11_W15_G0.6270.49
90_L118_L0.6230.48
113_L149_L0.6230.48
119_M142_S0.6220.48
24_P35_V0.6190.48
48_T71_D0.6170.48
9_E12_L0.6160.48
93_T135_I0.6150.47
105_G135_I0.6140.47
93_T109_G0.6140.47
31_A114_A0.6140.47
123_T131_W0.6110.47
137_L155_I0.6100.47
75_L181_N0.6090.47
115_R133_G0.6070.47
121_H125_H0.6060.46
180_R184_G0.6050.46
45_R83_L0.5960.45
105_G158_L0.5940.45
146_P156_G0.5940.45
42_R93_T0.5900.45
9_E14_E0.5890.45
148_A151_P0.5890.45
121_H124_A0.5890.45
172_N180_R0.5850.44
34_D154_L0.5840.44
51_F82_Y0.5840.44
2_R159_S0.5840.44
41_F75_L0.5800.44
12_L20_N0.5780.43
83_L156_G0.5780.43
163_L167_A0.5770.43
81_F84_H0.5760.43
70_S146_P0.5760.43
14_E21_P0.5750.43
30_G109_G0.5730.43
88_L140_Y0.5690.42
2_R49_A0.5690.42
35_V135_I0.5680.42
85_P144_K0.5660.42
32_T157_A0.5620.42
104_V142_S0.5600.41
6_R10_A0.5590.41
34_D133_G0.5570.41
97_V158_L0.5550.41
114_A177_A0.5540.41
133_G182_Q0.5540.41
29_N111_S0.5530.41
33_V160_F0.5510.41
83_L139_F0.5500.40
35_V155_I0.5460.40
111_S133_G0.5440.40
41_F151_P0.5430.40
82_Y150_R0.5410.39
13_D16_R0.5410.39
90_L137_L0.5410.39
108_D131_W0.5400.39
116_L188_S0.5380.39
29_N112_S0.5380.39
24_P71_D0.5370.39
42_R81_F0.5350.39
2_R104_V0.5350.39
42_R70_S0.5350.39
13_D22_R0.5350.39
134_C183_Q0.5310.38
109_G119_M0.5290.38
118_L126_R0.5220.37
81_F107_L0.5210.37
124_A128_D0.5200.37
133_G157_A0.5190.37
30_G114_A0.5170.37
173_R187_A0.5160.37
29_N110_R0.5130.37
104_V159_S0.5110.36
31_A167_A0.5080.36
105_G129_P0.5080.36
108_D125_H0.5070.36
51_F166_P0.5050.36
101_A173_R0.5040.36
105_G131_W0.5030.36
139_F149_L0.5020.35
114_A136_V0.5000.35
6_R14_E0.5000.35
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1xs1A 5 1 100 0.172 Contact Map
2qxxA 3 0.9534 100 0.202 Contact Map
1pkhA 5 0.8756 100 0.223 Contact Map
4xjcA 3 0.9067 100 0.242 Contact Map
4dhkA 5 0.8135 100 0.278 Contact Map
3km3A 4 0.7668 100 0.278 Contact Map
2r9qA 4 0.8549 100 0.28 Contact Map
2yzjA 3 0.8187 100 0.33 Contact Map
3lqwA 3 0.6425 99.9 0.626 Contact Map
1f7dA 3 0.5907 99.8 0.64 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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