GREMLIN Database
YIGZ - IMPACT family member YigZ
UniProt: P27862 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11484
Length: 204 (191)
Sequences: 3033 (2224)
Seq/√Len: 160.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
29_T96_T3.3931.00
53_C83_M2.8841.00
14_V21_R2.7641.00
97_A121_V2.7161.00
26_L97_A2.5071.00
78_T110_T2.4731.00
83_M121_V2.4051.00
25_M100_V2.3601.00
38_F96_T2.3021.00
27_A38_F2.2321.00
52_H100_V2.2311.00
123_Q126_R2.1791.00
103_Y107_L2.1401.00
90_S126_R2.0661.00
15_E119_G2.0181.00
13_V123_Q2.0111.00
52_H98_V1.9251.00
43_R72_D1.8891.00
148_L173_L1.8841.00
7_P26_L1.8751.00
181_K184_E1.8401.00
25_M46_H1.8151.00
41_S45_E1.7751.00
143_C151_I1.7631.00
15_E120_G1.7551.00
30_D34_A1.7291.00
39_V96_T1.7201.00
25_M42_V1.7151.00
148_L167_Y1.7151.00
57_V88_M1.7091.00
67_L88_M1.6871.00
140_T172_L1.6811.00
12_T45_E1.6641.00
24_T120_G1.6441.00
23_I102_Y1.6031.00
164_N174_R1.5901.00
32_V36_K1.5731.00
189_L197_L1.5681.00
27_A96_T1.5611.00
31_G34_A1.5421.00
193_S197_L1.5421.00
85_A88_M1.5011.00
44_A47_P1.4991.00
152_E165_S1.4921.00
15_E123_Q1.4561.00
148_L152_E1.4551.00
83_M99_V1.4511.00
166_D172_L1.4501.00
142_Q170_F1.4191.00
141_L197_L1.3851.00
59_G93_G1.3831.00
87_L97_A1.3621.00
152_E156_G1.3371.00
32_V68_G1.3371.00
140_T174_R1.3321.00
137_T179_A1.3261.00
166_D174_R1.3111.00
42_V100_V1.2831.00
27_A41_S1.2681.00
155_L160_G1.2661.00
138_E174_R1.2501.00
86_Q122_N1.2351.00
153_A157_Q1.2211.00
24_T124_A1.2131.00
25_M52_H1.2061.00
10_P27_A1.1931.00
142_Q172_L1.1901.00
24_T121_V1.1881.00
5_L132_R1.1751.00
183_A187_A1.1751.00
42_V98_V1.1651.00
53_C79_A1.1651.00
5_L130_T1.1631.00
158_C188_K1.1561.00
163_I176_A1.1531.00
138_E163_I1.1501.00
149_T152_E1.1441.00
92_V95_I1.1311.00
19_K106_I1.1231.00
87_L121_V1.1211.00
10_P28_H1.1181.00
35_A39_V1.1031.00
138_E176_A1.1001.00
50_R103_Y1.0961.00
110_T114_V1.0890.99
6_I131_Q1.0800.99
62_D93_G1.0760.99
139_Y182_V1.0740.99
56_W68_G1.0690.99
183_A186_S1.0670.99
29_T58_A1.0590.99
11_V128_L1.0570.99
50_R107_L1.0380.99
92_V125_L1.0360.99
12_T46_H1.0340.99
54_V70_S1.0270.99
43_R54_V1.0220.99
144_E147_Q1.0130.99
13_V24_T1.0110.99
122_N126_R1.0090.99
37_A40_E1.0040.99
154_L188_K1.0020.99
11_V127_Q0.9940.99
134_T178_P0.9910.99
90_S122_N0.9910.99
185_F188_K0.9880.99
137_T182_V0.9880.99
141_L175_V0.9880.99
37_A41_S0.9840.99
178_P181_K0.9810.99
24_T97_A0.9790.99
12_T25_M0.9730.99
135_P179_A0.9660.99
144_E170_F0.9570.99
26_L121_V0.9520.99
182_V186_S0.9480.99
8_A129_T0.9440.99
47_P52_H0.9440.99
57_V67_L0.9430.99
13_V120_G0.9270.98
89_G118_G0.9260.98
143_C148_L0.9250.98
85_A89_G0.9220.98
33_E37_A0.9210.98
9_A129_T0.9170.98
175_V185_F0.9160.98
111_G115_K0.9140.98
83_M87_L0.9100.98
143_C173_L0.9100.98
160_G185_F0.9070.98
119_G123_Q0.9060.98
11_V129_T0.9050.98
123_Q127_Q0.9040.98
34_A37_A0.9010.98
45_E48_D0.8970.98
114_V118_G0.8930.98
43_R52_H0.8890.98
16_E19_K0.8880.98
145_Y171_V0.8860.98
5_L91_G0.8850.98
57_V87_L0.8800.98
26_L125_L0.8560.97
38_F98_V0.8510.97
10_P41_S0.8510.97
38_F41_S0.8480.97
155_L175_V0.8460.97
13_V127_Q0.8410.97
147_Q196_S0.8390.97
187_A191_D0.8360.97
155_L162_I0.8350.97
26_L128_L0.8290.97
168_Q172_L0.8250.97
35_A96_T0.8220.97
30_D94_E0.8210.97
42_V46_H0.8200.96
7_P128_L0.8150.96
162_I165_S0.8150.96
25_M45_E0.8080.96
119_G122_N0.8070.96
38_F42_V0.7950.96
78_T113_L0.7910.96
106_I110_T0.7900.96
8_A131_Q0.7880.96
83_M97_A0.7850.96
157_Q188_K0.7840.95
29_T35_A0.7830.95
81_K88_M0.7780.95
89_G110_T0.7770.95
186_S190_A0.7700.95
97_A124_A0.7660.95
50_R106_I0.7650.95
58_A94_E0.7590.95
161_K176_A0.7560.94
159_D181_K0.7540.94
26_L124_A0.7530.94
145_Y167_Y0.7490.94
184_E188_K0.7480.94
154_L158_C0.7470.94
40_E44_A0.7370.94
118_G122_N0.7340.94
87_L95_I0.7320.94
55_A80_G0.7320.94
177_L185_F0.7240.93
145_Y148_L0.7240.93
149_T153_A0.7210.93
136_L176_A0.7190.93
92_V130_T0.7170.93
150_G153_A0.7130.93
54_V68_G0.7130.93
139_Y186_S0.7120.93
163_I174_R0.7120.93
187_A190_A0.7110.92
94_E133_K0.6970.92
32_V66_Q0.6940.92
78_T106_I0.6920.91
17_I106_I0.6810.91
184_E187_A0.6790.91
99_V120_G0.6780.91
35_A52_H0.6770.91
154_L192_F0.6770.91
147_Q193_S0.6750.90
27_A42_V0.6740.90
82_P112_G0.6660.90
53_C99_V0.6660.90
111_G114_V0.6640.90
85_A118_G0.6590.89
158_C185_F0.6570.89
148_L165_S0.6540.89
18_K50_R0.6520.89
59_G67_L0.6490.89
110_T122_N0.6470.89
154_L157_Q0.6430.88
42_V45_E0.6410.88
38_F52_H0.6380.88
62_D91_G0.6320.87
140_T166_D0.6320.87
191_D194_R0.6320.87
147_Q150_G0.6310.87
77_G81_K0.6260.87
69_F81_K0.6240.87
29_T38_F0.6240.87
36_K56_W0.6160.86
32_V58_A0.6150.86
142_Q198_Q0.6150.86
136_L178_P0.6140.86
14_V23_I0.6130.86
110_T115_K0.6120.86
57_V93_G0.6100.85
27_A98_V0.6100.85
60_A93_G0.6100.85
136_L161_K0.6020.85
86_Q118_G0.6000.84
36_K68_G0.6000.84
39_V100_V0.5990.84
19_K48_D0.5980.84
26_L87_L0.5890.83
17_I119_G0.5890.83
50_R102_Y0.5870.83
58_A66_Q0.5810.83
29_T34_A0.5800.82
67_L84_L0.5800.82
86_Q115_K0.5800.82
145_Y149_T0.5800.82
179_A182_V0.5800.82
23_I100_V0.5790.82
160_G177_L0.5740.82
46_H102_Y0.5740.82
125_L129_T0.5730.82
141_L173_L0.5730.82
50_R79_A0.5730.82
19_K110_T0.5720.82
148_L171_V0.5720.82
90_S130_T0.5690.81
17_I107_L0.5610.80
42_V52_H0.5550.80
50_R100_V0.5540.80
28_H94_E0.5540.80
53_C76_A0.5520.79
46_H52_H0.5470.79
120_G127_Q0.5470.79
48_D52_H0.5460.79
177_L181_K0.5450.78
151_I173_L0.5440.78
107_L136_L0.5420.78
19_K115_K0.5400.78
54_V83_M0.5350.77
188_K191_D0.5340.77
11_V124_A0.5330.77
124_A127_Q0.5290.76
69_F76_A0.5290.76
13_V17_I0.5290.76
79_A83_M0.5190.75
29_T37_A0.5150.74
179_A183_A0.5130.74
19_K111_G0.5130.74
112_G116_A0.5120.74
13_V124_A0.5090.74
36_K40_E0.5090.74
85_A110_T0.5090.74
56_W66_Q0.5090.74
17_I115_K0.5070.73
150_G154_L0.5060.73
142_Q168_Q0.5060.73
75_P117_Y0.5050.73
11_V26_L0.5040.73
95_I131_Q0.5000.72
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1vi7A 1 1 100 0.074 Contact Map
2cveA 1 0.9265 100 0.138 Contact Map
3lh2S 2 0.3382 98.8 0.841 Contact Map
4fn5A 1 0.9363 95 0.913 Contact Map
4w224 1 0.951 94.1 0.916 Contact Map
1n0uA 1 0.9461 91.8 0.923 Contact Map
3j25A 1 0.8922 90.8 0.925 Contact Map
4kiyV 1 0.951 89.1 0.927 Contact Map
2xexA 1 0.9608 88.7 0.928 Contact Map
2dy1A 1 0.8725 86.3 0.931 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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