GREMLIN Database
TATD - Tat-linked quality control protein TatD
UniProt: P27859 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11481
Length: 260 (250)
Sequences: 7104 (5051)
Seq/√Len: 319.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
78_I119_D3.3291.00
111_V141_P3.1181.00
232_R235_H2.7601.00
158_R192_L2.7231.00
96_F134_R2.5741.00
50_R83_Q2.5021.00
23_C222_E2.3991.00
114_L124_V2.3921.00
149_A169_I2.2081.00
250_A254_T2.1871.00
140_E163_A2.1341.00
231_Q241_A2.1271.00
187_R232_R2.0681.00
107_E134_R1.9631.00
128_C135_F1.9471.00
81_A89_I1.9011.00
115_R142_W1.8781.00
58_T88_A1.8651.00
22_A26_D1.8441.00
14_A17_R1.8381.00
239_E244_L1.8351.00
16_D220_R1.8321.00
6_V32_L1.8251.00
195_A237_R1.8251.00
195_A247_T1.8241.00
246_A250_A1.8171.00
111_V142_W1.7921.00
49_A57_S1.7511.00
190_L233_I1.7451.00
133_E137_T1.7311.00
96_F103_P1.7301.00
58_T125_F1.7271.00
230_L241_A1.7171.00
25_F54_S1.7171.00
195_A239_E1.6911.00
140_E167_H1.6901.00
158_R162_Q1.6611.00
108_R112_A1.6591.00
200_I230_L1.6591.00
57_S86_V1.6501.00
153_C174_T1.6421.00
92_C113_Q1.6201.00
31_G56_W1.6161.00
151_L164_C1.6151.00
163_A166_A1.6111.00
31_G253_K1.6071.00
4_I252_V1.5941.00
43_Q76_A1.5921.00
92_C124_V1.5681.00
18_D51_Q1.5551.00
112_A115_R1.5331.00
162_Q166_A1.5281.00
47_K51_Q1.5121.00
177_V233_I1.5121.00
128_C132_H1.4871.00
173_I190_L1.4861.00
107_E137_T1.4851.00
118_A146_L1.4781.00
162_Q192_L1.4761.00
110_F126_M1.4591.00
150_V255_L1.4441.00
231_Q235_H1.4371.00
184_L188_E1.4241.00
2_F31_G1.4141.00
170_Y197_K1.4131.00
78_I120_L1.4021.00
188_E191_P1.3971.00
137_T141_P1.3891.00
161_M171_I1.3841.00
184_L187_R1.3701.00
170_Y254_T1.3671.00
227_P231_Q1.3661.00
157_T160_E1.3631.00
38_N41_E1.3481.00
121_N148_G1.3441.00
24_A32_L1.3421.00
136_M163_A1.3231.00
74_E112_A1.2991.00
110_F135_F1.2971.00
111_V138_L1.2961.00
107_E111_V1.2951.00
2_F33_L1.2921.00
249_D253_K1.2911.00
76_A79_E1.2841.00
81_A120_L1.2821.00
228_H231_Q1.2761.00
9_T41_E1.2661.00
212_L228_H1.2601.00
187_R236_W1.2571.00
243_W246_A1.2511.00
33_L87_V1.2481.00
2_F249_D1.2441.00
45_A57_S1.2371.00
118_A142_W1.2341.00
96_F107_E1.2341.00
99_N103_P1.2331.00
171_I193_I1.2291.00
47_K50_R1.2201.00
194_P197_K1.2201.00
64_H98_R1.2141.00
36_G42_S1.2071.00
212_L225_H1.2061.00
249_D252_V1.2051.00
240_D243_W1.2041.00
6_V204_A1.1971.00
239_E243_W1.1911.00
102_T105_E1.1891.00
230_L248_T1.1841.00
107_E138_L1.1821.00
173_I198_L1.1801.00
233_I244_L1.1711.00
165_V197_K1.1601.00
39_L42_S1.1471.00
70_Q73_T1.1471.00
103_P107_E1.1461.00
34_I45_A1.1401.00
16_D19_D1.1381.00
46_Q57_S1.1371.00
248_T252_V1.1341.00
13_F220_R1.1281.00
199_L255_L1.1251.00
159_E162_Q1.1141.00
39_L73_T1.1141.00
50_R85_E1.1101.00
35_T125_F1.0961.00
232_R236_W1.0841.00
221_N225_H1.0781.00
79_E82_A1.0751.00
133_E160_E1.0741.00
19_D23_C1.0721.00
18_D22_A1.0661.00
64_H101_S1.0661.00
32_L55_C1.0621.00
121_N147_P1.0591.00
190_L237_R1.0571.00
133_E163_A1.0511.00
66_S109_A1.0501.00
200_I226_L1.0411.00
132_H160_E1.0371.00
104_E108_R1.0351.00
212_L219_R1.0291.00
2_F252_V1.0231.00
170_Y255_L1.0191.00
115_R119_D1.0131.00
104_E107_E1.0131.00
43_Q47_K1.0111.00
23_C224_A1.0081.00
78_I82_A1.0051.00
158_R189_L0.9991.00
46_Q83_Q0.9961.00
34_I55_C0.9931.00
19_D22_A0.9911.00
188_E192_L0.9811.00
39_L76_A0.9771.00
105_E108_R0.9771.00
65_D68_Q0.9751.00
44_Q47_K0.9651.00
200_I233_I0.9641.00
156_G160_E0.9631.00
179_D208_L0.9581.00
247_T250_A0.9551.00
46_Q59_A0.9531.00
181_R210_R0.9511.00
158_R188_E0.9431.00
245_A249_D0.9411.00
43_Q80_L0.9391.00
230_L245_A0.9361.00
173_I193_I0.9361.00
49_A55_C0.9361.00
200_I248_T0.9291.00
177_V190_L0.9271.00
149_A255_L0.9161.00
69_W74_E0.9091.00
18_D52_Y0.9061.00
222_E225_H0.9051.00
230_L244_L0.9021.00
243_W247_T0.8941.00
4_I199_L0.8921.00
78_I116_I0.8921.00
244_L248_T0.8921.00
172_G199_L0.8881.00
33_L252_V0.8881.00
46_Q50_R0.8871.00
136_M164_C0.8861.00
8_L223_P0.8851.00
227_P241_A0.8731.00
118_A143_L0.8711.00
150_V256_F0.8681.00
190_L236_W0.8671.00
45_A49_A0.8651.00
237_R244_L0.8631.00
21_V52_Y0.8531.00
195_A244_L0.8521.00
66_S105_E0.8391.00
126_M151_L0.8381.00
75_E79_E0.8371.00
165_V194_P0.8331.00
114_L118_A0.8301.00
69_W109_A0.8251.00
103_P134_R0.8211.00
97_N130_D0.8211.00
59_A86_V0.8181.00
241_A245_A0.8161.00
35_T58_T0.8121.00
99_N102_T0.8041.00
132_H156_G0.8031.00
126_M135_F0.8021.00
128_C156_G0.8021.00
138_L141_P0.7981.00
74_E78_I0.7951.00
86_V122_M0.7911.00
134_R137_T0.7901.00
82_A120_L0.7861.00
136_M160_E0.7861.00
37_T41_E0.7831.00
191_P236_W0.7821.00
4_I150_V0.7821.00
30_N249_D0.7791.00
61_V69_W0.7761.00
165_V171_I0.7741.00
226_L229_I0.7731.00
76_A80_L0.7721.00
23_C26_D0.7691.00
132_H164_C0.7670.99
75_E78_I0.7640.99
230_L234_A0.7640.99
116_I120_L0.7630.99
33_L58_T0.7540.99
170_Y199_L0.7470.99
242_A246_A0.7450.99
21_V32_L0.7430.99
118_A147_P0.7370.99
100_F103_P0.7350.99
73_T76_A0.7330.99
9_T44_Q0.7310.99
250_A253_K0.7290.99
69_W73_T0.7280.99
198_L244_L0.7280.99
89_I92_C0.7260.99
148_G257_G0.7230.99
140_E166_A0.7140.99
64_H100_F0.7120.99
233_I237_R0.7110.99
138_L142_W0.7030.99
176_W179_D0.7020.99
111_V115_R0.7010.99
41_E45_A0.7000.99
191_P238_G0.6990.99
198_L237_R0.6920.99
10_S206_Y0.6900.99
13_F17_R0.6870.99
239_E247_T0.6850.99
27_A227_P0.6820.99
150_V172_G0.6820.99
38_N68_Q0.6690.99
105_E109_A0.6690.99
36_G45_A0.6660.99
56_W85_E0.6650.99
88_A125_F0.6640.99
14_A44_Q0.6640.99
194_P237_R0.6620.99
42_S80_L0.6610.99
176_W207_L0.6590.98
22_A25_F0.6540.98
42_S77_I0.6530.98
114_L138_L0.6510.98
4_I125_F0.6450.98
128_C164_C0.6440.98
247_T254_T0.6430.98
161_M165_V0.6390.98
179_D211_D0.6380.98
10_S13_F0.6370.98
92_C109_A0.6360.98
59_A80_L0.6360.98
161_M193_I0.6340.98
164_C171_I0.6330.98
165_V193_I0.6330.98
21_V25_F0.6300.98
118_A145_K0.6290.98
161_M189_L0.6280.98
193_I198_L0.6270.98
79_E83_Q0.6260.98
143_L146_L0.6240.98
67_S102_T0.6200.98
154_F160_E0.6200.98
114_L142_W0.6170.98
74_E116_I0.6150.98
186_L189_L0.6140.98
136_M140_E0.6130.98
208_L225_H0.6120.98
165_V192_L0.6110.98
184_L191_P0.6110.98
121_N257_G0.6100.97
56_W87_V0.6080.97
42_S59_A0.6070.97
66_S101_S0.5990.97
125_F256_F0.5950.97
24_A222_E0.5930.97
198_L248_T0.5930.97
199_L252_V0.5930.97
178_C210_R0.5890.97
237_R247_T0.5870.97
185_E188_E0.5860.97
17_R20_V0.5850.97
42_S57_S0.5850.97
109_A113_Q0.5820.97
121_N146_L0.5800.97
17_R220_R0.5800.97
20_V220_R0.5790.97
9_T34_I0.5790.97
42_S45_A0.5780.97
132_H136_M0.5770.97
94_L131_A0.5770.97
9_T37_T0.5750.96
151_L172_G0.5750.96
13_F16_D0.5720.96
150_V199_L0.5720.96
71_A112_A0.5720.96
25_F30_N0.5710.96
16_D20_V0.5700.96
176_W186_L0.5680.96
163_A167_H0.5680.96
196_E254_T0.5670.96
27_A224_A0.5660.96
24_A29_V0.5660.96
71_A108_R0.5650.96
81_A86_V0.5620.96
21_V55_C0.5610.96
234_A241_A0.5600.96
2_F253_K0.5600.96
170_Y251_N0.5590.96
24_A28_G0.5560.96
179_D210_R0.5520.96
67_S101_S0.5490.95
143_L169_I0.5470.95
72_A75_E0.5460.95
136_M167_H0.5450.95
67_S105_E0.5440.95
40_R44_Q0.5430.95
40_R68_Q0.5430.95
60_G113_Q0.5410.95
247_T251_N0.5410.95
242_A245_A0.5410.95
196_E247_T0.5390.95
97_N129_R0.5380.95
187_R191_P0.5370.95
174_T207_L0.5350.95
177_V244_L0.5350.95
12_Q220_R0.5350.95
37_T65_D0.5330.95
142_W146_L0.5310.94
24_A224_A0.5280.94
33_L256_F0.5270.94
46_Q80_L0.5270.94
153_C207_L0.5240.94
20_V23_C0.5220.94
225_H228_H0.5200.94
115_R118_A0.5200.94
154_F164_C0.5190.94
48_L55_C0.5180.94
46_Q49_A0.5160.94
112_A116_I0.5150.94
251_N254_T0.5150.94
10_S37_T0.5110.93
176_W183_G0.5110.93
186_L190_L0.5100.93
53_S85_E0.5090.93
132_H135_F0.5070.93
160_E164_C0.5060.93
172_G207_L0.5040.93
183_G187_R0.5030.93
235_H238_G0.5020.93
116_I119_D0.5000.93
94_L107_E0.5000.93
177_V187_R0.5000.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3e2vA 1 0.9692 100 0.193 Contact Map
3ipwA 1 0.9846 100 0.246 Contact Map
1j6oA 1 0.9808 100 0.314 Contact Map
2xioA 1 0.9846 100 0.316 Contact Map
3gg7A 1 0.9231 100 0.349 Contact Map
1xwyA 1 0.9923 100 0.365 Contact Map
3rcmA 1 1 100 0.366 Contact Map
2gzxA 1 0.9692 100 0.382 Contact Map
2y1hA 2 0.9538 100 0.393 Contact Map
1zzmA 1 0.9731 100 0.396 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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