GREMLIN Database
YIGL - Pyridoxal phosphate phosphatase YigL
UniProt: P27848 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11470
Length: 266 (254)
Sequences: 10963 (9018)
Seq/√Len: 565.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
249_G258_H4.2701.00
16_P252_A3.6421.00
211_A225_A3.0691.00
250_T253_D2.7961.00
222_L228_G2.7211.00
3_Q208_D2.6971.00
21_S254_D2.6501.00
23_Y254_D2.5601.00
199_A209_C2.5511.00
223_S241_L2.4361.00
15_S19_T2.4131.00
196_E224_M2.3951.00
236_Q240_D2.3871.00
23_Y261_R2.3591.00
7_S38_F2.3251.00
42_T49_V2.1981.00
206_L224_M2.1401.00
79_F197_A2.0371.00
190_S220_E2.0111.00
219_A238_L1.9251.00
216_M237_R1.9161.00
228_G243_P1.8311.00
30_L33_A1.8261.00
216_M235_H1.8201.00
22_P26_E1.8131.00
230_I242_H1.7991.00
25_K55_N1.7691.00
197_A201_K1.7631.00
28_L38_F1.7591.00
219_A241_L1.7501.00
205_S208_D1.7491.00
249_G253_D1.7331.00
31_L36_I1.7231.00
236_Q239_K1.7171.00
30_L261_R1.7091.00
84_D87_I1.7061.00
4_V39_V1.7041.00
227_K246_E1.6701.00
196_E200_K1.6691.00
227_K243_P1.6651.00
30_L34_R1.6381.00
6_A195_L1.6331.00
197_A200_K1.6281.00
229_C259_Y1.6141.00
246_E263_L1.6031.00
192_G224_M1.5801.00
238_L241_L1.5751.00
96_N114_N1.5701.00
95_V149_F1.5541.00
81_H197_A1.5351.00
37_N202_L1.5291.00
193_H196_E1.5261.00
21_S24_A1.5001.00
195_L221_M1.5001.00
207_K226_G1.4811.00
212_F256_V1.4671.00
9_L14_L1.4631.00
246_E259_Y1.4631.00
211_A221_M1.4571.00
7_S212_F1.4561.00
26_E30_L1.4551.00
161_E165_N1.4551.00
24_A254_D1.4261.00
87_I171_R1.4171.00
23_Y258_H1.4151.00
25_K29_K1.4051.00
32_T60_S1.3921.00
90_D171_R1.3781.00
6_A41_A1.3571.00
27_T257_P1.3571.00
77_L80_A1.3501.00
239_K247_V1.3351.00
219_A223_S1.3321.00
232_G250_T1.3231.00
230_I234_A1.3071.00
212_F259_Y1.3071.00
199_A206_L1.2991.00
87_I90_D1.2921.00
259_Y263_L1.2841.00
85_R89_S1.2671.00
81_H186_A1.2611.00
156_Q159_P1.2531.00
222_L238_L1.2481.00
27_T261_R1.2461.00
32_T59_K1.2421.00
206_L209_C1.2341.00
237_R240_D1.2331.00
173_N220_E1.2311.00
80_A145_S1.2301.00
29_K33_A1.2161.00
246_E262_K1.2141.00
80_A143_G1.2111.00
69_R77_L1.1951.00
87_I172_V1.1951.00
4_V204_Y1.1761.00
257_P261_R1.1741.00
256_V260_L1.1661.00
39_V198_V1.1601.00
5_V260_L1.1601.00
63_I194_A1.1581.00
5_V31_L1.1471.00
61_Y202_L1.1391.00
209_C225_A1.1231.00
211_A222_L1.1201.00
15_S252_A1.1191.00
16_P251_N1.1121.00
5_V36_I1.1081.00
158_L162_Q1.1061.00
248_I259_Y1.0981.00
23_Y27_T1.0951.00
70_V197_A1.0891.00
210_I227_K1.0821.00
173_N188_G1.0821.00
39_V61_Y1.0711.00
175_S185_M1.0701.00
158_L176_F1.0691.00
229_C248_I1.0691.00
4_V199_A1.0641.00
210_I263_L1.0581.00
206_L226_G1.0531.00
259_Y262_K1.0501.00
22_P25_K1.0421.00
235_H238_L1.0391.00
190_S193_H1.0391.00
29_K32_T1.0371.00
229_C246_E1.0271.00
196_E206_L1.0221.00
29_K57_E1.0171.00
225_A228_G1.0161.00
192_G220_E1.0151.00
231_M255_A1.0131.00
195_L225_A1.0131.00
151_C156_Q1.0091.00
171_R187_G1.0001.00
199_A224_M0.9991.00
258_H262_K0.9991.00
6_A209_C0.9931.00
94_V97_D0.9921.00
70_V79_F0.9911.00
9_L52_I0.9911.00
13_L24_A0.9901.00
89_S93_G0.9781.00
68_A189_V0.9781.00
198_V202_L0.9741.00
186_A189_V0.9731.00
215_G235_H0.9711.00
210_I259_Y0.9711.00
81_H188_G0.9701.00
234_A239_K0.9611.00
248_I255_A0.9571.00
13_L28_L0.9571.00
82_N143_G0.9551.00
237_R241_L0.9531.00
210_I229_C0.9531.00
232_G239_K0.9511.00
46_H64_T0.9501.00
70_V194_A0.9481.00
151_C157_L0.9471.00
232_G249_G0.9451.00
4_V209_C0.9371.00
80_A108_D0.9361.00
93_G97_D0.9351.00
159_P162_Q0.9341.00
230_I238_L0.9301.00
216_M219_A0.9301.00
233_S251_N0.9271.00
99_P163_A0.9241.00
50_G75_G0.9241.00
258_H261_R0.9191.00
94_V99_P0.9171.00
146_K183_E0.9171.00
71_H77_L0.9131.00
64_T69_R0.9131.00
7_S256_V0.9121.00
199_A204_Y0.9101.00
26_E29_K0.9051.00
162_Q165_N0.9051.00
90_D93_G0.8901.00
243_P246_E0.8871.00
36_I210_I0.8831.00
6_A39_V0.8771.00
174_V184_V0.8741.00
31_L38_F0.8701.00
42_T64_T0.8651.00
50_G54_D0.8631.00
249_G255_A0.8621.00
185_M190_S0.8561.00
159_P163_A0.8561.00
24_A257_P0.8541.00
226_G243_P0.8461.00
94_V163_A0.8431.00
92_F96_N0.8431.00
27_T30_L0.8381.00
5_V210_I0.8321.00
41_A63_I0.8301.00
71_H75_G0.8291.00
83_L186_A0.8291.00
37_N61_Y0.8261.00
23_Y257_P0.8261.00
118_P122_R0.8241.00
63_I198_V0.8221.00
249_G262_K0.8221.00
110_E132_A0.8201.00
173_N190_S0.8191.00
46_H71_H0.8191.00
209_C226_G0.8181.00
154_H158_L0.8171.00
61_Y198_V0.8141.00
158_L161_E0.8141.00
78_I201_K0.8101.00
209_C224_M0.8081.00
37_N60_S0.8041.00
86_D90_D0.8031.00
7_S13_L0.8001.00
82_N145_S0.7981.00
15_S21_S0.7951.00
161_E176_F0.7941.00
94_V168_W0.7941.00
199_A226_G0.7931.00
232_G253_D0.7891.00
222_L241_L0.7871.00
90_D94_V0.7831.00
24_A27_T0.7821.00
231_M248_I0.7741.00
31_L260_L0.7711.00
121_M125_K0.7671.00
45_H65_S0.7651.00
193_H197_A0.7611.00
64_T71_H0.7561.00
36_I208_D0.7531.00
170_D187_G0.7491.00
211_A228_G0.7491.00
108_D143_G0.7421.00
13_L20_L0.7401.00
123_F126_E0.7381.00
49_V64_T0.7381.00
163_A166_A0.7331.00
9_L40_F0.7321.00
97_D163_A0.7291.00
99_P159_P0.7271.00
243_P247_V0.7241.00
90_D168_W0.7231.00
231_M234_A0.7201.00
234_A238_L0.7181.00
195_L211_A0.7151.00
23_Y26_E0.7111.00
173_N187_G0.7111.00
196_E199_A0.7101.00
123_F127_A0.7091.00
69_R145_S0.7031.00
222_L242_H0.7011.00
66_N183_E0.7001.00
49_V62_M0.6951.00
96_N103_T0.6941.00
41_A221_M0.6931.00
214_D234_A0.6861.00
13_L251_N0.6841.00
220_E223_S0.6811.00
208_D226_G0.6811.00
189_V193_H0.6771.00
89_S140_E0.6771.00
88_A144_V0.6721.00
85_R143_G0.6721.00
40_F49_V0.6701.00
100_D156_Q0.6681.00
68_A186_A0.6671.00
254_D257_P0.6631.00
228_G238_L0.6631.00
192_G196_E0.6621.00
246_E258_H0.6601.00
246_E249_G0.6601.00
46_H50_G0.6581.00
11_G231_M0.6581.00
219_A222_L0.6561.00
122_R125_K0.6561.00
157_L161_E0.6551.00
76_N201_K0.6541.00
15_S251_N0.6491.00
248_I258_H0.6481.00
137_G140_E0.6421.00
227_K259_Y0.6371.00
9_L49_V0.6361.00
53_R62_M0.6361.00
17_D252_A0.6351.00
124_F131_Y0.6341.00
9_L13_L0.6331.00
5_V212_F0.6331.00
118_P121_M0.6331.00
216_M238_L0.6311.00
86_D89_S0.6301.00
92_F105_V0.6281.00
148_F183_E0.6261.00
254_D258_H0.6241.00
70_V198_V0.6241.00
228_G242_H0.6221.00
233_S250_T0.6211.00
168_W171_R0.6211.00
212_F248_I0.6201.00
20_L25_K0.6181.00
233_S239_K0.6161.00
27_T31_L0.6161.00
104_N148_F0.6141.00
188_G193_H0.6111.00
212_F229_C0.6081.00
173_N185_M0.6061.00
154_H179_L0.6051.00
162_Q166_A0.6011.00
4_V198_V0.6001.00
77_L108_D0.5991.00
51_Q54_D0.5991.00
69_R108_D0.5981.00
107_R110_E0.5901.00
24_A28_L0.5901.00
214_D231_M0.5871.00
238_L242_H0.5871.00
174_V182_L0.5861.00
40_F53_R0.5851.00
124_F127_A0.5821.00
65_S145_S0.5811.00
116_H133_L0.5781.00
257_P260_L0.5761.00
107_R142_E0.5741.00
21_S257_P0.5741.00
157_L176_F0.5741.00
70_V201_K0.5700.99
116_H121_M0.5690.99
165_N174_V0.5680.99
249_G259_Y0.5670.99
14_L251_N0.5620.99
231_M251_N0.5620.99
88_A92_F0.5620.99
105_V144_V0.5620.99
204_Y226_G0.5600.99
13_L40_F0.5600.99
151_C160_L0.5540.99
3_Q36_I0.5530.99
154_H176_F0.5520.99
135_E138_L0.5510.99
155_E159_P0.5480.99
150_T181_C0.5470.99
4_V37_N0.5430.99
123_F128_V0.5430.99
28_L260_L0.5420.99
50_G53_R0.5410.99
125_K128_V0.5410.99
122_R126_E0.5400.99
81_H189_V0.5400.99
94_V164_I0.5370.99
101_I149_F0.5370.99
15_S254_D0.5350.99
93_G137_G0.5340.99
146_K177_S0.5300.99
31_L257_P0.5300.99
107_R144_V0.5290.99
103_T147_V0.5290.99
230_I241_L0.5270.99
151_C154_H0.5250.99
104_N111_W0.5230.99
204_Y208_D0.5220.99
157_L182_L0.5200.99
212_F260_L0.5200.99
108_D145_S0.5180.99
229_C243_P0.5180.99
26_E261_R0.5150.99
28_L32_T0.5150.99
121_M124_F0.5140.99
108_D142_E0.5120.99
53_R58_I0.5120.99
6_A199_A0.5100.99
149_F184_V0.5080.99
91_L184_V0.5080.99
45_H48_D0.5070.99
37_N204_Y0.5060.99
107_R112_F0.5050.99
49_V52_I0.5050.99
19_T55_N0.5040.99
177_S183_E0.5040.99
41_A66_N0.5020.99
232_G247_V0.5020.99
195_L209_C0.5010.99
235_H239_K0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3pgvA 3 0.9737 100 0.179 Contact Map
1nrwA 1 0.9699 100 0.203 Contact Map
4qjbA 1 0.985 100 0.225 Contact Map
1nf2A 4 0.9812 100 0.226 Contact Map
3l7yA 1 0.9812 100 0.228 Contact Map
2b30A 2 0.9812 100 0.231 Contact Map
1rkqA 1 0.985 100 0.237 Contact Map
2rbkA 1 0.9586 100 0.239 Contact Map
3daoA 1 0.9737 100 0.239 Contact Map
4dw8A 1 0.9774 100 0.249 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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