GREMLIN Database
YIGF - Uncharacterized protein YigF
UniProt: P27842 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11464
Length: 126 (115)
Sequences: 116 (89)
Seq/√Len: 8.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
66_L109_T5.0251.00
17_Y48_Q3.6750.96
76_I80_L3.2780.92
36_E49_R3.1150.90
57_I68_V2.8250.85
11_L117_E2.5470.78
67_F121_L2.3300.71
14_K69_L2.3200.71
57_I75_A2.2810.70
56_F60_F2.1780.66
57_I60_F2.1030.63
107_V119_K1.9840.58
36_E39_A1.8950.55
111_K115_E1.8810.54
73_K122_N1.8650.54
82_G102_A1.7930.51
73_K123_T1.7800.50
71_L116_K1.7480.49
78_V109_T1.6860.46
22_Y111_K1.6620.45
9_G118_V1.6190.43
73_K116_K1.6070.43
58_A109_T1.5960.42
80_L91_L1.4980.38
10_S73_K1.4650.37
73_K104_Y1.4270.36
21_F28_P1.4230.35
38_K88_V1.4090.35
18_R110_N1.3720.34
52_I85_S1.3500.33
14_K52_I1.3290.32
69_L75_A1.3190.32
115_E125_S1.3050.31
78_V87_F1.2870.30
67_F75_A1.2800.30
21_F25_H1.2720.30
108_N115_E1.2330.29
25_H109_T1.2290.28
35_P66_L1.2240.28
111_K125_S1.1810.27
112_W125_S1.1790.27
17_Y60_F1.1630.26
62_S81_L1.1530.26
20_N112_W1.1450.26
20_N102_A1.1110.25
43_A49_R1.0880.24
59_F103_A1.0870.24
54_M106_A1.0670.23
100_A103_A1.0480.23
41_F108_N1.0300.22
75_A105_V1.0260.22
15_W18_R1.0190.22
51_T84_L1.0170.22
68_V75_A1.0110.22
28_P40_A1.0100.22
115_E123_T0.9910.21
85_S99_I0.9830.21
99_I102_A0.9590.20
69_L97_L0.9380.20
46_V51_T0.9320.20
89_G102_A0.9290.19
56_F106_A0.9290.19
24_Q67_F0.9290.19
22_Y25_H0.9230.19
64_I68_V0.9080.19
66_L125_S0.9080.19
20_N83_I0.9010.19
13_E36_E0.9000.19
27_F102_A0.8920.18
26_G40_A0.8840.18
56_F68_V0.8690.18
12_S29_G0.8660.18
55_N72_W0.8600.18
56_F102_A0.8520.18
56_F92_I0.8480.17
41_F52_I0.8450.17
39_A47_R0.8250.17
108_N111_K0.8110.17
42_K49_R0.8100.17
25_H66_L0.8090.16
12_S98_G0.8080.16
11_L27_F0.8030.16
58_A74_K0.7960.16
23_D77_I0.7950.16
7_N49_R0.7910.16
50_L92_I0.7880.16
25_H63_W0.7870.16
89_G103_A0.7850.16
112_W115_E0.7820.16
45_K82_G0.7780.16
63_W105_V0.7730.16
71_L117_E0.7610.15
21_F40_A0.7550.15
22_Y76_I0.7490.15
77_I96_I0.7410.15
38_K50_L0.7390.15
18_R74_K0.7380.15
29_G49_R0.7380.15
44_L105_V0.7380.15
85_S90_A0.7370.15
13_E117_E0.7360.15
34_T42_K0.7210.15
51_T68_V0.7210.15
76_I125_S0.7160.14
34_T120_G0.7160.14
20_N118_V0.7040.14
60_F64_I0.6910.14
71_L97_L0.6860.14
96_I102_A0.6860.14
88_V101_V0.6850.14
22_Y38_K0.6780.14
22_Y115_E0.6730.14
11_L49_R0.6690.14
22_Y39_A0.6630.13
61_C65_Y0.6560.13
66_L112_W0.6550.13
49_R100_A0.6410.13
37_Y45_K0.6340.13
20_N107_V0.6340.13
43_A80_L0.6300.13
28_P55_N0.6260.13
99_I103_A0.6240.13
77_I122_N0.6210.13
97_L100_A0.6180.13
21_F39_A0.6160.13
66_L78_V0.6140.12
13_E20_N0.6140.12
63_W67_F0.6140.12
61_C72_W0.6070.12
34_T39_A0.6040.12
42_K81_L0.5930.12
14_K106_A0.5850.12
12_S55_N0.5820.12
106_A121_L0.5820.12
43_A88_V0.5780.12
17_Y105_V0.5780.12
67_F106_A0.5770.12
12_S51_T0.5770.12
16_K113_F0.5740.12
22_Y97_L0.5690.12
71_L122_N0.5670.12
48_Q119_K0.5660.12
16_K84_L0.5660.12
37_Y123_T0.5660.12
85_S88_V0.5650.12
59_F67_F0.5630.12
17_Y51_T0.5580.11
73_K77_I0.5560.11
59_F104_Y0.5550.11
116_K122_N0.5540.11
51_T57_I0.5530.11
16_K37_Y0.5490.11
108_N125_S0.5480.11
7_N100_A0.5430.11
25_H47_R0.5430.11
23_D46_V0.5400.11
37_Y69_L0.5400.11
57_I91_L0.5390.11
15_W110_N0.5380.11
26_G44_L0.5310.11
25_H36_E0.5300.11
24_Q91_L0.5290.11
49_R87_F0.5260.11
22_Y35_P0.5250.11
7_N90_A0.5210.11
22_Y27_F0.5130.11
88_V99_I0.5130.11
29_G118_V0.5090.11
52_I84_L0.5070.11
12_S54_M0.5020.11
12_S26_G0.5020.11
17_Y57_I0.5000.11
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4wd8A 3 0.4524 9.3 0.952 Contact Map
2vpzA 1 0.3492 5.7 0.956 Contact Map
1eysL 1 0.4841 4.4 0.959 Contact Map
3n2sA 2 0.3413 4.3 0.959 Contact Map
5a63B 1 0.4921 3.8 0.96 Contact Map
2yayA 2 0.3095 3.2 0.962 Contact Map
4aweA 1 0.3333 3.2 0.962 Contact Map
1eswA 1 0.3333 3 0.962 Contact Map
1wy9A 2 0.1984 2.9 0.962 Contact Map
3aqpA 1 0.746 2.8 0.963 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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