GREMLIN Database
YIGE - Uncharacterized protein YigE
UniProt: P27840 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11462
Length: 254 (230)
Sequences: 352 (259)
Seq/√Len: 17.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
40_D209_C5.3651.00
87_M195_F4.5391.00
41_P209_C3.6331.00
95_D101_L3.5231.00
196_L210_Y3.3140.99
103_L114_L3.0020.99
89_M183_N2.8200.98
132_Y141_V2.7370.97
85_V249_S2.6430.97
231_Y238_P2.6340.97
176_V206_D2.6130.97
69_W78_D2.6030.97
161_M164_E2.6000.97
91_G248_I2.6000.97
194_V217_V2.5950.96
180_K226_T2.5670.96
93_I245_V2.5000.96
115_N124_F2.4580.95
203_N206_D2.3890.94
37_A199_Q2.2370.92
75_L249_S2.2370.92
163_M168_I2.1870.91
165_N219_Q2.1840.91
114_L130_V2.1690.91
50_V57_V2.0790.89
180_K223_L2.0110.87
60_Y249_S1.9440.85
133_V248_I1.9380.85
47_A210_Y1.8630.83
184_G211_A1.8410.82
45_V202_T1.8290.81
232_M235_G1.8260.81
229_H241_R1.8220.81
132_Y152_I1.7980.80
114_L147_K1.7850.80
93_I101_L1.7220.77
72_L79_I1.7170.77
49_T194_V1.6770.75
184_G207_F1.6410.74
103_L116_L1.5730.70
61_W104_Y1.5720.70
35_D48_Y1.5220.68
93_I246_T1.5120.67
174_P203_N1.5120.67
58_K251_E1.5030.67
116_L143_L1.4990.66
147_K169_N1.4950.66
43_L200_Q1.4780.65
75_L247_M1.4640.65
124_F241_R1.4590.64
131_F154_F1.4390.63
91_G100_P1.4340.63
142_R169_N1.4320.63
230_M239_W1.4310.63
44_T199_Q1.4160.62
152_I229_H1.4110.62
172_I176_V1.3840.60
124_F229_H1.3760.60
134_A139_G1.3720.59
222_Y242_Y1.3530.58
134_A181_I1.3510.58
106_E143_L1.3460.58
104_Y143_L1.3410.58
68_A201_A1.3390.57
139_G187_I1.3370.57
169_N187_I1.3230.57
118_S143_L1.3210.56
103_L155_A1.3030.55
95_D124_F1.2610.53
107_N174_P1.2550.52
126_R169_N1.2540.52
186_G211_A1.2490.52
189_K218_E1.2490.52
103_L146_F1.2390.52
51_N138_V1.2350.51
63_K67_E1.2280.51
70_G98_Y1.2280.51
124_F132_Y1.2260.51
71_T243_P1.2110.50
114_L144_D1.2060.50
52_P191_G1.1990.49
69_W247_M1.1980.49
52_P174_P1.1910.49
188_N194_V1.1810.48
59_M91_G1.1490.46
79_I251_E1.1490.46
126_R144_D1.1470.46
179_S206_D1.1290.45
124_F152_I1.1210.44
205_Y209_C1.1210.44
49_T217_V1.1110.44
48_Y230_M1.1080.44
183_N245_V1.1040.43
173_H208_A1.0900.43
114_L222_Y1.0810.42
62_Q111_K1.0790.42
57_V172_I1.0770.42
125_I171_R1.0520.40
101_L124_F1.0510.40
179_S203_N1.0480.40
181_I186_G1.0440.40
121_G228_S1.0340.39
74_A77_A1.0230.39
36_C49_T1.0220.39
93_I183_N1.0170.38
143_L147_K1.0120.38
143_L146_F1.0110.38
140_I166_G1.0090.38
130_V227_I1.0040.38
47_A194_V1.0030.38
237_I246_T0.9990.37
114_L143_L0.9970.37
23_L26_L0.9960.37
47_A196_L0.9910.37
101_L246_T0.9900.37
128_G220_L0.9820.36
47_A59_M0.9820.36
147_K222_Y0.9760.36
96_E214_K0.9620.35
132_Y142_R0.9590.35
94_Y250_V0.9580.35
24_T27_P0.9560.35
107_N154_F0.9530.35
80_N83_G0.9400.34
193_A206_D0.9400.34
61_W217_V0.9380.34
156_V245_V0.9350.34
41_P205_Y0.9260.33
141_V173_H0.9240.33
197_L237_I0.9190.33
138_V193_A0.9170.33
139_G193_A0.9140.33
150_K153_Q0.9140.33
164_E233_K0.9130.33
132_Y180_K0.9090.33
51_N109_Q0.9060.32
87_M237_I0.8920.32
222_Y228_S0.8820.31
95_D246_T0.8740.31
135_G153_Q0.8710.31
178_S228_S0.8650.30
82_Q143_L0.8610.30
166_G197_L0.8590.30
105_I154_F0.8540.30
30_A33_A0.8470.29
103_L115_N0.8460.29
222_Y229_H0.8440.29
185_V195_F0.8390.29
196_L207_F0.8380.29
48_Y246_T0.8340.29
126_R218_E0.8260.28
49_T192_N0.8250.28
30_A219_Q0.8230.28
70_G243_P0.8220.28
52_P84_Q0.8160.28
109_Q236_A0.8140.28
83_G138_V0.8130.28
141_V152_I0.8120.28
111_K148_T0.8100.28
26_L29_F0.8090.27
87_M233_K0.8070.27
66_G83_G0.8010.27
161_M219_Q0.7990.27
140_I165_N0.7940.27
79_I142_R0.7890.27
195_F233_K0.7880.27
120_E124_F0.7820.26
118_S126_R0.7820.26
89_M227_I0.7810.26
191_G209_C0.7810.26
94_Y206_D0.7700.26
67_E84_Q0.7700.26
137_K165_N0.7690.26
35_D246_T0.7580.25
61_W101_L0.7580.25
177_A203_N0.7540.25
85_V251_E0.7520.25
61_W244_F0.7510.25
134_A137_K0.7510.25
101_L120_E0.7480.25
133_V138_V0.7470.25
115_N152_I0.7430.24
125_I148_T0.7380.24
120_E126_R0.7360.24
93_I161_M0.7310.24
48_Y245_V0.7300.24
121_G178_S0.7290.24
34_D151_E0.7260.24
186_G218_E0.7250.24
51_N167_V0.7230.24
45_V206_D0.7170.23
33_A57_V0.7150.23
75_L217_V0.7140.23
178_S226_T0.7110.23
47_A180_K0.7100.23
178_S244_F0.7100.23
52_P59_M0.7100.23
91_G223_L0.7100.23
84_Q148_T0.7050.23
132_Y173_H0.7050.23
199_Q237_I0.7010.23
101_L146_F0.7000.23
211_A220_L0.6980.23
34_D222_Y0.6960.22
139_G143_L0.6960.22
178_S227_I0.6940.22
165_N216_N0.6920.22
239_W246_T0.6890.22
103_L131_F0.6860.22
98_Y169_N0.6850.22
93_I164_E0.6820.22
207_F211_A0.6800.22
189_K216_N0.6780.22
179_S192_N0.6770.22
67_E154_F0.6760.22
154_F223_L0.6760.22
184_G198_S0.6760.22
107_N153_Q0.6760.22
205_Y222_Y0.6760.22
23_L29_F0.6740.22
94_Y227_I0.6720.21
125_I169_N0.6710.21
72_L173_H0.6690.21
57_V243_P0.6660.21
56_R62_Q0.6630.21
144_D147_K0.6620.21
231_Y249_S0.6620.21
126_R132_Y0.6590.21
120_E150_K0.6590.21
196_L219_Q0.6560.21
134_A150_K0.6470.20
194_V219_Q0.6470.20
40_D210_Y0.6470.20
202_T210_Y0.6460.20
110_Q155_A0.6440.20
70_G142_R0.6430.20
35_D161_M0.6420.20
75_L223_L0.6410.20
93_I186_G0.6410.20
44_T145_A0.6390.20
88_A202_T0.6370.20
146_F168_I0.6370.20
97_S101_L0.6360.20
124_F217_V0.6330.20
188_N217_V0.6310.20
43_L199_Q0.6300.20
61_W246_T0.6290.20
176_V205_Y0.6270.20
88_A125_I0.6270.20
173_H242_Y0.6230.20
78_D94_Y0.6210.19
161_M184_G0.6190.19
38_L214_K0.6180.19
132_Y139_G0.6180.19
203_N249_S0.6170.19
115_N132_Y0.6150.19
39_S42_T0.6140.19
67_E107_N0.6120.19
128_G143_L0.6080.19
62_Q68_A0.6080.19
73_H104_Y0.6050.19
24_T29_F0.6040.19
73_H208_A0.6010.19
180_K222_Y0.5990.19
85_V88_A0.5980.19
52_P203_N0.5970.19
24_T167_V0.5960.19
126_R143_L0.5950.19
204_F215_L0.5940.18
69_W143_L0.5920.18
195_F237_I0.5920.18
60_Y237_I0.5920.18
47_A155_A0.5910.18
181_I203_N0.5890.18
57_V91_G0.5870.18
132_Y229_H0.5850.18
171_R180_K0.5830.18
50_V111_K0.5820.18
165_N233_K0.5810.18
124_F232_M0.5800.18
42_T212_K0.5800.18
125_I228_S0.5790.18
72_L176_V0.5790.18
130_V153_Q0.5770.18
54_T208_A0.5760.18
35_D93_I0.5720.18
180_K229_H0.5720.18
229_H244_F0.5700.18
77_A108_G0.5660.17
97_S246_T0.5640.17
90_N224_D0.5560.17
169_N219_Q0.5550.17
66_G136_D0.5540.17
230_M237_I0.5510.17
58_K136_D0.5490.17
124_F244_F0.5470.17
126_R247_M0.5470.17
192_N247_M0.5470.17
24_T234_G0.5460.17
22_A27_P0.5460.17
109_Q167_V0.5450.17
128_G156_V0.5440.17
51_N250_V0.5430.17
86_Q249_S0.5420.17
48_Y239_W0.5420.17
169_N213_A0.5420.17
52_P244_F0.5410.17
173_H203_N0.5390.17
152_I241_R0.5390.17
117_A124_F0.5390.17
164_E219_Q0.5320.16
146_F233_K0.5320.16
89_M246_T0.5310.16
101_L245_V0.5290.16
72_L204_F0.5290.16
154_F205_Y0.5290.16
42_T140_I0.5280.16
103_L126_R0.5280.16
198_S204_F0.5270.16
89_M93_I0.5260.16
201_A243_P0.5260.16
53_Q191_G0.5230.16
114_L145_A0.5230.16
67_E118_S0.5210.16
75_L119_G0.5210.16
115_N241_R0.5210.16
128_G211_A0.5200.16
103_L138_V0.5180.16
31_V105_I0.5180.16
77_A165_N0.5170.16
209_C213_A0.5160.16
99_A145_A0.5140.16
196_L220_L0.5140.16
145_A251_E0.5140.16
203_N238_P0.5130.16
57_V193_A0.5100.16
60_Y93_I0.5100.16
62_Q140_I0.5070.16
178_S241_R0.5060.16
99_A112_V0.5050.15
183_N228_S0.5050.15
168_I209_C0.5040.15
46_Q236_A0.5030.15
89_M197_L0.5020.15
183_N197_L0.5000.15
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3ohgA 1 0.937 100 0.696 Contact Map
3oaeA 5 0.3543 16.8 0.975 Contact Map
3sreA 1 0.752 16.2 0.975 Contact Map
3vgzA 1 0.7756 14.5 0.975 Contact Map
3ilmA 2 0.4173 13 0.976 Contact Map
2ismA 2 0.7165 13 0.976 Contact Map
2r5iA 5 0.3543 12.9 0.976 Contact Map
3v64A 2 0.7362 12.6 0.976 Contact Map
1mg4A 1 0.2756 11.7 0.976 Contact Map
2wlrA 1 0.4724 10.8 0.977 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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