GREMLIN Database
CYAY - Protein CyaY
UniProt: P27838 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11653
Length: 106 (102)
Sequences: 458 (282)
Seq/√Len: 27.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
30_I41_I3.7231.00
62_L87_F3.2791.00
3_D58_H3.2711.00
59_Q72_D3.0131.00
85_E93_Q2.8301.00
21_L41_I2.5750.99
59_Q81_D2.2690.98
13_L60_V2.1220.97
54_Q57_L2.1150.97
47_S98_Q2.1100.97
72_D81_D2.1090.97
93_Q97_Q1.9860.96
40_T48_K1.9500.96
10_A60_V1.8790.95
86_T89_D1.7450.92
59_Q64_T1.6950.91
39_L82_R1.6160.89
2_N5_E1.6150.89
41_I51_I1.5920.88
80_C83_S1.5680.87
79_I84_G1.4290.82
45_N98_Q1.4090.81
49_I62_L1.3990.81
38_V48_K1.3790.80
69_Y80_C1.3660.79
48_K82_R1.3610.79
2_N35_N1.3350.77
64_T67_G1.3310.77
66_Q69_Y1.3270.77
59_Q66_Q1.3200.77
69_Y94_A1.3090.76
64_T94_A1.2950.75
13_L87_F1.2230.71
71_F90_L1.1940.69
44_E47_S1.1930.69
96_T104_S1.1800.68
14_W87_F1.1700.67
37_G57_L1.1650.67
1_M11_D1.1650.67
38_V55_E1.1600.67
3_D55_E1.1550.66
37_G42_T1.1350.65
35_N74_K1.1150.63
64_T98_Q1.1000.62
29_D56_P1.0890.62
5_E71_F1.0760.61
22_D32_C1.0560.59
7_H55_E1.0410.58
31_D53_R1.0290.57
14_W39_L1.0280.57
27_D44_E1.0240.57
74_K93_Q1.0230.57
92_E96_T0.9910.54
5_E58_H0.9800.53
50_I58_H0.9420.51
13_L28_S0.9370.50
65_K103_V0.9340.50
31_D37_G0.9210.49
19_E75_G0.9200.49
23_D71_F0.9190.49
41_I58_H0.9150.48
6_F16_T0.9080.48
53_R66_Q0.9010.47
6_F55_E0.8980.47
50_I98_Q0.8790.46
34_I39_L0.8780.46
73_L76_D0.8750.45
77_E86_T0.8500.44
47_S65_K0.8480.43
73_L77_E0.8440.43
52_N82_R0.8390.43
9_L73_L0.8360.42
21_L32_C0.8350.42
8_R74_K0.8060.40
36_G93_Q0.8020.40
10_A52_N0.7990.40
66_Q94_A0.7820.38
11_D53_R0.7820.38
60_V87_F0.7790.38
2_N38_V0.7730.38
16_T20_R0.7710.38
50_I83_S0.7700.38
3_D6_F0.7680.37
33_E87_F0.7530.36
77_E103_V0.7420.36
15_L87_F0.7320.35
36_G52_N0.7290.35
92_E95_A0.7200.34
19_E40_T0.7160.34
6_F53_R0.7150.34
39_L55_E0.7140.34
93_Q102_T0.7080.33
26_G101_E0.7060.33
66_Q97_Q0.7040.33
6_F30_I0.7020.33
34_I80_C0.7010.33
55_E71_F0.7000.33
59_Q67_G0.6920.32
6_F87_F0.6870.32
80_C92_E0.6700.31
19_E65_K0.6680.31
91_L97_Q0.6680.31
39_L49_I0.6650.30
31_D42_T0.6630.30
74_K89_D0.6590.30
67_G81_D0.6560.30
10_A16_T0.6520.30
87_F94_A0.6470.29
16_T95_A0.6440.29
7_H71_F0.6400.29
28_S44_E0.6300.28
13_L73_L0.6270.28
64_T97_Q0.6240.28
19_E89_D0.6230.28
42_T46_G0.6220.28
50_I93_Q0.6200.28
22_D41_I0.6140.27
29_D54_Q0.5960.26
16_T89_D0.5920.26
11_D19_E0.5850.25
38_V67_G0.5790.25
21_L103_V0.5780.25
29_D99_A0.5780.25
28_S51_I0.5770.25
53_R57_L0.5750.25
27_D35_N0.5750.25
18_E70_H0.5700.25
21_L29_D0.5660.24
50_I67_G0.5650.24
4_S46_G0.5610.24
40_T50_I0.5610.24
14_W88_W0.5600.24
79_I83_S0.5560.24
66_Q81_D0.5520.24
73_L104_S0.5510.24
13_L16_T0.5480.23
96_T99_A0.5420.23
34_I56_P0.5360.23
1_M5_E0.5350.23
27_D43_F0.5330.23
80_C90_L0.5320.23
13_L91_L0.5250.22
34_I71_F0.5240.22
37_G51_I0.5220.22
33_E53_R0.5170.22
94_A97_Q0.5170.22
36_G59_Q0.5140.22
76_D79_I0.5090.21
101_E104_S0.5080.21
4_S56_P0.5070.21
20_R86_T0.5060.21
49_I65_K0.5060.21
9_L50_I0.5000.21
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1ew4A 1 1 100 0.173 Contact Map
4jpdA 5 1 100 0.183 Contact Map
4hs5A 1 0.9811 100 0.189 Contact Map
3t3lA 1 1 100 0.206 Contact Map
3oeqA 3 0.9528 100 0.264 Contact Map
3ig4A 4 0.9528 26.6 0.929 Contact Map
4ux3B 1 0.2547 18.4 0.934 Contact Map
2hczX 1 0.8491 17.9 0.934 Contact Map
1n10A 1 0.8585 17.9 0.934 Contact Map
4jcwA 2 0.8019 16.6 0.935 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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