GREMLIN Database
YIFK - Probable transport protein YifK
UniProt: P27837 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11459
Length: 461 (423)
Sequences: 24683 (15963)
Seq/√Len: 776.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
136_A340_I4.4871.00
322_A334_A4.3551.00
384_R388_A3.3811.00
376_F411_M3.3091.00
53_G245_L3.2051.00
325_K334_A3.0531.00
231_V235_S2.9701.00
13_E227_K2.8731.00
226_A232_T2.7471.00
77_A316_N2.7281.00
228_N231_V2.6851.00
18_E239_K2.6831.00
168_G254_V2.6641.00
93_A313_L2.6251.00
314_A324_A2.5821.00
327_S333_V2.5641.00
322_A325_K2.5631.00
129_L344_L2.5291.00
14_A239_K2.4121.00
224_G315_K2.3921.00
166_V170_G2.3911.00
282_A286_I2.3501.00
65_E386_R2.2611.00
337_A341_A2.2131.00
81_H89_G2.2061.00
137_L141_A2.2001.00
225_E308_R2.1741.00
133_A344_L2.1621.00
311_Y315_K2.1511.00
17_I226_A2.1181.00
379_L410_T2.1121.00
432_F436_I2.1111.00
144_R148_E2.1071.00
273_L276_A2.0951.00
14_A232_T2.0931.00
140_L333_V2.0831.00
14_A18_E2.0691.00
136_A336_V2.0431.00
18_E243_R2.0421.00
408_Y412_A2.0281.00
235_S239_K2.0231.00
13_E16_H1.9941.00
442_T446_K1.9931.00
436_I439_L1.9901.00
84_M384_R1.9691.00
155_M159_T1.9511.00
323_M338_V1.9441.00
128_A347_S1.9321.00
263_E277_K1.9261.00
62_S379_L1.9261.00
97_W339_S1.9181.00
260_P263_E1.9011.00
8_L326_V1.8951.00
129_L347_S1.8861.00
184_G187_N1.8751.00
317_R321_A1.8561.00
81_H86_P1.8551.00
54_L58_F1.8531.00
37_T45_V1.8271.00
228_N232_T1.7731.00
84_M380_I1.7681.00
327_S331_V1.7601.00
133_A340_I1.7331.00
139_N300_N1.7281.00
238_G242_W1.7171.00
92_T377_V1.7151.00
80_A92_T1.7111.00
273_L277_K1.7061.00
439_L443_A1.7011.00
16_H151_F1.6881.00
48_A205_A1.6681.00
44_S202_F1.6521.00
441_V444_I1.6491.00
21_A240_V1.6471.00
405_W409_V1.6451.00
384_R387_R1.6431.00
132_V343_L1.6361.00
85_S88_F1.6331.00
140_L337_A1.6161.00
108_I299_C1.6161.00
329_H333_V1.6081.00
123_A126_I1.5891.00
12_L16_H1.5821.00
443_A447_V1.5781.00
440_A444_I1.5621.00
159_T163_V1.5571.00
104_G343_L1.5511.00
276_A284_A1.5351.00
380_I411_M1.5191.00
242_W246_I1.5171.00
412_A416_C1.5171.00
222_T304_Y1.5051.00
115_V127_P1.5051.00
55_F413_F1.4931.00
310_L335_G1.4921.00
9_Q330_G1.4901.00
141_A329_H1.4711.00
169_L254_V1.4611.00
80_A377_V1.4521.00
334_A338_V1.4331.00
160_T290_V1.4311.00
306_C339_S1.4311.00
393_I396_H1.4281.00
276_A281_T1.4271.00
60_M241_L1.4271.00
311_Y326_V1.4261.00
52_A209_V1.4061.00
8_L311_Y1.4051.00
73_T224_G1.4041.00
321_A324_A1.4031.00
228_N235_S1.3891.00
58_F409_V1.3871.00
108_I132_V1.3811.00
158_V162_I1.3811.00
84_M88_F1.3791.00
380_I384_R1.3771.00
111_I292_L1.3731.00
136_A337_A1.3621.00
425_E428_R1.3611.00
129_L133_A1.3581.00
16_H147_G1.3581.00
132_V340_I1.3491.00
285_G289_F1.3391.00
307_G336_V1.3361.00
60_M237_V1.3341.00
325_K333_V1.3301.00
87_F445_Y1.3261.00
12_L17_I1.3241.00
434_G438_M1.3241.00
44_S195_F1.3231.00
70_E82_R1.3211.00
403_F407_N1.3201.00
438_M442_T1.3191.00
410_T414_L1.3181.00
59_I379_L1.3171.00
111_I131_A1.3161.00
54_L409_V1.3151.00
321_A325_K1.3141.00
229_P234_R1.3041.00
165_I250_G1.3031.00
72_V78_V1.2951.00
14_A235_S1.2901.00
267_N273_L1.2841.00
246_I250_G1.2711.00
390_K396_H1.2651.00
107_E298_G1.2551.00
232_T235_S1.2531.00
12_L147_G1.2501.00
78_V82_R1.2471.00
83_Y381_S1.2441.00
135_V299_C1.2361.00
426_D429_M1.2311.00
428_R431_L1.2281.00
269_S273_L1.2271.00
61_R238_G1.2271.00
32_M110_A1.2261.00
25_T244_I1.2181.00
164_M168_G1.2161.00
97_W310_L1.2161.00
436_I440_A1.2101.00
62_S407_N1.2101.00
310_L319_L1.2091.00
125_W129_L1.2051.00
437_F441_V1.2041.00
15_R19_L1.2031.00
46_L253_F1.1911.00
416_C420_G1.1841.00
72_V82_R1.1831.00
387_R390_K1.1811.00
181_Q186_S1.1791.00
394_A397_P1.1771.00
168_G258_I1.1691.00
138_A149_I1.1681.00
21_A219_I1.1641.00
17_I236_A1.1641.00
435_I439_L1.1601.00
404_P408_Y1.1571.00
405_W408_Y1.1491.00
63_M76_F1.1391.00
90_Y94_W1.1361.00
20_I222_T1.1311.00
267_N270_P1.1311.00
390_K393_I1.1171.00
80_A88_F1.1081.00
150_E300_N1.1071.00
261_W264_I1.1061.00
149_I153_F1.1051.00
198_G201_G1.1031.00
69_L394_A1.1021.00
130_I134_L1.1001.00
424_N428_R1.0981.00
163_V167_I1.0971.00
334_A337_A1.0961.00
227_K232_T1.0961.00
22_L243_R1.0901.00
430_S434_G1.0881.00
69_L396_H1.0841.00
341_A345_I1.0791.00
11_G227_K1.0771.00
427_T431_L1.0731.00
148_E152_W1.0731.00
126_I130_I1.0671.00
315_K324_A1.0601.00
115_V119_F1.0581.00
77_A312_A1.0581.00
38_L45_V1.0581.00
143_V304_Y1.0531.00
67_L79_Y1.0531.00
402_L406_A1.0481.00
50_I249_V1.0371.00
22_L244_I1.0351.00
326_V330_G1.0341.00
65_E68_F1.0331.00
184_G188_L1.0331.00
426_D430_S1.0271.00
382_Q407_N1.0201.00
140_L331_V1.0191.00
185_F188_L1.0191.00
112_G127_P1.0171.00
203_L416_C1.0151.00
383_L408_Y1.0021.00
411_M415_I1.0011.00
389_H393_I0.9991.00
153_F297_S0.9931.00
136_A140_L0.9921.00
162_I166_V0.9901.00
82_R389_H0.9891.00
415_I419_I0.9841.00
407_N411_M0.9821.00
431_L434_G0.9791.00
402_L405_W0.9761.00
214_Q371_G0.9711.00
418_L421_M0.9691.00
133_A137_L0.9631.00
239_K243_R0.9351.00
122_M126_I0.9331.00
303_M340_I0.9301.00
223_A233_L0.9281.00
429_M432_F0.9281.00
245_L249_V0.9251.00
19_L151_F0.9221.00
265_G270_P0.9221.00
260_P277_K0.9201.00
165_I169_L0.9181.00
379_L411_M0.9171.00
134_L296_L0.9171.00
157_K294_A0.9151.00
181_Q184_G0.9131.00
376_F415_I0.9131.00
427_T430_S0.9121.00
217_E221_I0.9111.00
426_D440_A0.9101.00
8_L225_E0.9091.00
58_F406_A0.9061.00
112_G128_A0.9031.00
386_R390_K0.9001.00
165_I254_V0.9001.00
140_L327_S0.9001.00
8_L308_R0.8981.00
253_F257_T0.8981.00
376_F414_L0.8961.00
74_G77_A0.8891.00
127_P130_I0.8881.00
11_G144_R0.8861.00
376_F380_I0.8851.00
333_V337_A0.8831.00
74_G78_V0.8781.00
440_A446_K0.8771.00
183_I186_S0.8771.00
135_V300_N0.8751.00
50_I54_L0.8751.00
414_L417_V0.8701.00
53_G213_Y0.8691.00
407_N421_M0.8691.00
158_V247_F0.8681.00
16_H148_E0.8681.00
69_L397_P0.8671.00
181_Q185_F0.8651.00
106_S364_Y0.8621.00
323_M334_A0.8611.00
396_H399_R0.8611.00
81_H316_N0.8591.00
419_I423_F0.8561.00
87_F91_L0.8531.00
46_L256_V0.8511.00
57_F61_R0.8511.00
279_G283_A0.8481.00
429_M436_I0.8461.00
182_S185_F0.8461.00
417_V420_G0.8451.00
441_V445_Y0.8441.00
340_I344_L0.8441.00
432_F443_A0.8431.00
132_V347_S0.8401.00
407_N410_T0.8401.00
436_I441_V0.8391.00
204_T208_I0.8371.00
281_T285_G0.8361.00
15_R151_F0.8351.00
416_C419_I0.8351.00
111_I296_L0.8301.00
440_A447_V0.8291.00
68_F397_P0.8291.00
14_A236_A0.8291.00
327_S330_G0.8271.00
195_F202_F0.8251.00
88_F377_V0.8241.00
80_A381_S0.8221.00
218_L305_S0.8221.00
442_T445_Y0.8181.00
424_N427_T0.8161.00
187_N190_E0.8151.00
319_L323_M0.8141.00
266_S270_P0.8111.00
410_T413_F0.8081.00
444_I447_V0.8071.00
417_V421_M0.8071.00
425_E429_M0.8071.00
137_L140_L0.8061.00
111_I295_A0.8041.00
387_R404_P0.8041.00
432_F439_L0.8041.00
258_I274_T0.8031.00
186_S189_T0.8031.00
58_F62_S0.8001.00
94_W319_L0.8001.00
148_E151_F0.7981.00
112_G124_Q0.7971.00
433_V436_I0.7961.00
37_T41_A0.7941.00
125_W347_S0.7931.00
109_T363_V0.7921.00
135_V303_M0.7881.00
395_S399_R0.7861.00
269_S272_V0.7851.00
26_I29_G0.7841.00
85_S446_K0.7831.00
106_S211_A0.7801.00
389_H394_A0.7771.00
431_L441_V0.7761.00
103_V367_S0.7751.00
66_M79_Y0.7751.00
427_T440_A0.7741.00
413_F417_V0.7731.00
164_M275_F0.7731.00
115_V292_L0.7701.00
214_Q375_W0.7691.00
438_M441_V0.7671.00
383_L407_N0.7671.00
57_F238_G0.7671.00
47_L202_F0.7651.00
199_W202_F0.7641.00
169_L250_G0.7601.00
230_Q397_P0.7581.00
66_M382_Q0.7581.00
11_G143_V0.7571.00
25_T240_V0.7541.00
96_Y100_W0.7531.00
431_L435_I0.7501.00
15_R148_E0.7501.00
341_A344_L0.7461.00
101_M342_I0.7441.00
141_A145_L0.7441.00
366_A370_P0.7421.00
432_F435_I0.7421.00
182_S186_S0.7421.00
383_L387_R0.7411.00
382_Q386_R0.7411.00
23_G154_A0.7401.00
59_I414_L0.7391.00
30_L251_A0.7361.00
408_Y411_M0.7331.00
63_M378_I0.7331.00
429_M438_M0.7301.00
165_I251_A0.7251.00
47_L51_I0.7231.00
280_I283_A0.7211.00
381_S385_F0.7201.00
443_A446_K0.7191.00
116_Q124_Q0.7181.00
394_A399_R0.7151.00
24_G301_S0.7121.00
228_N234_R0.7111.00
84_M381_S0.7071.00
105_I363_V0.7071.00
400_S403_F0.7061.00
234_R237_V0.7041.00
77_A81_H0.7021.00
140_L329_H0.7011.00
398_F401_I0.7011.00
432_F437_F0.7001.00
185_F257_T0.6981.00
139_N304_Y0.6961.00
428_R432_F0.6931.00
102_A366_A0.6911.00
94_W436_I0.6911.00
403_F406_A0.6891.00
184_G189_T0.6881.00
26_I157_K0.6881.00
129_L348_C0.6851.00
145_L148_E0.6851.00
426_D432_F0.6851.00
125_W128_A0.6831.00
47_L50_I0.6811.00
370_P374_P0.6791.00
11_G15_R0.6791.00
322_A338_V0.6781.00
147_G151_F0.6751.00
95_S374_P0.6751.00
46_L50_I0.6731.00
26_I247_F0.6731.00
43_P256_V0.6721.00
170_G176_F0.6711.00
310_L338_V0.6671.00
139_N336_V0.6641.00
15_R18_E0.6631.00
58_F410_T0.6621.00
18_E236_A0.6611.00
203_L420_G0.6601.00
389_H396_H0.6591.00
56_V216_V0.6591.00
69_L390_K0.6591.00
51_I206_L0.6581.00
116_Q120_P0.6581.00
45_V252_I0.6541.00
439_L442_T0.6521.00
24_G302_G0.6521.00
27_G248_Y0.6511.00
431_L438_M0.6511.00
314_A323_M0.6511.00
224_G311_Y0.6511.00
323_M335_G0.6501.00
73_T311_Y0.6501.00
308_R311_Y0.6481.00
105_I346_G0.6441.00
131_A299_C0.6431.00
140_L336_V0.6431.00
275_F278_I0.6421.00
99_M371_G0.6421.00
83_Y384_R0.6411.00
83_Y385_F0.6401.00
117_F288_N0.6401.00
307_G335_G0.6401.00
401_I405_W0.6401.00
60_M216_V0.6391.00
282_A285_G0.6381.00
250_G254_V0.6351.00
108_I112_G0.6341.00
8_L11_G0.6311.00
156_I290_V0.6311.00
328_R333_V0.6301.00
18_E21_A0.6291.00
414_L418_L0.6281.00
77_A93_A0.6281.00
303_M307_G0.6271.00
425_E430_S0.6251.00
143_V222_T0.6241.00
64_G68_F0.6231.00
135_V296_L0.6231.00
114_Y291_V0.6211.00
239_K242_W0.6211.00
221_I305_S0.6211.00
159_T162_I0.6201.00
429_M440_A0.6201.00
34_A252_I0.6171.00
115_V131_A0.6161.00
390_K394_A0.6161.00
107_E110_A0.6151.00
425_E432_F0.6141.00
275_F280_I0.6131.00
225_E332_P0.6121.00
429_M434_G0.6121.00
407_N413_F0.6111.00
76_F217_E0.6111.00
426_D439_L0.6111.00
306_C310_L0.6101.00
103_V106_S0.6091.00
436_I443_A0.6081.00
220_G237_V0.6061.00
432_F441_V0.6041.00
214_Q217_E0.6041.00
22_L154_A0.6041.00
332_P335_G0.6031.00
433_V437_F0.6031.00
430_S433_V0.6031.00
243_R247_F0.6031.00
85_S89_G0.6021.00
62_S400_S0.6021.00
251_A255_I0.5991.00
270_P275_F0.5981.00
233_L237_V0.5961.00
46_L249_V0.5961.00
294_A297_S0.5951.00
400_S407_N0.5941.00
345_I348_C0.5921.00
103_V107_E0.5921.00
112_G115_V0.5921.00
62_S410_T0.5921.00
49_Y212_S0.5921.00
67_L233_L0.5881.00
147_G300_N0.5861.00
19_L154_A0.5851.00
407_N414_L0.5841.00
133_A136_A0.5831.00
36_S361_V0.5831.00
132_V344_L0.5831.00
100_W302_G0.5831.00
243_R246_I0.5811.00
254_V257_T0.5801.00
156_I160_T0.5801.00
274_T278_I0.5801.00
52_A210_V0.5771.00
437_F440_A0.5771.00
201_G204_T0.5761.00
152_W155_M0.5761.00
195_F199_W0.5761.00
66_M83_Y0.5741.00
118_W289_F0.5741.00
77_A89_G0.5741.00
430_S436_I0.5741.00
275_F283_A0.5731.00
265_G269_S0.5721.00
385_F389_H0.5721.00
426_D431_L0.5721.00
107_E299_C0.5711.00
151_F155_M0.5711.00
432_F444_I0.5701.00
412_A415_I0.5701.00
154_A157_K0.5701.00
376_F418_L0.5691.00
226_A233_L0.5691.00
432_F440_A0.5681.00
187_N191_H0.5681.00
432_F438_M0.5681.00
142_A145_L0.5681.00
33_G364_Y0.5671.00
80_A89_G0.5661.00
195_F198_G0.5651.00
419_I422_Y0.5651.00
350_N354_P0.5641.00
360_F364_Y0.5641.00
289_F293_T0.5641.00
439_L446_K0.5621.00
44_S194_F0.5621.00
431_L436_I0.5621.00
428_R435_I0.5621.00
184_G257_T0.5591.00
92_T374_P0.5591.00
61_R406_A0.5591.00
76_F221_I0.5571.00
134_L138_A0.5561.00
440_A443_A0.5561.00
67_L220_G0.5541.00
430_S443_A0.5541.00
190_E194_F0.5541.00
136_A303_M0.5531.00
427_T432_F0.5521.00
162_I165_I0.5501.00
13_E144_R0.5501.00
36_S39_K0.5491.00
383_L404_P0.5491.00
107_E295_A0.5471.00
310_L314_A0.5471.00
21_A25_T0.5441.00
182_S188_L0.5431.00
400_S406_A0.5421.00
417_V422_Y0.5421.00
199_W203_L0.5421.00
322_A326_V0.5411.00
145_L149_I0.5391.00
75_S220_G0.5391.00
217_E375_W0.5361.00
361_V364_Y0.5361.00
113_V124_Q0.5361.00
214_Q367_S0.5351.00
266_S269_S0.5341.00
40_W204_T0.5331.00
24_G218_L0.5331.00
101_M346_G0.5331.00
146_Y304_Y0.5331.00
338_V342_I0.5321.00
60_M64_G0.5321.00
35_A38_L0.5321.00
167_I280_I0.5301.00
185_F189_T0.5301.00
433_V438_M0.5301.00
243_R250_G0.5291.00
52_A213_Y0.5291.00
219_I233_L0.5291.00
131_A135_V0.5291.00
26_I31_F0.5281.00
95_S373_V0.5271.00
251_A271_F0.5261.00
427_T436_I0.5251.00
230_Q395_S0.5251.00
229_P232_T0.5241.00
114_Y272_V0.5231.00
416_C421_M0.5231.00
118_W288_N0.5231.00
30_L33_G0.5221.00
226_A236_A0.5201.00
437_F445_Y0.5191.00
428_R442_T0.5181.00
211_A367_S0.5181.00
34_A38_L0.5171.00
59_I217_E0.5171.00
286_I290_V0.5171.00
46_L49_Y0.5161.00
143_V147_G0.5161.00
10_R227_K0.5151.00
41_A205_A0.5151.00
190_E193_G0.5151.00
131_A296_L0.5151.00
130_I133_A0.5151.00
440_A445_Y0.5141.00
49_Y252_I0.5141.00
20_I23_G0.5111.00
371_G374_P0.5101.00
410_T421_M0.5101.00
22_L25_T0.5091.00
183_I188_L0.5081.00
308_R326_V0.5071.00
326_V329_H0.5071.00
372_M414_L0.5061.00
69_L385_F0.5061.00
17_I219_I0.5061.00
354_P362_Y0.5051.00
386_R403_F0.5051.00
28_V107_E0.5021.00
231_V234_R0.5011.00
150_E297_S0.5011.00
37_T205_A0.5011.00
48_A209_V0.5001.00
393_I397_P0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3l1lA 2 0.9089 100 0.292 Contact Map
4djkA 2 0.8959 100 0.357 Contact Map
3giaA 1 0.9132 100 0.362 Contact Map
3dh4A 3 0.9197 99.1 0.848 Contact Map
2xq2A 2 0.9197 99 0.853 Contact Map
2jlnA 1 0.898 99 0.857 Contact Map
4wgvA 2 0.8069 98.1 0.891 Contact Map
2a65A 2 0.9241 97.8 0.898 Contact Map
4xp4A 1 0.9328 97.2 0.909 Contact Map
4us3A 1 0.8286 97 0.913 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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