GREMLIN Database
WECG - UDP-N-acetyl-D-mannosaminuronic acid transferase
UniProt: P27836 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11458
Length: 246 (232)
Sequences: 2546 (2115)
Seq/√Len: 138.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
110_P162_Q3.6431.00
112_F155_R2.9231.00
154_E158_A2.8511.00
110_P135_N2.8301.00
118_P141_D2.7321.00
112_F138_G2.6021.00
123_Q202_H2.5211.00
118_P122_A2.4371.00
33_D39_G2.4061.00
208_K212_T2.3631.00
52_I62_I2.3221.00
125_E129_R2.2701.00
140_Q155_R2.2131.00
55_N175_I2.2021.00
150_Q183_V2.0951.00
157_H185_P2.0871.00
209_I213_L2.0841.00
177_M191_G2.0671.00
176_I180_C1.9971.00
16_Q63_N1.9871.00
99_E102_A1.9861.00
92_A95_D1.9851.00
164_V186_D1.9791.00
228_I232_L1.9321.00
127_K131_Q1.8721.00
121_L139_S1.8651.00
35_Q107_E1.8591.00
23_M99_E1.8531.00
19_G88_V1.8331.00
105_G133_N1.8191.00
177_M189_Y1.7861.00
123_Q126_A1.7761.00
127_K130_N1.7651.00
194_G198_V1.7581.00
149_R176_I1.7531.00
166_V177_M1.7371.00
153_F157_H1.7071.00
150_Q154_E1.7061.00
31_F107_E1.7051.00
22_D25_H1.6631.00
101_M128_L1.6441.00
221_L231_Q1.6341.00
154_E157_H1.6321.00
110_P137_V1.6181.00
24_Q99_E1.6111.00
59_R63_N1.6071.00
149_R179_D1.6011.00
48_K170_S1.5581.00
60_E64_A1.5571.00
121_L125_E1.5331.00
94_A195_T1.5311.00
117_K143_Y1.5191.00
97_W165_T1.5151.00
53_E240_W1.5031.00
31_F103_R1.4991.00
117_K120_V1.4921.00
54_D236_R1.4811.00
229_K233_R1.4731.00
30_L188_L1.4671.00
104_A163_I1.4661.00
57_E175_I1.4531.00
26_A67_F1.4341.00
61_L175_I1.4271.00
113_L128_L1.4171.00
31_F109_T1.4001.00
103_R107_E1.3961.00
28_D103_R1.3861.00
109_T162_Q1.3711.00
117_K202_H1.3631.00
46_A74_S1.3591.00
42_V65_A1.3401.00
219_Y223_S1.3361.00
43_A48_K1.3251.00
125_E139_S1.3191.00
40_T177_M1.3181.00
123_Q127_K1.3121.00
73_I76_V1.3031.00
94_A198_V1.2901.00
112_F156_I1.2761.00
215_L218_L1.2571.00
97_W195_T1.2561.00
157_H183_V1.2551.00
148_Q151_A1.2521.00
97_W192_V1.2521.00
205_R216_E1.2511.00
33_D37_K1.2351.00
78_S241_H1.2251.00
164_V189_Y1.2201.00
34_G109_T1.2171.00
90_R211_Q1.2001.00
113_L196_Y1.1951.00
105_G134_V1.1881.00
43_A69_Y1.1851.00
38_Q181_R1.1851.00
48_K58_V1.1620.99
32_A36_L1.1590.99
149_R153_F1.1450.99
210_W215_L1.1400.99
78_S237_Y1.1310.99
108_G135_N1.1280.99
11_T16_Q1.1250.99
228_I231_Q1.1200.99
224_Q227_R1.1190.99
104_A111_V1.1170.99
119_E122_A1.1120.99
92_A205_R1.1050.99
165_T196_Y1.1000.99
11_T14_G1.0980.99
64_A178_R1.0950.99
230_R234_L1.0910.99
97_W199_F1.0810.99
204_K219_Y1.0700.99
221_L229_K1.0670.99
111_V165_T1.0620.99
114_V144_F1.0600.99
164_V180_C1.0580.99
100_L163_I1.0530.99
38_Q187_A1.0480.99
95_D205_R1.0430.99
102_A106_K1.0400.99
124_T196_Y1.0300.99
122_A126_A1.0230.99
180_C183_V1.0220.99
44_I75_V1.0210.99
112_F140_Q1.0210.99
206_A211_Q1.0180.99
205_R211_Q1.0150.99
29_Y32_A1.0120.99
38_Q189_Y1.0100.98
20_W26_A0.9890.98
113_L124_T0.9860.98
50_L240_W0.9830.98
140_Q143_Y0.9770.98
145_K148_Q0.9720.98
207_P219_Y0.9530.98
117_K121_L0.9520.98
46_A73_I0.9520.98
167_A196_Y0.9520.98
149_R180_C0.9430.98
48_K62_I0.9430.98
98_E131_Q0.9410.98
56_A60_E0.9390.98
76_V90_R0.9310.97
137_V159_S0.9300.97
192_V196_Y0.9270.97
28_D32_A0.9210.97
208_K211_Q0.9180.97
104_A109_T0.9060.97
210_W213_L0.9040.97
39_G66_E0.9030.97
144_F148_Q0.9010.97
44_I48_K0.9010.97
126_A130_N0.8950.97
94_A98_E0.8930.97
110_P160_G0.8920.97
41_L190_M0.8920.97
26_A69_Y0.8920.97
47_E51_T0.8900.97
47_E194_G0.8870.97
206_A216_E0.8790.96
27_L31_F0.8760.96
101_M111_V0.8550.96
229_K232_L0.8530.96
17_L44_I0.8490.96
20_W29_Y0.8460.95
101_M165_T0.8430.95
155_R159_S0.8430.95
23_M27_L0.8410.95
226_S231_Q0.8410.95
66_E181_R0.8380.95
116_G121_L0.8330.95
57_E179_D0.8290.95
203_V224_Q0.8290.95
164_V187_A0.8230.95
41_L188_L0.8210.95
113_L125_E0.8120.94
69_Y96_L0.8110.94
204_K223_S0.8110.94
30_L41_L0.8100.94
152_L155_R0.8080.94
56_A59_R0.8070.94
51_T55_N0.8070.94
97_W101_M0.7990.94
73_I214_G0.7990.94
52_I58_V0.7940.94
103_R109_T0.7900.94
206_A219_Y0.7890.93
40_T181_R0.7820.93
40_T65_A0.7760.93
62_I68_K0.7750.93
26_A96_L0.7700.93
231_Q234_L0.7700.93
79_V87_Q0.7680.93
164_V176_I0.7620.92
51_T170_S0.7510.92
95_D216_E0.7460.91
238_L242_Y0.7440.91
41_L69_Y0.7410.91
18_I29_Y0.7390.91
110_P159_S0.7380.91
218_L222_L0.7340.91
23_M26_A0.7330.91
73_I77_R0.7330.91
197_D202_H0.7290.90
239_R243_T0.7290.90
44_I68_K0.7280.90
29_Y33_D0.7240.90
155_R158_A0.7200.90
123_Q200_T0.7140.90
81_K242_Y0.7130.89
221_L233_R0.7120.89
92_A211_Q0.7110.89
226_S229_K0.7100.89
175_I178_R0.7080.89
47_E231_Q0.7060.89
120_V200_T0.7060.89
221_L234_L0.6970.88
22_D88_V0.6930.88
70_A76_V0.6930.88
94_A194_G0.6930.88
169_G173_Q0.6930.88
181_R189_Y0.6910.88
101_M105_G0.6900.88
26_A91_V0.6840.87
165_T192_V0.6830.87
119_E139_S0.6780.87
240_W243_T0.6760.87
114_V164_V0.6750.87
184_H189_Y0.6740.87
114_V156_I0.6730.87
157_H184_H0.6700.86
116_G197_D0.6690.86
140_Q144_F0.6690.86
32_A35_Q0.6690.86
93_G192_V0.6650.86
14_G59_R0.6640.86
43_A170_S0.6600.86
84_P88_V0.6580.85
74_S77_R0.6540.85
77_R80_R0.6530.85
76_V79_V0.6500.85
122_A125_E0.6490.85
95_D211_Q0.6490.85
26_A41_L0.6430.84
167_A192_V0.6390.84
114_V140_Q0.6380.84
141_D144_F0.6370.84
176_I221_L0.6360.83
31_F35_Q0.6350.83
151_A155_R0.6340.83
157_H186_D0.6340.83
140_Q152_L0.6310.83
198_V206_A0.6310.83
142_G194_G0.6290.83
235_L239_R0.6280.83
30_L96_L0.6270.83
22_D89_S0.6250.82
122_A139_S0.6220.82
138_G159_S0.6220.82
26_A30_L0.6200.82
93_G191_G0.6190.82
79_V88_V0.6150.81
238_L241_H0.6110.81
144_F152_L0.6110.81
74_S142_G0.6100.81
38_Q185_P0.6090.81
42_V62_I0.6020.80
79_V84_P0.6010.80
58_V62_I0.6010.80
128_L134_V0.6000.80
45_N71_D0.5990.80
198_V203_V0.5990.80
109_T163_I0.5960.79
195_T198_V0.5930.79
153_F183_V0.5920.79
168_M176_I0.5900.79
162_Q187_A0.5890.78
102_A131_Q0.5890.78
102_A105_G0.5860.78
154_E183_V0.5850.78
101_M134_V0.5820.78
57_E60_E0.5820.78
31_F34_G0.5800.77
120_V197_D0.5770.77
47_E232_L0.5770.77
60_E63_N0.5760.77
49_M75_V0.5750.77
153_F180_C0.5740.77
77_R214_G0.5730.77
27_L103_R0.5730.77
76_V80_R0.5730.77
236_R240_W0.5710.76
43_A92_A0.5690.76
46_A232_L0.5680.76
98_E102_A0.5670.76
23_M96_L0.5670.76
111_V134_V0.5660.76
85_Q88_V0.5660.76
45_N48_K0.5630.75
121_L124_T0.5620.75
47_E228_I0.5620.75
116_G120_V0.5600.75
94_A142_G0.5590.75
57_E61_L0.5570.75
50_L53_E0.5570.75
71_D220_R0.5540.74
50_L236_R0.5540.74
126_A129_R0.5540.74
30_L100_L0.5510.74
151_A154_E0.5510.74
213_L222_L0.5500.74
146_P150_Q0.5500.74
74_S78_S0.5500.74
142_G198_V0.5480.73
184_H187_A0.5460.73
12_L75_V0.5460.73
36_L39_G0.5430.73
103_R106_K0.5430.73
209_I212_T0.5390.72
29_Y67_F0.5390.72
129_R133_N0.5360.72
197_D227_R0.5350.72
109_T161_A0.5330.71
192_V195_T0.5330.71
108_G134_V0.5250.70
114_V152_L0.5250.70
16_Q68_K0.5250.70
70_A74_S0.5240.70
194_G231_Q0.5210.70
156_I164_V0.5200.69
224_Q232_L0.5200.69
40_T189_Y0.5180.69
43_A47_E0.5180.69
93_G205_R0.5170.69
46_A50_L0.5160.69
42_V68_K0.5150.69
142_G172_K0.5100.68
194_G232_L0.5090.68
46_A70_A0.5090.68
164_V184_H0.5090.68
164_V177_M0.5080.68
76_V92_A0.5080.68
110_P161_A0.5070.68
60_E126_A0.5060.67
105_G132_W0.5050.67
94_A97_W0.5030.67
119_E125_E0.5030.67
34_G163_I0.5000.67
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4jgiA 2 0.7886 77.4 0.937 Contact Map
1y80A 1 0.4675 69.9 0.94 Contact Map
4mptA 1 0.9106 61.9 0.943 Contact Map
2xdqA 1 0.8171 60 0.944 Contact Map
3lopA 1 0.9065 57 0.945 Contact Map
4r3uC 1 0.4715 54.9 0.946 Contact Map
2lpmA 1 0.4919 53.7 0.946 Contact Map
2zayA 1 0.4797 53.4 0.946 Contact Map
2mswA 1 0.4553 53.4 0.946 Contact Map
4fq5B 4 0.8577 52.8 0.946 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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