GREMLIN Database
RFFA - dTDP-4-amino-4,6-dideoxygalactose transaminase
UniProt: P27833 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11456
Length: 376 (351)
Sequences: 10916 (8282)
Seq/√Len: 442.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
265_Y293_F3.6321.00
39_W244_W3.0241.00
113_E144_K2.8981.00
267_A368_I2.7591.00
139_M143_K2.6221.00
19_S32_F2.6131.00
134_E137_T2.6021.00
345_K349_R2.5631.00
14_L18_Q2.5391.00
296_K349_R2.4971.00
263_N364_Q2.4491.00
43_R251_D2.3971.00
313_A370_T2.3941.00
160_T165_A2.3931.00
139_M149_V2.3781.00
136_D162_K2.3761.00
263_N365_R2.2311.00
111_L114_A2.2251.00
132_A166_L2.1481.00
112_I138_I2.1171.00
48_K197_K2.1031.00
47_A195_N2.0731.00
35_R39_W2.0501.00
39_W248_E2.0341.00
110_T137_T2.0111.00
256_Q259_A2.0071.00
14_L22_G1.9911.00
360_S363_N1.9791.00
160_T287_V1.9751.00
313_A373_N1.9631.00
11_G15_D1.9281.00
366_T370_T1.9261.00
101_R104_T1.9161.00
108_D111_L1.8991.00
302_D305_A1.8841.00
148_F171_H1.8631.00
326_G344_T1.8541.00
12_T248_E1.8491.00
66_L148_F1.8441.00
111_L115_A1.8361.00
308_N312_E1.8311.00
98_V115_A1.8121.00
192_T203_A1.7871.00
236_S239_Q1.7801.00
140_A144_K1.7761.00
197_K201_E1.7711.00
40_L191_A1.7601.00
267_A365_R1.7471.00
62_A172_I1.7381.00
58_S174_C1.7351.00
47_A197_K1.7331.00
185_A243_L1.7281.00
32_F244_W1.7171.00
177_F191_A1.7151.00
175_F193_L1.7111.00
263_N361_P1.7101.00
263_N267_A1.7091.00
18_Q22_G1.7061.00
194_I200_I1.6931.00
309_F313_A1.6911.00
309_F312_E1.6751.00
202_R228_D1.6661.00
73_E120_T1.6371.00
123_I142_A1.6051.00
38_Q42_Q1.6031.00
41_E49_V1.6021.00
53_P57_A1.5881.00
172_I199_L1.5681.00
50_L200_I1.5491.00
73_E94_K1.5441.00
142_A149_V1.5421.00
364_Q368_I1.5341.00
72_D121_R1.5271.00
310_L317_A1.5251.00
80_T324_L1.5121.00
68_I93_A1.5001.00
102_P342_Y1.4941.00
258_L287_V1.4911.00
35_R244_W1.4841.00
156_G166_L1.4831.00
116_I141_L1.4611.00
270_P372_L1.4601.00
73_E117_T1.4591.00
43_R165_A1.4551.00
49_V191_A1.4531.00
171_H196_D1.4511.00
200_I204_E1.4461.00
73_E119_K1.4311.00
164_R168_T1.4231.00
40_L157_V1.3951.00
271_L276_R1.3951.00
278_E296_K1.3941.00
196_D199_L1.3711.00
267_A372_L1.3591.00
262_Q266_D1.3561.00
143_K171_H1.3461.00
105_M346_E1.3461.00
137_T140_A1.3421.00
117_T120_T1.3381.00
136_D161_Y1.3371.00
307_I317_A1.3311.00
78_S343_T1.3301.00
127_H135_M1.3261.00
76_M88_F1.3251.00
32_F35_R1.3231.00
256_Q260_L1.3131.00
102_P345_K1.3121.00
255_Q259_A1.3051.00
98_V111_L1.2971.00
13_E245_A1.2931.00
131_V283_P1.2811.00
306_L351_L1.2781.00
245_A248_E1.2661.00
315_I370_T1.2501.00
306_L371_L1.2501.00
62_A150_V1.2491.00
268_L371_L1.2461.00
271_L372_L1.2441.00
39_W42_Q1.2441.00
44_F193_L1.2401.00
297_L306_L1.2401.00
139_M169_I1.2361.00
256_Q361_P1.2341.00
36_C243_L1.2321.00
162_K285_G1.2321.00
69_Q72_D1.2271.00
75_I98_V1.2201.00
212_N227_R1.2171.00
103_D281_S1.2141.00
100_V346_E1.2131.00
12_T15_D1.2071.00
138_I149_V1.2011.00
15_D18_Q1.1991.00
15_D19_S1.1981.00
105_M296_K1.1951.00
60_E90_L1.1851.00
12_T249_A1.1811.00
365_R369_A1.1781.00
16_Y245_A1.1781.00
307_I351_L1.1771.00
66_L150_V1.1671.00
66_L172_I1.1601.00
342_Y345_K1.1491.00
125_P149_V1.1491.00
34_R38_Q1.1451.00
205_I228_D1.1451.00
279_L293_F1.1451.00
60_E233_Y1.1381.00
107_I112_I1.1341.00
263_N368_I1.1301.00
61_M203_A1.1271.00
294_Y350_L1.1261.00
305_A309_F1.1231.00
278_E298_R1.1181.00
259_A361_P1.1151.00
112_I141_L1.1141.00
61_M206_I1.1111.00
78_S325_H1.1091.00
48_K200_I1.1031.00
127_H170_G1.0991.00
325_H344_T1.0941.00
31_G35_R1.0821.00
60_E231_S1.0821.00
113_E145_H1.0801.00
260_L364_Q1.0731.00
113_E137_T1.0731.00
60_E64_L1.0731.00
16_Y248_E1.0691.00
13_E242_Y1.0671.00
225_T328_P1.0651.00
70_P92_G1.0631.00
29_D207_R1.0601.00
113_E117_T1.0571.00
64_L91_R1.0511.00
52_T61_M1.0491.00
325_H340_D1.0481.00
109_E141_L1.0461.00
101_R108_D1.0451.00
69_Q93_A1.0341.00
16_Y32_F1.0301.00
10_V14_L1.0261.00
135_M169_I1.0201.00
51_L235_M1.0181.00
260_L355_L1.0111.00
16_Y19_S1.0071.00
39_W247_L1.0041.00
157_V250_A1.0041.00
122_V148_F1.0031.00
249_A252_R1.0021.00
75_I112_I0.9971.00
10_V13_E0.9961.00
265_Y282_I0.9841.00
142_A147_L0.9831.00
370_T373_N0.9831.00
78_S340_D0.9811.00
63_A124_V0.9801.00
265_Y279_L0.9711.00
65_L203_A0.9681.00
98_V107_I0.9681.00
55_C58_S0.9671.00
48_K194_I0.9641.00
369_A373_N0.9621.00
89_V330_G0.9621.00
10_V249_A0.9601.00
105_M280_P0.9581.00
227_R328_P0.9581.00
182_N291_H0.9511.00
139_M171_H0.9471.00
86_N209_K0.9441.00
63_A88_F0.9441.00
255_Q258_L0.9411.00
260_L359_L0.9381.00
361_P364_Q0.9371.00
85_A97_F0.9371.00
62_A174_C0.9361.00
235_M240_A0.9351.00
261_W290_A0.9321.00
304_S308_N0.9321.00
85_A324_L0.9321.00
67_D202_R0.9281.00
307_I311_K0.9261.00
298_R349_R0.9231.00
361_P365_R0.9191.00
141_L145_H0.9191.00
309_F370_T0.9161.00
46_S195_N0.9161.00
276_R298_R0.9161.00
110_T113_E0.9151.00
113_E141_L0.9141.00
258_L282_I0.9101.00
222_D225_T0.9041.00
294_Y352_R0.9031.00
153_A166_L0.9031.00
53_P233_Y0.9011.00
185_A189_G0.9001.00
305_A308_N0.8991.00
46_S168_T0.8931.00
49_V193_L0.8881.00
306_L309_F0.8841.00
73_E96_V0.8821.00
68_I74_V0.8821.00
40_L175_F0.8781.00
338_G344_T0.8781.00
33_T240_A0.8771.00
131_V286_C0.8741.00
308_N311_K0.8741.00
38_Q41_E0.8711.00
50_L204_E0.8701.00
362_V365_R0.8691.00
194_I199_L0.8681.00
57_A233_Y0.8641.00
262_Q265_Y0.8621.00
122_V150_V0.8571.00
225_T322_I0.8551.00
313_A366_T0.8541.00
323_P343_T0.8541.00
340_D343_T0.8531.00
345_K348_E0.8511.00
76_M85_A0.8471.00
258_L262_Q0.8451.00
256_Q358_N0.8401.00
252_R255_Q0.8361.00
68_I122_V0.8341.00
31_G34_R0.8331.00
35_R38_Q0.8331.00
359_L367_V0.8321.00
125_P138_I0.8301.00
10_V22_G0.8251.00
159_S289_N0.8251.00
264_Y367_V0.8231.00
254_N289_N0.8221.00
140_A143_K0.8211.00
252_R256_Q0.8191.00
37_Q51_L0.8171.00
165_A168_T0.8121.00
133_C138_I0.8111.00
44_F165_A0.8111.00
41_E44_F0.8101.00
17_M238_L0.8091.00
164_R169_I0.8071.00
298_R301_D0.8071.00
32_F237_D0.8061.00
77_P88_F0.8061.00
125_P133_C0.8031.00
320_H352_R0.8001.00
88_F95_I0.7991.00
263_N266_D0.7981.00
366_T369_A0.7971.00
127_H151_E0.7941.00
88_F93_A0.7931.00
303_R319_F0.7911.00
337_H348_E0.7881.00
259_A262_Q0.7821.00
306_L310_L0.7821.00
43_R158_M0.7801.00
135_M139_M0.7801.00
17_M21_M0.7761.00
52_T192_T0.7731.00
11_G14_L0.7731.00
101_R109_E0.7731.00
251_D255_Q0.7711.00
61_M207_R0.7711.00
72_D93_A0.7661.00
205_I227_R0.7661.00
265_Y290_A0.7651.00
198_A201_E0.7621.00
69_Q121_R0.7621.00
11_G22_G0.7611.00
29_D33_T0.7591.00
75_I115_A0.7531.00
136_D140_A0.7531.00
17_M242_Y0.7521.00
259_A263_N0.7511.00
283_P286_C0.7501.00
89_V95_I0.7481.00
63_A150_V0.7471.00
158_M254_N0.7471.00
267_A270_P0.7471.00
20_A241_A0.7451.00
201_E212_N0.7411.00
169_I173_G0.7381.00
109_E133_C0.7371.00
64_L90_L0.7351.00
261_W293_F0.7341.00
142_A145_H0.7321.00
323_P326_G0.7311.00
265_Y281_S0.7281.00
74_V88_F0.7271.00
62_A192_T0.7271.00
266_D269_A0.7261.00
363_N366_T0.7261.00
68_I121_R0.7251.00
65_L172_I0.7221.00
19_S23_S0.7221.00
87_A91_R0.7201.00
166_L173_G0.7191.00
365_R368_I0.7161.00
84_T87_A0.7161.00
267_A369_A0.7151.00
182_N254_N0.7141.00
40_L247_L0.7131.00
101_R134_E0.7131.00
86_N330_G0.7121.00
336_F339_E0.7111.00
33_T235_M0.7101.00
123_I147_L0.7091.00
33_T51_L0.7081.00
160_T163_G0.7071.00
81_F224_Y0.7061.00
170_G173_G0.7061.00
342_Y346_E0.7051.00
8_P358_N0.7031.00
74_V122_V0.7021.00
268_L372_L0.7021.00
63_A68_I0.6981.00
368_I372_L0.6981.00
168_T195_N0.6981.00
60_E91_R0.6971.00
55_C174_C0.6961.00
40_L49_V0.6961.00
79_Y320_H0.6951.00
161_Y286_C0.6951.00
187_G238_L0.6931.00
112_I123_I0.6931.00
131_V282_I0.6881.00
356_F359_L0.6881.00
344_T348_E0.6861.00
172_I192_T0.6861.00
116_I147_L0.6851.00
151_E170_G0.6851.00
139_M170_G0.6821.00
50_L203_A0.6821.00
75_I120_T0.6811.00
44_F168_T0.6801.00
77_P126_V0.6791.00
260_L264_Y0.6791.00
90_L231_S0.6781.00
151_E173_G0.6721.00
189_G235_M0.6671.00
109_E138_I0.6621.00
165_A251_D0.6621.00
272_A276_R0.6621.00
323_P347_S0.6611.00
44_F49_V0.6601.00
46_S193_L0.6571.00
12_T245_A0.6551.00
52_T58_S0.6531.00
13_E249_A0.6521.00
229_I329_A0.6511.00
326_G338_G0.6500.99
128_Y155_Q0.6490.99
258_L290_A0.6450.99
260_L263_N0.6440.99
328_P331_E0.6440.99
261_W265_Y0.6430.99
135_M149_V0.6420.99
339_E344_T0.6410.99
254_N258_L0.6360.99
202_R206_I0.6340.99
58_S192_T0.6340.99
88_F124_V0.6340.99
80_T84_T0.6330.99
125_P135_M0.6330.99
159_S166_L0.6320.99
16_Y241_A0.6320.99
8_P249_A0.6300.99
209_K234_L0.6290.99
277_I295_I0.6280.99
89_V329_A0.6270.99
103_D278_E0.6270.99
249_A253_I0.6260.99
311_K317_A0.6240.99
20_A32_F0.6240.99
9_V13_E0.6220.99
87_A124_V0.6200.99
172_I194_I0.6170.99
251_D287_V0.6160.99
261_W355_L0.6160.99
64_L231_S0.6140.99
173_G193_L0.6130.99
127_H133_C0.6130.99
23_S31_G0.6130.99
161_Y169_I0.6120.99
64_L206_I0.6110.99
153_A173_G0.6090.99
19_S35_R0.6080.99
127_H166_L0.6080.99
296_K345_K0.6070.99
46_S173_G0.6060.99
99_D342_Y0.6060.99
14_L21_M0.6030.99
187_G239_Q0.6020.99
63_A91_R0.6020.99
78_S97_F0.6000.99
79_Y350_L0.6000.99
54_S232_S0.5990.99
84_T124_V0.5990.99
297_L302_D0.5980.99
54_S57_A0.5970.99
12_T16_Y0.5970.99
296_K350_L0.5940.99
81_F211_T0.5940.99
89_V229_I0.5940.99
41_E48_K0.5920.99
137_T161_Y0.5880.99
309_F373_N0.5880.99
201_E205_I0.5870.99
20_A23_S0.5870.99
235_M239_Q0.5870.99
84_T126_V0.5850.99
62_A66_L0.5850.99
69_Q91_R0.5850.99
129_A294_Y0.5830.99
282_I290_A0.5820.99
74_V124_V0.5800.99
132_A159_S0.5780.99
55_C154_A0.5770.99
168_T173_G0.5760.99
100_V343_T0.5730.99
265_Y269_A0.5710.99
304_S307_I0.5710.99
292_M352_R0.5700.99
132_A161_Y0.5690.99
295_I351_L0.5690.99
67_D93_A0.5660.99
131_V288_Q0.5630.99
129_A320_H0.5630.99
100_V342_Y0.5620.99
85_A330_G0.5610.99
29_D237_D0.5600.99
171_H195_N0.5600.99
74_V93_A0.5570.98
137_T141_L0.5560.98
205_I212_N0.5540.98
178_H188_E0.5540.98
41_E46_S0.5530.98
250_A254_N0.5490.98
116_I145_H0.5490.98
156_G159_S0.5480.98
341_R344_T0.5460.98
264_Y364_Q0.5460.98
13_E17_M0.5440.98
154_A181_K0.5440.98
121_R148_F0.5430.98
16_Y20_A0.5430.98
79_Y128_Y0.5430.98
132_A286_C0.5420.98
151_E167_G0.5410.98
298_R302_D0.5400.98
161_Y164_R0.5390.98
296_K346_E0.5390.98
60_E87_A0.5390.98
326_G348_E0.5390.98
251_D254_N0.5390.98
33_T237_D0.5390.98
177_F243_L0.5370.98
267_A364_Q0.5370.98
68_I72_D0.5350.98
109_E134_E0.5340.98
51_L191_A0.5330.98
282_I288_Q0.5320.98
48_K204_E0.5300.98
158_M250_A0.5280.98
108_D137_T0.5280.98
172_I203_A0.5280.98
204_E207_R0.5250.98
136_D164_R0.5240.98
109_E137_T0.5240.98
14_L17_M0.5240.98
127_H153_A0.5230.98
23_S32_F0.5210.98
71_G94_K0.5190.98
245_A249_A0.5180.98
76_M84_T0.5160.97
18_Q21_M0.5140.97
182_N289_N0.5130.97
295_I371_L0.5100.97
167_G175_F0.5070.97
138_I141_L0.5060.97
310_L371_L0.5060.97
124_V150_V0.5040.97
195_N199_L0.5040.97
161_Y285_G0.5030.97
334_G338_G0.5020.97
107_I125_P0.5020.97
59_L87_A0.5000.97
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4zwvA 2 0.9628 100 0.409 Contact Map
1o69A 2 0.9309 100 0.448 Contact Map
2fnuA 2 0.9681 100 0.449 Contact Map
3frkA 2 0.9521 100 0.454 Contact Map
4lc3A 2 0.9734 100 0.454 Contact Map
3b8xA 2 0.9707 100 0.464 Contact Map
3bb8A 2 0.9787 100 0.466 Contact Map
2c81A 2 0.9761 100 0.475 Contact Map
4zahA 2 0.9814 100 0.479 Contact Map
3nytA 2 0.9388 100 0.481 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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