WECD - ECOLI - GREMLIN Contacts

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WECD - dTDP-fucosamine acetyltransferase

UniProt:	P27832	Sequences: MPVRASIEPLTWENAFFGVNSAIVRITSEAPLLTPDALAPWSRVQAKIAASNTGELDALQQLGFSLVEGEVDLALPVNNASDSGAVVAQETDIPALRQLASAAFAQSRFRAPWYAPDASSRFYAQWIENAVRGTFDHQCLILRAASGDIRGYVSLRELNATDARIGLLAGRGAGAELMQTALNWAYARGKTTLRVATQMGNTAALKRYIQSGANVESTAYWLYR	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG11455
Length:	224 (214)
Sequences:	285 (224)
Seq/√Len:	15.3

ECOLI - WECD
BACSU - SPSD

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
103_A	169_A	5.282	1.00
86_V	143_R	3.861	1.00
12_W	16_F	3.339	0.99
127_I	154_S	3.296	0.99
12_W	108_R	3.274	0.99
174_G	208_Y	3.191	0.99
149_I	206_K	2.849	0.97
204_A	208_Y	2.804	0.97
26_I	46_A	2.711	0.96
68_E	222_L	2.572	0.95
125_Q	129_N	2.546	0.95
86_V	206_K	2.537	0.94
14_N	20_N	2.450	0.93
175_A	210_Q	2.435	0.93
20_N	42_S	2.428	0.93
169_A	180_T	2.403	0.93
104_F	119_S	2.354	0.92
96_L	127_I	2.264	0.90
151_G	173_A	2.244	0.90
47_K	221_W	2.134	0.87
71_V	175_A	2.079	0.86
107_S	204_A	2.003	0.84
56_L	222_L	1.957	0.82
107_S	208_Y	1.918	0.81
14_N	19_V	1.915	0.81
75_L	182_L	1.848	0.78
73_L	205_L	1.820	0.77
154_S	166_G	1.808	0.77
107_S	174_G	1.807	0.76
68_E	223_Y	1.800	0.76
96_L	131_V	1.704	0.72
14_N	177_L	1.674	0.71
165_I	195_V	1.673	0.71
45_Q	108_R	1.667	0.70
72_D	196_A	1.642	0.69
108_R	208_Y	1.620	0.68
10_L	16_F	1.617	0.68
130_A	136_D	1.569	0.65
70_E	122_F	1.561	0.65
213_A	223_Y	1.540	0.64
100_A	152_Y	1.534	0.64
8_E	92_D	1.533	0.64
42_S	77_V	1.512	0.62
49_A	52_N	1.502	0.62
205_L	215_V	1.489	0.61
16_F	108_R	1.478	0.61
123_Y	126_W	1.473	0.60
136_D	139_C	1.458	0.60
177_L	197_T	1.454	0.59
45_Q	221_W	1.450	0.59
168_L	204_A	1.450	0.59
16_F	208_Y	1.408	0.57
122_F	197_T	1.380	0.55
70_E	104_F	1.369	0.55
174_G	207_R	1.347	0.53
115_A	118_A	1.343	0.53
22_A	41_W	1.340	0.53
14_N	21_S	1.334	0.53
154_S	182_L	1.322	0.52
107_S	165_I	1.319	0.52
9_P	37_A	1.318	0.52
73_L	209_I	1.292	0.50
142_L	179_Q	1.282	0.50
47_K	70_E	1.280	0.50
43_R	207_R	1.276	0.49
69_G	223_Y	1.276	0.49
70_E	221_W	1.274	0.49
19_V	191_T	1.266	0.49
144_A	148_D	1.243	0.47
195_V	198_Q	1.240	0.47
174_G	204_A	1.227	0.47
47_K	104_F	1.217	0.46
121_R	140_L	1.204	0.45
45_Q	104_F	1.202	0.45
129_N	132_R	1.196	0.45
107_S	198_Q	1.188	0.44
143_R	149_I	1.182	0.44
47_K	64_F	1.178	0.44
122_F	198_Q	1.163	0.43
20_N	34_T	1.162	0.43
126_W	167_L	1.158	0.43
92_D	143_R	1.154	0.43
54_G	202_T	1.153	0.42
10_L	204_A	1.145	0.42
198_Q	208_Y	1.126	0.41
32_L	36_D	1.117	0.40
81_S	89_Q	1.114	0.40
86_V	176_E	1.111	0.40
154_S	206_K	1.104	0.40
195_V	204_A	1.101	0.40
37_A	161_T	1.099	0.39
12_W	24_V	1.082	0.39
65_S	190_K	1.071	0.38
16_F	109_F	1.066	0.38
104_F	122_F	1.061	0.37
24_V	148_D	1.057	0.37
94_P	165_I	1.046	0.37
85_A	206_K	1.027	0.36
150_R	175_A	1.025	0.36
70_E	196_A	1.021	0.35
135_F	223_Y	1.019	0.35
89_Q	214_N	1.018	0.35
21_S	104_F	1.018	0.35
39_A	90_E	1.012	0.35
16_F	204_A	1.010	0.35
117_D	129_N	1.010	0.35
52_N	55_E	1.002	0.34
16_F	221_W	0.988	0.34
114_Y	223_Y	0.986	0.34
97_R	128_E	0.983	0.33
122_F	196_A	0.980	0.33
8_E	87_V	0.974	0.33
68_E	131_V	0.969	0.33
108_R	174_G	0.968	0.33
136_D	223_Y	0.967	0.33
122_F	136_D	0.966	0.33
21_S	43_R	0.966	0.33
142_L	176_E	0.965	0.33
53_T	98_Q	0.962	0.32
88_A	140_L	0.960	0.32
110_R	119_S	0.952	0.32
197_T	204_A	0.947	0.32
69_G	110_R	0.943	0.31
50_A	171_R	0.942	0.31
198_Q	204_A	0.938	0.31
15_A	53_T	0.933	0.31
165_I	208_Y	0.927	0.31
165_I	193_L	0.918	0.30
18_G	90_E	0.911	0.30
52_N	137_H	0.903	0.30
83_S	141_I	0.889	0.29
136_D	221_W	0.889	0.29
58_A	78_N	0.875	0.28
166_G	204_A	0.869	0.28
71_V	80_A	0.868	0.28
56_L	82_D	0.863	0.28
130_A	156_R	0.862	0.28
94_P	191_T	0.861	0.28
52_N	116_P	0.860	0.28
16_F	122_F	0.857	0.27
39_A	173_A	0.851	0.27
122_F	204_A	0.849	0.27
24_V	41_W	0.841	0.27
45_Q	70_E	0.840	0.27
15_A	189_G	0.837	0.26
166_G	196_A	0.836	0.26
168_L	208_Y	0.822	0.26
142_L	185_A	0.819	0.26
135_F	221_W	0.811	0.25
96_L	210_Q	0.810	0.25
99_L	103_A	0.808	0.25
152_Y	172_G	0.805	0.25
71_V	205_L	0.795	0.25
109_F	208_Y	0.790	0.24
155_L	181_A	0.788	0.24
36_D	206_K	0.787	0.24
107_S	153_V	0.784	0.24
77_V	189_G	0.781	0.24
108_R	221_W	0.775	0.24
84_G	87_V	0.763	0.23
110_R	120_S	0.763	0.23
183_N	188_R	0.760	0.23
17_F	123_Y	0.757	0.23
108_R	122_F	0.757	0.23
41_W	173_A	0.754	0.23
51_S	90_E	0.751	0.23
45_Q	136_D	0.751	0.23
178_M	197_T	0.749	0.23
70_E	204_A	0.748	0.23
176_E	192_T	0.748	0.23
76_P	80_A	0.747	0.23
107_S	195_V	0.742	0.23
140_L	180_T	0.740	0.22
93_I	135_F	0.738	0.22
176_E	222_L	0.738	0.22
28_S	37_A	0.735	0.22
176_E	189_G	0.734	0.22
70_E	109_F	0.733	0.22
88_A	92_D	0.732	0.22
122_F	135_F	0.732	0.22
117_D	203_A	0.729	0.22
10_L	198_Q	0.728	0.22
45_Q	223_Y	0.726	0.22
149_I	161_T	0.725	0.22
26_I	193_L	0.724	0.22
79_N	187_A	0.719	0.22
100_A	107_S	0.716	0.22
46_A	222_L	0.713	0.21
24_V	108_R	0.711	0.21
22_A	44_V	0.708	0.21
114_Y	118_A	0.704	0.21
90_E	98_Q	0.700	0.21
99_L	149_I	0.697	0.21
106_Q	211_S	0.696	0.21
178_M	198_Q	0.694	0.21
36_D	189_G	0.692	0.21
98_Q	159_N	0.691	0.21
165_I	181_A	0.691	0.21
153_V	197_T	0.688	0.20
64_F	88_A	0.686	0.20
34_T	37_A	0.686	0.20
8_E	30_A	0.684	0.20
10_L	197_T	0.680	0.20
59_L	63_G	0.679	0.20
71_V	81_S	0.679	0.20
17_F	120_S	0.677	0.20
68_E	113_W	0.675	0.20
16_F	114_Y	0.674	0.20
45_Q	119_S	0.673	0.20
172_G	185_A	0.671	0.20
67_V	142_L	0.667	0.20
90_E	132_R	0.665	0.20
103_A	173_A	0.664	0.20
35_P	146_S	0.660	0.19
127_I	185_A	0.660	0.19
167_L	198_Q	0.657	0.19
34_T	98_Q	0.655	0.19
43_R	173_A	0.654	0.19
10_L	122_F	0.654	0.19
44_V	124_A	0.654	0.19
161_T	191_T	0.652	0.19
153_V	165_I	0.650	0.19
85_A	143_R	0.650	0.19
86_V	142_L	0.649	0.19
18_G	129_N	0.647	0.19
35_P	189_G	0.645	0.19
86_V	183_N	0.640	0.19
107_S	110_R	0.633	0.18
115_A	150_R	0.631	0.18
52_N	190_K	0.629	0.18
71_V	171_R	0.625	0.18
200_G	222_L	0.621	0.18
109_F	156_R	0.618	0.18
82_D	182_L	0.616	0.18
135_F	166_G	0.611	0.18
142_L	202_T	0.610	0.18
95_A	160_A	0.608	0.18
73_L	208_Y	0.608	0.18
63_G	110_R	0.606	0.18
55_E	202_T	0.606	0.18
114_Y	196_A	0.605	0.18
87_V	175_A	0.604	0.18
153_V	204_A	0.602	0.17
23_I	67_V	0.601	0.17
99_L	104_F	0.600	0.17
209_I	214_N	0.599	0.17
202_T	210_Q	0.598	0.17
118_A	202_T	0.596	0.17
139_C	221_W	0.596	0.17
62_L	75_L	0.594	0.17
132_R	191_T	0.593	0.17
13_E	188_R	0.591	0.17
113_W	223_Y	0.591	0.17
18_G	106_Q	0.590	0.17
81_S	189_G	0.589	0.17
107_S	166_G	0.586	0.17
166_G	221_W	0.585	0.17
69_G	139_C	0.585	0.17
48_I	220_Y	0.584	0.17
117_D	149_I	0.583	0.17
64_F	104_F	0.582	0.17
84_G	89_Q	0.582	0.17
88_A	133_G	0.581	0.17
191_T	217_S	0.581	0.17
118_A	121_R	0.578	0.17
29_E	32_L	0.578	0.17
171_R	200_G	0.576	0.17
77_V	80_A	0.576	0.17
51_S	159_N	0.575	0.17
139_C	223_Y	0.570	0.16
95_A	171_R	0.569	0.16
22_A	95_A	0.568	0.16
148_D	190_K	0.568	0.16
60_Q	176_E	0.565	0.16
48_I	222_L	0.562	0.16
72_D	164_R	0.562	0.16
10_L	17_F	0.556	0.16
98_Q	146_S	0.556	0.16
85_A	116_P	0.555	0.16
85_A	154_S	0.554	0.16
13_E	17_F	0.552	0.16
149_I	217_S	0.549	0.16
70_E	136_D	0.549	0.16
11_T	15_A	0.549	0.16
50_A	200_G	0.548	0.16
108_R	204_A	0.548	0.16
70_E	205_L	0.547	0.16
104_F	205_L	0.546	0.16
129_N	207_R	0.542	0.16
120_S	190_K	0.538	0.15
54_G	181_A	0.538	0.15
61_Q	182_L	0.535	0.15
12_W	174_G	0.535	0.15
129_N	142_L	0.535	0.15
89_Q	161_T	0.535	0.15
135_F	139_C	0.534	0.15
8_E	182_L	0.531	0.15
203_A	207_R	0.529	0.15
66_L	216_E	0.529	0.15
149_I	187_A	0.529	0.15
207_R	211_S	0.529	0.15
68_E	114_Y	0.529	0.15
16_F	198_Q	0.527	0.15
96_L	209_I	0.527	0.15
78_N	146_S	0.525	0.15
70_E	119_S	0.525	0.15
140_L	178_M	0.522	0.15
22_A	75_L	0.521	0.15
123_Y	196_A	0.520	0.15
160_A	189_G	0.520	0.15
24_V	192_T	0.518	0.15
153_V	213_A	0.517	0.15
48_I	56_L	0.516	0.15
110_R	139_C	0.511	0.15
168_L	184_W	0.510	0.15
150_R	159_N	0.510	0.15
146_S	169_A	0.510	0.15
35_P	160_A	0.506	0.15
110_R	118_A	0.505	0.15
204_A	221_W	0.505	0.15
11_T	35_P	0.500	0.14

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2ft0A	2	0.9911	100	0.481	Contact Map
3frmA	3	0.9286	99.5	0.748	Contact Map
3tt2A	1	0.9286	99.5	0.751	Contact Map
3jvnA	2	0.4821	99.5	0.752	Contact Map
4e0aA	2	0.625	99.5	0.756	Contact Map
2wpxA	1	0.933	99.5	0.757	Contact Map
1p0hA	1	0.933	99.5	0.759	Contact Map
3owcA	1	0.6339	99.5	0.76	Contact Map
3g8wA	2	0.6116	99.5	0.76	Contact Map
3pp9A	2	0.6384	99.5	0.76	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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