GREMLIN Database
WECD - dTDP-fucosamine acetyltransferase
UniProt: P27832 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11455
Length: 224 (214)
Sequences: 285 (224)
Seq/√Len: 15.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
103_A169_A5.2821.00
86_V143_R3.8611.00
12_W16_F3.3390.99
127_I154_S3.2960.99
12_W108_R3.2740.99
174_G208_Y3.1910.99
149_I206_K2.8490.97
204_A208_Y2.8040.97
26_I46_A2.7110.96
68_E222_L2.5720.95
125_Q129_N2.5460.95
86_V206_K2.5370.94
14_N20_N2.4500.93
175_A210_Q2.4350.93
20_N42_S2.4280.93
169_A180_T2.4030.93
104_F119_S2.3540.92
96_L127_I2.2640.90
151_G173_A2.2440.90
47_K221_W2.1340.87
71_V175_A2.0790.86
107_S204_A2.0030.84
56_L222_L1.9570.82
107_S208_Y1.9180.81
14_N19_V1.9150.81
75_L182_L1.8480.78
73_L205_L1.8200.77
154_S166_G1.8080.77
107_S174_G1.8070.76
68_E223_Y1.8000.76
96_L131_V1.7040.72
14_N177_L1.6740.71
165_I195_V1.6730.71
45_Q108_R1.6670.70
72_D196_A1.6420.69
108_R208_Y1.6200.68
10_L16_F1.6170.68
130_A136_D1.5690.65
70_E122_F1.5610.65
213_A223_Y1.5400.64
100_A152_Y1.5340.64
8_E92_D1.5330.64
42_S77_V1.5120.62
49_A52_N1.5020.62
205_L215_V1.4890.61
16_F108_R1.4780.61
123_Y126_W1.4730.60
136_D139_C1.4580.60
177_L197_T1.4540.59
45_Q221_W1.4500.59
168_L204_A1.4500.59
16_F208_Y1.4080.57
122_F197_T1.3800.55
70_E104_F1.3690.55
174_G207_R1.3470.53
115_A118_A1.3430.53
22_A41_W1.3400.53
14_N21_S1.3340.53
154_S182_L1.3220.52
107_S165_I1.3190.52
9_P37_A1.3180.52
73_L209_I1.2920.50
142_L179_Q1.2820.50
47_K70_E1.2800.50
43_R207_R1.2760.49
69_G223_Y1.2760.49
70_E221_W1.2740.49
19_V191_T1.2660.49
144_A148_D1.2430.47
195_V198_Q1.2400.47
174_G204_A1.2270.47
47_K104_F1.2170.46
121_R140_L1.2040.45
45_Q104_F1.2020.45
129_N132_R1.1960.45
107_S198_Q1.1880.44
143_R149_I1.1820.44
47_K64_F1.1780.44
122_F198_Q1.1630.43
20_N34_T1.1620.43
126_W167_L1.1580.43
92_D143_R1.1540.43
54_G202_T1.1530.42
10_L204_A1.1450.42
198_Q208_Y1.1260.41
32_L36_D1.1170.40
81_S89_Q1.1140.40
86_V176_E1.1110.40
154_S206_K1.1040.40
195_V204_A1.1010.40
37_A161_T1.0990.39
12_W24_V1.0820.39
65_S190_K1.0710.38
16_F109_F1.0660.38
104_F122_F1.0610.37
24_V148_D1.0570.37
94_P165_I1.0460.37
85_A206_K1.0270.36
150_R175_A1.0250.36
70_E196_A1.0210.35
135_F223_Y1.0190.35
89_Q214_N1.0180.35
21_S104_F1.0180.35
39_A90_E1.0120.35
16_F204_A1.0100.35
117_D129_N1.0100.35
52_N55_E1.0020.34
16_F221_W0.9880.34
114_Y223_Y0.9860.34
97_R128_E0.9830.33
122_F196_A0.9800.33
8_E87_V0.9740.33
68_E131_V0.9690.33
108_R174_G0.9680.33
136_D223_Y0.9670.33
122_F136_D0.9660.33
21_S43_R0.9660.33
142_L176_E0.9650.33
53_T98_Q0.9620.32
88_A140_L0.9600.32
110_R119_S0.9520.32
197_T204_A0.9470.32
69_G110_R0.9430.31
50_A171_R0.9420.31
198_Q204_A0.9380.31
15_A53_T0.9330.31
165_I208_Y0.9270.31
165_I193_L0.9180.30
18_G90_E0.9110.30
52_N137_H0.9030.30
83_S141_I0.8890.29
136_D221_W0.8890.29
58_A78_N0.8750.28
166_G204_A0.8690.28
71_V80_A0.8680.28
56_L82_D0.8630.28
130_A156_R0.8620.28
94_P191_T0.8610.28
52_N116_P0.8600.28
16_F122_F0.8570.27
39_A173_A0.8510.27
122_F204_A0.8490.27
24_V41_W0.8410.27
45_Q70_E0.8400.27
15_A189_G0.8370.26
166_G196_A0.8360.26
168_L208_Y0.8220.26
142_L185_A0.8190.26
135_F221_W0.8110.25
96_L210_Q0.8100.25
99_L103_A0.8080.25
152_Y172_G0.8050.25
71_V205_L0.7950.25
109_F208_Y0.7900.24
155_L181_A0.7880.24
36_D206_K0.7870.24
107_S153_V0.7840.24
77_V189_G0.7810.24
108_R221_W0.7750.24
84_G87_V0.7630.23
110_R120_S0.7630.23
183_N188_R0.7600.23
17_F123_Y0.7570.23
108_R122_F0.7570.23
41_W173_A0.7540.23
51_S90_E0.7510.23
45_Q136_D0.7510.23
178_M197_T0.7490.23
70_E204_A0.7480.23
176_E192_T0.7480.23
76_P80_A0.7470.23
107_S195_V0.7420.23
140_L180_T0.7400.22
93_I135_F0.7380.22
176_E222_L0.7380.22
28_S37_A0.7350.22
176_E189_G0.7340.22
70_E109_F0.7330.22
88_A92_D0.7320.22
122_F135_F0.7320.22
117_D203_A0.7290.22
10_L198_Q0.7280.22
45_Q223_Y0.7260.22
149_I161_T0.7250.22
26_I193_L0.7240.22
79_N187_A0.7190.22
100_A107_S0.7160.22
46_A222_L0.7130.21
24_V108_R0.7110.21
22_A44_V0.7080.21
114_Y118_A0.7040.21
90_E98_Q0.7000.21
99_L149_I0.6970.21
106_Q211_S0.6960.21
178_M198_Q0.6940.21
36_D189_G0.6920.21
98_Q159_N0.6910.21
165_I181_A0.6910.21
153_V197_T0.6880.20
64_F88_A0.6860.20
34_T37_A0.6860.20
8_E30_A0.6840.20
10_L197_T0.6800.20
59_L63_G0.6790.20
71_V81_S0.6790.20
17_F120_S0.6770.20
68_E113_W0.6750.20
16_F114_Y0.6740.20
45_Q119_S0.6730.20
172_G185_A0.6710.20
67_V142_L0.6670.20
90_E132_R0.6650.20
103_A173_A0.6640.20
35_P146_S0.6600.19
127_I185_A0.6600.19
167_L198_Q0.6570.19
34_T98_Q0.6550.19
43_R173_A0.6540.19
10_L122_F0.6540.19
44_V124_A0.6540.19
161_T191_T0.6520.19
153_V165_I0.6500.19
85_A143_R0.6500.19
86_V142_L0.6490.19
18_G129_N0.6470.19
35_P189_G0.6450.19
86_V183_N0.6400.19
107_S110_R0.6330.18
115_A150_R0.6310.18
52_N190_K0.6290.18
71_V171_R0.6250.18
200_G222_L0.6210.18
109_F156_R0.6180.18
82_D182_L0.6160.18
135_F166_G0.6110.18
142_L202_T0.6100.18
95_A160_A0.6080.18
73_L208_Y0.6080.18
63_G110_R0.6060.18
55_E202_T0.6060.18
114_Y196_A0.6050.18
87_V175_A0.6040.18
153_V204_A0.6020.17
23_I67_V0.6010.17
99_L104_F0.6000.17
209_I214_N0.5990.17
202_T210_Q0.5980.17
118_A202_T0.5960.17
139_C221_W0.5960.17
62_L75_L0.5940.17
132_R191_T0.5930.17
13_E188_R0.5910.17
113_W223_Y0.5910.17
18_G106_Q0.5900.17
81_S189_G0.5890.17
107_S166_G0.5860.17
166_G221_W0.5850.17
69_G139_C0.5850.17
48_I220_Y0.5840.17
117_D149_I0.5830.17
64_F104_F0.5820.17
84_G89_Q0.5820.17
88_A133_G0.5810.17
191_T217_S0.5810.17
118_A121_R0.5780.17
29_E32_L0.5780.17
171_R200_G0.5760.17
77_V80_A0.5760.17
51_S159_N0.5750.17
139_C223_Y0.5700.16
95_A171_R0.5690.16
22_A95_A0.5680.16
148_D190_K0.5680.16
60_Q176_E0.5650.16
48_I222_L0.5620.16
72_D164_R0.5620.16
10_L17_F0.5560.16
98_Q146_S0.5560.16
85_A116_P0.5550.16
85_A154_S0.5540.16
13_E17_F0.5520.16
149_I217_S0.5490.16
70_E136_D0.5490.16
11_T15_A0.5490.16
50_A200_G0.5480.16
108_R204_A0.5480.16
70_E205_L0.5470.16
104_F205_L0.5460.16
129_N207_R0.5420.16
120_S190_K0.5380.15
54_G181_A0.5380.15
61_Q182_L0.5350.15
12_W174_G0.5350.15
129_N142_L0.5350.15
89_Q161_T0.5350.15
135_F139_C0.5340.15
8_E182_L0.5310.15
203_A207_R0.5290.15
66_L216_E0.5290.15
149_I187_A0.5290.15
207_R211_S0.5290.15
68_E114_Y0.5290.15
16_F198_Q0.5270.15
96_L209_I0.5270.15
78_N146_S0.5250.15
70_E119_S0.5250.15
140_L178_M0.5220.15
22_A75_L0.5210.15
123_Y196_A0.5200.15
160_A189_G0.5200.15
24_V192_T0.5180.15
153_V213_A0.5170.15
48_I56_L0.5160.15
110_R139_C0.5110.15
168_L184_W0.5100.15
150_R159_N0.5100.15
146_S169_A0.5100.15
35_P160_A0.5060.15
110_R118_A0.5050.15
204_A221_W0.5050.15
11_T35_P0.5000.14
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2ft0A 2 0.9911 100 0.481 Contact Map
3frmA 3 0.9286 99.5 0.748 Contact Map
3tt2A 1 0.9286 99.5 0.751 Contact Map
3jvnA 2 0.4821 99.5 0.752 Contact Map
4e0aA 2 0.625 99.5 0.756 Contact Map
2wpxA 1 0.933 99.5 0.757 Contact Map
1p0hA 1 0.933 99.5 0.759 Contact Map
3owcA 1 0.6339 99.5 0.76 Contact Map
3g8wA 2 0.6116 99.5 0.76 Contact Map
3pp9A 2 0.6384 99.5 0.76 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0081 seconds.