GREMLIN Database
WECC - UDP-N-acetyl-D-mannosamine dehydrogenase
UniProt: P27829 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11452
Length: 420 (390)
Sequences: 8355 (5054)
Seq/√Len: 255.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
127_E206_R5.0411.00
36_Q40_D4.8151.00
360_V399_F4.1981.00
5_T28_Q3.5071.00
303_V391_V3.4601.00
333_N397_S3.3631.00
322_K356_E3.3241.00
181_T184_C3.2141.00
322_K358_L3.1631.00
41_T46_E3.0751.00
155_A188_A2.9251.00
203_T242_E2.7121.00
303_V389_V2.7081.00
324_A387_A2.6411.00
24_S60_T2.5321.00
297_F348_L2.5191.00
153_N181_T2.4821.00
325_C346_A2.4731.00
7_S76_A2.4351.00
131_E154_I2.4351.00
103_R136_M2.4251.00
234_A302_Q2.4141.00
204_N207_T2.3961.00
43_N69_A2.3341.00
283_R290_E2.2891.00
40_D44_R2.2581.00
345_I393_L2.2301.00
329_A364_I2.2281.00
110_K113_A2.2151.00
239_N242_E2.1561.00
28_Q68_R2.1321.00
168_V172_K2.1301.00
27_K194_I2.0981.00
78_A191_L2.0801.00
358_L387_A2.0251.00
11_L31_G1.9991.00
392_M418_V1.9941.00
323_I355_G1.9911.00
103_R132_W1.9631.00
36_Q71_T1.9341.00
215_E247_A1.9311.00
37_H40_D1.8941.00
217_S225_F1.8881.00
203_T211_C1.8761.00
28_Q66_F1.8751.00
88_K92_E1.8541.00
47_I58_V1.8271.00
384_L407_V1.8261.00
379_Q382_E1.8041.00
186_A190_E1.7991.00
79_W113_A1.7961.00
279_P286_R1.7881.00
210_M233_C1.7771.00
221_V288_A1.7711.00
324_A383_A1.7421.00
185_S202_V1.7411.00
358_L377_L1.7391.00
35_N38_A1.7211.00
100_S103_R1.7201.00
185_S189_S1.6891.00
281_Q286_R1.6711.00
5_T75_E1.6451.00
5_T30_I1.6391.00
403_N406_N1.6361.00
6_I191_L1.6211.00
99_E103_R1.6141.00
20_A58_V1.5811.00
24_S61_A1.5731.00
99_E128_K1.5731.00
40_D43_N1.5701.00
7_S79_W1.5681.00
218_F222_N1.5661.00
298_W302_Q1.5621.00
114_L187_R1.5401.00
286_R290_E1.5321.00
189_S202_V1.5301.00
275_V286_R1.5261.00
33_D39_V1.5251.00
218_F254_N1.5191.00
186_A201_V1.5121.00
348_L351_Q1.5021.00
21_A24_S1.4801.00
20_A67_L1.4771.00
328_L359_V1.4751.00
42_I69_A1.4671.00
22_F191_L1.4641.00
349_I355_G1.4511.00
231_L298_W1.4481.00
332_P395_D1.4451.00
397_S400_K1.4451.00
381_D406_N1.4411.00
182_P186_A1.4391.00
41_T48_H1.4351.00
55_A59_K1.4351.00
53_D56_S1.4201.00
234_A298_W1.4171.00
303_V413_V1.4091.00
232_I282_A1.3971.00
78_A114_L1.3941.00
260_P415_A1.3891.00
56_S60_T1.3821.00
99_E129_M1.3721.00
231_L295_K1.3701.00
39_V71_T1.3541.00
20_A57_V1.3511.00
190_E193_K1.3471.00
343_M347_E1.3431.00
300_I345_I1.3421.00
109_L113_A1.3361.00
37_H41_T1.3251.00
21_A171_I1.3101.00
226_A244_I1.3001.00
242_E245_R1.2941.00
180_M185_S1.2891.00
106_A137_R1.2731.00
363_N398_Q1.2641.00
221_V225_F1.2531.00
112_G153_N1.2421.00
187_R190_E1.2411.00
39_V69_A1.2351.00
231_L235_D1.2331.00
96_T100_S1.2251.00
284_L287_T1.2181.00
384_L390_L1.2141.00
302_Q413_V1.2111.00
306_A413_V1.2041.00
300_I348_L1.2031.00
324_A390_L1.2021.00
211_C246_L1.1941.00
30_I76_A1.1931.00
322_K386_T1.1921.00
221_V284_L1.1881.00
153_N183_V1.1881.00
41_T44_R1.1861.00
165_Q168_V1.1841.00
24_S171_I1.1831.00
284_L291_V1.1821.00
74_V110_K1.1791.00
43_N68_R1.1781.00
103_R107_P1.1781.00
131_E135_E1.1761.00
42_I67_L1.1751.00
30_I68_R1.1751.00
57_V167_M1.1721.00
128_K132_W1.1711.00
180_M184_C1.1651.00
356_E375_C1.1651.00
233_C240_V1.1601.00
78_A187_R1.1571.00
157_C192_Y1.1531.00
125_S129_M1.1481.00
204_N242_E1.1461.00
153_N184_C1.1421.00
9_I101_A1.1411.00
61_A66_F1.1381.00
262_V289_R1.1371.00
324_A358_L1.1371.00
30_I75_E1.1341.00
388_D408_H1.1331.00
344_E347_E1.1241.00
397_S401_V1.1211.00
297_F301_D1.1101.00
251_P254_N1.1091.00
323_I389_V1.1001.00
347_E350_A1.0971.00
214_T229_L1.0941.00
326_F402_I1.0921.00
102_A106_A1.0921.00
130_A134_A1.0911.00
283_R294_H1.0841.00
172_K197_E1.0831.00
112_G151_D1.0781.00
38_A48_H1.0761.00
86_P94_D1.0751.00
9_I79_W1.0751.00
304_K355_G1.0751.00
127_E131_E1.0711.00
75_E110_K1.0621.00
169_E172_K1.0571.00
183_V187_R1.0571.00
229_L240_V1.0531.00
189_S193_K1.0531.00
114_L155_A1.0531.00
11_L19_A1.0511.00
346_A350_A1.0501.00
193_K199_E1.0481.00
207_T238_I1.0421.00
117_L126_T1.0391.00
238_I243_L1.0381.00
369_K375_C1.0341.00
30_I70_S1.0301.00
241_W245_R1.0241.00
103_R133_L1.0231.00
39_V43_N1.0221.00
7_S73_P1.0221.00
321_L388_D1.0191.00
100_S104_S1.0171.00
115_V133_L1.0171.00
77_D113_A1.0121.00
81_I105_I1.0021.00
57_V60_T0.9981.00
106_A136_M0.9941.00
7_S32_V0.9901.00
24_S56_S0.9891.00
151_D183_V0.9891.00
344_E348_L0.9881.00
184_C188_A0.9861.00
231_L294_H0.9791.00
207_T243_L0.9771.00
178_G188_A0.9741.00
6_I22_F0.9731.00
111_K151_D0.9711.00
19_A31_G0.9681.00
301_D305_A0.9641.00
126_T205_S0.9601.00
304_K318_A0.9581.00
303_V415_A0.9571.00
189_S201_V0.9571.00
127_E205_S0.9531.00
364_I376_T0.9521.00
326_F390_L0.9511.00
182_P185_S0.9511.00
93_P122_P0.9501.00
220_D289_R0.9491.00
104_S107_P0.9481.00
347_E351_Q0.9431.00
294_H297_F0.9431.00
171_I197_E0.9411.00
382_E385_A0.9371.00
133_L137_R0.9341.00
392_M412_V0.9331.00
114_L184_C0.9321.00
322_K387_A0.9321.00
328_L337_L0.9281.00
109_L152_V0.9241.00
233_C243_L0.9221.00
186_A189_S0.9191.00
282_A285_I0.9191.00
21_A170_L0.9171.00
296_P344_E0.9131.00
395_D416_K0.9131.00
328_L340_S0.9121.00
277_Q280_Q0.9101.00
318_A355_G0.9091.00
7_S30_I0.9041.00
389_V411_Y0.9011.00
54_L58_V0.9011.00
6_I27_K0.8971.00
186_A202_V0.8911.00
116_I188_A0.8891.00
306_A411_Y0.8871.00
105_I115_V0.8851.00
323_I391_V0.8851.00
129_M133_L0.8821.00
25_R194_I0.8811.00
19_A67_L0.8791.00
302_Q305_A0.8781.00
61_A64_G0.8761.00
307_V321_L0.8751.00
18_T170_L0.8711.00
112_G183_V0.8711.00
78_A116_I0.8701.00
326_F399_F0.8681.00
337_L368_P0.8641.00
320_E356_E0.8601.00
342_A393_L0.8601.00
303_V323_I0.8590.99
276_A280_Q0.8530.99
99_E132_W0.8500.99
350_A374_L0.8460.99
102_A117_L0.8460.99
130_A205_S0.8450.99
11_L67_L0.8430.99
377_L383_A0.8430.99
248_N255_I0.8410.99
81_I98_V0.8400.99
260_P393_L0.8390.99
128_K131_E0.8380.99
185_S201_V0.8350.99
109_L134_A0.8340.99
189_S199_E0.8340.99
278_N282_A0.8340.99
32_V70_S0.8320.99
78_A188_A0.8310.99
272_W289_R0.8300.99
262_V271_P0.8290.99
34_I104_S0.8250.99
102_A130_A0.8210.99
358_L386_T0.8160.99
260_P299_V0.8090.99
244_I258_P0.8090.99
232_I274_I0.8080.99
77_D187_R0.8050.99
293_D344_E0.8030.99
25_R195_F0.8030.99
377_L382_E0.8010.99
201_V249_R0.8010.99
276_A279_P0.7930.99
365_H376_T0.7930.99
93_P273_F0.7900.99
161_V170_L0.7890.99
340_S343_M0.7870.99
106_A133_L0.7850.99
102_A133_L0.7790.99
358_L375_C0.7790.99
337_L364_I0.7770.99
303_V349_I0.7740.99
275_V285_I0.7740.99
275_V289_R0.7710.99
380_L384_L0.7680.99
299_V413_V0.7670.99
105_I108_V0.7640.99
328_L346_A0.7630.99
337_L343_M0.7630.99
32_V71_T0.7620.99
118_E192_Y0.7620.99
58_V67_L0.7600.99
299_V415_A0.7590.99
222_N256_L0.7580.99
111_K150_A0.7580.99
308_A317_R0.7570.99
32_V104_S0.7570.99
294_H301_D0.7550.99
179_G185_S0.7510.99
116_I191_L0.7490.99
395_D400_K0.7450.99
326_F384_L0.7440.99
46_E55_A0.7440.99
112_G152_V0.7420.99
8_V19_A0.7410.99
332_P397_S0.7400.99
369_K373_G0.7390.98
324_A384_L0.7380.98
346_A359_V0.7350.98
81_I115_V0.7330.98
297_F344_E0.7320.98
103_R137_R0.7300.98
380_L398_Q0.7290.98
217_S285_I0.7270.98
155_A180_M0.7200.98
79_W105_I0.7180.98
218_F256_L0.7180.98
174_D251_P0.7130.98
308_A318_A0.7120.98
132_W135_E0.7080.98
240_V244_I0.7070.98
241_W257_Q0.7070.98
11_L33_D0.7050.98
162_L165_Q0.7050.98
180_M202_V0.7040.98
46_E59_K0.7040.98
73_P79_W0.7030.98
18_T175_R0.7010.98
369_K372_T0.7000.98
378_A382_E0.6990.98
222_N226_A0.6990.98
38_A41_T0.6970.98
404_G407_V0.6960.98
131_E134_A0.6940.98
65_G68_R0.6940.98
350_A357_T0.6930.98
207_T242_E0.6930.98
390_L399_F0.6920.98
260_P332_P0.6920.98
370_K373_G0.6910.98
107_P136_M0.6910.98
235_D281_Q0.6890.98
38_A42_I0.6880.98
27_K78_A0.6880.98
50_V363_N0.6840.98
18_T22_F0.6840.98
21_A167_M0.6840.98
103_R135_E0.6820.97
325_C391_V0.6820.97
102_A129_M0.6810.97
98_V102_A0.6810.97
232_I278_N0.6800.97
228_E291_V0.6800.97
46_E54_L0.6790.97
126_T156_Y0.6780.97
98_V125_S0.6780.97
106_A115_V0.6760.97
308_A321_L0.6750.97
229_L274_I0.6740.97
241_W259_G0.6740.97
28_Q75_E0.6740.97
308_A319_S0.6730.97
79_W108_V0.6650.97
55_A58_V0.6640.97
203_T207_T0.6610.97
102_A132_W0.6600.97
225_F229_L0.6580.97
32_V101_A0.6570.97
326_F380_L0.6570.97
307_V389_V0.6550.97
307_V323_I0.6530.97
34_I97_Y0.6530.97
350_A373_G0.6520.97
23_A61_A0.6520.97
241_W417_G0.6520.97
199_E249_R0.6510.97
80_L191_L0.6500.97
245_R248_N0.6500.97
177_I199_E0.6490.97
386_T408_H0.6480.97
8_V18_T0.6460.96
271_P289_R0.6460.96
13_Y338_R0.6460.96
33_D71_T0.6460.96
293_D296_P0.6450.96
326_F392_M0.6440.96
87_F272_W0.6440.96
188_A192_Y0.6440.96
27_K191_L0.6420.96
404_G412_V0.6410.96
275_V282_A0.6370.96
117_L129_M0.6370.96
220_D262_V0.6360.96
362_P399_F0.6350.96
73_P104_S0.6350.96
244_I257_Q0.6350.96
155_A178_G0.6340.96
259_G341_P0.6340.96
250_H253_V0.6340.96
74_V108_V0.6320.96
402_I406_N0.6310.96
177_I211_C0.6310.96
118_E157_C0.6300.96
244_I248_N0.6300.96
161_V166_V0.6290.96
283_R287_T0.6280.96
300_I304_K0.6270.96
73_P113_A0.6270.96
287_T290_E0.6240.96
390_L407_V0.6220.96
120_T266_C0.6210.96
177_I185_S0.6210.96
272_W293_D0.6200.96
95_M99_E0.6200.96
88_K99_E0.6200.96
296_P345_I0.6200.96
371_L374_L0.6200.96
128_K277_Q0.6200.96
177_I189_S0.6190.96
98_V117_L0.6180.95
245_R257_Q0.6180.95
176_V211_C0.6170.95
25_R171_I0.6170.95
304_K308_A0.6170.95
81_I117_L0.6160.95
360_V380_L0.6130.95
189_S200_C0.6130.95
104_S108_V0.6110.95
153_N187_R0.6070.95
328_L342_A0.6070.95
364_I368_P0.6070.95
359_V365_H0.6060.95
282_A286_R0.6050.95
163_P330_F0.6050.95
11_L42_I0.6040.95
137_R150_A0.6040.95
106_A152_V0.6030.95
180_M205_S0.6030.95
47_I55_A0.6030.95
216_N270_D0.6020.95
226_A229_L0.6010.95
120_T270_D0.5980.95
231_L234_A0.5970.95
295_K298_W0.5950.94
53_D57_V0.5940.94
57_V61_A0.5930.94
275_V279_P0.5920.94
271_P285_I0.5910.94
9_I73_P0.5900.94
24_S57_V0.5880.94
300_I318_A0.5880.94
346_A374_L0.5880.94
302_Q306_A0.5870.94
77_D111_K0.5870.94
159_E266_C0.5860.94
85_T119_S0.5840.94
108_V113_A0.5840.94
183_V186_A0.5830.94
265_H269_V0.5820.94
189_S196_L0.5820.94
337_L342_A0.5810.94
83_V97_Y0.5800.94
99_E133_L0.5780.94
296_P341_P0.5770.94
403_N407_V0.5770.94
54_L57_V0.5770.94
175_R215_E0.5750.93
118_E175_R0.5740.93
359_V374_L0.5740.93
25_R197_E0.5730.93
350_A356_E0.5730.93
207_T211_C0.5730.93
224_A284_L0.5720.93
68_R75_E0.5710.93
218_F226_A0.5710.93
123_V134_A0.5680.93
232_I236_Q0.5660.93
175_R192_Y0.5650.93
210_M229_L0.5650.93
214_T217_S0.5640.93
118_E269_V0.5630.93
283_R286_R0.5630.93
196_L200_C0.5620.93
73_P76_A0.5620.93
116_I155_A0.5600.93
109_L137_R0.5600.93
39_V42_I0.5580.92
5_T77_D0.5570.92
118_E163_P0.5560.92
160_R215_E0.5560.92
382_E386_T0.5550.92
163_P269_V0.5540.92
97_Y101_A0.5530.92
303_V318_A0.5520.92
230_S295_K0.5510.92
375_C386_T0.5510.92
359_V376_T0.5500.92
87_F91_H0.5490.92
107_P111_K0.5470.92
76_A79_W0.5470.92
346_A393_L0.5440.91
92_E280_Q0.5430.91
170_L195_F0.5410.91
56_S59_K0.5370.91
150_A153_N0.5360.91
300_I391_V0.5360.91
266_C269_V0.5360.91
306_A389_V0.5350.91
149_Q184_C0.5350.91
285_I288_A0.5330.91
20_A24_S0.5330.91
216_N331_K0.5320.91
202_V246_L0.5310.90
284_L288_A0.5290.90
169_E173_N0.5290.90
91_H293_D0.5290.90
229_L233_C0.5280.90
319_S354_S0.5280.90
86_P339_E0.5270.90
371_L376_T0.5270.90
178_G185_S0.5260.90
9_I104_S0.5260.90
346_A357_T0.5250.90
402_I407_V0.5250.90
80_L192_Y0.5240.90
218_F255_I0.5230.90
379_Q398_Q0.5220.90
86_P336_D0.5210.90
230_S234_A0.5210.90
384_L387_A0.5190.89
149_Q180_M0.5180.89
210_M238_I0.5180.89
52_P57_V0.5170.89
32_V73_P0.5170.89
42_I48_H0.5160.89
134_A154_I0.5160.89
123_V277_Q0.5160.89
84_P269_V0.5150.89
216_N266_C0.5140.89
106_A134_A0.5140.89
279_P283_R0.5130.89
107_P137_R0.5120.89
270_D338_R0.5110.89
14_I338_R0.5100.89
105_I109_L0.5090.89
287_T291_V0.5090.89
366_Q378_A0.5060.88
389_V413_V0.5050.88
289_R293_D0.5050.88
117_L154_I0.5040.88
307_V411_Y0.5040.88
8_V22_F0.5040.88
43_N46_E0.5030.88
159_E338_R0.5030.88
324_A379_Q0.5030.88
301_D304_K0.5010.88
317_R321_L0.5010.88
299_V345_I0.5010.88
73_P108_V0.5010.88
96_T99_E0.5000.88
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3ojoA 2 0.9381 100 0.263 Contact Map
2y0cA 4 0.9643 100 0.273 Contact Map
3gg2A 3 0.9619 100 0.282 Contact Map
2q3eA 5 0.9571 100 0.291 Contact Map
3g79A 2 0.9619 100 0.293 Contact Map
2o3jA 4 0.9524 100 0.294 Contact Map
4a7pA 2 0.9524 100 0.31 Contact Map
4xr9A 2 0.9714 100 0.312 Contact Map
3vtfA 2 0.9452 100 0.32 Contact Map
1mv8A 2 0.9452 100 0.33 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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