GREMLIN Database
WECB - UDP-N-acetylglucosamine 2-epimerase
UniProt: P27828 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11451
Length: 376 (353)
Sequences: 4331 (2959)
Seq/√Len: 157.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
99_T138_T3.1941.00
167_F368_A2.9771.00
360_Q363_S2.9041.00
89_V114_G2.8611.00
360_Q364_R2.8371.00
153_R157_L2.8321.00
231_D329_K2.8321.00
26_D370_K2.7661.00
22_A363_S2.7591.00
22_A25_K2.6621.00
83_A109_Q2.5611.00
139_G145_H2.5111.00
4_L34_C2.4791.00
5_T31_A2.4731.00
79_K109_Q2.4191.00
154_Q158_R2.4061.00
136_T140_H2.3551.00
100_L137_L2.3381.00
240_Q266_I2.2741.00
28_F370_K2.2721.00
153_R168_I2.2541.00
150_E154_Q2.2201.00
335_E338_R2.2041.00
210_V241_I2.1601.00
91_L114_G2.1441.00
236_H341_K2.1361.00
305_L325_V2.1291.00
82_L111_I2.1271.00
227_H329_K2.1231.00
208_I241_I2.1071.00
32_K85_F2.0951.00
75_L105_A2.0831.00
181_R281_N2.0721.00
236_H337_T2.0241.00
287_L307_M2.0051.00
316_A322_V1.9731.00
77_G80_P1.9651.00
206_K284_W1.9531.00
2_K30_E1.9161.00
223_E257_R1.8961.00
162_A165_R1.8921.00
276_F293_I1.8891.00
285_L336_V1.8751.00
29_F370_K1.8641.00
253_E257_R1.8551.00
358_D364_R1.8531.00
90_V106_A1.8491.00
153_R163_D1.8371.00
235_T337_T1.8271.00
231_D333_V1.8141.00
6_V102_T1.8131.00
114_G146_F1.7701.00
21_H24_A1.7371.00
89_V369_L1.7351.00
26_D367_E1.7311.00
36_T98_T1.6951.00
23_L29_F1.6901.00
328_D331_R1.6691.00
220_R223_E1.6621.00
280_M286_I1.6571.00
72_C76_E1.6241.00
325_V335_E1.5951.00
125_L143_M1.5871.00
125_L133_A1.5841.00
242_V279_L1.5811.00
73_R76_E1.5641.00
205_K240_Q1.5641.00
69_E80_P1.5621.00
80_P84_E1.5501.00
47_L54_P1.5411.00
306_V322_V1.5371.00
331_R335_E1.5311.00
22_A26_D1.5031.00
151_T318_T1.5021.00
68_T109_Q1.4861.00
146_F365_I1.4771.00
56_Y81_I1.4721.00
56_Y85_F1.4681.00
147_S156_L1.4621.00
209_L280_M1.4571.00
232_I336_V1.4521.00
82_L105_A1.4511.00
5_T20_V1.4501.00
20_V33_V1.4481.00
283_A302_K1.4421.00
207_M282_H1.4411.00
233_A264_N1.4351.00
73_R77_G1.4141.00
45_Q48_K1.4141.00
89_V144_Y1.4131.00
37_A59_N1.4111.00
19_L362_C1.4101.00
81_I85_F1.4081.00
19_L172_T1.4001.00
140_H161_V1.3981.00
6_V36_T1.3951.00
69_E76_E1.3871.00
71_T101_A1.3841.00
112_P143_M1.3831.00
75_L104_L1.3811.00
5_T23_L1.3601.00
68_T79_K1.3571.00
323_R335_E1.3441.00
82_L90_V1.3411.00
6_V78_L1.3391.00
24_A31_A1.3381.00
185_M281_N1.3231.00
206_K239_I1.3171.00
363_S367_E1.3151.00
210_V229_L1.3141.00
23_L31_A1.3131.00
66_G79_K1.3131.00
92_V113_V1.3011.00
26_D366_L1.2871.00
246_H256_N1.2811.00
23_L369_L1.2761.00
252_R256_N1.2751.00
218_F250_N1.2751.00
103_S138_T1.2741.00
147_S153_R1.2701.00
6_V90_V1.2691.00
318_T324_L1.2681.00
4_L32_K1.2641.00
305_L335_E1.2611.00
230_A234_T1.2581.00
299_S354_N1.2471.00
169_T361_A1.2451.00
2_K85_F1.2391.00
338_R342_D1.2371.00
146_F368_A1.2331.00
116_V365_I1.2321.00
208_I287_L1.2251.00
4_L82_L1.2241.00
306_V316_A1.2201.00
78_L102_T1.2191.00
93_H99_T1.2141.00
226_C255_V1.2101.00
206_K238_D1.2091.00
139_G156_L1.2081.00
171_N295_E1.2081.00
235_T333_V1.2071.00
317_V324_L1.2041.00
69_E73_R1.1991.00
220_R224_E1.1911.00
60_I70_I1.1811.00
234_T329_K1.1791.00
19_L91_L1.1791.00
21_H179_W1.1741.00
305_L339_L1.1691.00
79_K83_A1.1691.00
92_V103_S1.1681.00
139_G161_V1.1641.00
150_E153_R1.1511.00
113_V141_L1.1501.00
298_P355_P1.1381.00
172_T361_A1.1361.00
250_N254_P1.1361.00
262_V265_V1.1331.00
245_V267_L1.1331.00
280_M297_A1.1191.00
329_K333_V1.1131.00
331_R334_E1.1121.00
106_A113_V1.1081.00
330_Q334_E1.1071.00
144_Y369_L1.1051.00
208_I239_I1.1021.00
278_W282_H1.1021.00
306_V324_L1.0950.99
230_A262_V1.0870.99
37_A44_D1.0750.99
280_M293_I1.0720.99
239_I284_W1.0700.99
272_E275_P1.0700.99
234_T262_V1.0680.99
124_D310_T1.0650.99
70_I74_I1.0640.99
68_T72_C1.0500.99
286_I297_A1.0420.99
177_L300_L1.0410.99
3_V89_V1.0380.99
49_L274_L1.0330.99
333_V337_T1.0270.99
151_T154_Q1.0250.99
121_R132_E1.0240.99
35_V54_P1.0170.99
287_L336_V1.0100.99
74_I78_L1.0080.99
114_G369_L1.0070.99
78_L82_L1.0040.99
71_T108_Y0.9960.99
40_R57_D0.9950.99
178_L181_R0.9940.99
51_S183_Q0.9930.99
174_I299_S0.9930.99
139_G142_A0.9920.99
142_A145_H0.9860.99
117_E295_E0.9860.99
208_I285_L0.9840.99
20_V31_A0.9840.99
252_R269_D0.9820.99
339_L349_M0.9810.99
230_A329_K0.9780.99
163_D166_I0.9730.99
187_S190_L0.9660.99
210_V232_I0.9590.99
40_R61_M0.9590.99
82_L106_A0.9580.99
212_G307_M0.9550.99
207_M283_A0.9510.99
280_M300_L0.9490.99
175_D359_G0.9480.98
144_Y368_A0.9390.98
32_K56_Y0.9380.98
54_P84_E0.9350.98
193_E275_P0.9320.98
16_M93_H0.9320.98
68_T75_L0.9280.98
238_D264_N0.9230.98
22_A366_L0.9220.98
203_P206_K0.9220.98
40_R44_D0.9190.98
40_R59_N0.9190.98
123_G136_T0.9180.98
13_A48_K0.9140.98
117_E171_N0.9110.98
68_T108_Y0.9070.98
4_L85_F0.9050.98
157_L163_D0.9020.98
34_C78_L0.9000.98
252_R255_V0.8980.98
42_M247_L0.8960.98
71_T75_L0.8950.98
17_A52_I0.8890.98
150_E168_I0.8880.98
286_I293_I0.8870.98
287_L332_I0.8840.98
56_Y84_E0.8800.98
175_D361_A0.8800.98
21_H25_K0.8710.97
254_P258_I0.8700.97
212_G243_Y0.8700.97
271_Q276_F0.8690.97
212_G225_I0.8660.97
133_A141_L0.8630.97
229_L241_I0.8620.97
305_L336_V0.8610.97
116_V146_F0.8610.97
337_T341_K0.8580.97
60_I73_R0.8560.97
103_S113_V0.8530.97
26_D29_F0.8510.97
74_I101_A0.8490.97
89_V112_P0.8480.97
3_V23_L0.8450.97
334_E338_R0.8440.97
149_T315_E0.8420.97
74_I102_T0.8420.97
223_E227_H0.8370.97
110_R126_Y0.8340.97
16_M91_L0.8320.97
209_L276_F0.8320.97
125_L136_T0.8290.96
99_T103_S0.8280.96
206_K240_Q0.8240.96
218_F248_N0.8230.96
239_I340_L0.8230.96
323_R338_R0.8150.96
145_H161_V0.8110.96
204_D282_H0.8050.96
231_D235_T0.8040.96
157_L166_I0.8020.96
92_V99_T0.8000.96
80_P83_A0.7990.96
103_S141_L0.7990.96
226_C230_A0.7990.96
9_T12_E0.7990.96
19_L366_L0.7980.96
2_K88_D0.7970.96
146_F167_F0.7940.96
4_L87_P0.7930.95
23_L366_L0.7890.95
271_Q279_L0.7850.95
245_V255_V0.7840.95
133_A137_L0.7830.95
207_M302_K0.7800.95
66_G69_E0.7800.95
207_M242_V0.7780.95
188_D275_P0.7710.95
241_I264_N0.7710.95
207_M239_I0.7690.95
16_M116_V0.7640.94
120_L148_P0.7630.94
64_G250_N0.7590.94
231_D234_T0.7590.94
100_L104_L0.7570.94
298_P354_N0.7560.94
57_D60_I0.7560.94
22_A362_C0.7530.94
308_R312_E0.7520.94
21_H51_S0.7520.94
154_Q157_L0.7460.94
184_V278_W0.7450.94
333_V336_V0.7450.94
177_L277_V0.7440.94
147_S168_I0.7420.94
49_L272_E0.7400.93
71_T97_T0.7400.93
7_F33_V0.7390.93
273_Y277_V0.7380.93
70_I97_T0.7370.93
169_T365_I0.7350.93
18_P179_W0.7340.93
61_M65_Q0.7330.93
295_E313_R0.7330.93
304_V321_T0.7330.93
25_K363_S0.7330.93
229_L253_E0.7330.93
47_L55_D0.7310.93
319_A355_P0.7280.93
64_G70_I0.7280.93
206_K340_L0.7230.93
222_F226_C0.7220.93
144_Y167_F0.7210.93
64_G69_E0.7200.93
227_H258_I0.7190.92
97_T108_Y0.7170.92
143_M165_R0.7130.92
212_G222_F0.7120.92
175_D357_G0.7110.92
215_R218_F0.7100.92
181_R185_M0.7090.92
243_Y249_P0.7080.92
37_A40_R0.7060.92
2_K32_K0.7040.92
227_H231_D0.7020.92
136_T161_V0.7010.92
326_G331_R0.6980.91
309_D312_E0.6970.91
44_D47_L0.6970.91
366_L370_K0.6960.91
8_G102_T0.6960.91
233_A262_V0.6930.91
188_D192_S0.6930.91
211_T244_P0.6900.91
4_L81_I0.6900.91
13_A35_V0.6890.91
209_L283_A0.6890.91
175_D362_C0.6890.91
67_L108_Y0.6830.90
188_D193_E0.6820.90
24_A55_D0.6820.90
224_E228_A0.6810.90
285_L340_L0.6790.90
69_E79_K0.6790.90
61_M64_G0.6760.90
61_M70_I0.6700.90
323_R331_R0.6690.90
107_F125_L0.6660.89
65_Q69_E0.6640.89
207_M240_Q0.6640.89
42_M269_D0.6630.89
33_V52_I0.6630.89
60_I77_G0.6610.89
153_R166_I0.6590.89
233_A241_I0.6570.89
339_L342_D0.6550.89
107_F143_M0.6510.88
247_L252_R0.6510.88
185_M278_W0.6500.88
35_V47_L0.6500.88
78_L105_A0.6480.88
125_L140_H0.6440.88
107_F126_Y0.6440.88
342_D349_M0.6410.87
245_V269_D0.6400.87
242_V268_I0.6380.87
91_L369_L0.6370.87
187_S275_P0.6360.87
235_T336_V0.6350.87
7_F35_V0.6320.87
236_H241_I0.6310.87
285_L339_L0.6310.87
76_E79_K0.6310.87
29_F366_L0.6310.87
367_E370_K0.6300.87
8_G12_E0.6300.87
210_V243_Y0.6280.86
212_G224_E0.6260.86
276_F310_T0.6250.86
281_N302_K0.6250.86
112_P144_Y0.6230.86
117_E120_L0.6220.86
305_L323_R0.6210.86
234_T264_N0.6170.85
224_E329_K0.6170.85
280_M283_A0.6170.85
223_E258_I0.6160.85
317_V322_V0.6150.85
155_N158_R0.6110.85
169_T368_A0.6090.85
210_V307_M0.6090.85
102_T106_A0.6080.85
149_T317_V0.6070.85
235_T341_K0.6060.84
8_G38_Q0.6050.84
301_G321_T0.6020.84
245_V256_N0.6010.84
283_A286_I0.6010.84
182_D185_M0.6010.84
268_I271_Q0.6010.84
74_I77_G0.6000.84
15_K117_E0.6000.84
349_M352_A0.5990.84
122_T310_T0.5980.84
171_N313_R0.5980.84
178_L299_S0.5970.84
59_N77_G0.5970.84
5_T91_L0.5960.83
189_K193_E0.5960.83
222_F225_I0.5960.83
228_A231_D0.5950.83
137_L140_H0.5930.83
301_G352_A0.5930.83
148_P172_T0.5930.83
93_H322_V0.5930.83
9_T15_K0.5890.83
222_F254_P0.5880.83
174_I359_G0.5880.83
221_G226_C0.5870.83
82_L102_T0.5870.83
309_D327_T0.5860.82
164_S167_F0.5860.82
184_V277_V0.5850.82
12_E96_T0.5850.82
3_V114_G0.5820.82
120_L152_S0.5810.82
123_G158_R0.5800.82
76_E80_P0.5790.82
245_V252_R0.5790.82
300_L321_T0.5740.81
278_W281_N0.5740.81
184_V187_S0.5710.81
47_L52_I0.5670.80
284_W340_L0.5660.80
325_V332_I0.5650.80
298_P321_T0.5640.80
32_K84_E0.5640.80
39_H213_H0.5630.80
251_V255_V0.5620.80
321_T352_A0.5610.80
186_S189_K0.5610.80
104_L108_Y0.5590.79
336_V340_L0.5580.79
326_G332_I0.5570.79
189_K192_S0.5530.79
226_C254_P0.5530.79
16_M20_V0.5510.78
44_D57_D0.5510.78
256_N260_G0.5510.78
287_L333_V0.5510.78
231_D330_Q0.5510.78
11_P15_K0.5500.78
259_L267_L0.5490.78
38_Q248_N0.5480.78
41_E59_N0.5480.78
44_D59_N0.5470.78
89_V167_F0.5470.78
228_A232_I0.5470.78
18_P21_H0.5440.78
205_K238_D0.5430.77
156_L166_I0.5430.77
330_Q333_V0.5420.77
212_G218_F0.5400.77
234_T333_V0.5390.77
9_T14_I0.5390.77
93_H173_V0.5390.77
71_T100_L0.5390.77
178_L360_Q0.5380.77
209_L279_L0.5380.77
187_S278_W0.5380.77
227_H230_A0.5370.77
2_K87_P0.5370.77
147_S152_S0.5370.77
301_G349_M0.5370.77
235_T238_D0.5360.77
182_D186_S0.5350.76
285_L305_L0.5350.76
4_L78_L0.5350.76
123_G151_T0.5340.76
244_P268_I0.5340.76
230_A258_I0.5340.76
38_Q117_E0.5330.76
209_L271_Q0.5310.76
24_A27_P0.5310.76
208_I232_I0.5300.76
42_M45_Q0.5300.76
211_T272_E0.5240.75
34_C81_I0.5230.75
250_N253_E0.5200.74
89_V143_M0.5200.74
311_T324_L0.5200.74
18_P362_C0.5200.74
225_I332_I0.5190.74
297_A304_V0.5180.74
32_K55_D0.5180.74
67_L71_T0.5170.74
7_F16_M0.5170.74
194_L240_Q0.5170.74
309_D331_R0.5150.74
75_L101_A0.5140.74
15_K93_H0.5140.74
71_T104_L0.5140.74
338_R343_E0.5140.74
311_T317_V0.5140.74
225_I228_A0.5130.73
18_P22_A0.5130.73
107_F141_L0.5130.73
302_K316_A0.5130.73
149_T152_S0.5110.73
161_V165_R0.5100.73
362_C366_L0.5100.73
133_A143_M0.5090.73
12_E93_H0.5070.72
160_N164_S0.5060.72
298_P319_A0.5050.72
314_P318_T0.5050.72
18_P180_V0.5040.72
157_L162_A0.5020.72
173_V273_Y0.5020.72
209_L293_I0.5000.71
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1vgvA 2 0.9867 100 0.527 Contact Map
1v4vA 2 0.9628 100 0.53 Contact Map
3dzcA 2 0.9734 100 0.552 Contact Map
4nesA 2 0.9388 100 0.649 Contact Map
4fkzA 2 0.9761 100 0.671 Contact Map
4hwgA 5 0.9335 100 0.691 Contact Map
3ot5A 2 0.9734 100 0.692 Contact Map
3l7iA 4 0.9202 99.9 0.786 Contact Map
3otgA 2 0.891 99.8 0.814 Contact Map
3wadA 2 0.9202 99.8 0.818 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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