ACSA - ECOLI - GREMLIN Contacts

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ACSA - Acetyl-coenzyme A synthetase

UniProt:	P27550	Sequences: MSQIHKHTIPANIADRCLINPQQYEAMYQQSINVPDTFWGEQGKILDWIKPYQKVKNTSFAPGNVSIKWYEDGTLNLAANCLDRHLQENGDRTAIIWEGDDASQSKHISYKELHRDVCRFANTLLELGIKKGDVVAIYMPMVPEAAVAMLACARIGAVHSVIFGGFSPEAVAGRIIDSNSRLVITSDEGVRAGRSIPLKKNVDDALKNPNVTSVEHVVVLKRTGGKIDWQEGRDLWWHDLVEQASDQHQAEEMNAEDPLFILYTSGSTGKPKGVLHTTGGYLVYAALTFKYVFDYHPGDIYWCTADVGWVTGHSYLLYGPLACGATTLMFEGVPNWPTPARMAQVVDKHQVNILYTAPTAIRALMAEGDKAIEGTDRSSLRILGSVGEPINPEAWEWYWKKIGNEKCPVVDTWWQTETGGFMITPLPGATELKAGSATRPFFGVQPALVDNEGNPLEGATEGSLVITDSWPGQARTLFGDHERFEQTYFSTFKNMYFSGDGARRDEDGYYWITGRVDDVLNVSGHRLGTAEIESALVAHPKIAEAAVVGIPHNIKGQAIYAYVTLNHGEEPSPELYAEVRNWVRKEIGPLATPDVLHWTDSLPKTRSGKIMRRILRKIAAGDTSNLGDTSTLADPGVVEKLLEEKQAIAMPS	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG11448
Length:	652 (506)
Sequences:	62313 (43983)
Seq/√Len:	1955.3

ECOLI - ACSA ENTF AAS PRPE FADK LCFA ENTE CAIC MENE
BACSU - PPSE SRFAC PPSB PPSC DHBF ACSA LCFB LCFA YNGI DHBE YDAB YTCI MENE DLTA YHFT SRFAA PKSJ PPSD SRFAB PPSA PKSN
HALSA - Q9HQU8 Q9HRY8 Q9HSM3 Q9HNK0 Q9HQ43 Q9HQN8
SULSO - Q97UX8 Q97U22 Q97WQ9 Q97WQ0 Q97WK0 Q97YK9 Q97UW7 Q97VT6 Q97VU7 Q97XW4 Q97UF6 Q97V27 Q97WS5 Q980E4 Q97X52

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
258_P	275_L	3.999	1.00
539_H	582_W	3.200	1.00
464_L	502_A	3.014	1.00
480_D	483_R	2.951	1.00
118_C	154_R	2.916	1.00
277_T	475_R	2.864	1.00
445_Q	467_T	2.843	1.00
177_D	263_Y	2.813	1.00
136_A	180_S	2.777	1.00
114_H	154_R	2.765	1.00
129_I	157_A	2.759	1.00
133_D	181_R	2.742	1.00
96_I	326_T	2.688	1.00
503_R	511_W	2.678	1.00
300_I	326_T	2.511	1.00
179_N	479_G	2.464	1.00
93_T	107_H	2.454	1.00
83_D	114_H	2.430	1.00
89_N	92_R	2.380	1.00
123_T	127_L	2.377	1.00
134_V	160_S	2.368	1.00
463_S	497_F	2.355	1.00
449_V	465_V	2.280	1.00
544_E	604_K	2.252	1.00
461_E	501_G	2.243	1.00
85_H	89_N	2.210	1.00
447_A	455_P	2.208	1.00
536_L	561_A	2.186	1.00
148_A	184_I	2.172	1.00
537_V	545_A	2.165	1.00
521_N	526_R	2.164	1.00
116_D	147_V	2.164	1.00
177_D	480_D	2.157	1.00
450_D	454_N	2.157	1.00
173_G	270_K	2.117	1.00
114_H	118_C	2.101	1.00
538_A	586_E	2.100	1.00
344_Q	348_K	2.094	1.00
505_D	511_W	2.088	1.00
483_R	486_Q	2.043	1.00
254_N	257_D	2.038	1.00
465_V	497_F	2.030	1.00
611_M	614_I	2.028	1.00
97_W	143_P	2.007	1.00
518_D	612_R	1.985	1.00
131_K	257_D	1.976	1.00
560_Y	597_H	1.970	1.00
172_A	176_I	1.954	1.00
299_D	381_R	1.948	1.00
181_R	215_E	1.938	1.00
96_I	107_H	1.932	1.00
481_H	485_E	1.930	1.00
120_F	147_V	1.909	1.00
91_D	111_K	1.898	1.00
152_C	157_A	1.878	1.00
132_G	257_D	1.877	1.00
505_D	509_Y	1.872	1.00
436_S	511_W	1.862	1.00
76_N	84_R	1.854	1.00
392_P	396_E	1.853	1.00
125_L	155_I	1.832	1.00
96_I	349_H	1.820	1.00
350_Q	379_S	1.812	1.00
299_D	352_N	1.811	1.00
117_V	154_R	1.789	1.00
461_E	513_T	1.763	1.00
84_R	88_E	1.761	1.00
130_K	133_D	1.757	1.00
111_K	115_R	1.753	1.00
503_R	513_T	1.745	1.00
533_E	547_V	1.722	1.00
543_A	566_N	1.710	1.00
458_G	504_R	1.700	1.00
614_I	617_K	1.697	1.00
504_R	510_Y	1.688	1.00
447_A	465_V	1.680	1.00
140_P	186_S	1.672	1.00
328_L	351_V	1.662	1.00
277_T	280_G	1.654	1.00
127_L	216_H	1.633	1.00
537_V	544_E	1.629	1.00
153_A	259_L	1.625	1.00
109_S	112_E	1.614	1.00
522_V	527_L	1.613	1.00
541_K	578_E	1.607	1.00
83_D	154_R	1.604	1.00
341_R	344_Q	1.603	1.00
258_P	475_R	1.602	1.00
482_E	486_Q	1.596	1.00
90_G	111_K	1.595	1.00
85_H	88_E	1.593	1.00
563_V	598_W	1.563	1.00
408_P	426_L	1.547	1.00
86_L	114_H	1.547	1.00
290_K	323_C	1.547	1.00
146_A	317_L	1.545	1.00
564_T	602_L	1.542	1.00
535_A	586_E	1.542	1.00
422_M	466_I	1.541	1.00
123_T	240_L	1.536	1.00
93_T	96_I	1.524	1.00
547_V	561_A	1.520	1.00
134_V	158_V	1.519	1.00
531_E	591_A	1.512	1.00
548_V	562_Y	1.503	1.00
136_A	162_I	1.503	1.00
93_T	326_T	1.494	1.00
423_I	446_P	1.490	1.00
108_I	147_V	1.489	1.00
448_L	502_A	1.478	1.00
275_L	478_F	1.476	1.00
261_I	478_F	1.467	1.00
580_R	596_L	1.466	1.00
291_Y	442_F	1.465	1.00
565_L	598_W	1.461	1.00
256_E	279_G	1.461	1.00
562_Y	615_L	1.460	1.00
457_E	460_T	1.453	1.00
551_P	557_Q	1.449	1.00
541_K	569_E	1.442	1.00
108_I	143_P	1.442	1.00
582_W	586_E	1.437	1.00
347_D	375_T	1.435	1.00
320_P	325_A	1.426	1.00
280_G	419_G	1.425	1.00
126_E	244_A	1.422	1.00
577_A	581_N	1.418	1.00
92_R	298_G	1.414	1.00
118_C	122_N	1.412	1.00
474_A	488_Y	1.400	1.00
275_L	476_T	1.393	1.00
175_I	180_S	1.393	1.00
396_E	400_K	1.392	1.00
134_V	261_I	1.391	1.00
359_T	388_E	1.388	1.00
132_G	475_R	1.387	1.00
338_T	341_R	1.385	1.00
356_T	361_I	1.384	1.00
502_A	512_I	1.371	1.00
302_W	351_V	1.370	1.00
446_P	466_I	1.369	1.00
563_V	596_L	1.369	1.00
345_V	349_H	1.364	1.00
135_V	152_C	1.362	1.00
172_A	210_N	1.359	1.00
489_F	493_K	1.359	1.00
97_W	106_K	1.358	1.00
135_V	157_A	1.354	1.00
160_S	178_S	1.349	1.00
501_G	516_V	1.346	1.00
300_I	328_L	1.344	1.00
487_T	496_Y	1.338	1.00
461_E	503_R	1.334	1.00
136_A	175_I	1.332	1.00
415_Q	496_Y	1.329	1.00
178_S	263_Y	1.324	1.00
450_D	456_L	1.324	1.00
296_H	299_D	1.323	1.00
433_K	507_D	1.314	1.00
77_L	80_N	1.309	1.00
114_H	248_H	1.307	1.00
158_V	258_P	1.306	1.00
255_A	279_G	1.302	1.00
263_Y	273_G	1.297	1.00
562_Y	599_T	1.296	1.00
94_A	113_L	1.292	1.00
605_T	611_M	1.283	1.00
187_D	221_K	1.282	1.00
236_W	239_D	1.282	1.00
177_D	270_K	1.282	1.00
330_F	345_V	1.273	1.00
581_N	585_K	1.273	1.00
299_D	353_I	1.271	1.00
129_I	133_D	1.271	1.00
116_D	119_R	1.269	1.00
520_L	529_T	1.261	1.00
275_L	475_R	1.257	1.00
549_G	557_Q	1.253	1.00
439_R	509_Y	1.252	1.00
467_T	495_M	1.245	1.00
300_I	351_V	1.242	1.00
425_P	509_Y	1.238	1.00
279_G	471_P	1.238	1.00
311_T	355_Y	1.232	1.00
173_G	177_D	1.230	1.00
129_I	135_V	1.224	1.00
550_I	560_Y	1.224	1.00
354_L	380_L	1.222	1.00
580_R	584_R	1.221	1.00
584_R	592_T	1.219	1.00
106_K	143_P	1.217	1.00
137_I	148_A	1.213	1.00
361_I	383_L	1.210	1.00
177_D	479_G	1.208	1.00
385_S	390_I	1.208	1.00
253_M	257_D	1.207	1.00
489_F	492_F	1.204	1.00
168_P	172_A	1.204	1.00
182_L	216_H	1.201	1.00
150_L	321_L	1.197	1.00
525_H	590_L	1.196	1.00
451_N	516_V	1.195	1.00
584_R	589_P	1.195	1.00
76_N	80_N	1.194	1.00
489_F	497_F	1.191	1.00
134_V	478_F	1.185	1.00
120_F	151_A	1.180	1.00
98_E	331_E	1.180	1.00
560_Y	595_V	1.176	1.00
256_E	277_T	1.170	1.00
145_A	307_V	1.169	1.00
120_F	184_I	1.168	1.00
115_R	119_R	1.164	1.00
483_R	487_T	1.163	1.00
139_M	220_L	1.158	1.00
168_P	204_D	1.154	1.00
544_E	564_T	1.152	1.00
552_H	558_A	1.149	1.00
123_T	244_A	1.147	1.00
366_A	397_W	1.145	1.00
176_I	270_K	1.144	1.00
558_A	594_D	1.143	1.00
129_I	182_L	1.142	1.00
264_T	274_V	1.140	1.00
123_T	126_E	1.138	1.00
353_I	382_I	1.133	1.00
561_A	596_L	1.129	1.00
107_H	349_H	1.129	1.00
116_D	144_E	1.126	1.00
112_E	115_R	1.123	1.00
582_W	585_K	1.122	1.00
83_D	118_C	1.115	1.00
440_P	446_P	1.115	1.00
535_A	538_A	1.113	1.00
530_A	534_S	1.111	1.00
138_Y	171_V	1.110	1.00
447_A	495_M	1.108	1.00
433_K	509_Y	1.106	1.00
391_N	394_A	1.106	1.00
115_R	246_D	1.105	1.00
340_A	367_E	1.102	1.00
444_V	472_G	1.101	1.00
362_R	394_A	1.100	1.00
108_I	116_D	1.096	1.00
346_V	379_S	1.095	1.00
562_Y	616_R	1.095	1.00
98_E	106_K	1.095	1.00
558_A	595_V	1.095	1.00
425_P	436_S	1.090	1.00
456_L	460_T	1.083	1.00
151_A	155_I	1.082	1.00
578_E	581_N	1.082	1.00
96_I	328_L	1.081	1.00
398_Y	402_I	1.080	1.00
113_L	150_L	1.079	1.00
94_A	110_Y	1.075	1.00
261_I	273_G	1.068	1.00
599_T	602_L	1.067	1.00
162_I	171_V	1.064	1.00
113_L	147_V	1.051	1.00
276_H	280_G	1.049	1.00
562_Y	619_A	1.047	1.00
463_S	516_V	1.044	1.00
599_T	618_I	1.040	1.00
464_L	512_I	1.039	1.00
572_S	578_E	1.035	1.00
546_A	602_L	1.033	1.00
300_I	352_N	1.032	1.00
465_V	489_F	1.031	1.00
301_Y	320_P	1.027	1.00
121_A	154_R	1.026	1.00
133_D	157_A	1.021	1.00
519_V	528_G	1.017	1.00
186_S	189_G	1.016	1.00
305_A	311_T	1.015	1.00
274_V	474_A	1.014	1.00
437_A	512_I	1.011	1.00
328_L	345_V	1.010	1.00
550_I	595_V	1.009	1.00
539_H	579_V	1.005	1.00
95_I	146_A	0.998	1.00
397_W	401_K	0.994	1.00
108_I	113_L	0.993	1.00
423_I	510_Y	0.993	1.00
328_L	349_H	0.986	1.00
134_V	179_N	0.984	1.00
614_I	618_I	0.983	1.00
284_Y	420_G	0.981	1.00
280_G	473_Q	0.978	1.00
169_E	586_E	0.978	1.00
613_R	617_K	0.976	1.00
533_E	612_R	0.976	1.00
299_D	325_A	0.974	1.00
583_V	592_T	0.973	1.00
125_L	249_Q	0.971	1.00
265_S	607_S	0.965	1.00
166_F	174_R	0.963	1.00
543_A	564_T	0.962	1.00
467_T	493_K	0.962	1.00
466_I	498_S	0.961	1.00
173_G	263_Y	0.960	1.00
169_E	172_A	0.958	1.00
446_P	510_Y	0.956	1.00
465_V	495_M	0.948	1.00
283_V	443_G	0.943	1.00
92_R	326_T	0.942	1.00
93_T	109_S	0.941	1.00
170_A	591_A	0.941	1.00
539_H	578_E	0.940	1.00
365_M	397_W	0.939	1.00
127_L	182_L	0.937	1.00
522_V	549_G	0.936	1.00
393_E	397_W	0.936	1.00
82_L	86_L	0.935	1.00
581_N	584_R	0.935	1.00
602_L	610_I	0.935	1.00
403_G	407_C	0.929	1.00
436_S	509_Y	0.928	1.00
448_L	456_L	0.925	1.00
302_W	330_F	0.924	1.00
538_A	582_W	0.923	1.00
117_V	151_A	0.919	1.00
136_A	183_V	0.916	1.00
106_K	116_D	0.916	1.00
79_A	253_M	0.913	1.00
262_L	416_T	0.913	1.00
451_N	463_S	0.905	1.00
173_G	176_I	0.900	1.00
518_D	530_A	0.898	1.00
95_I	143_P	0.897	1.00
169_E	173_G	0.895	1.00
362_R	391_N	0.893	1.00
120_F	148_A	0.892	1.00
397_W	400_K	0.889	1.00
501_G	514_G	0.888	1.00
122_N	245_S	0.888	1.00
139_M	142_V	0.887	1.00
535_A	583_V	0.886	1.00
113_L	117_V	0.884	1.00
283_V	471_P	0.881	1.00
125_L	130_K	0.880	1.00
112_E	116_D	0.880	1.00
122_N	125_L	0.879	1.00
163_F	308_G	0.877	1.00
143_P	147_V	0.877	1.00
446_P	464_L	0.877	1.00
588_G	591_A	0.875	1.00
124_L	184_I	0.875	1.00
276_H	474_A	0.873	1.00
450_D	460_T	0.872	1.00
84_R	87_Q	0.872	1.00
187_D	222_R	0.872	1.00
122_N	249_Q	0.869	1.00
578_E	582_W	0.866	1.00
310_V	415_Q	0.865	1.00
124_L	152_C	0.865	1.00
83_D	87_Q	0.864	1.00
355_Y	421_F	0.861	1.00
453_G	465_V	0.861	1.00
140_P	188_E	0.859	1.00
173_G	480_D	0.857	1.00
390_I	395_W	0.856	1.00
320_P	327_T	0.856	1.00
114_H	117_V	0.854	1.00
285_A	322_A	0.852	1.00
99_G	106_K	0.851	1.00
459_A	506_E	0.848	1.00
81_C	287_L	0.845	1.00
520_L	559_I	0.844	1.00
384_G	412_T	0.840	1.00
168_P	201_N	0.837	1.00
149_M	159_H	0.837	1.00
129_I	155_I	0.835	1.00
347_D	376_D	0.833	1.00
382_I	410_V	0.828	1.00
80_N	84_R	0.825	1.00
560_Y	619_A	0.823	1.00
551_P	554_I	0.820	1.00
433_K	505_D	0.819	1.00
482_E	485_E	0.813	1.00
518_D	533_E	0.813	1.00
448_L	510_Y	0.810	1.00
361_I	398_Y	0.808	1.00
253_M	278_T	0.807	1.00
79_A	153_A	0.806	1.00
146_A	329_M	0.806	1.00
579_V	596_L	0.805	1.00
152_C	159_H	0.803	1.00
468_D	473_Q	0.802	1.00
160_S	180_S	0.802	1.00
136_A	160_S	0.801	1.00
187_D	219_V	0.799	1.00
144_E	147_V	0.797	1.00
137_I	159_H	0.797	1.00
523_S	555_K	0.796	1.00
96_I	300_I	0.795	1.00
276_H	419_G	0.793	1.00
82_L	114_H	0.792	1.00
447_A	467_T	0.792	1.00
92_R	297_P	0.791	1.00
259_L	281_Y	0.786	1.00
340_A	344_Q	0.782	1.00
119_R	245_S	0.781	1.00
119_R	246_D	0.780	1.00
93_T	97_W	0.779	1.00
79_A	278_T	0.776	1.00
361_I	385_S	0.772	1.00
565_L	571_P	0.772	1.00
80_N	83_D	0.771	1.00
418_T	422_M	0.771	1.00
126_E	243_Q	0.771	1.00
127_L	235_L	0.770	1.00
149_M	313_H	0.769	1.00
337_P	360_A	0.767	1.00
573_P	577_A	0.767	1.00
300_I	350_Q	0.767	1.00
147_V	151_A	0.766	1.00
295_Y	353_I	0.766	1.00
363_A	554_I	0.766	1.00
617_K	620_A	0.763	1.00
418_T	496_Y	0.761	1.00
418_T	473_Q	0.760	1.00
147_V	237_W	0.757	1.00
185_T	219_V	0.756	1.00
489_F	495_M	0.756	1.00
352_N	381_R	0.755	1.00
201_N	204_D	0.754	1.00
410_V	426_L	0.754	1.00
565_L	569_E	0.753	1.00
530_A	533_E	0.751	1.00
176_I	213_S	0.751	1.00
122_N	247_Q	0.750	1.00
106_K	144_E	0.749	1.00
541_K	566_N	0.749	1.00
315_Y	355_Y	0.748	1.00
412_T	421_F	0.745	1.00
125_L	251_E	0.745	1.00
310_V	420_G	0.745	1.00
393_E	396_E	0.745	1.00
82_L	150_L	0.742	1.00
81_C	85_H	0.741	1.00
362_R	397_W	0.740	1.00
136_A	178_S	0.739	1.00
121_A	155_I	0.736	1.00
304_T	360_A	0.735	1.00
332_G	336_W	0.735	1.00
85_H	324_G	0.734	1.00
86_L	90_G	0.733	1.00
357_A	360_A	0.732	1.00
382_I	408_P	0.732	1.00
418_T	466_I	0.732	1.00
130_K	181_R	0.731	1.00
375_T	378_S	0.730	1.00
122_N	246_D	0.729	1.00
346_V	351_V	0.727	1.00
119_R	123_T	0.726	1.00
446_P	502_A	0.726	1.00
91_D	109_S	0.722	1.00
258_P	277_T	0.722	1.00
169_E	270_K	0.722	1.00
468_D	472_G	0.722	1.00
284_Y	315_Y	0.721	1.00
344_Q	347_D	0.721	1.00
77_L	278_T	0.719	1.00
580_R	592_T	0.719	1.00
344_Q	375_T	0.719	1.00
362_R	366_A	0.717	1.00
546_A	610_I	0.715	1.00
260_F	276_H	0.715	1.00
449_V	455_P	0.714	1.00
139_M	145_A	0.712	1.00
290_K	319_G	0.711	1.00
120_F	124_L	0.711	1.00
259_L	278_T	0.708	1.00
107_H	326_T	0.708	1.00
113_L	146_A	0.708	1.00
79_A	83_D	0.707	1.00
577_A	580_R	0.706	1.00
135_V	182_L	0.706	1.00
461_E	516_V	0.705	1.00
311_T	386_V	0.704	1.00
488_Y	497_F	0.701	1.00
563_V	579_V	0.701	1.00
185_T	217_V	0.701	1.00
564_T	601_S	0.700	1.00
138_Y	183_V	0.699	1.00
144_E	186_S	0.698	1.00
131_K	251_E	0.698	1.00
75_L	279_G	0.697	1.00
550_I	558_A	0.696	1.00
369_D	397_W	0.696	1.00
362_R	393_E	0.695	1.00
302_W	345_V	0.694	1.00
138_Y	189_G	0.694	1.00
89_N	111_K	0.692	1.00
134_V	479_G	0.692	1.00
81_C	282_L	0.691	1.00
347_D	378_S	0.690	1.00
296_H	381_R	0.688	1.00
497_F	516_V	0.688	1.00
89_N	297_P	0.686	1.00
174_R	273_G	0.686	1.00
298_G	352_N	0.686	1.00
464_L	510_Y	0.686	1.00
152_C	155_I	0.685	1.00
170_A	531_E	0.685	1.00
346_V	354_L	0.684	1.00
122_N	244_A	0.683	1.00
522_V	559_I	0.683	1.00
148_A	152_C	0.683	1.00
502_A	510_Y	0.681	1.00
270_K	480_D	0.681	1.00
458_G	506_E	0.681	1.00
583_V	587_I	0.680	1.00
287_L	291_Y	0.680	1.00
536_L	545_A	0.678	1.00
355_Y	412_T	0.678	1.00
368_G	372_I	0.678	1.00
131_K	253_M	0.676	1.00
302_W	346_V	0.676	1.00
480_D	484_F	0.676	1.00
185_T	189_G	0.675	1.00
239_D	242_E	0.672	1.00
316_L	355_Y	0.671	1.00
87_Q	114_H	0.668	1.00
541_K	565_L	0.667	1.00
467_T	494_N	0.665	1.00
355_Y	386_V	0.664	1.00
304_T	357_A	0.661	1.00
284_Y	421_F	0.660	1.00
123_T	241_V	0.660	1.00
182_L	218_V	0.659	1.00
380_L	383_L	0.659	1.00
81_C	322_A	0.658	1.00
150_L	318_Y	0.658	1.00
546_A	615_L	0.658	1.00
125_L	250_A	0.657	1.00
330_F	342_M	0.657	1.00
122_N	248_H	0.657	1.00
445_Q	495_M	0.657	1.00
142_V	186_S	0.653	1.00
284_Y	419_G	0.651	1.00
415_Q	418_T	0.650	1.00
373_E	401_K	0.650	1.00
390_I	409_V	0.650	1.00
562_Y	618_I	0.648	1.00
116_D	143_P	0.647	1.00
128_G	157_A	0.646	1.00
441_F	444_V	0.645	1.00
580_R	583_V	0.645	1.00
326_T	349_H	0.644	1.00
383_L	398_Y	0.644	1.00
303_C	316_L	0.643	1.00
492_F	497_F	0.642	1.00
216_H	235_L	0.642	1.00
207_K	210_N	0.642	1.00
535_A	582_W	0.642	1.00
89_N	324_G	0.640	1.00
97_W	331_E	0.639	1.00
502_A	513_T	0.639	1.00
399_W	408_P	0.639	1.00
548_V	616_R	0.639	1.00
411_D	435_G	0.639	1.00
542_I	563_V	0.638	1.00
413_W	422_M	0.637	1.00
484_F	488_Y	0.637	1.00
120_F	123_T	0.637	1.00
480_D	486_Q	0.637	1.00
125_L	248_H	0.636	1.00
589_P	592_T	0.635	1.00
529_T	547_V	0.634	1.00
149_M	153_A	0.634	1.00
179_N	213_S	0.633	1.00
256_E	475_R	0.632	1.00
309_W	525_H	0.632	1.00
93_T	300_I	0.632	1.00
573_P	598_W	0.631	1.00
139_M	186_S	0.630	1.00
394_A	397_W	0.630	1.00
204_D	207_K	0.629	1.00
161_V	262_L	0.629	1.00
121_A	151_A	0.628	1.00
130_K	157_A	0.628	1.00
149_M	317_L	0.627	1.00
139_M	148_A	0.627	1.00
448_L	504_R	0.626	1.00
295_Y	325_A	0.624	1.00
183_V	202_V	0.624	1.00
288_T	292_V	0.623	1.00
116_D	241_V	0.622	1.00
120_F	237_W	0.620	1.00
341_R	345_V	0.617	1.00
548_V	619_A	0.616	1.00
301_Y	353_I	0.615	1.00
473_Q	496_Y	0.614	1.00
522_V	557_Q	0.613	1.00
345_V	348_K	0.610	1.00
118_C	248_H	0.609	1.00
573_P	596_L	0.609	1.00
543_A	567_H	0.608	1.00
354_L	383_L	0.608	1.00
158_V	261_I	0.606	1.00
315_Y	421_F	0.605	1.00
522_V	594_D	0.604	1.00
543_A	565_L	0.604	1.00
389_P	512_I	0.604	1.00
423_I	437_A	0.601	1.00
79_A	154_R	0.601	1.00
303_C	327_T	0.601	1.00
402_I	407_C	0.601	1.00
597_H	618_I	0.601	1.00
285_A	319_G	0.598	1.00
285_A	318_Y	0.595	1.00
179_N	478_F	0.593	1.00
166_F	308_G	0.592	1.00
190_V	219_V	0.592	1.00
562_Y	597_H	0.591	1.00
129_I	181_R	0.590	1.00
269_G	528_G	0.588	1.00
534_S	538_A	0.588	1.00
177_D	478_F	0.588	1.00
108_I	112_E	0.588	1.00
292_V	442_F	0.587	1.00
124_L	182_L	0.586	1.00
536_L	583_V	0.586	1.00
595_V	598_W	0.586	1.00
95_I	327_T	0.586	1.00
202_V	205_A	0.586	1.00
532_I	559_I	0.586	1.00
517_D	557_Q	0.585	1.00
149_M	318_Y	0.584	1.00
80_N	252_E	0.583	1.00
476_T	481_H	0.582	1.00
533_E	561_A	0.582	1.00
363_A	366_A	0.582	1.00
412_T	424_T	0.576	1.00
303_C	329_M	0.574	1.00
280_G	475_R	0.574	1.00
139_M	185_T	0.574	1.00
95_I	108_I	0.573	1.00
295_Y	299_D	0.573	1.00
166_F	171_V	0.571	1.00
474_A	487_T	0.571	1.00
551_P	620_A	0.571	1.00
140_P	332_G	0.570	1.00
347_D	379_S	0.570	1.00
98_E	348_K	0.569	1.00
302_W	342_M	0.569	1.00
385_S	409_V	0.568	1.00
390_I	411_D	0.568	1.00
110_Y	321_L	0.568	1.00
261_I	275_L	0.567	1.00
453_G	489_F	0.566	1.00
287_L	290_K	0.564	1.00
160_S	263_Y	0.564	1.00
78_A	153_A	0.563	1.00
398_Y	409_V	0.563	1.00
304_T	356_T	0.562	1.00
343_A	368_G	0.561	1.00
305_A	355_Y	0.561	1.00
597_H	622_D	0.560	1.00
185_T	190_V	0.560	1.00
158_V	478_F	0.559	1.00
331_E	341_R	0.558	1.00
542_I	545_A	0.557	1.00
191_R	201_N	0.556	1.00
303_C	312_G	0.556	1.00
617_K	621_G	0.555	1.00
165_G	332_G	0.555	1.00
249_Q	253_M	0.555	1.00
544_E	602_L	0.553	1.00
139_M	184_I	0.553	1.00
315_Y	412_T	0.553	1.00
448_L	462_G	0.553	1.00
449_V	495_M	0.550	1.00
396_E	399_W	0.550	1.00
95_I	113_L	0.550	1.00
386_V	421_F	0.549	1.00
422_M	444_V	0.549	1.00
369_D	374_G	0.549	1.00
118_C	125_L	0.548	1.00
459_A	503_R	0.548	1.00
415_Q	498_S	0.548	1.00
489_F	494_N	0.548	1.00
546_A	612_R	0.547	1.00
535_A	587_I	0.547	1.00
241_V	244_A	0.547	1.00
117_V	120_F	0.547	1.00
455_P	465_V	0.547	1.00
342_M	360_A	0.545	1.00
202_V	206_L	0.545	1.00
466_I	473_Q	0.544	1.00
117_V	121_A	0.541	1.00
284_Y	289_F	0.541	1.00
448_L	464_L	0.540	1.00
292_V	426_L	0.540	1.00
445_Q	493_K	0.539	1.00
203_D	206_L	0.539	1.00
260_F	281_Y	0.537	1.00
306_D	309_W	0.537	1.00
311_T	420_G	0.536	1.00
134_V	180_S	0.535	1.00
301_Y	325_A	0.534	1.00
201_N	205_A	0.534	1.00
352_N	379_S	0.534	1.00
539_H	542_I	0.533	1.00
178_S	261_I	0.532	1.00
142_V	220_L	0.532	1.00
449_V	453_G	0.531	1.00
337_P	342_M	0.530	1.00
110_Y	325_A	0.529	1.00
124_L	157_A	0.528	1.00
342_M	346_V	0.528	1.00
219_V	223_T	0.527	1.00
289_F	315_Y	0.527	1.00
127_L	240_L	0.526	1.00
111_K	114_H	0.526	1.00
119_R	244_A	0.525	1.00
140_P	189_G	0.525	1.00
573_P	580_R	0.524	1.00
552_H	556_G	0.524	1.00
426_L	439_R	0.522	1.00
437_A	502_A	0.521	1.00
212_T	215_E	0.521	1.00
123_T	218_V	0.520	1.00
83_D	250_A	0.520	1.00
162_I	175_I	0.520	1.00
425_P	428_G	0.519	1.00
488_Y	496_Y	0.519	1.00
119_R	122_N	0.517	1.00
300_I	303_C	0.516	1.00
557_Q	616_R	0.516	1.00
77_L	253_M	0.516	1.00
484_F	487_T	0.516	1.00
552_H	555_K	0.515	1.00
184_I	218_V	0.515	1.00
522_V	555_K	0.514	1.00
96_I	99_G	0.514	1.00
137_I	152_C	0.514	1.00
365_M	394_A	0.513	1.00
87_Q	248_H	0.513	1.00
314_S	420_G	0.512	1.00
177_D	273_G	0.511	1.00
455_P	504_R	0.511	1.00
520_L	549_G	0.510	1.00
343_A	377_R	0.509	1.00
160_S	174_R	0.508	1.00
274_V	416_T	0.507	1.00
284_Y	422_M	0.507	1.00
311_T	412_T	0.507	1.00
166_F	590_L	0.506	1.00
386_V	412_T	0.506	1.00
167_S	170_A	0.505	1.00
260_F	313_H	0.504	1.00
383_L	407_C	0.504	1.00
146_A	321_L	0.503	1.00
603_P	615_L	0.503	1.00
551_P	555_K	0.501	1.00
311_T	384_G	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2vsqA	1	0.9156	100	0.134	Contact Map
1pg4A	1	0.9785	100	0.177	Contact Map
1ry2A	1	0.9294	100	0.201	Contact Map
4wd1A	1	0.9601	100	0.212	Contact Map
3tsyA	2	0.6933	100	0.22	Contact Map
4d4iA	1	0.7209	100	0.221	Contact Map
1amuA	1	0.7669	100	0.223	Contact Map
4dg8A	1	0.7469	100	0.228	Contact Map
4iz6A	2	0.8558	100	0.23	Contact Map
3etcA	2	0.8113	100	0.237	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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