GREMLIN Database
RODZ - Cytoskeleton protein RodZ
UniProt: P27434 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10015
Length: 337 (312)
Sequences: 1219 (1129)
Seq/√Len: 63.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
259_F280_Q5.0861.00
261_A303_A4.7881.00
33_V71_L4.7841.00
14_T50_D4.4041.00
266_E277_S3.9331.00
22_A26_L3.6191.00
20_R24_E3.2921.00
290_G294_Y3.1491.00
30_Q44_V3.1231.00
51_K54_A2.9241.00
39_L43_T2.9201.00
262_D281_R2.8601.00
260_T305_Q2.8561.00
37_L293_P2.7071.00
258_N285_N2.6491.00
45_R49_E2.6201.00
264_W299_G2.5821.00
33_V68_Y2.5431.00
43_T64_Y2.5341.00
268_T274_K2.5251.00
266_E297_K2.5031.00
98_Q101_S2.4261.00
47_I65_I2.4031.00
22_A72_V2.3621.00
276_F286_L2.3361.00
300_A303_A2.3061.00
297_K326_R2.2901.00
22_A25_Q2.2621.00
62_R84_E2.2051.00
263_C298_I2.1921.00
46_D51_K2.0881.00
39_L64_Y2.0871.00
46_D55_D2.0411.00
38_C67_S1.9801.00
259_F304_V1.9471.00
263_C304_V1.9121.00
30_Q41_V1.8551.00
253_N309_Q1.8491.00
40_K67_S1.8091.00
278_G284_G1.8061.00
57_A64_Y1.8031.00
60_F64_Y1.7941.00
262_D279_M1.7911.00
205_P239_P1.7881.00
63_G66_R1.7481.00
75_P78_E1.6910.99
298_I304_V1.6830.99
258_N305_Q1.6770.99
281_R284_G1.6660.99
15_T52_A1.6650.99
40_K43_T1.6650.99
256_V287_N1.6560.99
38_C64_Y1.6190.99
188_A195_A1.6190.99
217_N223_T1.6170.99
47_I72_V1.6000.99
196_V199_P1.5900.99
257_M267_V1.5840.99
18_R79_L1.5620.99
37_L71_L1.5330.99
203_V208_N1.5260.99
213_P218_V1.5120.99
42_S64_Y1.4870.98
189_T192_Q1.4850.98
301_P323_Q1.4840.98
38_C61_L1.4810.98
44_V71_L1.4790.98
306_I315_L1.4550.98
30_Q259_F1.4550.98
268_T297_K1.4210.98
210_V215_Q1.4010.98
290_G293_P1.3960.98
22_A74_I1.3900.97
44_V266_E1.3650.97
280_Q284_G1.3590.97
34_A47_I1.3500.97
266_E274_K1.3440.97
127_L131_W1.3400.97
217_N220_T1.3360.97
172_T177_T1.3280.97
97_M100_F1.3250.97
230_T234_G1.3160.96
255_L329_L1.3080.96
41_V45_R1.2930.96
259_F266_E1.2860.96
21_N24_E1.2800.96
274_K277_S1.2720.96
17_A20_R1.2450.95
74_I78_E1.2400.95
28_L71_L1.2320.95
127_L130_A1.2310.95
15_T86_Q1.2260.95
28_L33_V1.2230.95
64_Y259_F1.2190.95
190_N196_V1.2180.95
208_N213_P1.2120.94
102_L298_I1.2100.94
39_L325_A1.2030.94
21_N25_Q1.1960.94
59_T313_V1.1950.94
29_S32_A1.1930.94
19_L23_R1.1900.94
68_Y71_L1.1780.93
263_C322_N1.1770.93
131_W275_L1.1730.93
132_W136_R1.1700.93
158_S163_S1.1670.93
191_T211_V1.1570.93
314_D318_F1.1570.93
62_R80_L1.1510.93
186_T193_T1.1490.93
50_D61_L1.1380.92
38_C66_R1.1360.92
323_Q327_L1.1340.92
117_T132_W1.1290.92
153_E156_S1.1250.92
14_T44_V1.1150.91
298_I325_A1.1110.91
62_R88_P1.1100.91
31_Q44_V1.1080.91
255_L308_Y1.1070.91
314_D325_A1.1030.91
20_R49_E1.1010.91
267_V272_G1.0830.90
155_S161_G1.0720.90
167_N236_A1.0720.90
47_I78_E1.0630.89
168_T205_P1.0600.89
156_S170_T1.0590.89
15_T79_L1.0580.89
201_P211_V1.0540.89
29_S49_E1.0490.89
261_A300_A1.0470.89
33_V44_V1.0340.88
192_Q207_Q1.0320.88
63_G71_L1.0260.88
61_L83_L1.0210.87
38_C280_Q1.0190.87
65_I80_L1.0180.87
57_A61_L1.0100.87
295_K328_T1.0060.87
139_Q142_E1.0020.86
301_P317_R1.0000.86
158_S161_G0.9960.86
17_A21_N0.9900.86
308_Y330_N0.9880.86
263_C288_L0.9870.86
234_G237_P0.9850.85
186_T204_D0.9820.85
302_A317_R0.9790.85
50_D294_Y0.9780.85
206_Q214_S0.9770.85
222_A227_T0.9750.85
44_V60_F0.9710.85
160_Q165_P0.9700.85
256_V285_N0.9630.84
32_A41_V0.9590.84
205_P209_A0.9530.84
269_D293_P0.9530.84
278_G286_L0.9520.83
259_F314_D0.9430.83
261_A282_K0.9370.82
261_A304_V0.9360.82
36_R71_L0.9320.82
198_A227_T0.9290.82
172_T237_P0.9270.82
114_M117_T0.9250.82
191_T196_V0.9230.82
212_S221_A0.9220.81
206_Q209_A0.9190.81
40_K60_F0.9180.81
16_G23_R0.9160.81
63_G68_Y0.9100.81
63_G67_S0.9100.81
55_D61_L0.9070.80
269_D290_G0.9070.80
175_A227_T0.9060.80
172_T176_T0.9040.80
257_M304_V0.8950.79
161_G164_V0.8940.79
187_T224_P0.8930.79
203_V209_A0.8930.79
215_Q250_A0.8900.79
254_A309_Q0.8860.79
276_F284_G0.8840.79
160_Q169_S0.8830.79
162_Q166_L0.8820.78
167_N237_P0.8810.78
186_T219_D0.8800.78
216_A223_T0.8790.78
70_R76_E0.8780.78
33_V72_V0.8750.78
150_S154_L0.8750.78
300_A324_V0.8720.78
118_W124_V0.8710.78
197_T220_T0.8700.78
223_T236_A0.8680.77
31_Q35_E0.8680.77
177_T205_P0.8660.77
120_V126_G0.8650.77
200_A205_P0.8650.77
205_P208_N0.8630.77
207_Q239_P0.8600.77
206_Q211_V0.8560.76
268_T281_R0.8550.76
128_S135_D0.8530.76
57_A277_S0.8520.76
114_M118_W0.8510.76
168_T172_T0.8510.76
280_Q286_L0.8500.76
205_P211_V0.8470.76
171_T174_P0.8460.76
65_I83_L0.8450.75
111_G130_A0.8430.75
18_R22_A0.8390.75
185_D189_T0.8370.75
172_T248_P0.8370.75
167_N171_T0.8360.75
65_I79_L0.8350.75
43_T46_D0.8330.74
230_T235_A0.8310.74
215_Q233_D0.8310.74
226_P229_A0.8260.74
254_A289_T0.8210.73
252_P289_T0.8180.73
30_Q34_A0.8130.73
50_D67_S0.8130.73
210_V229_A0.8120.72
47_I294_Y0.8110.72
275_L279_M0.8100.72
196_V204_D0.8090.72
22_A62_R0.8040.72
22_A31_Q0.7990.71
191_T237_P0.7960.71
208_N216_A0.7940.71
100_F112_W0.7930.71
256_V279_M0.7930.71
152_A170_T0.7930.71
210_V216_A0.7930.71
40_K64_Y0.7910.71
114_M134_Q0.7890.70
117_T126_G0.7880.70
254_A287_N0.7840.70
262_D282_K0.7830.70
264_W267_V0.7790.69
39_L60_F0.7770.69
204_D228_A0.7770.69
221_A225_A0.7740.69
158_S165_P0.7700.68
297_K324_V0.7690.68
211_V223_T0.7660.68
197_T209_A0.7610.68
197_T200_A0.7610.68
156_S159_E0.7580.67
193_T222_A0.7580.67
223_T233_D0.7550.67
173_D185_D0.7530.67
98_Q103_G0.7520.67
302_A323_Q0.7480.66
26_L73_H0.7480.66
70_R324_V0.7470.66
109_R124_V0.7390.65
65_I297_K0.7380.65
184_V194_P0.7370.65
271_T292_A0.7350.65
116_F121_L0.7350.65
118_W130_A0.7330.65
175_A187_T0.7310.64
208_N215_Q0.7300.64
227_T230_T0.7260.64
293_P326_R0.7210.63
58_S83_L0.7190.63
307_Q311_K0.7170.63
78_E81_P0.7160.63
23_R48_E0.7130.62
174_P177_T0.7120.62
170_T174_P0.7110.62
157_N165_P0.7110.62
97_M101_S0.7070.62
276_F298_I0.7060.62
263_C278_G0.7050.62
42_S57_A0.7040.61
67_S124_V0.7040.61
113_L133_W0.7030.61
55_D301_P0.7010.61
153_E212_S0.7000.61
162_Q169_S0.6960.61
203_V213_P0.6940.60
165_P171_T0.6920.60
265_L276_F0.6920.60
34_A63_G0.6890.60
142_E146_M0.6890.60
218_V226_P0.6860.60
42_S88_P0.6820.59
222_A232_P0.6780.59
65_I86_Q0.6770.58
326_R329_L0.6760.58
174_P196_V0.6760.58
39_L259_F0.6730.58
60_F70_R0.6730.58
47_I79_L0.6720.58
121_L134_Q0.6690.58
171_T175_A0.6690.58
15_T84_E0.6660.57
219_D239_P0.6640.57
173_D215_Q0.6640.57
194_P199_P0.6610.57
201_P221_A0.6600.57
107_K112_W0.6600.57
117_T280_Q0.6600.57
214_S220_T0.6590.56
46_D108_K0.6590.56
260_T299_G0.6590.56
207_Q213_P0.6520.56
185_D193_T0.6510.56
119_L122_F0.6510.56
59_T63_G0.6450.55
166_L169_S0.6400.54
44_V57_A0.6390.54
184_V214_S0.6380.54
197_T239_P0.6370.54
110_D113_L0.6360.54
323_Q326_R0.6340.54
216_A226_P0.6330.53
44_V56_L0.6330.53
72_V135_D0.6330.53
64_Y68_Y0.6320.53
40_K55_D0.6280.53
62_R255_L0.6280.53
203_V210_V0.6250.53
189_T194_P0.6250.53
41_V294_Y0.6250.53
185_D232_P0.6210.52
206_Q217_N0.6200.52
227_T239_P0.6190.52
277_S297_K0.6180.52
255_L298_I0.6180.52
110_D114_M0.6160.52
197_T205_P0.6160.52
16_G19_L0.6160.52
140_Q143_I0.6140.51
167_N221_A0.6120.51
210_V243_A0.6120.51
192_Q230_T0.6110.51
201_P206_Q0.6100.51
202_A227_T0.6070.50
60_F259_F0.6070.50
213_P230_T0.6070.50
214_S241_D0.6070.50
317_R321_T0.6050.50
259_F284_G0.6030.50
161_G171_T0.6030.50
65_I68_Y0.6030.50
189_T193_T0.6030.50
56_L61_L0.6020.50
296_L327_L0.6000.50
157_N162_Q0.5990.50
263_C286_L0.5990.50
262_D312_P0.5980.49
186_T190_N0.5980.49
15_T32_A0.5980.49
31_Q41_V0.5970.49
220_T234_G0.5920.49
37_L288_L0.5920.49
176_T188_A0.5910.49
195_A226_P0.5860.48
166_L224_P0.5840.48
114_M127_L0.5830.48
191_T202_A0.5830.48
273_K277_S0.5820.48
212_S228_A0.5820.48
30_Q45_R0.5810.47
109_R112_W0.5790.47
34_A37_L0.5790.47
268_T272_G0.5760.47
220_T227_T0.5750.47
155_S210_V0.5720.46
212_S217_N0.5720.46
192_Q238_L0.5680.46
161_G166_L0.5680.46
206_Q210_V0.5680.46
278_G290_G0.5680.46
212_S230_T0.5670.46
214_S222_A0.5670.46
35_E41_V0.5660.46
100_F110_D0.5660.46
33_V93_K0.5660.46
199_P211_V0.5650.46
111_G115_T0.5650.46
143_I151_S0.5640.45
225_A246_T0.5630.45
215_Q241_D0.5620.45
22_A303_A0.5620.45
189_T211_V0.5610.45
184_V213_P0.5600.45
62_R304_V0.5600.45
291_Q311_K0.5600.45
15_T64_Y0.5590.45
240_T245_V0.5580.45
226_P231_T0.5580.45
14_T47_I0.5570.45
268_T310_G0.5550.44
138_A142_E0.5540.44
66_R329_L0.5510.44
57_A301_P0.5510.44
171_T209_A0.5500.44
121_L129_G0.5480.44
66_R80_L0.5470.44
158_S164_V0.5470.44
269_D288_L0.5470.44
228_A231_T0.5460.43
297_K325_A0.5460.43
285_N305_Q0.5440.43
171_T176_T0.5430.43
72_V83_L0.5420.43
221_A226_P0.5420.43
196_V227_T0.5410.43
52_A82_G0.5400.43
114_M122_F0.5380.43
158_S212_S0.5370.42
51_K55_D0.5370.42
175_A188_A0.5370.42
186_T237_P0.5370.42
15_T80_L0.5370.42
144_T296_L0.5370.42
188_A218_V0.5370.42
80_L259_F0.5360.42
43_T327_L0.5360.42
219_D246_T0.5350.42
26_L74_I0.5350.42
267_V286_L0.5350.42
16_G47_I0.5310.42
40_K324_V0.5300.42
222_A237_P0.5290.42
173_D241_D0.5260.41
163_S168_T0.5250.41
231_T236_A0.5250.41
195_A216_A0.5240.41
40_K59_T0.5240.41
203_V227_T0.5230.41
266_E322_N0.5220.41
25_Q58_S0.5190.40
187_T192_Q0.5180.40
222_A226_P0.5180.40
85_K167_N0.5180.40
246_T249_V0.5170.40
224_P230_T0.5170.40
227_T231_T0.5160.40
142_E147_A0.5140.40
307_Q312_P0.5130.40
270_A293_P0.5130.40
194_P223_T0.5130.40
33_V63_G0.5130.40
120_V131_W0.5110.39
190_N198_A0.5090.39
159_E164_V0.5080.39
37_L262_D0.5080.39
264_W297_K0.5060.39
79_L82_G0.5060.39
79_L271_T0.5050.39
25_Q261_A0.5040.39
208_N211_V0.5040.39
32_A299_G0.5030.39
114_M130_A0.5020.39
197_T224_P0.5020.39
69_A73_H0.5010.38
121_L125_I0.5010.38
18_R40_K0.5000.38
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3fymA 1 0.2433 99.7 0.747 Contact Map
4gqmA 2 0.2849 99.2 0.808 Contact Map
2wusR 1 0.2582 99.2 0.809 Contact Map
3eusA 2 0.2404 98.3 0.864 Contact Map
3kz3A 2 0.2344 98.2 0.864 Contact Map
1y7yA 2 0.2047 98.2 0.865 Contact Map
2ef8A 2 0.2493 98.2 0.865 Contact Map
1lmb3 2 0.2641 98.2 0.866 Contact Map
2ofyA 2 0.2374 98.2 0.866 Contact Map
3f6wA 2 0.2404 98.2 0.867 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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