GREMLIN Database
YCFD - 50S ribosomal protein L16 arginine hydroxylase
UniProt: P27431 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11430
Length: 373 (361)
Sequences: 1354 (983)
Seq/√Len: 51.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
139_R174_E9.8061.00
118_P193_E6.8751.00
141_R170_D5.3151.00
11_D15_R4.6411.00
93_T111_L3.9661.00
15_R20_R3.7541.00
143_R188_E3.6531.00
8_N11_D3.5151.00
121_G188_E3.3261.00
144_V185_F3.2531.00
268_F272_I3.0891.00
141_R192_L2.9151.00
143_R170_D2.8431.00
25_K174_E2.8111.00
19_K232_D2.7751.00
85_A88_H2.6081.00
343_T346_N2.5771.00
139_R192_L2.5071.00
101_R105_D2.3881.00
10_P14_E2.3791.00
121_G143_R2.3121.00
141_R172_E2.2871.00
126_L186_P2.2821.00
134_I178_I2.2501.00
42_G46_E2.2491.00
139_R193_E2.2271.00
204_A227_Y2.2251.00
31_F136_G2.2021.00
27_G178_I2.1871.00
23_V171_E2.1761.00
228_Y233_V2.1311.00
133_I197_N2.0981.00
31_F134_I1.9751.00
173_L178_I1.9751.00
23_V173_L1.9751.00
57_Q62_Q1.9130.99
16_H22_V1.9110.99
255_L258_I1.8690.99
247_M257_L1.8450.99
16_H20_R1.8360.99
134_I200_V1.8260.99
330_R334_D1.8150.99
120_G123_G1.8130.99
110_D199_S1.7910.99
37_P41_A1.7660.99
136_G198_Y1.7440.99
241_D244_P1.7160.99
112_M140_R1.7130.99
110_D129_Y1.6900.99
24_L178_I1.6810.99
334_D338_S1.6790.99
264_F272_I1.6590.98
11_D16_H1.6480.98
363_L368_Y1.6470.98
113_I196_M1.6370.98
17_W21_P1.6290.98
126_L148_L1.6280.98
144_V181_I1.6250.98
108_I201_G1.6050.98
110_D122_V1.5990.98
260_Q263_H1.5730.98
233_V246_E1.5560.98
318_V321_N1.5450.97
228_Y232_D1.5340.97
112_M199_S1.5250.97
7_L16_H1.5160.97
227_Y230_D1.5150.97
93_T198_Y1.5080.97
143_R190_Y1.5070.97
78_N119_G1.5050.97
348_G358_A1.4840.97
82_L129_Y1.4830.97
140_R195_A1.4820.97
113_I198_Y1.4820.97
254_M257_L1.4630.96
251_R259_N1.4540.96
6_T9_W1.4530.96
121_G195_A1.4510.96
146_E168_I1.4500.96
125_H140_R1.4240.96
241_D315_G1.4200.96
362_A366_S1.4130.96
133_I189_G1.4130.96
333_L337_A1.4050.95
238_H241_D1.3960.95
228_Y231_P1.3890.95
26_R30_N1.3790.95
118_P192_L1.3720.95
183_P199_S1.3610.95
71_Y75_G1.3570.95
111_L198_Y1.3470.94
244_P248_D1.3470.94
361_A365_N1.3460.94
214_F217_Y1.3430.94
122_V129_Y1.3420.94
217_Y220_Q1.3410.94
272_I275_S1.3370.94
252_E256_E1.3290.94
114_S123_G1.3280.94
112_M183_P1.3270.94
139_R172_E1.3250.94
110_D183_P1.3210.94
125_H187_H1.3010.93
82_L86_V1.2960.93
57_Q64_S1.2950.93
148_L186_P1.2830.93
109_D198_Y1.2660.92
114_S199_S1.2660.92
118_P194_N1.2630.92
112_M129_Y1.2490.92
11_D14_E1.2370.91
78_N184_G1.2370.91
183_P197_N1.2320.91
128_Q184_G1.2320.91
82_L112_M1.2300.91
226_N251_R1.2280.91
222_E225_G1.2270.91
86_V93_T1.2270.91
54_V80_S1.2120.90
38_D42_G1.2100.90
127_D187_H1.2030.90
251_R261_P1.1830.89
266_Q319_Y1.1690.89
7_L22_V1.1650.89
86_V198_Y1.1640.89
129_Y199_S1.1610.88
129_Y201_G1.1580.88
144_V171_E1.1390.87
172_E192_L1.1390.87
97_M108_I1.1290.87
229_S233_V1.1230.87
290_P294_Y1.1220.87
124_P200_V1.1210.87
267_W272_I1.1130.86
343_T360_L1.1090.86
358_A362_A1.1020.86
124_P196_M1.0980.85
155_P163_D1.0940.85
112_M197_N1.0930.85
112_M122_V1.0880.85
335_A346_N1.0870.85
37_P137_T1.0820.85
165_F186_P1.0810.84
147_K185_F1.0790.84
107_R230_D1.0740.84
250_L253_M1.0650.84
335_A342_L1.0640.84
54_V68_F1.0560.83
109_D129_Y1.0560.83
25_K173_L1.0510.83
181_I185_F1.0460.82
226_N229_S1.0410.82
87_N310_R1.0360.82
16_H19_K1.0360.82
304_V307_G1.0360.82
347_F355_S1.0350.82
13_L233_V1.0300.82
151_K163_D1.0270.81
228_Y246_E1.0270.81
119_G191_A1.0240.81
84_Q201_G1.0240.81
108_I129_Y1.0230.81
263_H266_Q1.0200.81
253_M256_E1.0170.81
114_S117_V1.0150.81
207_T253_M1.0140.80
332_A356_F1.0050.80
114_S189_G1.0000.80
313_R338_S0.9930.79
319_Y324_K0.9890.79
57_Q60_K0.9840.78
110_D197_N0.9840.78
355_S366_S0.9820.78
48_E234_P0.9790.78
282_A285_E0.9750.78
31_F198_Y0.9740.78
107_R183_P0.9730.78
85_A277_H0.9730.78
83_V86_V0.9720.78
288_Y369_W0.9710.78
273_S312_L0.9680.77
157_P161_Q0.9670.77
122_V199_S0.9640.77
132_F180_Y0.9580.77
24_L40_L0.9580.77
54_V81_L0.9530.76
251_R258_I0.9450.76
56_H78_N0.9420.75
254_M258_I0.9370.75
113_I136_G0.9300.74
208_R219_L0.9270.74
248_D261_P0.9250.74
323_E326_D0.9240.74
51_S66_G0.9230.74
82_L201_G0.9210.74
355_S358_A0.9210.74
234_P237_A0.9190.73
292_E295_D0.9140.73
30_N103_L0.9100.73
86_V201_G0.9070.73
53_L82_L0.9050.72
218_V260_Q0.9030.72
147_K151_K0.8990.72
131_V201_G0.8980.72
35_I198_Y0.8920.71
152_Q183_P0.8920.71
88_H145_G0.8900.71
82_L195_A0.8860.71
229_S232_D0.8840.71
334_D350_A0.8810.70
80_S114_S0.8810.70
32_I244_P0.8760.70
212_S216_D0.8750.70
84_Q129_Y0.8710.69
207_T214_F0.8710.69
56_H71_Y0.8700.69
110_D189_G0.8690.69
55_S121_G0.8650.69
93_T275_S0.8640.69
133_I199_S0.8560.68
125_H142_W0.8550.68
311_V318_V0.8510.68
168_I185_F0.8510.68
114_S197_N0.8490.67
107_R165_F0.8450.67
82_L197_N0.8450.67
82_L122_V0.8440.67
252_E255_L0.8440.67
217_Y336_L0.8410.67
114_S119_G0.8370.66
321_N337_A0.8350.66
6_T30_N0.8350.66
162_V205_P0.8280.65
189_G199_S0.8270.65
139_R153_H0.8270.65
130_D181_I0.8270.65
138_G182_P0.8230.65
86_V113_I0.8210.65
167_A170_D0.8190.65
63_V130_D0.8180.65
112_M189_G0.8180.65
301_E341_A0.8170.64
56_H121_G0.8170.64
216_D219_L0.8130.64
343_T348_G0.8130.64
172_E320_A0.8100.64
36_S39_E0.8050.63
34_P98_R0.8030.63
97_M200_V0.8000.63
261_P265_K0.7960.62
268_F271_F0.7950.62
113_I124_P0.7930.62
266_Q270_E0.7930.62
320_A323_E0.7900.62
345_E357_L0.7900.62
227_Y233_V0.7890.62
110_D114_S0.7850.61
48_E51_S0.7830.61
130_D203_R0.7830.61
359_M363_L0.7810.61
147_K184_G0.7770.61
91_E307_G0.7740.60
277_H280_D0.7730.60
244_P316_D0.7730.60
236_R258_I0.7710.60
53_L68_F0.7690.60
213_G216_D0.7690.60
111_L136_G0.7680.60
244_P292_E0.7680.60
126_L149_Q0.7680.60
33_D169_I0.7670.60
246_E250_L0.7660.59
251_R255_L0.7650.59
97_M109_D0.7650.59
114_S120_G0.7650.59
52_R55_S0.7640.59
144_V169_I0.7630.59
82_L85_A0.7620.59
107_R114_S0.7610.59
129_Y203_R0.7600.59
250_L256_E0.7590.59
246_E258_I0.7580.59
104_P120_G0.7560.58
31_F34_P0.7560.58
243_L249_K0.7530.58
115_F189_G0.7520.58
80_S121_G0.7480.58
138_G176_G0.7460.57
323_E327_S0.7450.57
52_R68_F0.7450.57
52_R129_Y0.7440.57
153_H156_H0.7430.57
345_E350_A0.7430.57
31_F178_I0.7420.57
147_K211_I0.7420.57
215_A281_I0.7380.57
322_G326_D0.7380.57
260_Q265_K0.7380.57
276_R279_L0.7360.56
83_V129_Y0.7350.56
305_R310_R0.7310.56
21_P25_K0.7300.56
354_P358_A0.7290.56
339_N345_E0.7290.56
299_Q302_V0.7280.56
107_R199_S0.7260.55
63_V126_L0.7250.55
107_R197_N0.7230.55
354_P357_L0.7230.55
267_W271_F0.7210.55
154_C157_P0.7170.54
272_I278_E0.7160.54
113_I118_P0.7150.54
318_V322_G0.7150.54
95_A295_D0.7100.54
207_T218_V0.7100.54
19_K231_P0.7100.54
336_L342_L0.7090.54
244_P252_E0.7090.54
136_G273_S0.7070.53
355_S359_M0.7060.53
51_S123_G0.7040.53
140_R187_H0.7000.53
164_P186_P0.7000.53
130_D201_G0.6980.52
225_G229_S0.6970.52
110_D201_G0.6920.52
148_L151_K0.6890.52
86_V114_S0.6880.51
61_W67_P0.6880.51
107_R110_D0.6860.51
146_E185_F0.6830.51
207_T210_L0.6820.51
114_S188_E0.6820.51
41_A81_L0.6790.50
16_H21_P0.6790.50
199_S203_R0.6790.50
321_N324_K0.6790.50
57_Q111_L0.6780.50
159_L163_D0.6780.50
110_D140_R0.6750.50
148_L167_A0.6730.50
236_R252_E0.6710.50
127_D138_G0.6710.50
57_Q191_A0.6700.50
24_L27_G0.6690.49
55_S60_K0.6680.49
239_P250_L0.6680.49
238_H338_S0.6670.49
40_L86_V0.6660.49
68_F130_D0.6650.49
66_G123_G0.6650.49
79_W84_Q0.6640.49
246_E254_M0.6610.49
28_F199_S0.6600.48
87_N312_L0.6590.48
14_E20_R0.6580.48
107_R203_R0.6570.48
31_F367_G0.6550.48
166_E259_N0.6540.48
356_F359_M0.6520.48
248_D252_E0.6520.48
301_E311_V0.6510.48
254_M264_F0.6510.48
318_V324_K0.6500.47
41_A75_G0.6430.47
303_L310_R0.6420.47
11_D304_V0.6420.47
122_V189_G0.6410.47
112_M203_R0.6400.46
122_V197_N0.6400.46
89_W144_V0.6390.46
19_K279_L0.6390.46
32_I237_A0.6380.46
223_L301_E0.6370.46
110_D120_G0.6370.46
268_F312_L0.6370.46
127_D140_R0.6360.46
41_A115_F0.6360.46
53_L56_H0.6360.46
143_R166_E0.6360.46
120_G269_G0.6350.46
176_G182_P0.6350.46
124_P186_P0.6320.46
26_R29_N0.6320.46
66_G81_L0.6300.45
41_A70_S0.6300.45
40_L66_G0.6280.45
138_G142_W0.6270.45
255_L259_N0.6270.45
177_D182_P0.6270.45
85_A131_V0.6260.45
26_R31_F0.6250.45
79_W319_Y0.6250.45
35_I335_A0.6240.45
122_V140_R0.6230.45
41_A83_V0.6230.45
152_Q162_V0.6230.45
84_Q196_M0.6220.45
167_A188_E0.6210.44
62_Q211_I0.6200.44
127_D142_W0.6190.44
280_D283_P0.6180.44
50_D275_S0.6180.44
12_F180_Y0.6170.44
364_V369_W0.6150.44
345_E353_D0.6150.44
328_P359_M0.6140.44
288_Y293_I0.6140.44
39_E42_G0.6140.44
220_Q276_R0.6110.43
35_I89_W0.6110.43
106_W203_R0.6100.43
14_E25_K0.6100.43
141_R174_E0.6090.43
43_L131_V0.6080.43
297_L357_L0.6080.43
37_P196_M0.6070.43
26_R324_K0.6060.43
79_W106_W0.6040.43
149_Q153_H0.6020.42
235_P334_D0.6020.42
329_H353_D0.6000.42
234_P252_E0.5970.42
115_F194_N0.5960.42
82_L110_D0.5930.42
265_K272_I0.5920.41
112_M125_H0.5910.41
237_A294_Y0.5900.41
87_N267_W0.5900.41
7_L221_R0.5890.41
248_D338_S0.5880.41
15_R143_R0.5870.41
50_D117_V0.5870.41
262_E266_Q0.5860.41
291_D295_D0.5860.41
61_W104_P0.5860.41
44_A107_R0.5850.41
164_P204_A0.5820.40
195_A275_S0.5820.40
71_Y78_N0.5800.40
165_F269_G0.5800.40
135_Q138_G0.5790.40
161_Q186_P0.5770.40
196_M305_R0.5770.40
242_V254_M0.5760.40
174_E193_E0.5760.40
223_L252_E0.5750.40
119_G199_S0.5740.40
293_I301_E0.5730.40
232_D249_K0.5730.40
110_D203_R0.5710.39
335_A348_G0.5690.39
273_S318_V0.5690.39
128_Q188_E0.5690.39
28_F31_F0.5660.39
71_Y74_L0.5660.39
17_W105_D0.5650.39
87_N94_A0.5640.39
212_S262_E0.5630.39
131_V177_D0.5620.38
131_V203_R0.5610.38
84_Q130_D0.5600.38
305_R312_L0.5600.38
330_R340_I0.5600.38
354_P359_M0.5590.38
134_I296_A0.5580.38
52_R66_G0.5570.38
342_L348_G0.5570.38
280_D308_G0.5570.38
10_P212_S0.5570.38
158_D161_Q0.5550.38
50_D276_R0.5540.38
322_G328_P0.5540.38
129_Y140_R0.5530.38
227_Y232_D0.5520.37
109_D140_R0.5520.37
80_S191_A0.5520.37
103_L109_D0.5520.37
82_L114_S0.5520.37
172_E185_F0.5480.37
145_G163_D0.5480.37
284_P342_L0.5460.37
298_K301_E0.5440.37
333_L339_N0.5440.37
41_A46_E0.5440.37
206_N227_Y0.5430.37
109_D112_M0.5420.37
133_I195_A0.5410.36
106_W129_Y0.5410.36
44_A122_V0.5400.36
81_L230_D0.5390.36
344_A350_A0.5380.36
52_R61_W0.5370.36
262_E325_I0.5350.36
28_F99_P0.5350.36
58_D354_P0.5340.36
270_E318_V0.5330.36
85_A106_W0.5330.36
16_H24_L0.5320.36
221_R266_Q0.5320.36
319_Y323_E0.5310.35
104_P130_D0.5310.35
244_P344_A0.5300.35
85_A145_G0.5300.35
303_L311_V0.5290.35
110_D121_G0.5280.35
186_P199_S0.5280.35
272_I281_I0.5270.35
62_Q252_E0.5260.35
142_W187_H0.5250.35
81_L85_A0.5240.35
80_S91_E0.5230.35
33_D136_G0.5230.35
42_G45_M0.5230.35
51_S201_G0.5220.35
14_E342_L0.5200.34
223_L247_M0.5190.34
109_D120_G0.5180.34
288_Y302_V0.5170.34
120_G199_S0.5170.34
142_W182_P0.5160.34
248_D256_E0.5160.34
189_G197_N0.5160.34
135_Q187_H0.5150.34
243_L247_M0.5140.34
184_G195_A0.5120.34
248_D295_D0.5110.34
281_I284_P0.5100.33
61_W66_G0.5080.33
245_Q249_K0.5080.33
9_W22_V0.5080.33
25_K181_I0.5070.33
133_I306_L0.5050.33
251_R303_L0.5040.33
140_R197_N0.5040.33
57_Q63_V0.5030.33
82_L199_S0.5020.33
86_V228_Y0.5020.33
96_L210_L0.5010.33
41_A44_A0.5010.33
38_D287_P0.5000.33
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4litA 2 0.9598 100 0.388 Contact Map
4ccjA 3 0.9946 100 0.402 Contact Map
4bxfA 2 0.9839 100 0.407 Contact Map
4cswA 2 0.9973 100 0.415 Contact Map
1vrbA 2 0.7534 100 0.521 Contact Map
3al5A 2 0.6971 100 0.71 Contact Map
4qszA 2 0.5979 99.9 0.724 Contact Map
3kv5D 2 0.807 99.9 0.728 Contact Map
3k2oA 2 0.6542 99.9 0.738 Contact Map
3kv4A 1 0.8123 99.9 0.746 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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