GREMLIN Database
STHA - Soluble pyridine nucleotide transhydrogenase
UniProt: P27306 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11428
Length: 466 (448)
Sequences: 13711 (8887)
Seq/√Len: 419.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
180_L262_A4.1991.00
296_N300_Q4.0811.00
37_R116_N3.8721.00
286_E294_K2.9331.00
410_I424_G2.9211.00
121_D124_T2.9131.00
178_H201_K2.8751.00
7_Y111_E2.7951.00
201_K233_V2.7831.00
203_D235_R2.7361.00
372_P403_E2.7181.00
149_R276_D2.6601.00
6_D140_E2.5951.00
423_I445_F2.5581.00
7_Y33_A2.5571.00
224_S228_W2.5251.00
279_A282_N2.5081.00
372_P402_R2.4661.00
6_D138_T2.4571.00
175_E200_V2.4291.00
21_A143_V2.3441.00
217_Q364_Q2.2931.00
139_A142_F2.2881.00
149_R274_N2.2821.00
151_Y272_T2.2471.00
178_H263_D2.2391.00
33_A113_L2.2321.00
242_K253_H2.2181.00
361_K366_L2.2051.00
124_T136_T2.2051.00
401_H404_T2.1991.00
244_E253_H2.1711.00
374_E402_R2.1681.00
361_K369_M2.1641.00
251_I259_K2.1441.00
10_I137_L2.1331.00
180_L205_I2.1151.00
412_C417_A2.1031.00
126_A136_T2.1021.00
329_A333_L2.0911.00
405_K438_E2.0751.00
288_D292_Q2.0591.00
430_Q435_N2.0581.00
406_E434_G2.0531.00
118_R126_A2.0331.00
156_V242_K2.0011.00
17_G309_V1.9801.00
10_I35_I1.9731.00
189_C204_L1.9651.00
9_A25_L1.9651.00
10_I125_L1.9451.00
75_H82_S1.9451.00
120_V126_A1.9261.00
251_I261_K1.9001.00
241_E255_K1.8991.00
165_D168_S1.8781.00
209_D237_N1.8651.00
239_E255_K1.8461.00
235_R258_K1.8381.00
373_Y399_L1.8301.00
120_V136_T1.8251.00
149_R272_T1.8211.00
427_I435_N1.7951.00
180_L252_M1.7741.00
363_E397_K1.7701.00
244_E251_I1.7621.00
196_R201_K1.7431.00
363_E367_T1.7411.00
253_H259_K1.7041.00
364_Q368_A1.6961.00
128_D132_G1.6961.00
119_F142_F1.6931.00
189_C352_T1.6821.00
12_I117_A1.6631.00
141_K305_H1.6601.00
300_Q304_P1.6591.00
10_I139_A1.6531.00
82_S85_D1.6441.00
355_E418_A1.6431.00
398_I410_I1.6391.00
75_H80_R1.6301.00
143_V333_L1.6271.00
10_I33_A1.6241.00
366_L373_Y1.6131.00
124_T138_T1.6061.00
144_I312_V1.5981.00
179_V200_V1.5891.00
8_D140_E1.5881.00
179_V195_F1.5771.00
210_R220_S1.5751.00
113_L137_L1.5481.00
177_R201_K1.5461.00
246_C251_I1.5261.00
85_D88_N1.4861.00
371_V408_L1.4841.00
218_E377_R1.4831.00
164_Y264_C1.4781.00
163_I243_I1.4771.00
102_Q114_Q1.4771.00
241_E253_H1.4631.00
235_R238_E1.4611.00
164_Y172_M1.4601.00
307_Y332_A1.4451.00
115_G127_L1.4401.00
207_T239_E1.4231.00
366_L399_L1.4171.00
436_T439_Y1.4161.00
177_R263_D1.4071.00
141_K333_L1.4031.00
398_I458_A1.3911.00
9_A30_A1.3901.00
365_Q368_A1.3871.00
300_Q305_H1.3721.00
216_D397_K1.3661.00
7_Y113_L1.3641.00
197_G230_S1.3621.00
222_S413_F1.3611.00
62_R65_E1.3601.00
41_V112_I1.3591.00
254_L260_L1.3581.00
246_C249_G1.3451.00
203_D233_V1.3371.00
35_I137_L1.3361.00
119_F125_L1.3351.00
298_M332_A1.3351.00
146_C312_V1.3221.00
299_Y313_I1.3161.00
143_V309_V1.3141.00
8_D31_R1.3021.00
33_A137_L1.2971.00
249_G261_K1.2961.00
196_R232_V1.2951.00
169_I195_F1.2941.00
91_D95_N1.2871.00
24_G331_Q1.2861.00
372_P401_H1.2741.00
9_A143_V1.2731.00
375_V399_L1.2711.00
184_A211_L1.2691.00
119_F144_I1.2661.00
288_D294_K1.2431.00
75_H85_D1.2431.00
48_W167_D1.2411.00
125_L129_C1.2401.00
225_Y228_W1.2351.00
219_M413_F1.2161.00
204_L234_I1.2141.00
219_M395_T1.2101.00
283_I303_Q1.2071.00
205_I260_L1.1971.00
215_L348_T1.1941.00
210_R217_Q1.1861.00
286_E302_A1.1861.00
123_H305_H1.1821.00
303_Q306_V1.1811.00
223_L413_F1.1731.00
224_S234_I1.1711.00
87_L91_D1.1671.00
206_N236_H1.1671.00
356_I413_F1.1621.00
152_H165_D1.1601.00
238_E256_S1.1571.00
215_L358_S1.1571.00
217_Q221_D1.1571.00
398_I424_G1.1551.00
205_I254_L1.1521.00
380_F414_G1.1501.00
218_E397_K1.1501.00
396_L453_A1.1471.00
157_D160_H1.1471.00
246_C261_K1.1451.00
280_L285_L1.1441.00
12_I144_I1.1441.00
34_V105_Y1.1401.00
162_R245_G1.1401.00
297_S340_A1.1391.00
326_G330_A1.1391.00
122_E303_Q1.1381.00
118_R279_A1.1301.00
113_L135_E1.1261.00
238_E254_L1.1261.00
111_E135_E1.1241.00
31_R111_E1.1241.00
182_Y265_L1.1231.00
401_H406_E1.1201.00
424_G454_Y1.1161.00
293_L312_V1.1111.00
349_G446_N1.1081.00
35_I117_A1.0991.00
430_Q439_Y1.0911.00
422_H446_N1.0901.00
363_E375_V1.0891.00
243_I250_V1.0881.00
365_Q369_M1.0871.00
68_Q71_L1.0861.00
377_R395_T1.0801.00
285_L293_L1.0651.00
226_H229_N1.0631.00
88_N92_N1.0601.00
224_S236_H1.0571.00
164_Y168_S1.0541.00
162_R250_V1.0531.00
23_M108_N1.0521.00
367_T373_Y1.0511.00
210_R224_S1.0491.00
363_E373_Y1.0491.00
160_H245_G1.0481.00
309_V329_A1.0421.00
225_Y229_N1.0401.00
362_T365_Q1.0391.00
116_N277_S1.0391.00
348_T358_S1.0391.00
17_G322_A1.0371.00
245_G249_G1.0341.00
119_F139_A1.0311.00
357_S421_I1.0291.00
162_R264_C1.0261.00
118_R128_D1.0251.00
125_L305_H1.0211.00
164_Y169_I1.0171.00
84_A173_H1.0161.00
58_H62_R1.0121.00
129_C135_E1.0101.00
299_Y329_A1.0061.00
345_D428_M1.0051.00
154_T158_F1.0041.00
357_S417_A1.0031.00
227_F232_V1.0011.00
119_F282_N0.9991.00
228_W233_V0.9991.00
120_V124_T0.9981.00
83_F87_L0.9971.00
371_V401_H0.9921.00
179_V264_C0.9881.00
349_G418_A0.9871.00
178_H200_V0.9851.00
275_T287_T0.9831.00
243_I265_L0.9831.00
366_L371_V0.9801.00
92_N96_Q0.9761.00
223_L356_I0.9731.00
295_V313_I0.9731.00
30_A334_V0.9721.00
342_L429_E0.9681.00
416_R419_E0.9651.00
245_G248_D0.9651.00
45_C50_T0.9631.00
405_K437_I0.9621.00
374_E405_K0.9591.00
7_Y31_R0.9581.00
316_P346_I0.9581.00
179_V266_L0.9581.00
102_Q106_E0.9571.00
35_I115_G0.9571.00
245_G250_V0.9551.00
211_L234_I0.9531.00
283_I306_V0.9501.00
219_M411_H0.9501.00
155_D158_F0.9471.00
189_C227_F0.9471.00
244_E259_K0.9441.00
28_Q334_V0.9431.00
229_N393_V0.9431.00
254_L258_K0.9421.00
118_R282_N0.9411.00
235_R260_L0.9411.00
30_A140_E0.9401.00
210_R364_Q0.9371.00
14_S34_V0.9361.00
359_V428_M0.9341.00
39_Q48_W0.9341.00
28_Q331_Q0.9321.00
14_S41_V0.9321.00
422_H451_A0.9311.00
24_G28_Q0.9281.00
184_A206_N0.9271.00
294_K302_A0.9221.00
371_V399_L0.9211.00
211_L224_S0.9211.00
180_L260_L0.9151.00
222_S225_Y0.9151.00
59_A86_I0.9151.00
63_I67_N0.9141.00
178_H249_G0.9101.00
435_N439_Y0.9091.00
363_E399_L0.9031.00
308_A312_V0.9011.00
119_F279_A0.8991.00
119_F283_I0.8971.00
174_H264_C0.8971.00
47_H98_T0.8961.00
396_L412_C0.8961.00
300_Q332_A0.8951.00
178_H262_A0.8941.00
178_H203_D0.8921.00
277_S280_L0.8911.00
285_L303_Q0.8901.00
205_I235_R0.8901.00
233_V258_K0.8891.00
142_F306_V0.8881.00
30_A141_K0.8881.00
329_A332_A0.8871.00
250_V265_L0.8851.00
219_M356_I0.8851.00
287_T294_K0.8841.00
122_E305_H0.8841.00
330_A334_V0.8821.00
377_R397_K0.8811.00
59_A89_H0.8811.00
64_I67_N0.8801.00
361_K365_Q0.8791.00
64_I230_S0.8791.00
221_D225_Y0.8761.00
182_Y267_Y0.8711.00
178_H261_K0.8661.00
118_R277_S0.8661.00
222_S226_H0.8601.00
60_V197_G0.8541.00
285_L302_A0.8501.00
328_I332_A0.8501.00
70_P85_D0.8471.00
300_Q307_Y0.8451.00
105_Y110_C0.8451.00
141_K307_Y0.8431.00
12_I278_L0.8421.00
20_G323_Y0.8391.00
87_L90_A0.8381.00
188_G206_N0.8351.00
211_L236_H0.8351.00
295_V308_A0.8341.00
299_Y332_A0.8331.00
182_Y269_N0.8331.00
221_D224_S0.8291.00
284_G303_Q0.8271.00
328_I341_H0.8271.00
161_P245_G0.8271.00
64_I197_G0.8261.00
238_E258_K0.8261.00
12_I125_L0.8241.00
186_V350_I0.8231.00
95_N99_R0.8211.00
122_E284_G0.8191.00
273_G292_Q0.8171.00
163_I267_Y0.8171.00
226_H393_V0.8171.00
182_Y240_Y0.8161.00
168_S171_S0.8161.00
151_Y269_N0.8131.00
57_R194_I0.8121.00
105_Y112_I0.8121.00
94_I97_Q0.8101.00
61_S65_E0.8081.00
10_I142_F0.8081.00
9_A330_A0.8051.00
30_A333_L0.8041.00
226_H230_S0.8031.00
103_G107_R0.8031.00
77_R80_R0.8011.00
25_L330_A0.8011.00
435_N440_F0.7981.00
76_S79_L0.7961.00
156_V160_H0.7961.00
423_I426_A0.7951.00
407_I424_G0.7951.00
226_H413_F0.7941.00
64_I68_Q0.7921.00
88_N173_H0.7921.00
427_I440_F0.7891.00
96_Q387_Q0.7871.00
196_R230_S0.7861.00
410_I428_M0.7851.00
362_T411_H0.7841.00
374_E400_F0.7841.00
235_R254_L0.7841.00
90_A94_I0.7831.00
205_I238_E0.7821.00
56_L87_L0.7811.00
208_R213_A0.7801.00
160_H168_S0.7801.00
8_D30_A0.7791.00
156_V159_T0.7781.00
24_G27_K0.7771.00
11_V18_G0.7731.00
210_R221_D0.7731.00
25_L30_A0.7721.00
243_I252_M0.7701.00
203_D262_A0.7671.00
181_I266_L0.7651.00
99_R102_Q0.7641.00
53_S191_Y0.7631.00
292_Q317_S0.7621.00
129_C132_G0.7621.00
24_G330_A0.7611.00
279_A283_I0.7611.00
359_V425_Q0.7601.00
92_N95_N0.7601.00
101_R105_Y0.7591.00
21_A326_G0.7581.00
66_F76_S0.7571.00
36_E40_N0.7541.00
39_Q114_Q0.7531.00
66_F69_N0.7531.00
155_D159_T0.7521.00
331_Q336_G0.7511.00
223_L352_T0.7511.00
276_D281_Q0.7501.00
367_T370_K0.7501.00
424_G428_M0.7501.00
143_V329_A0.7491.00
366_L408_L0.7461.00
379_Q382_H0.7411.00
21_A330_A0.7391.00
188_G207_T0.7391.00
123_H138_T0.7391.00
99_R103_G0.7381.00
227_F234_I0.7361.00
283_I302_A0.7361.00
197_G353_I0.7361.00
398_I457_A0.7351.00
151_Y154_T0.7351.00
376_G457_A0.7281.00
194_I198_M0.7251.00
67_N78_L0.7241.00
207_T213_A0.7221.00
293_L308_A0.7221.00
283_I287_T0.7211.00
193_S197_G0.7201.00
142_F305_H0.7171.00
344_E369_M0.7161.00
401_H408_L0.7151.00
172_M264_C0.7111.00
406_E436_T0.7101.00
429_E442_N0.7091.00
325_Q343_I0.7081.00
84_A88_N0.7071.00
152_H158_F0.7051.00
355_E416_R0.7041.00
215_L350_I0.7031.00
148_S271_R0.7031.00
68_Q390_G0.7021.00
280_L287_T0.7021.00
127_L137_L0.7011.00
209_D217_Q0.7011.00
240_Y252_M0.7001.00
59_A72_Y0.7001.00
321_A346_I0.6981.00
58_H61_S0.6971.00
212_L223_L0.6971.00
128_D131_D0.6961.00
280_L283_I0.6951.00
216_D411_H0.6941.00
7_Y10_I0.6931.00
399_L402_R0.6921.00
21_A329_A0.6911.00
447_Y452_E0.6911.00
146_C278_L0.6891.00
192_A204_L0.6861.00
407_I428_M0.6861.00
66_F74_D0.6861.00
53_S57_R0.6861.00
40_N48_W0.6821.00
123_H303_Q0.6761.00
122_E283_I0.6751.00
275_T312_V0.6751.00
192_A232_V0.6741.00
324_D327_R0.6711.00
66_F79_L0.6711.00
89_H93_V0.6691.00
115_G131_D0.6660.99
404_T434_G0.6660.99
299_Y328_I0.6650.99
181_I188_G0.6650.99
167_D271_R0.6620.99
250_V264_C0.6620.99
81_S86_I0.6610.99
189_C211_L0.6590.99
206_N213_A0.6580.99
152_H157_D0.6570.99
91_D171_S0.6570.99
380_F453_A0.6560.99
158_F163_I0.6560.99
86_I198_M0.6550.99
100_M104_F0.6550.99
90_A171_S0.6540.99
376_G400_F0.6540.99
331_Q335_K0.6500.99
426_A440_F0.6470.99
152_H267_Y0.6470.99
155_D240_Y0.6440.99
419_E451_A0.6420.99
70_P75_H0.6400.99
166_S271_R0.6400.99
437_I441_V0.6400.99
426_A443_T0.6390.99
8_D33_A0.6380.99
439_Y442_N0.6360.99
425_Q429_E0.6360.99
292_Q314_G0.6360.99
103_G106_E0.6330.99
414_G417_A0.6330.99
426_A435_N0.6310.99
426_A430_Q0.6290.99
287_T293_L0.6290.99
412_C420_I0.6270.99
28_Q336_G0.6260.99
410_I454_Y0.6250.99
295_V299_Y0.6200.99
126_A132_G0.6180.99
373_Y408_L0.6150.99
186_V348_T0.6150.99
132_G135_E0.6150.99
298_M337_E0.6150.99
215_L356_I0.6140.99
238_E255_K0.6140.99
219_M222_S0.6140.99
189_C234_I0.6120.99
400_F437_I0.6120.99
321_A343_I0.6110.99
289_S294_K0.6100.99
115_G125_L0.6090.99
69_N72_Y0.6070.99
331_Q339_T0.6060.99
158_F267_Y0.6060.99
115_G128_D0.6050.99
440_F458_A0.6040.99
36_E112_I0.6030.99
222_S395_T0.6030.99
150_P166_S0.6010.99
191_Y194_I0.6010.99
172_M195_F0.6000.99
153_P158_F0.6000.99
361_K371_V0.6000.99
300_Q303_Q0.6000.99
113_L127_L0.6000.99
153_P267_Y0.5970.99
163_I265_L0.5900.99
102_Q112_I0.5890.99
95_N98_T0.5880.99
34_V110_C0.5880.99
400_F405_K0.5870.99
72_Y89_H0.5860.99
84_A87_L0.5860.99
25_L32_V0.5840.99
97_Q387_Q0.5840.99
391_M415_E0.5840.99
301_T308_A0.5830.99
345_D359_V0.5830.99
297_S339_T0.5820.99
386_A450_M0.5820.99
180_L265_L0.5820.99
193_S230_S0.5810.99
285_L306_V0.5810.99
51_I384_A0.5800.99
26_V110_C0.5800.99
358_S411_H0.5800.99
176_P200_V0.5790.99
50_T54_K0.5790.99
88_N91_D0.5780.99
91_D94_I0.5770.99
298_M340_A0.5750.99
131_D135_E0.5750.99
62_R69_N0.5750.99
23_M27_K0.5740.98
87_L173_H0.5740.98
193_S227_F0.5730.98
150_P153_P0.5730.98
309_V326_G0.5730.98
345_D429_E0.5730.98
44_G166_S0.5720.98
85_D89_H0.5710.98
58_H65_E0.5680.98
40_N98_T0.5670.98
58_H389_V0.5670.98
74_D81_S0.5650.98
41_V105_Y0.5640.98
61_S353_I0.5640.98
35_I127_L0.5620.98
89_H390_G0.5610.98
387_Q392_N0.5610.98
376_G398_I0.5590.98
63_I74_D0.5590.98
429_E443_T0.5590.98
314_G317_S0.5580.98
144_I293_L0.5580.98
396_L457_A0.5580.98
420_I450_M0.5550.98
203_D260_L0.5540.98
430_Q434_G0.5520.98
120_V282_N0.5520.98
158_F165_D0.5510.98
154_T159_T0.5500.98
182_Y205_I0.5500.98
307_Y333_L0.5500.98
361_K409_G0.5490.98
373_Y402_R0.5490.98
143_V330_A0.5490.98
455_R459_L0.5470.98
261_K264_C0.5470.98
178_H196_R0.5470.98
119_F305_H0.5460.98
345_D425_Q0.5460.98
188_G268_A0.5440.98
313_I325_Q0.5440.98
230_S353_I0.5440.98
324_D328_I0.5440.98
148_S317_S0.5430.98
166_S187_I0.5420.98
428_M435_N0.5420.98
6_D31_R0.5420.98
11_V32_V0.5420.98
128_D135_E0.5410.98
40_N47_H0.5400.98
423_I451_A0.5390.98
398_I407_I0.5390.98
206_N240_Y0.5390.98
364_Q367_T0.5390.98
101_R104_F0.5390.98
243_I267_Y0.5380.98
100_M103_G0.5370.98
195_F200_V0.5360.98
321_A325_Q0.5360.98
323_Y455_R0.5360.98
122_E306_V0.5350.98
41_V102_Q0.5340.98
205_I262_A0.5340.98
62_R66_F0.5330.98
324_D455_R0.5320.98
27_K108_N0.5320.98
84_A174_H0.5300.97
384_A388_I0.5290.97
116_N128_D0.5280.97
193_S353_I0.5270.97
438_E442_N0.5260.97
60_V63_I0.5260.97
332_A338_A0.5260.97
327_R331_Q0.5260.97
383_L386_A0.5250.97
60_V198_M0.5250.97
417_A420_I0.5250.97
422_H425_Q0.5240.97
200_V263_D0.5240.97
145_A309_V0.5240.97
380_F450_M0.5220.97
277_S281_Q0.5220.97
11_V22_A0.5210.97
26_V31_R0.5210.97
342_L345_D0.5210.97
392_N415_E0.5190.97
273_G287_T0.5190.97
188_G213_A0.5180.97
90_A93_V0.5170.97
53_S194_I0.5170.97
426_A445_F0.5160.97
254_L259_K0.5160.97
58_H72_Y0.5150.97
353_I391_M0.5130.97
121_D125_L0.5130.97
358_S365_Q0.5120.97
207_T269_N0.5100.97
411_H424_G0.5100.97
407_I410_I0.5090.97
141_K300_Q0.5070.97
17_G145_A0.5070.97
410_I421_I0.5060.97
65_E68_Q0.5060.97
355_E450_M0.5040.97
75_H79_L0.5040.97
425_Q443_T0.5030.97
401_H405_K0.5020.97
140_E305_H0.5020.97
285_L301_T0.5010.96
57_R61_S0.5000.96
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1ojtA 2 0.9871 100 0.205 Contact Map
3ladA 2 0.985 100 0.211 Contact Map
1zmdA 4 0.9893 100 0.218 Contact Map
3ic9A 2 0.9785 100 0.221 Contact Map
1xdiA 3 0.9657 100 0.222 Contact Map
3urhA 2 0.9742 100 0.223 Contact Map
2a8xA 2 0.9807 100 0.227 Contact Map
2wpfA 2 0.9871 100 0.228 Contact Map
4jq9A 3 0.9828 100 0.229 Contact Map
3o0hA 2 0.97 100 0.229 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0134 seconds.