GLUQ - ECOLI - GREMLIN Contacts

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GLUQ - Glutamyl-Q tRNA(Asp) synthetase

UniProt:	P27305	Sequences: MLPPYFLFKEMTDTQYIGRFAPSPSGELHFGSLIAALGSYLQARARQGRWLVRIEDIDPPREVPGAAETILRQLEHYGLHWDGDVLWQSQRHDAYREALAWLHEQGLSYYCTCTRARIQSIGGIYDGHCRVLHHGPDNAAVRIRQQHPVTQFTDQLRGIIHADEKLAREDFIIHRRDGLFAYNLAVVVDDHFQGVTEIVRGADLIEPTVRQISLYQLFGWKVPDYIHLPLALNPQGAKLSKQNHAPALPKGDPRPVLIAALQFLGQQAEAHWQDFSVEQILQSAVKNWRLTAVPESAIVNSTFSNASC	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG11362
Length:	308 (278)
Sequences:	7558 (3761)
Seq/√Len:	225.5

ECOLI - GLUQ SYE SYQ
BACSU - SYE
HALSA - SYE
SULSO - SYE

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
101_W	105_Q	4.034	1.00
153_T	159_I	3.565	1.00
113_C	129_C	3.548	1.00
191_H	220_W	3.099	1.00
100_A	104_E	3.075	1.00
67_A	87_W	3.055	1.00
64_P	68_E	2.719	1.00
94_A	192_F	2.671	1.00
15_Q	49_R	2.590	1.00
215_Y	225_Y	2.425	1.00
68_E	72_R	2.406	1.00
197_E	224_D	2.389	1.00
17_I	49_R	2.379	1.00
216_Q	222_V	2.323	1.00
112_T	139_A	2.239	1.00
52_V	71_L	2.144	1.00
151_Q	161_H	2.126	1.00
143_I	217_L	2.115	1.00
87_W	90_Q	2.077	1.00
17_I	195_V	2.071	1.00
133_H	136_P	2.068	1.00
99_L	174_H	2.000	1.00
103_H	108_S	1.996	1.00
212_I	222_V	1.895	1.00
121_I	126_D	1.892	1.00
112_T	132_L	1.878	1.00
108_S	141_V	1.869	1.00
55_E	186_V	1.860	1.00
91_R	94_A	1.845	1.00
27_E	69_T	1.841	1.00
183_N	211_Q	1.814	1.00
150_T	164_E	1.775	1.00
151_Q	159_I	1.752	1.00
99_L	141_V	1.730	1.00
126_D	131_V	1.719	1.00
103_H	141_V	1.711	1.00
149_V	161_H	1.691	1.00
96_R	174_H	1.691	1.00
98_A	192_F	1.688	1.00
107_L	217_L	1.669	1.00
72_R	75_E	1.660	1.00
114_T	117_R	1.657	1.00
94_A	98_A	1.636	1.00
63_V	66_A	1.634	1.00
76_H	252_D	1.633	1.00
93_D	97_E	1.631	1.00
111_C	129_C	1.626	1.00
98_A	188_V	1.625	1.00
42_Q	197_E	1.618	1.00
132_L	136_P	1.613	1.00
28_L	32_S	1.613	1.00
75_E	81_W	1.597	1.00
157_R	202_A	1.566	1.00
117_R	121_I	1.555	1.00
42_Q	46_R	1.553	1.00
95_Y	189_D	1.550	1.00
44_R	82_D	1.545	1.00
96_R	100_A	1.537	1.00
110_Y	139_A	1.537	1.00
143_I	213_S	1.533	1.00
117_R	126_D	1.524	1.00
75_E	80_H	1.519	1.00
49_R	83_G	1.515	1.00
17_I	83_G	1.513	1.00
127_G	130_R	1.511	1.00
33_L	77_Y	1.503	1.00
98_A	218_F	1.499	1.00
156_L	226_I	1.491	1.00
101_W	104_E	1.473	1.00
155_Q	224_D	1.471	1.00
20_F	32_S	1.450	1.00
18_G	39_S	1.447	1.00
113_C	121_I	1.439	1.00
160_I	205_I	1.430	1.00
145_Q	213_S	1.401	1.00
171_F	210_R	1.394	1.00
149_V	163_D	1.388	1.00
49_R	82_D	1.383	1.00
59_P	62_E	1.377	1.00
277_V	281_L	1.376	1.00
86_L	91_R	1.367	1.00
38_G	228_L	1.361	1.00
112_T	137_D	1.324	1.00
51_L	195_V	1.306	1.00
276_S	279_Q	1.303	1.00
130_R	144_R	1.294	1.00
152_F	205_I	1.277	1.00
86_L	193_Q	1.266	1.00
40_Y	44_R	1.266	1.00
199_V	226_I	1.260	1.00
86_L	192_F	1.251	1.00
94_A	97_E	1.249	1.00
17_I	51_L	1.248	1.00
204_L	207_P	1.243	1.00
117_R	128_H	1.238	1.00
233_N	237_A	1.220	1.00
98_A	220_W	1.216	1.00
233_N	243_N	1.215	1.00
72_R	249_P	1.209	1.00
144_R	147_H	1.205	1.00
121_I	128_H	1.193	1.00
213_S	217_L	1.186	1.00
155_Q	226_I	1.182	1.00
113_C	125_Y	1.175	1.00
54_I	67_A	1.171	1.00
97_E	101_W	1.166	1.00
93_D	96_R	1.165	1.00
212_I	216_Q	1.165	1.00
245_A	249_P	1.164	1.00
191_H	221_K	1.154	1.00
81_W	84_D	1.151	1.00
113_C	127_G	1.147	1.00
100_A	103_H	1.133	1.00
86_L	94_A	1.130	1.00
164_E	170_D	1.130	1.00
191_H	215_Y	1.125	1.00
17_I	194_G	1.123	1.00
71_L	85_V	1.122	1.00
93_D	171_F	1.120	1.00
183_N	207_P	1.110	1.00
109_Y	170_D	1.106	1.00
110_Y	141_V	1.100	1.00
97_E	100_A	1.096	1.00
187_V	214_L	1.093	1.00
51_L	84_D	1.090	1.00
272_W	279_Q	1.084	1.00
237_A	243_N	1.082	1.00
260_A	263_F	1.079	1.00
129_C	132_L	1.078	1.00
272_W	283_S	1.077	1.00
140_A	144_R	1.071	1.00
71_L	75_E	1.069	1.00
108_S	173_I	1.062	1.00
278_E	282_Q	1.059	1.00
131_V	144_R	1.052	1.00
112_T	133_H	1.050	1.00
285_V	288_W	1.049	1.00
16_Y	42_Q	1.046	1.00
71_L	81_W	1.041	1.00
51_L	83_G	1.041	1.00
215_Y	222_V	1.040	1.00
187_V	215_Y	1.040	1.00
40_Y	80_H	1.039	1.00
250_K	253_P	1.037	1.00
246_P	250_K	1.031	1.00
92_H	179_L	1.029	1.00
102_L	107_L	1.027	1.00
48_G	196_T	1.027	1.00
153_T	224_D	1.020	1.00
64_P	67_A	1.019	1.00
101_W	219_G	1.005	1.00
65_G	68_E	1.003	1.00
103_H	110_Y	0.997	1.00
62_E	66_A	0.995	1.00
117_R	129_C	0.994	1.00
83_G	86_L	0.989	1.00
260_A	264_L	0.988	1.00
152_F	212_I	0.987	1.00
99_L	103_H	0.986	1.00
113_C	128_H	0.979	1.00
69_T	249_P	0.978	1.00
259_A	263_F	0.977	1.00
37_L	79_L	0.972	1.00
96_R	180_F	0.955	1.00
112_T	138_N	0.948	1.00
117_R	120_S	0.939	1.00
62_E	65_G	0.939	1.00
88_Q	189_D	0.938	1.00
27_E	249_P	0.933	1.00
69_T	73_Q	0.929	1.00
88_Q	185_A	0.926	1.00
68_E	71_L	0.924	1.00
120_S	123_G	0.912	0.99
44_R	80_H	0.903	0.99
50_W	79_L	0.903	0.99
35_A	201_G	0.898	0.99
91_R	192_F	0.896	0.99
40_Y	50_W	0.895	0.99
77_Y	256_V	0.892	0.99
130_R	170_D	0.892	0.99
119_Q	123_G	0.889	0.99
215_Y	220_W	0.885	0.99
125_Y	128_H	0.881	0.99
239_L	245_A	0.881	0.99
259_A	265_G	0.877	0.99
289_R	293_V	0.873	0.99
34_I	231_A	0.873	0.99
155_Q	197_E	0.865	0.99
35_A	39_S	0.862	0.99
157_R	205_I	0.858	0.99
52_V	81_W	0.857	0.99
260_A	265_G	0.851	0.99
150_T	212_I	0.850	0.99
162_A	209_V	0.849	0.99
42_Q	199_V	0.846	0.99
115_R	119_Q	0.845	0.99
263_F	266_Q	0.843	0.99
59_P	179_L	0.840	0.99
163_D	167_A	0.840	0.99
51_L	86_L	0.839	0.99
98_A	101_W	0.838	0.99
204_L	211_Q	0.836	0.99
57_I	179_L	0.833	0.99
16_Y	46_R	0.833	0.99
72_R	252_D	0.829	0.99
262_Q	266_Q	0.827	0.99
41_L	280_I	0.825	0.99
279_Q	282_Q	0.823	0.99
121_I	125_Y	0.823	0.99
74_L	79_L	0.822	0.99
143_I	171_F	0.822	0.99
18_G	42_Q	0.819	0.99
208_T	212_I	0.819	0.99
99_L	108_S	0.818	0.99
268_A	272_W	0.816	0.99
263_F	267_Q	0.813	0.99
39_S	42_Q	0.812	0.99
249_P	253_P	0.801	0.99
208_T	225_Y	0.800	0.99
188_V	220_W	0.798	0.99
138_N	176_R	0.797	0.99
257_L	289_R	0.794	0.99
36_A	50_W	0.794	0.99
112_T	136_P	0.792	0.99
259_A	262_Q	0.789	0.98
32_S	203_D	0.787	0.98
105_Q	219_G	0.786	0.98
286_K	289_R	0.784	0.98
164_E	213_S	0.784	0.98
116_A	120_S	0.782	0.98
105_Q	217_L	0.781	0.98
46_R	197_E	0.779	0.98
260_A	266_Q	0.777	0.98
283_S	287_N	0.775	0.98
59_P	92_H	0.772	0.98
140_A	143_I	0.771	0.98
150_T	216_Q	0.769	0.98
20_F	70_I	0.768	0.98
98_A	184_L	0.759	0.98
183_N	204_L	0.754	0.98
150_T	213_S	0.754	0.98
81_W	85_V	0.750	0.98
20_F	28_L	0.749	0.98
95_Y	185_A	0.747	0.98
110_Y	138_N	0.746	0.98
250_K	254_R	0.746	0.98
17_I	84_D	0.745	0.98
279_Q	283_S	0.743	0.98
267_Q	270_A	0.743	0.98
207_P	210_R	0.741	0.98
39_S	50_W	0.737	0.98
148_P	165_K	0.736	0.98
206_E	209_V	0.736	0.98
92_H	180_F	0.735	0.98
55_E	193_Q	0.734	0.98
275_F	280_I	0.732	0.98
59_P	89_S	0.732	0.98
259_A	266_Q	0.732	0.98
42_Q	45_A	0.730	0.98
35_A	199_V	0.726	0.97
214_L	218_F	0.725	0.97
54_I	70_I	0.722	0.97
91_R	95_Y	0.721	0.97
112_T	134_H	0.716	0.97
198_I	225_Y	0.716	0.97
18_G	50_W	0.710	0.97
34_I	38_G	0.706	0.97
40_Y	79_L	0.706	0.97
180_F	185_A	0.704	0.97
152_F	208_T	0.704	0.97
27_E	65_G	0.703	0.97
226_I	286_K	0.703	0.97
188_V	218_F	0.702	0.97
86_L	90_Q	0.700	0.97
265_G	268_A	0.694	0.97
148_P	216_Q	0.693	0.97
157_R	214_L	0.689	0.96
272_W	275_F	0.688	0.96
175_R	185_A	0.687	0.96
262_Q	265_G	0.686	0.96
67_A	71_L	0.685	0.96
111_C	118_I	0.681	0.96
35_A	38_G	0.680	0.96
235_Q	243_N	0.678	0.96
118_I	121_I	0.677	0.96
215_Y	223_P	0.673	0.96
20_F	36_A	0.670	0.96
214_L	217_L	0.669	0.96
152_F	162_A	0.667	0.96
109_Y	118_I	0.666	0.96
275_F	279_Q	0.665	0.96
92_H	96_R	0.664	0.96
126_D	130_R	0.662	0.96
27_E	66_A	0.654	0.95
33_L	248_L	0.654	0.95
154_D	158_G	0.653	0.95
18_G	199_V	0.652	0.95
151_Q	207_P	0.652	0.95
142_R	147_H	0.652	0.95
59_P	177_D	0.649	0.95
118_I	125_Y	0.647	0.95
243_N	246_P	0.647	0.95
145_Q	171_F	0.645	0.95
76_H	258_I	0.645	0.95
69_T	72_R	0.644	0.95
45_A	285_V	0.644	0.95
131_V	134_H	0.640	0.95
264_L	268_A	0.640	0.95
55_E	88_Q	0.639	0.95
97_E	104_E	0.637	0.95
35_A	228_L	0.636	0.95
127_G	147_H	0.636	0.95
30_F	231_A	0.633	0.94
109_Y	130_R	0.633	0.94
98_A	102_L	0.633	0.94
141_V	144_R	0.632	0.94
15_Q	194_G	0.630	0.94
17_I	196_T	0.627	0.94
71_L	84_D	0.623	0.94
16_Y	48_G	0.621	0.94
124_I	127_G	0.617	0.94
269_E	288_W	0.613	0.93
261_L	266_Q	0.613	0.93
244_H	247_A	0.611	0.93
132_L	135_G	0.610	0.93
50_W	81_W	0.610	0.93
182_Y	186_V	0.607	0.93
174_H	180_F	0.606	0.93
215_Y	218_F	0.606	0.93
60_P	63_V	0.604	0.93
182_Y	241_K	0.604	0.93
280_I	284_A	0.602	0.93
94_A	101_W	0.602	0.93
148_P	163_D	0.602	0.93
269_E	272_W	0.601	0.93
278_E	281_L	0.598	0.93
146_Q	213_S	0.597	0.92
263_F	268_A	0.597	0.92
99_L	173_I	0.596	0.92
42_Q	155_Q	0.596	0.92
104_E	107_L	0.594	0.92
281_L	285_V	0.594	0.92
284_A	288_W	0.594	0.92
143_I	173_I	0.592	0.92
25_S	242_Q	0.592	0.92
252_D	255_P	0.592	0.92
113_C	118_I	0.590	0.92
36_A	74_L	0.587	0.92
246_P	254_R	0.586	0.92
18_G	43_A	0.582	0.92
281_L	284_A	0.578	0.91
155_Q	286_K	0.578	0.91
94_A	188_V	0.578	0.91
269_E	283_S	0.578	0.91
202_A	230_L	0.570	0.91
143_I	214_L	0.569	0.91
195_V	198_I	0.568	0.91
261_L	265_G	0.567	0.90
162_A	167_A	0.567	0.90
268_A	271_H	0.566	0.90
60_P	66_A	0.564	0.90
28_L	69_T	0.560	0.90
109_Y	125_Y	0.560	0.90
58_D	61_R	0.557	0.90
199_V	286_K	0.556	0.90
162_A	168_R	0.555	0.89
16_Y	197_E	0.554	0.89
132_L	137_D	0.553	0.89
284_A	289_R	0.551	0.89
268_A	283_S	0.550	0.89
162_A	173_I	0.549	0.89
46_R	196_T	0.549	0.89
33_L	76_H	0.548	0.89
90_Q	94_A	0.548	0.89
191_H	223_P	0.547	0.89
183_N	210_R	0.547	0.89
290_L	293_V	0.547	0.89
127_G	144_R	0.546	0.89
202_A	205_I	0.543	0.88
262_Q	280_I	0.543	0.88
141_V	174_H	0.542	0.88
192_F	220_W	0.542	0.88
74_L	230_L	0.542	0.88
265_G	270_A	0.539	0.88
74_L	201_G	0.538	0.88
212_I	225_Y	0.535	0.88
89_S	179_L	0.532	0.87
95_Y	188_V	0.529	0.87
110_Y	134_H	0.529	0.87
96_R	178_G	0.528	0.87
259_A	289_R	0.527	0.87
111_C	127_G	0.527	0.87
118_I	122_G	0.526	0.87
288_W	293_V	0.525	0.87
113_C	117_R	0.525	0.87
55_E	215_Y	0.520	0.86
112_T	117_R	0.518	0.86
51_L	193_Q	0.516	0.86
37_L	41_L	0.515	0.86
183_N	186_V	0.513	0.86
174_H	179_L	0.513	0.86
282_Q	285_V	0.510	0.85
277_V	280_I	0.508	0.85
286_K	290_L	0.507	0.85
131_V	135_G	0.507	0.85
51_L	85_V	0.507	0.85
66_A	69_T	0.507	0.85
133_H	137_D	0.506	0.85
19_R	22_P	0.505	0.85
22_P	26_G	0.505	0.85
128_H	132_L	0.505	0.85
216_Q	219_G	0.504	0.85
152_F	160_I	0.504	0.85
125_Y	129_C	0.502	0.84
213_S	216_Q	0.501	0.84
60_P	179_L	0.501	0.84
57_I	180_F	0.500	0.84

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2ja2A	1	0.9675	100	0.208	Contact Map
2cfoA	1	0.9513	100	0.214	Contact Map
4griA	1	0.9513	100	0.224	Contact Map
1j09A	1	0.9513	100	0.225	Contact Map
3afhA	1	0.9416	100	0.236	Contact Map
3al0C	1	0.9773	100	0.237	Contact Map
4g6zA	1	0.9188	100	0.248	Contact Map
2o5rA	1	0.9513	100	0.258	Contact Map
2hz7A	1	0.9838	100	0.307	Contact Map
4r3zC	1	0.9545	100	0.327	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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