GREMLIN Database
GLUQ - Glutamyl-Q tRNA(Asp) synthetase
UniProt: P27305 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11362
Length: 308 (278)
Sequences: 7558 (3761)
Seq/√Len: 225.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
101_W105_Q4.0341.00
153_T159_I3.5651.00
113_C129_C3.5481.00
191_H220_W3.0991.00
100_A104_E3.0751.00
67_A87_W3.0551.00
64_P68_E2.7191.00
94_A192_F2.6711.00
15_Q49_R2.5901.00
215_Y225_Y2.4251.00
68_E72_R2.4061.00
197_E224_D2.3891.00
17_I49_R2.3791.00
216_Q222_V2.3231.00
112_T139_A2.2391.00
52_V71_L2.1441.00
151_Q161_H2.1261.00
143_I217_L2.1151.00
87_W90_Q2.0771.00
17_I195_V2.0711.00
133_H136_P2.0681.00
99_L174_H2.0001.00
103_H108_S1.9961.00
212_I222_V1.8951.00
121_I126_D1.8921.00
112_T132_L1.8781.00
108_S141_V1.8691.00
55_E186_V1.8601.00
91_R94_A1.8451.00
27_E69_T1.8411.00
183_N211_Q1.8141.00
150_T164_E1.7751.00
151_Q159_I1.7521.00
99_L141_V1.7301.00
126_D131_V1.7191.00
103_H141_V1.7111.00
149_V161_H1.6911.00
96_R174_H1.6911.00
98_A192_F1.6881.00
107_L217_L1.6691.00
72_R75_E1.6601.00
114_T117_R1.6571.00
94_A98_A1.6361.00
63_V66_A1.6341.00
76_H252_D1.6331.00
93_D97_E1.6311.00
111_C129_C1.6261.00
98_A188_V1.6251.00
42_Q197_E1.6181.00
132_L136_P1.6131.00
28_L32_S1.6131.00
75_E81_W1.5971.00
157_R202_A1.5661.00
117_R121_I1.5551.00
42_Q46_R1.5531.00
95_Y189_D1.5501.00
44_R82_D1.5451.00
96_R100_A1.5371.00
110_Y139_A1.5371.00
143_I213_S1.5331.00
117_R126_D1.5241.00
75_E80_H1.5191.00
49_R83_G1.5151.00
17_I83_G1.5131.00
127_G130_R1.5111.00
33_L77_Y1.5031.00
98_A218_F1.4991.00
156_L226_I1.4911.00
101_W104_E1.4731.00
155_Q224_D1.4711.00
20_F32_S1.4501.00
18_G39_S1.4471.00
113_C121_I1.4391.00
160_I205_I1.4301.00
145_Q213_S1.4011.00
171_F210_R1.3941.00
149_V163_D1.3881.00
49_R82_D1.3831.00
59_P62_E1.3771.00
277_V281_L1.3761.00
86_L91_R1.3671.00
38_G228_L1.3611.00
112_T137_D1.3241.00
51_L195_V1.3061.00
276_S279_Q1.3031.00
130_R144_R1.2941.00
152_F205_I1.2771.00
86_L193_Q1.2661.00
40_Y44_R1.2661.00
199_V226_I1.2601.00
86_L192_F1.2511.00
94_A97_E1.2491.00
17_I51_L1.2481.00
204_L207_P1.2431.00
117_R128_H1.2381.00
233_N237_A1.2201.00
98_A220_W1.2161.00
233_N243_N1.2151.00
72_R249_P1.2091.00
144_R147_H1.2051.00
121_I128_H1.1931.00
213_S217_L1.1861.00
155_Q226_I1.1821.00
113_C125_Y1.1751.00
54_I67_A1.1711.00
97_E101_W1.1661.00
93_D96_R1.1651.00
212_I216_Q1.1651.00
245_A249_P1.1641.00
191_H221_K1.1541.00
81_W84_D1.1511.00
113_C127_G1.1471.00
100_A103_H1.1331.00
86_L94_A1.1301.00
164_E170_D1.1301.00
191_H215_Y1.1251.00
17_I194_G1.1231.00
71_L85_V1.1221.00
93_D171_F1.1201.00
183_N207_P1.1101.00
109_Y170_D1.1061.00
110_Y141_V1.1001.00
97_E100_A1.0961.00
187_V214_L1.0931.00
51_L84_D1.0901.00
272_W279_Q1.0841.00
237_A243_N1.0821.00
260_A263_F1.0791.00
129_C132_L1.0781.00
272_W283_S1.0771.00
140_A144_R1.0711.00
71_L75_E1.0691.00
108_S173_I1.0621.00
278_E282_Q1.0591.00
131_V144_R1.0521.00
112_T133_H1.0501.00
285_V288_W1.0491.00
16_Y42_Q1.0461.00
71_L81_W1.0411.00
51_L83_G1.0411.00
215_Y222_V1.0401.00
187_V215_Y1.0401.00
40_Y80_H1.0391.00
250_K253_P1.0371.00
246_P250_K1.0311.00
92_H179_L1.0291.00
102_L107_L1.0271.00
48_G196_T1.0271.00
153_T224_D1.0201.00
64_P67_A1.0191.00
101_W219_G1.0051.00
65_G68_E1.0031.00
103_H110_Y0.9971.00
62_E66_A0.9951.00
117_R129_C0.9941.00
83_G86_L0.9891.00
260_A264_L0.9881.00
152_F212_I0.9871.00
99_L103_H0.9861.00
113_C128_H0.9791.00
69_T249_P0.9781.00
259_A263_F0.9771.00
37_L79_L0.9721.00
96_R180_F0.9551.00
112_T138_N0.9481.00
117_R120_S0.9391.00
62_E65_G0.9391.00
88_Q189_D0.9381.00
27_E249_P0.9331.00
69_T73_Q0.9291.00
88_Q185_A0.9261.00
68_E71_L0.9241.00
120_S123_G0.9120.99
44_R80_H0.9030.99
50_W79_L0.9030.99
35_A201_G0.8980.99
91_R192_F0.8960.99
40_Y50_W0.8950.99
77_Y256_V0.8920.99
130_R170_D0.8920.99
119_Q123_G0.8890.99
215_Y220_W0.8850.99
125_Y128_H0.8810.99
239_L245_A0.8810.99
259_A265_G0.8770.99
289_R293_V0.8730.99
34_I231_A0.8730.99
155_Q197_E0.8650.99
35_A39_S0.8620.99
157_R205_I0.8580.99
52_V81_W0.8570.99
260_A265_G0.8510.99
150_T212_I0.8500.99
162_A209_V0.8490.99
42_Q199_V0.8460.99
115_R119_Q0.8450.99
263_F266_Q0.8430.99
59_P179_L0.8400.99
163_D167_A0.8400.99
51_L86_L0.8390.99
98_A101_W0.8380.99
204_L211_Q0.8360.99
57_I179_L0.8330.99
16_Y46_R0.8330.99
72_R252_D0.8290.99
262_Q266_Q0.8270.99
41_L280_I0.8250.99
279_Q282_Q0.8230.99
121_I125_Y0.8230.99
74_L79_L0.8220.99
143_I171_F0.8220.99
18_G42_Q0.8190.99
208_T212_I0.8190.99
99_L108_S0.8180.99
268_A272_W0.8160.99
263_F267_Q0.8130.99
39_S42_Q0.8120.99
249_P253_P0.8010.99
208_T225_Y0.8000.99
188_V220_W0.7980.99
138_N176_R0.7970.99
257_L289_R0.7940.99
36_A50_W0.7940.99
112_T136_P0.7920.99
259_A262_Q0.7890.98
32_S203_D0.7870.98
105_Q219_G0.7860.98
286_K289_R0.7840.98
164_E213_S0.7840.98
116_A120_S0.7820.98
105_Q217_L0.7810.98
46_R197_E0.7790.98
260_A266_Q0.7770.98
283_S287_N0.7750.98
59_P92_H0.7720.98
140_A143_I0.7710.98
150_T216_Q0.7690.98
20_F70_I0.7680.98
98_A184_L0.7590.98
183_N204_L0.7540.98
150_T213_S0.7540.98
81_W85_V0.7500.98
20_F28_L0.7490.98
95_Y185_A0.7470.98
110_Y138_N0.7460.98
250_K254_R0.7460.98
17_I84_D0.7450.98
279_Q283_S0.7430.98
267_Q270_A0.7430.98
207_P210_R0.7410.98
39_S50_W0.7370.98
148_P165_K0.7360.98
206_E209_V0.7360.98
92_H180_F0.7350.98
55_E193_Q0.7340.98
275_F280_I0.7320.98
59_P89_S0.7320.98
259_A266_Q0.7320.98
42_Q45_A0.7300.98
35_A199_V0.7260.97
214_L218_F0.7250.97
54_I70_I0.7220.97
91_R95_Y0.7210.97
112_T134_H0.7160.97
198_I225_Y0.7160.97
18_G50_W0.7100.97
34_I38_G0.7060.97
40_Y79_L0.7060.97
180_F185_A0.7040.97
152_F208_T0.7040.97
27_E65_G0.7030.97
226_I286_K0.7030.97
188_V218_F0.7020.97
86_L90_Q0.7000.97
265_G268_A0.6940.97
148_P216_Q0.6930.97
157_R214_L0.6890.96
272_W275_F0.6880.96
175_R185_A0.6870.96
262_Q265_G0.6860.96
67_A71_L0.6850.96
111_C118_I0.6810.96
35_A38_G0.6800.96
235_Q243_N0.6780.96
118_I121_I0.6770.96
215_Y223_P0.6730.96
20_F36_A0.6700.96
214_L217_L0.6690.96
152_F162_A0.6670.96
109_Y118_I0.6660.96
275_F279_Q0.6650.96
92_H96_R0.6640.96
126_D130_R0.6620.96
27_E66_A0.6540.95
33_L248_L0.6540.95
154_D158_G0.6530.95
18_G199_V0.6520.95
151_Q207_P0.6520.95
142_R147_H0.6520.95
59_P177_D0.6490.95
118_I125_Y0.6470.95
243_N246_P0.6470.95
145_Q171_F0.6450.95
76_H258_I0.6450.95
69_T72_R0.6440.95
45_A285_V0.6440.95
131_V134_H0.6400.95
264_L268_A0.6400.95
55_E88_Q0.6390.95
97_E104_E0.6370.95
35_A228_L0.6360.95
127_G147_H0.6360.95
30_F231_A0.6330.94
109_Y130_R0.6330.94
98_A102_L0.6330.94
141_V144_R0.6320.94
15_Q194_G0.6300.94
17_I196_T0.6270.94
71_L84_D0.6230.94
16_Y48_G0.6210.94
124_I127_G0.6170.94
269_E288_W0.6130.93
261_L266_Q0.6130.93
244_H247_A0.6110.93
132_L135_G0.6100.93
50_W81_W0.6100.93
182_Y186_V0.6070.93
174_H180_F0.6060.93
215_Y218_F0.6060.93
60_P63_V0.6040.93
182_Y241_K0.6040.93
280_I284_A0.6020.93
94_A101_W0.6020.93
148_P163_D0.6020.93
269_E272_W0.6010.93
278_E281_L0.5980.93
146_Q213_S0.5970.92
263_F268_A0.5970.92
99_L173_I0.5960.92
42_Q155_Q0.5960.92
104_E107_L0.5940.92
281_L285_V0.5940.92
284_A288_W0.5940.92
143_I173_I0.5920.92
25_S242_Q0.5920.92
252_D255_P0.5920.92
113_C118_I0.5900.92
36_A74_L0.5870.92
246_P254_R0.5860.92
18_G43_A0.5820.92
281_L284_A0.5780.91
155_Q286_K0.5780.91
94_A188_V0.5780.91
269_E283_S0.5780.91
202_A230_L0.5700.91
143_I214_L0.5690.91
195_V198_I0.5680.91
261_L265_G0.5670.90
162_A167_A0.5670.90
268_A271_H0.5660.90
60_P66_A0.5640.90
28_L69_T0.5600.90
109_Y125_Y0.5600.90
58_D61_R0.5570.90
199_V286_K0.5560.90
162_A168_R0.5550.89
16_Y197_E0.5540.89
132_L137_D0.5530.89
284_A289_R0.5510.89
268_A283_S0.5500.89
162_A173_I0.5490.89
46_R196_T0.5490.89
33_L76_H0.5480.89
90_Q94_A0.5480.89
191_H223_P0.5470.89
183_N210_R0.5470.89
290_L293_V0.5470.89
127_G144_R0.5460.89
202_A205_I0.5430.88
262_Q280_I0.5430.88
141_V174_H0.5420.88
192_F220_W0.5420.88
74_L230_L0.5420.88
265_G270_A0.5390.88
74_L201_G0.5380.88
212_I225_Y0.5350.88
89_S179_L0.5320.87
95_Y188_V0.5290.87
110_Y134_H0.5290.87
96_R178_G0.5280.87
259_A289_R0.5270.87
111_C127_G0.5270.87
118_I122_G0.5260.87
288_W293_V0.5250.87
113_C117_R0.5250.87
55_E215_Y0.5200.86
112_T117_R0.5180.86
51_L193_Q0.5160.86
37_L41_L0.5150.86
183_N186_V0.5130.86
174_H179_L0.5130.86
282_Q285_V0.5100.85
277_V280_I0.5080.85
286_K290_L0.5070.85
131_V135_G0.5070.85
51_L85_V0.5070.85
66_A69_T0.5070.85
133_H137_D0.5060.85
19_R22_P0.5050.85
22_P26_G0.5050.85
128_H132_L0.5050.85
216_Q219_G0.5040.85
152_F160_I0.5040.85
125_Y129_C0.5020.84
213_S216_Q0.5010.84
60_P179_L0.5010.84
57_I180_F0.5000.84
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2ja2A 1 0.9675 100 0.208 Contact Map
2cfoA 1 0.9513 100 0.214 Contact Map
4griA 1 0.9513 100 0.224 Contact Map
1j09A 1 0.9513 100 0.225 Contact Map
3afhA 1 0.9416 100 0.236 Contact Map
3al0C 1 0.9773 100 0.237 Contact Map
4g6zA 1 0.9188 100 0.248 Contact Map
2o5rA 1 0.9513 100 0.258 Contact Map
2hz7A 1 0.9838 100 0.307 Contact Map
4r3zC 1 0.9545 100 0.327 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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