GREMLIN Database
TKT1 - Transketolase 1
UniProt: P27302 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11427
Length: 663 (589)
Sequences: 9064 (4918)
Seq/√Len: 202.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
203_M206_E4.2941.00
552_L659_A4.2841.00
418_A431_T3.5911.00
213_I239_S3.3951.00
551_E577_K3.2601.00
220_D223_S3.1971.00
540_G583_M3.1141.00
598_E603_K3.1021.00
544_K568_Y2.9661.00
509_R512_G2.9341.00
315_A326_T2.8701.00
652_V656_V2.8551.00
234_V237_K2.7931.00
282_A285_E2.7311.00
200_D203_M2.7251.00
590_D622_Y2.6481.00
211_H239_S2.6471.00
148_Y179_I2.6211.00
594_A598_E2.5771.00
570_K656_V2.4941.00
229_E233_A2.4681.00
428_L454_R2.4491.00
304_E308_N2.4211.00
616_A631_G2.3861.00
211_H234_V2.3401.00
569_E573_A2.3311.00
167_C205_F2.3081.00
628_A658_K2.2891.00
164_H208_Y2.2791.00
173_L176_G2.2521.00
85_E88_K2.2471.00
610_A629_I2.2451.00
552_L578_A2.2291.00
491_W502_A2.2161.00
213_I227_A2.1941.00
566_A569_E2.1881.00
643_L646_E2.1771.00
298_E302_A2.1611.00
555_I583_M2.1591.00
436_M478_Q2.0841.00
308_N312_A2.0791.00
153_M180_A2.0791.00
606_T626_N2.0371.00
445_V488_M2.0301.00
288_S292_A2.0191.00
176_G211_H1.9971.00
505_Y508_E1.9961.00
154_G157_C1.9961.00
489_S585_S1.9941.00
305_S309_E1.9881.00
570_K573_A1.9821.00
111_T122_N1.9821.00
213_I230_E1.9791.00
554_F564_A1.9711.00
567_A571_L1.9691.00
421_I427_F1.9601.00
225_K229_E1.9421.00
271_A275_E1.9261.00
488_M515_A1.9181.00
452_K511_D1.9171.00
540_G544_K1.9091.00
654_N658_K1.8951.00
519_S523_L1.8931.00
489_S512_G1.8911.00
127_A149_T1.8861.00
583_M586_T1.8861.00
570_K652_V1.8681.00
76_H291_Y1.8301.00
448_A457_M1.8161.00
355_I360_A1.8051.00
292_A295_D1.8011.00
202_A206_E1.8001.00
590_D621_K1.7971.00
534_A537_A1.7891.00
422_S454_R1.7781.00
142_H310_K1.7701.00
535_N539_G1.7511.00
218_G245_T1.7491.00
172_T198_T1.7411.00
478_Q517_I1.7411.00
184_D242_M1.7251.00
302_A306_A1.7171.00
148_Y232_R1.7151.00
55_A325_F1.7091.00
545_D579_R1.7071.00
534_A538_R1.7071.00
167_C208_Y1.7031.00
327_R374_E1.6961.00
98_P106_T1.6951.00
246_I255_A1.6911.00
646_E653_D1.6831.00
106_T109_V1.6771.00
253_N272_L1.6641.00
174_K397_N1.6411.00
309_E313_A1.6341.00
570_K653_D1.6251.00
476_V632_M1.6191.00
540_G543_L1.6191.00
565_V580_V1.6091.00
75_L108_G1.6071.00
422_S429_P1.6031.00
556_A564_A1.5981.00
202_A242_M1.5901.00
562_E566_A1.5891.00
624_G627_G1.5841.00
246_I256_G1.5831.00
547_A572_T1.5791.00
504_K508_E1.5791.00
479_V517_I1.5781.00
422_S453_Q1.5741.00
281_Y285_E1.5701.00
254_K259_D1.5681.00
145_V325_F1.5651.00
93_L643_L1.5601.00
226_R230_E1.5551.00
623_V629_I1.5481.00
202_A212_V1.5471.00
654_N657_A1.5451.00
181_F228_V1.5431.00
572_T578_A1.5381.00
93_L639_A1.5381.00
309_E312_A1.5341.00
442_R481_S1.5301.00
251_S273_T1.5211.00
616_A633_T1.5171.00
643_L647_E1.5071.00
519_S559_S1.4891.00
176_G236_D1.4891.00
480_A614_G1.4881.00
570_K574_E1.4871.00
169_L173_L1.4811.00
489_S588_A1.4801.00
283_P287_P1.4801.00
147_H424_H1.4741.00
485_T488_M1.4731.00
533_L537_A1.4701.00
84_M88_K1.4621.00
564_A611_V1.4591.00
86_E89_N1.4561.00
418_A432_S1.4481.00
389_L394_K1.4461.00
415_T441_A1.4381.00
494_C561_V1.4331.00
550_P577_K1.4331.00
597_R600_V1.4301.00
563_L652_V1.4281.00
418_A455_Q1.4191.00
186_G244_K1.4191.00
61_V126_M1.4181.00
390_W393_S1.4151.00
489_S509_R1.4111.00
162_I412_F1.4101.00
143_D146_D1.4081.00
566_A652_V1.4071.00
645_F650_F1.4071.00
93_L647_E1.4031.00
328_R331_G1.3991.00
554_F659_A1.3991.00
123_A151_A1.3951.00
435_L482_L1.3911.00
544_K569_E1.3871.00
355_I363_N1.3851.00
367_A370_P1.3821.00
301_Q305_S1.3791.00
564_A580_V1.3771.00
377_G430_Y1.3771.00
123_A180_A1.3691.00
556_A561_V1.3681.00
505_Y509_R1.3571.00
354_K522_N1.3541.00
359_K522_N1.3471.00
359_K387_L1.3451.00
94_H647_E1.3361.00
641_A645_F1.3341.00
295_D298_E1.3311.00
644_L648_F1.3311.00
609_V630_V1.3261.00
536_I539_G1.3231.00
499_S518_L1.3201.00
535_N538_R1.3161.00
608_R611_V1.3121.00
324_E327_R1.2971.00
325_F329_M1.2811.00
447_M488_M1.2781.00
114_G117_G1.2771.00
540_G546_C1.2751.00
355_I359_K1.2751.00
606_T625_L1.2751.00
512_G591_K1.2741.00
553_I602_P1.2711.00
438_V481_S1.2641.00
435_L517_I1.2621.00
607_A610_A1.2571.00
168_S197_F1.2551.00
586_T590_D1.2511.00
248_G260_S1.2511.00
542_V545_D1.2481.00
546_C577_K1.2441.00
293_Q297_K1.2361.00
143_D310_K1.2321.00
149_T177_K1.2301.00
501_V536_I1.2281.00
181_F243_C1.2281.00
131_K400_A1.2251.00
491_W514_T1.2141.00
389_L392_G1.2111.00
546_C550_P1.2061.00
306_A310_K1.2031.00
257_T260_S1.2031.00
120_I180_A1.2001.00
323_A327_R1.1991.00
132_T376_L1.1901.00
445_V459_Y1.1901.00
594_A597_R1.1871.00
306_A309_E1.1841.00
211_H230_E1.1791.00
502_A516_L1.1761.00
156_G188_S1.1731.00
229_E232_R1.1691.00
272_L275_E1.1661.00
121_A166_V1.1621.00
176_G235_T1.1621.00
532_Q535_N1.1611.00
326_T330_K1.1571.00
182_Y202_A1.1571.00
297_K301_Q1.1531.00
128_I173_L1.1521.00
130_E149_T1.1501.00
568_Y580_V1.1501.00
441_A445_V1.1501.00
415_T458_V1.1501.00
99_G102_E1.1471.00
541_Y544_K1.1461.00
377_G404_Y1.1431.00
264_P270_I1.1411.00
212_V242_M1.1401.00
213_I231_A1.1381.00
489_S587_D1.1371.00
359_K363_N1.1361.00
524_A562_E1.1361.00
539_G542_V1.1341.00
386_N432_S1.1321.00
360_A496_Q1.1311.00
150_Y179_I1.1291.00
205_F240_L1.1291.00
422_S455_Q1.1291.00
598_E604_A1.1281.00
64_N154_G1.1261.00
610_A616_A1.1231.00
363_N391_S1.1211.00
392_G396_I1.1201.00
312_A315_A1.1181.00
458_V518_L1.1141.00
120_I167_C1.1121.00
216_I223_S1.1111.00
390_W396_I1.1101.00
551_E576_V1.1091.00
310_K313_A1.1091.00
533_L539_G1.1071.00
392_G395_A1.1051.00
415_T457_M1.1031.00
368_F375_F1.1021.00
640_P643_L1.1021.00
465_G645_F1.1011.00
393_S396_I1.0991.00
532_Q537_A1.0981.00
532_Q538_R1.0981.00
598_E602_P1.0881.00
228_V232_R1.0881.00
85_E89_N1.0861.00
533_L536_I1.0851.00
121_A413_G1.0831.00
188_S409_V1.0831.00
383_A406_H1.0821.00
634_T638_S1.0821.00
357_S523_L1.0821.00
340_K344_F1.0791.00
566_A570_K1.0781.00
560_E563_L1.0761.00
253_N269_E1.0731.00
198_T216_I1.0701.00
572_T577_K1.0671.00
609_V658_K1.0631.00
110_E113_T1.0601.00
361_S503_W1.0601.00
376_L421_I1.0581.00
55_A329_M1.0571.00
635_F638_S1.0551.00
641_A644_L1.0551.00
55_A145_V1.0551.00
639_A644_L1.0541.00
151_A180_A1.0521.00
64_N152_F1.0511.00
586_T622_Y1.0441.00
332_E335_S1.0411.00
225_K232_R1.0401.00
594_A603_K1.0391.00
365_I430_Y1.0381.00
148_Y177_K1.0371.00
567_A570_K1.0361.00
567_A656_V1.0331.00
653_D657_A1.0291.00
550_P605_V1.0261.00
553_I601_L1.0241.00
480_A618_Y1.0201.00
482_L515_A1.0191.00
489_S514_T1.0151.00
609_V628_A1.0131.00
161_G165_E1.0111.00
340_K343_E1.0081.00
650_F654_N1.0081.00
634_T647_E1.0061.00
269_E272_L1.0041.00
639_A643_L0.9981.00
289_E292_A0.9961.00
553_I581_V0.9951.00
506_G509_R0.9941.00
230_E234_V0.9941.00
368_F372_L0.9921.00
556_A560_E0.9891.00
609_V659_A0.9891.00
595_A599_S0.9881.00
176_G239_S0.9881.00
359_K362_Q0.9871.00
129_A421_I0.9861.00
610_A623_V0.9851.00
634_T648_F0.9841.00
204_R208_Y0.9831.00
315_A322_A0.9821.00
120_I163_S0.9821.00
506_G514_T0.9801.00
479_V484_V0.9781.00
352_P525_Q0.9771.00
482_L485_T0.9771.00
121_A416_A0.9761.00
505_Y537_A0.9741.00
331_G334_P0.9731.00
544_K572_T0.9731.00
267_D271_A0.9731.00
642_E646_E0.9721.00
202_A215_D0.9711.00
592_Q596_Y0.9711.00
132_T427_F0.9691.00
131_K177_K0.9650.99
590_D597_R0.9640.99
526_Q565_V0.9620.99
124_V166_V0.9580.99
546_C572_T0.9520.99
318_Y321_E0.9490.99
324_E328_R0.9490.99
389_L395_A0.9450.99
395_A406_H0.9440.99
268_A271_A0.9430.99
481_S485_T0.9430.99
504_K537_A0.9400.99
255_A276_Q0.9400.99
327_R332_E0.9390.99
130_E177_K0.9390.99
333_M336_D0.9390.99
586_T618_Y0.9370.99
634_T640_P0.9350.99
634_T637_E0.9340.99
616_A629_I0.9320.99
445_V515_A0.9310.99
443_N448_A0.9310.99
547_A577_K0.9280.99
445_V457_M0.9270.99
211_H236_D0.9270.99
362_Q387_L0.9260.99
390_W394_K0.9230.99
159_M188_S0.9210.99
646_E651_T0.9190.99
459_Y515_A0.9190.99
174_K236_D0.9170.99
282_A286_I0.9170.99
630_V655_V0.9170.99
333_M337_F0.9150.99
69_M87_L0.9110.99
279_W287_P0.9090.99
439_E478_Q0.9080.99
153_M158_M0.9050.99
550_P579_R0.9050.99
128_I417_I0.9030.99
442_R458_V0.8990.99
629_I632_M0.8990.99
489_S591_K0.8960.99
344_F363_N0.8950.99
340_K371_L0.8930.99
182_Y240_L0.8910.99
566_A653_D0.8890.99
332_E510_Q0.8890.99
251_S272_L0.8880.99
549_Q577_K0.8850.99
439_E442_R0.8840.99
384_P406_H0.8840.99
134_A142_H0.8830.99
268_A272_L0.8830.99
325_F328_R0.8830.99
271_A281_Y0.8800.99
322_A326_T0.8780.99
546_C549_Q0.8770.99
532_Q539_G0.8720.99
356_A359_K0.8700.99
162_I416_A0.8690.99
612_E619_W0.8670.99
130_E424_H0.8670.99
480_A617_D0.8650.99
407_Y418_A0.8650.99
273_T276_Q0.8650.99
117_G120_I0.8590.99
412_F444_A0.8580.99
537_A540_G0.8560.99
140_P143_D0.8550.99
534_A539_G0.8550.99
235_T238_P0.8530.99
551_E578_A0.8520.99
480_A484_V0.8520.99
176_G234_V0.8520.99
290_I294_W0.8500.99
544_K565_V0.8470.99
305_S308_N0.8450.99
585_S588_A0.8450.99
114_G119_G0.8440.99
142_H317_A0.8420.99
339_A343_E0.8420.99
366_E391_S0.8390.99
376_L427_F0.8380.99
284_F288_S0.8380.99
532_Q536_I0.8370.99
222_A226_R0.8370.99
223_S227_A0.8350.99
283_P286_I0.8350.99
557_T583_M0.8340.99
296_A299_A0.8330.98
56_D310_K0.8330.98
215_D242_M0.8330.98
278_G283_P0.8320.98
120_I151_A0.8320.98
61_V123_A0.8320.98
655_V658_K0.8310.98
118_Q416_A0.8300.98
542_V579_R0.8300.98
236_D239_S0.8290.98
539_G543_L0.8290.98
596_Y599_S0.8270.98
390_W395_A0.8270.98
186_G192_H0.8270.98
98_P102_E0.8250.98
407_Y413_G0.8240.98
314_Y318_Y0.8230.98
620_Y629_I0.8230.98
502_A536_I0.8210.98
438_V459_Y0.8200.98
556_A580_V0.8200.98
548_G577_K0.8190.98
369_G390_W0.8180.98
211_H235_T0.8130.98
152_F181_F0.8120.98
635_F641_A0.8100.98
443_N447_M0.8100.98
224_I228_V0.8100.98
334_P337_F0.8090.98
617_D621_K0.8080.98
300_G304_E0.8060.98
554_F611_V0.8040.98
64_N67_G0.8030.98
62_L71_I0.8020.98
491_W585_S0.8020.98
479_V614_G0.8010.98
555_I601_L0.7990.98
378_G414_M0.7960.98
179_I231_A0.7960.98
481_S484_V0.7960.98
109_V113_T0.7950.98
338_D342_K0.7950.98
216_I243_C0.7920.98
523_L559_S0.7910.98
349_Q352_P0.7900.98
133_L424_H0.7900.98
351_N354_K0.7870.98
164_H167_C0.7860.98
111_T423_L0.7860.98
95_S98_P0.7860.98
599_S603_K0.7850.98
336_D340_K0.7850.98
540_G586_T0.7850.98
153_M157_C0.7840.98
564_A655_V0.7830.98
651_T654_N0.7830.98
365_I390_W0.7810.98
338_D508_E0.7810.98
597_R622_Y0.7790.98
230_E233_A0.7790.98
190_D384_P0.7780.98
311_F322_A0.7770.98
632_M650_F0.7770.98
601_L608_R0.7770.98
555_I586_T0.7760.98
616_A620_Y0.7750.98
335_S338_D0.7750.98
391_S396_I0.7730.98
130_E147_H0.7730.98
418_A422_S0.7720.98
415_T459_Y0.7700.97
109_V112_T0.7680.97
496_Q525_Q0.7680.97
391_S394_K0.7670.97
97_T102_E0.7660.97
478_Q615_I0.7650.97
211_H237_K0.7630.97
554_F578_A0.7630.97
568_Y572_T0.7630.97
533_L538_R0.7620.97
590_D594_A0.7610.97
634_T641_A0.7610.97
364_A500_A0.7600.97
418_A429_P0.7590.97
254_K260_S0.7560.97
444_A448_A0.7520.97
131_K176_G0.7490.97
549_Q576_V0.7490.97
312_A316_K0.7480.97
69_M73_S0.7440.97
490_T517_I0.7440.97
254_K269_E0.7430.97
578_A659_A0.7420.97
128_I421_I0.7410.97
448_A455_Q0.7410.97
266_G269_E0.7410.97
124_V175_L0.7390.97
350_A353_A0.7390.97
97_T100_H0.7380.97
128_I396_I0.7380.97
508_E537_A0.7370.97
235_T239_S0.7360.97
339_A342_K0.7360.97
228_V241_L0.7350.97
418_A457_M0.7340.97
593_D599_S0.7330.97
129_A424_H0.7320.97
495_D565_V0.7320.97
128_I405_I0.7310.97
635_F639_A0.7290.97
489_S505_Y0.7290.97
182_Y242_M0.7280.96
300_G303_K0.7270.96
192_H258_H0.7250.96
598_E601_L0.7240.96
611_V655_V0.7230.96
553_I605_V0.7220.96
583_M619_W0.7200.96
467_G474_Q0.7190.96
567_A659_A0.7190.96
538_R542_V0.7180.96
552_L609_V0.7160.96
542_V546_C0.7160.96
341_A500_A0.7160.96
553_I604_A0.7140.96
415_T445_V0.7130.96
539_G544_K0.7110.96
649_G654_N0.7110.96
589_F594_A0.7110.96
366_E390_W0.7100.96
568_Y578_A0.7090.96
326_T329_M0.7070.96
617_D620_Y0.7060.96
103_V451_M0.7060.96
493_P502_A0.7050.96
637_E644_L0.7010.96
150_Y232_R0.7010.96
379_S386_N0.7000.96
466_L641_A0.7000.96
554_F580_V0.6990.96
145_V236_D0.6990.96
108_G111_T0.6980.96
485_T490_T0.6970.95
630_V658_K0.6960.95
461_H559_S0.6960.95
284_F287_P0.6950.95
223_S226_R0.6950.95
609_V612_E0.6940.95
571_L575_G0.6920.95
74_L78_T0.6920.95
540_G600_V0.6920.95
286_I291_Y0.6900.95
504_K533_L0.6890.95
78_T296_A0.6880.95
553_I598_E0.6880.95
620_Y623_V0.6870.95
366_E370_P0.6870.95
231_A239_S0.6860.95
421_I424_H0.6840.95
141_G144_I0.6830.95
593_D597_R0.6820.95
285_E288_S0.6800.95
303_K306_A0.6800.95
98_P101_P0.6790.95
607_A611_V0.6790.95
533_L540_G0.6760.95
103_V423_L0.6750.95
274_R283_P0.6740.95
618_Y622_Y0.6740.95
428_L456_V0.6730.95
252_P269_E0.6700.94
550_P553_I0.6700.94
365_I369_G0.6700.94
313_A317_A0.6690.94
116_L119_G0.6690.94
557_T586_T0.6690.94
563_L645_F0.6690.94
337_F508_E0.6690.94
597_R601_L0.6690.94
142_H318_Y0.6650.94
98_P109_V0.6640.94
169_L408_G0.6630.94
217_D220_D0.6630.94
377_G382_L0.6620.94
368_F507_V0.6620.94
267_D270_I0.6610.94
544_K547_A0.6610.94
632_M644_L0.6600.94
92_Q640_P0.6580.94
100_H103_V0.6580.94
494_C523_L0.6570.94
334_P338_D0.6550.94
572_T576_V0.6550.94
445_V482_L0.6540.94
114_G118_Q0.6530.94
273_T277_L0.6520.94
355_I522_N0.6510.94
464_I648_F0.6500.94
412_F443_N0.6490.93
616_A632_M0.6490.93
93_L637_E0.6490.93
456_V503_W0.6490.93
158_M240_L0.6460.93
501_V504_K0.6450.93
615_I633_T0.6450.93
527_E569_E0.6440.93
435_L479_V0.6440.93
619_W623_V0.6440.93
299_A303_K0.6420.93
128_I376_L0.6410.93
370_P392_G0.6410.93
633_T638_S0.6400.93
499_S502_A0.6400.93
480_A615_I0.6390.93
596_Y600_V0.6390.93
184_D244_K0.6360.93
441_A444_A0.6350.93
369_G375_F0.6350.93
526_Q562_E0.6340.93
122_N419_N0.6340.93
514_T585_S0.6330.93
545_D548_G0.6320.93
635_F640_P0.6310.92
441_A459_Y0.6300.92
432_S458_V0.6300.92
227_A231_A0.6290.92
505_Y588_A0.6280.92
128_I132_T0.6280.92
169_L413_G0.6260.92
535_N540_G0.6260.92
441_A457_M0.6250.92
256_G259_D0.6230.92
274_R279_W0.6230.92
391_S395_A0.6220.92
614_G617_D0.6220.92
549_Q604_A0.6210.92
606_T609_V0.6200.92
126_M149_T0.6200.92
144_I311_F0.6180.92
300_G305_S0.6180.92
76_H84_M0.6170.92
615_I618_Y0.6160.92
314_Y319_P0.6160.92
428_L507_V0.6160.92
100_H111_T0.6140.91
122_N451_M0.6140.91
608_R612_E0.6130.91
286_I292_A0.6120.91
349_Q354_K0.6120.91
308_N317_A0.6120.91
336_D339_A0.6110.91
99_G104_G0.6110.91
389_L393_S0.6110.91
274_R278_G0.6100.91
454_R510_Q0.6100.91
541_Y546_C0.6100.91
340_K367_A0.6100.91
637_E647_E0.6090.91
360_A499_S0.6080.91
638_S641_A0.6080.91
431_T457_M0.6070.91
299_A302_A0.6070.91
421_I429_P0.6060.91
491_W588_A0.6060.91
134_A144_I0.6060.91
442_R478_Q0.6040.91
286_I293_Q0.6030.91
436_M466_L0.6030.91
180_A240_L0.6020.91
210_W240_L0.6010.91
541_Y545_D0.6010.91
234_V239_S0.6010.91
505_Y512_G0.6000.90
313_A316_K0.5990.90
328_R374_E0.5990.90
538_R541_Y0.5990.90
423_L453_Q0.5980.90
420_G424_H0.5980.90
505_Y514_T0.5980.90
327_R331_G0.5970.90
436_M439_E0.5970.90
422_S428_L0.5970.90
452_K487_N0.5970.90
394_K399_D0.5970.90
285_E289_E0.5960.90
561_V580_V0.5940.90
115_P119_G0.5940.90
275_E278_G0.5930.90
383_A389_L0.5920.90
362_Q366_E0.5920.90
491_W505_Y0.5900.90
632_M648_F0.5890.90
621_K624_G0.5880.90
168_S408_G0.5860.89
534_A540_G0.5860.89
528_R531_E0.5860.89
445_V485_T0.5840.89
129_A427_F0.5840.89
274_R277_L0.5820.89
646_E654_N0.5810.89
249_F255_A0.5800.89
72_Y97_T0.5800.89
389_L432_S0.5800.89
459_Y518_L0.5800.89
589_F619_W0.5790.89
407_Y417_I0.5780.89
206_E212_V0.5780.89
553_I579_R0.5770.89
656_V659_A0.5770.89
546_C551_E0.5760.89
224_I243_C0.5750.89
267_D283_P0.5750.89
495_D543_L0.5730.88
628_A632_M0.5730.88
55_A313_A0.5730.88
461_H519_S0.5720.88
64_N153_M0.5720.88
107_A111_T0.5720.88
248_G254_K0.5710.88
118_Q440_Y0.5710.88
132_T135_A0.5700.88
337_F504_K0.5690.88
192_H195_G0.5670.88
219_H243_C0.5660.88
372_L507_V0.5660.88
164_H204_R0.5650.88
568_Y577_K0.5640.88
294_W298_E0.5640.88
543_L561_V0.5630.88
321_E324_E0.5630.88
368_F371_L0.5620.87
366_E369_G0.5610.87
482_L490_T0.5610.87
122_N412_F0.5610.87
479_V490_T0.5610.87
478_Q557_T0.5600.87
337_F372_L0.5600.87
555_I594_A0.5600.87
298_E301_Q0.5590.87
555_I608_R0.5590.87
613_A645_F0.5590.87
543_L546_C0.5580.87
329_M336_D0.5570.87
291_Y296_A0.5570.87
416_A444_A0.5560.87
148_Y228_V0.5540.87
619_W622_Y0.5540.87
97_T101_P0.5540.87
634_T643_L0.5540.87
251_S269_E0.5540.87
120_I153_M0.5530.87
605_V608_R0.5530.87
496_Q529_T0.5530.87
628_A631_G0.5520.86
613_A619_W0.5510.86
360_A364_A0.5490.86
149_T424_H0.5480.86
344_F349_Q0.5470.86
645_F649_G0.5470.86
467_G521_Q0.5460.86
501_V533_L0.5450.86
546_C568_Y0.5450.86
389_L396_I0.5440.86
563_L566_A0.5440.86
150_Y228_V0.5430.86
302_A305_S0.5410.85
323_A326_T0.5410.85
80_Y87_L0.5400.85
434_F469_D0.5400.85
104_G452_K0.5400.85
350_A354_K0.5400.85
197_F201_T0.5390.85
531_E535_N0.5380.85
114_G120_I0.5370.85
166_V413_G0.5370.85
311_F314_Y0.5350.85
489_S510_Q0.5350.85
225_K228_V0.5350.85
212_V240_L0.5350.85
215_D244_K0.5350.85
54_W57_R0.5330.85
195_G406_H0.5320.84
95_S99_G0.5320.84
396_I400_A0.5320.84
452_K455_Q0.5320.84
416_A441_A0.5310.84
554_F571_L0.5300.84
121_A162_I0.5290.84
231_A241_L0.5290.84
128_I169_L0.5290.84
189_I386_N0.5290.84
123_A149_T0.5280.84
67_G70_L0.5280.84
103_V453_Q0.5280.84
156_G196_W0.5280.84
650_F658_K0.5280.84
295_D299_A0.5270.84
363_N366_E0.5270.84
438_V445_V0.5260.84
164_H380_A0.5260.84
608_R625_L0.5250.84
628_A659_A0.5250.84
124_V170_A0.5240.84
485_T615_I0.5240.84
282_A300_G0.5230.83
134_A143_D0.5230.83
633_T640_P0.5220.83
381_D385_S0.5210.83
552_L568_Y0.5210.83
217_D223_S0.5210.83
108_G113_T0.5200.83
224_I245_T0.5200.83
423_L451_M0.5200.83
633_T641_A0.5190.83
206_E211_H0.5170.83
164_H413_G0.5160.83
620_Y624_G0.5160.83
459_Y516_L0.5160.83
193_V196_W0.5150.83
490_T587_D0.5150.83
563_L656_V0.5140.82
503_W516_L0.5140.82
392_G404_Y0.5140.82
491_W516_L0.5140.82
476_V517_I0.5140.82
456_V460_T0.5140.82
106_T113_T0.5130.82
569_E572_T0.5130.82
551_E605_V0.5120.82
118_Q412_F0.5120.82
95_S101_P0.5110.82
634_T644_L0.5110.82
99_G103_V0.5110.82
439_E481_S0.5110.82
158_M164_H0.5110.82
501_V537_A0.5100.82
142_H313_A0.5100.82
532_Q540_G0.5090.82
456_V509_R0.5080.82
364_A368_F0.5070.82
446_R458_V0.5070.82
75_L78_T0.5060.81
145_V329_M0.5060.81
354_K642_E0.5030.81
259_D384_P0.5020.81
600_V604_A0.5020.81
480_A616_A0.5020.81
612_E616_A0.5010.81
438_V484_V0.5010.81
366_E404_Y0.5010.81
313_A318_Y0.5000.81
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2r8oA 2 0.991 100 0.214 Contact Map
1r9jA 2 0.9698 100 0.225 Contact Map
3komA 2 0.9819 100 0.226 Contact Map
3uk1A 2 0.9879 100 0.229 Contact Map
1itzA 2 0.9804 100 0.233 Contact Map
3m49A 2 0.9849 100 0.238 Contact Map
3rimA 2 0.9834 100 0.239 Contact Map
4c7vA 2 0.9804 100 0.244 Contact Map
2e6kA 2 0.9668 100 0.25 Contact Map
1gpuA 2 0.9729 100 0.252 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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