TKT1 - ECOLI - GREMLIN Contacts

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TKT1 - Transketolase 1

UniProt:	P27302	Sequences: MSSRKELANAIRALSMDAVQKAKSGHPGAPMGMADIAEVLWRDFLKHNPQNPSWADRDRFVLSNGHGSMLIYSLLHLTGYDLPMEELKNFRQLHSKTPGHPEVGYTAGVETTTGPLGQGIANAVGMAIAEKTLAAQFNRPGHDIVDHYTYAFMGDGCMMEGISHEVCSLAGTLKLGKLIAFYDDNGISIDGHVEGWFTDDTAMRFEAYGWHVIRDIDGHDAASIKRAVEEARAVTDKPSLLMCKTIIGFGSPNKAGTHDSHGAPLGDAEIALTREQLGWKYAPFEIPSEIYAQWDAKEAGQAKESAWNEKFAAYAKAYPQEAAEFTRRMKGEMPSDFDAKAKEFIAKLQANPAKIASRKASQNAIEAFGPLLPEFLGGSADLAPSNLTLWSGSKAINEDAAGNYIHYGVREFGMTAIANGISLHGGFLPYTSTFLMFVEYARNAVRMAALMKQRQVMVYTHDSIGLGEDGPTHQPVEQVASLRVTPNMSTWRPCDQVESAVAWKYGVERQDGPTALILSRQNLAQQERTEEQLANIARGGYVLKDCAGQPELIFIATGSEVELAVAAYEKLTAEGVKARVVSMPSTDAFDKQDAAYRESVLPKAVTARVAVEAGIADYWYKYVGLNGAIVGMTTFGESAPAELLFEEFGFTVDNVVAKAKELL	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG11427
Length:	663 (589)
Sequences:	9064 (4918)
Seq/√Len:	202.6

ECOLI - TKT1 TKT2 DXS ODP1
BACSU - TKT DXS

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
203_M	206_E	4.294	1.00
552_L	659_A	4.284	1.00
418_A	431_T	3.591	1.00
213_I	239_S	3.395	1.00
551_E	577_K	3.260	1.00
220_D	223_S	3.197	1.00
540_G	583_M	3.114	1.00
598_E	603_K	3.102	1.00
544_K	568_Y	2.966	1.00
509_R	512_G	2.934	1.00
315_A	326_T	2.870	1.00
652_V	656_V	2.855	1.00
234_V	237_K	2.793	1.00
282_A	285_E	2.731	1.00
200_D	203_M	2.725	1.00
590_D	622_Y	2.648	1.00
211_H	239_S	2.647	1.00
148_Y	179_I	2.621	1.00
594_A	598_E	2.577	1.00
570_K	656_V	2.494	1.00
229_E	233_A	2.468	1.00
428_L	454_R	2.449	1.00
304_E	308_N	2.421	1.00
616_A	631_G	2.386	1.00
211_H	234_V	2.340	1.00
569_E	573_A	2.331	1.00
167_C	205_F	2.308	1.00
628_A	658_K	2.289	1.00
164_H	208_Y	2.279	1.00
173_L	176_G	2.252	1.00
85_E	88_K	2.247	1.00
610_A	629_I	2.245	1.00
552_L	578_A	2.229	1.00
491_W	502_A	2.216	1.00
213_I	227_A	2.194	1.00
566_A	569_E	2.188	1.00
643_L	646_E	2.177	1.00
298_E	302_A	2.161	1.00
555_I	583_M	2.159	1.00
436_M	478_Q	2.084	1.00
308_N	312_A	2.079	1.00
153_M	180_A	2.079	1.00
606_T	626_N	2.037	1.00
445_V	488_M	2.030	1.00
288_S	292_A	2.019	1.00
176_G	211_H	1.997	1.00
505_Y	508_E	1.996	1.00
154_G	157_C	1.996	1.00
489_S	585_S	1.994	1.00
305_S	309_E	1.988	1.00
570_K	573_A	1.982	1.00
111_T	122_N	1.982	1.00
213_I	230_E	1.979	1.00
554_F	564_A	1.971	1.00
567_A	571_L	1.969	1.00
421_I	427_F	1.960	1.00
225_K	229_E	1.942	1.00
271_A	275_E	1.926	1.00
488_M	515_A	1.918	1.00
452_K	511_D	1.917	1.00
540_G	544_K	1.909	1.00
654_N	658_K	1.895	1.00
519_S	523_L	1.893	1.00
489_S	512_G	1.891	1.00
127_A	149_T	1.886	1.00
583_M	586_T	1.886	1.00
570_K	652_V	1.868	1.00
76_H	291_Y	1.830	1.00
448_A	457_M	1.816	1.00
355_I	360_A	1.805	1.00
292_A	295_D	1.801	1.00
202_A	206_E	1.800	1.00
590_D	621_K	1.797	1.00
534_A	537_A	1.789	1.00
422_S	454_R	1.778	1.00
142_H	310_K	1.770	1.00
535_N	539_G	1.751	1.00
218_G	245_T	1.749	1.00
172_T	198_T	1.741	1.00
478_Q	517_I	1.741	1.00
184_D	242_M	1.725	1.00
302_A	306_A	1.717	1.00
148_Y	232_R	1.715	1.00
55_A	325_F	1.709	1.00
545_D	579_R	1.707	1.00
534_A	538_R	1.707	1.00
167_C	208_Y	1.703	1.00
327_R	374_E	1.696	1.00
98_P	106_T	1.695	1.00
246_I	255_A	1.691	1.00
646_E	653_D	1.683	1.00
106_T	109_V	1.677	1.00
253_N	272_L	1.664	1.00
174_K	397_N	1.641	1.00
309_E	313_A	1.634	1.00
570_K	653_D	1.625	1.00
476_V	632_M	1.619	1.00
540_G	543_L	1.619	1.00
565_V	580_V	1.609	1.00
75_L	108_G	1.607	1.00
422_S	429_P	1.603	1.00
556_A	564_A	1.598	1.00
202_A	242_M	1.590	1.00
562_E	566_A	1.589	1.00
624_G	627_G	1.584	1.00
246_I	256_G	1.583	1.00
547_A	572_T	1.579	1.00
504_K	508_E	1.579	1.00
479_V	517_I	1.578	1.00
422_S	453_Q	1.574	1.00
281_Y	285_E	1.570	1.00
254_K	259_D	1.568	1.00
145_V	325_F	1.565	1.00
93_L	643_L	1.560	1.00
226_R	230_E	1.555	1.00
623_V	629_I	1.548	1.00
202_A	212_V	1.547	1.00
654_N	657_A	1.545	1.00
181_F	228_V	1.543	1.00
572_T	578_A	1.538	1.00
93_L	639_A	1.538	1.00
309_E	312_A	1.534	1.00
442_R	481_S	1.530	1.00
251_S	273_T	1.521	1.00
616_A	633_T	1.517	1.00
643_L	647_E	1.507	1.00
519_S	559_S	1.489	1.00
176_G	236_D	1.489	1.00
480_A	614_G	1.488	1.00
570_K	574_E	1.487	1.00
169_L	173_L	1.481	1.00
489_S	588_A	1.480	1.00
283_P	287_P	1.480	1.00
147_H	424_H	1.474	1.00
485_T	488_M	1.473	1.00
533_L	537_A	1.470	1.00
84_M	88_K	1.462	1.00
564_A	611_V	1.459	1.00
86_E	89_N	1.456	1.00
418_A	432_S	1.448	1.00
389_L	394_K	1.446	1.00
415_T	441_A	1.438	1.00
494_C	561_V	1.433	1.00
550_P	577_K	1.433	1.00
597_R	600_V	1.430	1.00
563_L	652_V	1.428	1.00
418_A	455_Q	1.419	1.00
186_G	244_K	1.419	1.00
61_V	126_M	1.418	1.00
390_W	393_S	1.415	1.00
489_S	509_R	1.411	1.00
162_I	412_F	1.410	1.00
143_D	146_D	1.408	1.00
566_A	652_V	1.407	1.00
645_F	650_F	1.407	1.00
93_L	647_E	1.403	1.00
328_R	331_G	1.399	1.00
554_F	659_A	1.399	1.00
123_A	151_A	1.395	1.00
435_L	482_L	1.391	1.00
544_K	569_E	1.387	1.00
355_I	363_N	1.385	1.00
367_A	370_P	1.382	1.00
301_Q	305_S	1.379	1.00
564_A	580_V	1.377	1.00
377_G	430_Y	1.377	1.00
123_A	180_A	1.369	1.00
556_A	561_V	1.368	1.00
505_Y	509_R	1.357	1.00
354_K	522_N	1.354	1.00
359_K	522_N	1.347	1.00
359_K	387_L	1.345	1.00
94_H	647_E	1.336	1.00
641_A	645_F	1.334	1.00
295_D	298_E	1.331	1.00
644_L	648_F	1.331	1.00
609_V	630_V	1.326	1.00
536_I	539_G	1.323	1.00
499_S	518_L	1.320	1.00
535_N	538_R	1.316	1.00
608_R	611_V	1.312	1.00
324_E	327_R	1.297	1.00
325_F	329_M	1.281	1.00
447_M	488_M	1.278	1.00
114_G	117_G	1.277	1.00
540_G	546_C	1.275	1.00
355_I	359_K	1.275	1.00
606_T	625_L	1.275	1.00
512_G	591_K	1.274	1.00
553_I	602_P	1.271	1.00
438_V	481_S	1.264	1.00
435_L	517_I	1.262	1.00
607_A	610_A	1.257	1.00
168_S	197_F	1.255	1.00
586_T	590_D	1.251	1.00
248_G	260_S	1.251	1.00
542_V	545_D	1.248	1.00
546_C	577_K	1.244	1.00
293_Q	297_K	1.236	1.00
143_D	310_K	1.232	1.00
149_T	177_K	1.230	1.00
501_V	536_I	1.228	1.00
181_F	243_C	1.228	1.00
131_K	400_A	1.225	1.00
491_W	514_T	1.214	1.00
389_L	392_G	1.211	1.00
546_C	550_P	1.206	1.00
306_A	310_K	1.203	1.00
257_T	260_S	1.203	1.00
120_I	180_A	1.200	1.00
323_A	327_R	1.199	1.00
132_T	376_L	1.190	1.00
445_V	459_Y	1.190	1.00
594_A	597_R	1.187	1.00
306_A	309_E	1.184	1.00
211_H	230_E	1.179	1.00
502_A	516_L	1.176	1.00
156_G	188_S	1.173	1.00
229_E	232_R	1.169	1.00
272_L	275_E	1.166	1.00
121_A	166_V	1.162	1.00
176_G	235_T	1.162	1.00
532_Q	535_N	1.161	1.00
326_T	330_K	1.157	1.00
182_Y	202_A	1.157	1.00
297_K	301_Q	1.153	1.00
128_I	173_L	1.152	1.00
130_E	149_T	1.150	1.00
568_Y	580_V	1.150	1.00
441_A	445_V	1.150	1.00
415_T	458_V	1.150	1.00
99_G	102_E	1.147	1.00
541_Y	544_K	1.146	1.00
377_G	404_Y	1.143	1.00
264_P	270_I	1.141	1.00
212_V	242_M	1.140	1.00
213_I	231_A	1.138	1.00
489_S	587_D	1.137	1.00
359_K	363_N	1.136	1.00
524_A	562_E	1.136	1.00
539_G	542_V	1.134	1.00
386_N	432_S	1.132	1.00
360_A	496_Q	1.131	1.00
150_Y	179_I	1.129	1.00
205_F	240_L	1.129	1.00
422_S	455_Q	1.129	1.00
598_E	604_A	1.128	1.00
64_N	154_G	1.126	1.00
610_A	616_A	1.123	1.00
363_N	391_S	1.121	1.00
392_G	396_I	1.120	1.00
312_A	315_A	1.118	1.00
458_V	518_L	1.114	1.00
120_I	167_C	1.112	1.00
216_I	223_S	1.111	1.00
390_W	396_I	1.110	1.00
551_E	576_V	1.109	1.00
310_K	313_A	1.109	1.00
533_L	539_G	1.107	1.00
392_G	395_A	1.105	1.00
415_T	457_M	1.103	1.00
368_F	375_F	1.102	1.00
640_P	643_L	1.102	1.00
465_G	645_F	1.101	1.00
393_S	396_I	1.099	1.00
532_Q	537_A	1.098	1.00
532_Q	538_R	1.098	1.00
598_E	602_P	1.088	1.00
228_V	232_R	1.088	1.00
85_E	89_N	1.086	1.00
533_L	536_I	1.085	1.00
121_A	413_G	1.083	1.00
188_S	409_V	1.083	1.00
383_A	406_H	1.082	1.00
634_T	638_S	1.082	1.00
357_S	523_L	1.082	1.00
340_K	344_F	1.079	1.00
566_A	570_K	1.078	1.00
560_E	563_L	1.076	1.00
253_N	269_E	1.073	1.00
198_T	216_I	1.070	1.00
572_T	577_K	1.067	1.00
609_V	658_K	1.063	1.00
110_E	113_T	1.060	1.00
361_S	503_W	1.060	1.00
376_L	421_I	1.058	1.00
55_A	329_M	1.057	1.00
635_F	638_S	1.055	1.00
641_A	644_L	1.055	1.00
55_A	145_V	1.055	1.00
639_A	644_L	1.054	1.00
151_A	180_A	1.052	1.00
64_N	152_F	1.051	1.00
586_T	622_Y	1.044	1.00
332_E	335_S	1.041	1.00
225_K	232_R	1.040	1.00
594_A	603_K	1.039	1.00
365_I	430_Y	1.038	1.00
148_Y	177_K	1.037	1.00
567_A	570_K	1.036	1.00
567_A	656_V	1.033	1.00
653_D	657_A	1.029	1.00
550_P	605_V	1.026	1.00
553_I	601_L	1.024	1.00
480_A	618_Y	1.020	1.00
482_L	515_A	1.019	1.00
489_S	514_T	1.015	1.00
609_V	628_A	1.013	1.00
161_G	165_E	1.011	1.00
340_K	343_E	1.008	1.00
650_F	654_N	1.008	1.00
634_T	647_E	1.006	1.00
269_E	272_L	1.004	1.00
639_A	643_L	0.998	1.00
289_E	292_A	0.996	1.00
553_I	581_V	0.995	1.00
506_G	509_R	0.994	1.00
230_E	234_V	0.994	1.00
368_F	372_L	0.992	1.00
556_A	560_E	0.989	1.00
609_V	659_A	0.989	1.00
595_A	599_S	0.988	1.00
176_G	239_S	0.988	1.00
359_K	362_Q	0.987	1.00
129_A	421_I	0.986	1.00
610_A	623_V	0.985	1.00
634_T	648_F	0.984	1.00
204_R	208_Y	0.983	1.00
315_A	322_A	0.982	1.00
120_I	163_S	0.982	1.00
506_G	514_T	0.980	1.00
479_V	484_V	0.978	1.00
352_P	525_Q	0.977	1.00
482_L	485_T	0.977	1.00
121_A	416_A	0.976	1.00
505_Y	537_A	0.974	1.00
331_G	334_P	0.973	1.00
544_K	572_T	0.973	1.00
267_D	271_A	0.973	1.00
642_E	646_E	0.972	1.00
202_A	215_D	0.971	1.00
592_Q	596_Y	0.971	1.00
132_T	427_F	0.969	1.00
131_K	177_K	0.965	0.99
590_D	597_R	0.964	0.99
526_Q	565_V	0.962	0.99
124_V	166_V	0.958	0.99
546_C	572_T	0.952	0.99
318_Y	321_E	0.949	0.99
324_E	328_R	0.949	0.99
389_L	395_A	0.945	0.99
395_A	406_H	0.944	0.99
268_A	271_A	0.943	0.99
481_S	485_T	0.943	0.99
504_K	537_A	0.940	0.99
255_A	276_Q	0.940	0.99
327_R	332_E	0.939	0.99
130_E	177_K	0.939	0.99
333_M	336_D	0.939	0.99
586_T	618_Y	0.937	0.99
634_T	640_P	0.935	0.99
634_T	637_E	0.934	0.99
616_A	629_I	0.932	0.99
445_V	515_A	0.931	0.99
443_N	448_A	0.931	0.99
547_A	577_K	0.928	0.99
445_V	457_M	0.927	0.99
211_H	236_D	0.927	0.99
362_Q	387_L	0.926	0.99
390_W	394_K	0.923	0.99
159_M	188_S	0.921	0.99
646_E	651_T	0.919	0.99
459_Y	515_A	0.919	0.99
174_K	236_D	0.917	0.99
282_A	286_I	0.917	0.99
630_V	655_V	0.917	0.99
333_M	337_F	0.915	0.99
69_M	87_L	0.911	0.99
279_W	287_P	0.909	0.99
439_E	478_Q	0.908	0.99
153_M	158_M	0.905	0.99
550_P	579_R	0.905	0.99
128_I	417_I	0.903	0.99
442_R	458_V	0.899	0.99
629_I	632_M	0.899	0.99
489_S	591_K	0.896	0.99
344_F	363_N	0.895	0.99
340_K	371_L	0.893	0.99
182_Y	240_L	0.891	0.99
566_A	653_D	0.889	0.99
332_E	510_Q	0.889	0.99
251_S	272_L	0.888	0.99
549_Q	577_K	0.885	0.99
439_E	442_R	0.884	0.99
384_P	406_H	0.884	0.99
134_A	142_H	0.883	0.99
268_A	272_L	0.883	0.99
325_F	328_R	0.883	0.99
271_A	281_Y	0.880	0.99
322_A	326_T	0.878	0.99
546_C	549_Q	0.877	0.99
532_Q	539_G	0.872	0.99
356_A	359_K	0.870	0.99
162_I	416_A	0.869	0.99
612_E	619_W	0.867	0.99
130_E	424_H	0.867	0.99
480_A	617_D	0.865	0.99
407_Y	418_A	0.865	0.99
273_T	276_Q	0.865	0.99
117_G	120_I	0.859	0.99
412_F	444_A	0.858	0.99
537_A	540_G	0.856	0.99
140_P	143_D	0.855	0.99
534_A	539_G	0.855	0.99
235_T	238_P	0.853	0.99
551_E	578_A	0.852	0.99
480_A	484_V	0.852	0.99
176_G	234_V	0.852	0.99
290_I	294_W	0.850	0.99
544_K	565_V	0.847	0.99
305_S	308_N	0.845	0.99
585_S	588_A	0.845	0.99
114_G	119_G	0.844	0.99
142_H	317_A	0.842	0.99
339_A	343_E	0.842	0.99
366_E	391_S	0.839	0.99
376_L	427_F	0.838	0.99
284_F	288_S	0.838	0.99
532_Q	536_I	0.837	0.99
222_A	226_R	0.837	0.99
223_S	227_A	0.835	0.99
283_P	286_I	0.835	0.99
557_T	583_M	0.834	0.99
296_A	299_A	0.833	0.98
56_D	310_K	0.833	0.98
215_D	242_M	0.833	0.98
278_G	283_P	0.832	0.98
120_I	151_A	0.832	0.98
61_V	123_A	0.832	0.98
655_V	658_K	0.831	0.98
118_Q	416_A	0.830	0.98
542_V	579_R	0.830	0.98
236_D	239_S	0.829	0.98
539_G	543_L	0.829	0.98
596_Y	599_S	0.827	0.98
390_W	395_A	0.827	0.98
186_G	192_H	0.827	0.98
98_P	102_E	0.825	0.98
407_Y	413_G	0.824	0.98
314_Y	318_Y	0.823	0.98
620_Y	629_I	0.823	0.98
502_A	536_I	0.821	0.98
438_V	459_Y	0.820	0.98
556_A	580_V	0.820	0.98
548_G	577_K	0.819	0.98
369_G	390_W	0.818	0.98
211_H	235_T	0.813	0.98
152_F	181_F	0.812	0.98
635_F	641_A	0.810	0.98
443_N	447_M	0.810	0.98
224_I	228_V	0.810	0.98
334_P	337_F	0.809	0.98
617_D	621_K	0.808	0.98
300_G	304_E	0.806	0.98
554_F	611_V	0.804	0.98
64_N	67_G	0.803	0.98
62_L	71_I	0.802	0.98
491_W	585_S	0.802	0.98
479_V	614_G	0.801	0.98
555_I	601_L	0.799	0.98
378_G	414_M	0.796	0.98
179_I	231_A	0.796	0.98
481_S	484_V	0.796	0.98
109_V	113_T	0.795	0.98
338_D	342_K	0.795	0.98
216_I	243_C	0.792	0.98
523_L	559_S	0.791	0.98
349_Q	352_P	0.790	0.98
133_L	424_H	0.790	0.98
351_N	354_K	0.787	0.98
164_H	167_C	0.786	0.98
111_T	423_L	0.786	0.98
95_S	98_P	0.786	0.98
599_S	603_K	0.785	0.98
336_D	340_K	0.785	0.98
540_G	586_T	0.785	0.98
153_M	157_C	0.784	0.98
564_A	655_V	0.783	0.98
651_T	654_N	0.783	0.98
365_I	390_W	0.781	0.98
338_D	508_E	0.781	0.98
597_R	622_Y	0.779	0.98
230_E	233_A	0.779	0.98
190_D	384_P	0.778	0.98
311_F	322_A	0.777	0.98
632_M	650_F	0.777	0.98
601_L	608_R	0.777	0.98
555_I	586_T	0.776	0.98
616_A	620_Y	0.775	0.98
335_S	338_D	0.775	0.98
391_S	396_I	0.773	0.98
130_E	147_H	0.773	0.98
418_A	422_S	0.772	0.98
415_T	459_Y	0.770	0.97
109_V	112_T	0.768	0.97
496_Q	525_Q	0.768	0.97
391_S	394_K	0.767	0.97
97_T	102_E	0.766	0.97
478_Q	615_I	0.765	0.97
211_H	237_K	0.763	0.97
554_F	578_A	0.763	0.97
568_Y	572_T	0.763	0.97
533_L	538_R	0.762	0.97
590_D	594_A	0.761	0.97
634_T	641_A	0.761	0.97
364_A	500_A	0.760	0.97
418_A	429_P	0.759	0.97
254_K	260_S	0.756	0.97
444_A	448_A	0.752	0.97
131_K	176_G	0.749	0.97
549_Q	576_V	0.749	0.97
312_A	316_K	0.748	0.97
69_M	73_S	0.744	0.97
490_T	517_I	0.744	0.97
254_K	269_E	0.743	0.97
578_A	659_A	0.742	0.97
128_I	421_I	0.741	0.97
448_A	455_Q	0.741	0.97
266_G	269_E	0.741	0.97
124_V	175_L	0.739	0.97
350_A	353_A	0.739	0.97
97_T	100_H	0.738	0.97
128_I	396_I	0.738	0.97
508_E	537_A	0.737	0.97
235_T	239_S	0.736	0.97
339_A	342_K	0.736	0.97
228_V	241_L	0.735	0.97
418_A	457_M	0.734	0.97
593_D	599_S	0.733	0.97
129_A	424_H	0.732	0.97
495_D	565_V	0.732	0.97
128_I	405_I	0.731	0.97
635_F	639_A	0.729	0.97
489_S	505_Y	0.729	0.97
182_Y	242_M	0.728	0.96
300_G	303_K	0.727	0.96
192_H	258_H	0.725	0.96
598_E	601_L	0.724	0.96
611_V	655_V	0.723	0.96
553_I	605_V	0.722	0.96
583_M	619_W	0.720	0.96
467_G	474_Q	0.719	0.96
567_A	659_A	0.719	0.96
538_R	542_V	0.718	0.96
552_L	609_V	0.716	0.96
542_V	546_C	0.716	0.96
341_A	500_A	0.716	0.96
553_I	604_A	0.714	0.96
415_T	445_V	0.713	0.96
539_G	544_K	0.711	0.96
649_G	654_N	0.711	0.96
589_F	594_A	0.711	0.96
366_E	390_W	0.710	0.96
568_Y	578_A	0.709	0.96
326_T	329_M	0.707	0.96
617_D	620_Y	0.706	0.96
103_V	451_M	0.706	0.96
493_P	502_A	0.705	0.96
637_E	644_L	0.701	0.96
150_Y	232_R	0.701	0.96
379_S	386_N	0.700	0.96
466_L	641_A	0.700	0.96
554_F	580_V	0.699	0.96
145_V	236_D	0.699	0.96
108_G	111_T	0.698	0.96
485_T	490_T	0.697	0.95
630_V	658_K	0.696	0.95
461_H	559_S	0.696	0.95
284_F	287_P	0.695	0.95
223_S	226_R	0.695	0.95
609_V	612_E	0.694	0.95
571_L	575_G	0.692	0.95
74_L	78_T	0.692	0.95
540_G	600_V	0.692	0.95
286_I	291_Y	0.690	0.95
504_K	533_L	0.689	0.95
78_T	296_A	0.688	0.95
553_I	598_E	0.688	0.95
620_Y	623_V	0.687	0.95
366_E	370_P	0.687	0.95
231_A	239_S	0.686	0.95
421_I	424_H	0.684	0.95
141_G	144_I	0.683	0.95
593_D	597_R	0.682	0.95
285_E	288_S	0.680	0.95
303_K	306_A	0.680	0.95
98_P	101_P	0.679	0.95
607_A	611_V	0.679	0.95
533_L	540_G	0.676	0.95
103_V	423_L	0.675	0.95
274_R	283_P	0.674	0.95
618_Y	622_Y	0.674	0.95
428_L	456_V	0.673	0.95
252_P	269_E	0.670	0.94
550_P	553_I	0.670	0.94
365_I	369_G	0.670	0.94
313_A	317_A	0.669	0.94
116_L	119_G	0.669	0.94
557_T	586_T	0.669	0.94
563_L	645_F	0.669	0.94
337_F	508_E	0.669	0.94
597_R	601_L	0.669	0.94
142_H	318_Y	0.665	0.94
98_P	109_V	0.664	0.94
169_L	408_G	0.663	0.94
217_D	220_D	0.663	0.94
377_G	382_L	0.662	0.94
368_F	507_V	0.662	0.94
267_D	270_I	0.661	0.94
544_K	547_A	0.661	0.94
632_M	644_L	0.660	0.94
92_Q	640_P	0.658	0.94
100_H	103_V	0.658	0.94
494_C	523_L	0.657	0.94
334_P	338_D	0.655	0.94
572_T	576_V	0.655	0.94
445_V	482_L	0.654	0.94
114_G	118_Q	0.653	0.94
273_T	277_L	0.652	0.94
355_I	522_N	0.651	0.94
464_I	648_F	0.650	0.94
412_F	443_N	0.649	0.93
616_A	632_M	0.649	0.93
93_L	637_E	0.649	0.93
456_V	503_W	0.649	0.93
158_M	240_L	0.646	0.93
501_V	504_K	0.645	0.93
615_I	633_T	0.645	0.93
527_E	569_E	0.644	0.93
435_L	479_V	0.644	0.93
619_W	623_V	0.644	0.93
299_A	303_K	0.642	0.93
128_I	376_L	0.641	0.93
370_P	392_G	0.641	0.93
633_T	638_S	0.640	0.93
499_S	502_A	0.640	0.93
480_A	615_I	0.639	0.93
596_Y	600_V	0.639	0.93
184_D	244_K	0.636	0.93
441_A	444_A	0.635	0.93
369_G	375_F	0.635	0.93
526_Q	562_E	0.634	0.93
122_N	419_N	0.634	0.93
514_T	585_S	0.633	0.93
545_D	548_G	0.632	0.93
635_F	640_P	0.631	0.92
441_A	459_Y	0.630	0.92
432_S	458_V	0.630	0.92
227_A	231_A	0.629	0.92
505_Y	588_A	0.628	0.92
128_I	132_T	0.628	0.92
169_L	413_G	0.626	0.92
535_N	540_G	0.626	0.92
441_A	457_M	0.625	0.92
256_G	259_D	0.623	0.92
274_R	279_W	0.623	0.92
391_S	395_A	0.622	0.92
614_G	617_D	0.622	0.92
549_Q	604_A	0.621	0.92
606_T	609_V	0.620	0.92
126_M	149_T	0.620	0.92
144_I	311_F	0.618	0.92
300_G	305_S	0.618	0.92
76_H	84_M	0.617	0.92
615_I	618_Y	0.616	0.92
314_Y	319_P	0.616	0.92
428_L	507_V	0.616	0.92
100_H	111_T	0.614	0.91
122_N	451_M	0.614	0.91
608_R	612_E	0.613	0.91
286_I	292_A	0.612	0.91
349_Q	354_K	0.612	0.91
308_N	317_A	0.612	0.91
336_D	339_A	0.611	0.91
99_G	104_G	0.611	0.91
389_L	393_S	0.611	0.91
274_R	278_G	0.610	0.91
454_R	510_Q	0.610	0.91
541_Y	546_C	0.610	0.91
340_K	367_A	0.610	0.91
637_E	647_E	0.609	0.91
360_A	499_S	0.608	0.91
638_S	641_A	0.608	0.91
431_T	457_M	0.607	0.91
299_A	302_A	0.607	0.91
421_I	429_P	0.606	0.91
491_W	588_A	0.606	0.91
134_A	144_I	0.606	0.91
442_R	478_Q	0.604	0.91
286_I	293_Q	0.603	0.91
436_M	466_L	0.603	0.91
180_A	240_L	0.602	0.91
210_W	240_L	0.601	0.91
541_Y	545_D	0.601	0.91
234_V	239_S	0.601	0.91
505_Y	512_G	0.600	0.90
313_A	316_K	0.599	0.90
328_R	374_E	0.599	0.90
538_R	541_Y	0.599	0.90
423_L	453_Q	0.598	0.90
420_G	424_H	0.598	0.90
505_Y	514_T	0.598	0.90
327_R	331_G	0.597	0.90
436_M	439_E	0.597	0.90
422_S	428_L	0.597	0.90
452_K	487_N	0.597	0.90
394_K	399_D	0.597	0.90
285_E	289_E	0.596	0.90
561_V	580_V	0.594	0.90
115_P	119_G	0.594	0.90
275_E	278_G	0.593	0.90
383_A	389_L	0.592	0.90
362_Q	366_E	0.592	0.90
491_W	505_Y	0.590	0.90
632_M	648_F	0.589	0.90
621_K	624_G	0.588	0.90
168_S	408_G	0.586	0.89
534_A	540_G	0.586	0.89
528_R	531_E	0.586	0.89
445_V	485_T	0.584	0.89
129_A	427_F	0.584	0.89
274_R	277_L	0.582	0.89
646_E	654_N	0.581	0.89
249_F	255_A	0.580	0.89
72_Y	97_T	0.580	0.89
389_L	432_S	0.580	0.89
459_Y	518_L	0.580	0.89
589_F	619_W	0.579	0.89
407_Y	417_I	0.578	0.89
206_E	212_V	0.578	0.89
553_I	579_R	0.577	0.89
656_V	659_A	0.577	0.89
546_C	551_E	0.576	0.89
224_I	243_C	0.575	0.89
267_D	283_P	0.575	0.89
495_D	543_L	0.573	0.88
628_A	632_M	0.573	0.88
55_A	313_A	0.573	0.88
461_H	519_S	0.572	0.88
64_N	153_M	0.572	0.88
107_A	111_T	0.572	0.88
248_G	254_K	0.571	0.88
118_Q	440_Y	0.571	0.88
132_T	135_A	0.570	0.88
337_F	504_K	0.569	0.88
192_H	195_G	0.567	0.88
219_H	243_C	0.566	0.88
372_L	507_V	0.566	0.88
164_H	204_R	0.565	0.88
568_Y	577_K	0.564	0.88
294_W	298_E	0.564	0.88
543_L	561_V	0.563	0.88
321_E	324_E	0.563	0.88
368_F	371_L	0.562	0.87
366_E	369_G	0.561	0.87
482_L	490_T	0.561	0.87
122_N	412_F	0.561	0.87
479_V	490_T	0.561	0.87
478_Q	557_T	0.560	0.87
337_F	372_L	0.560	0.87
555_I	594_A	0.560	0.87
298_E	301_Q	0.559	0.87
555_I	608_R	0.559	0.87
613_A	645_F	0.559	0.87
543_L	546_C	0.558	0.87
329_M	336_D	0.557	0.87
291_Y	296_A	0.557	0.87
416_A	444_A	0.556	0.87
148_Y	228_V	0.554	0.87
619_W	622_Y	0.554	0.87
97_T	101_P	0.554	0.87
634_T	643_L	0.554	0.87
251_S	269_E	0.554	0.87
120_I	153_M	0.553	0.87
605_V	608_R	0.553	0.87
496_Q	529_T	0.553	0.87
628_A	631_G	0.552	0.86
613_A	619_W	0.551	0.86
360_A	364_A	0.549	0.86
149_T	424_H	0.548	0.86
344_F	349_Q	0.547	0.86
645_F	649_G	0.547	0.86
467_G	521_Q	0.546	0.86
501_V	533_L	0.545	0.86
546_C	568_Y	0.545	0.86
389_L	396_I	0.544	0.86
563_L	566_A	0.544	0.86
150_Y	228_V	0.543	0.86
302_A	305_S	0.541	0.85
323_A	326_T	0.541	0.85
80_Y	87_L	0.540	0.85
434_F	469_D	0.540	0.85
104_G	452_K	0.540	0.85
350_A	354_K	0.540	0.85
197_F	201_T	0.539	0.85
531_E	535_N	0.538	0.85
114_G	120_I	0.537	0.85
166_V	413_G	0.537	0.85
311_F	314_Y	0.535	0.85
489_S	510_Q	0.535	0.85
225_K	228_V	0.535	0.85
212_V	240_L	0.535	0.85
215_D	244_K	0.535	0.85
54_W	57_R	0.533	0.85
195_G	406_H	0.532	0.84
95_S	99_G	0.532	0.84
396_I	400_A	0.532	0.84
452_K	455_Q	0.532	0.84
416_A	441_A	0.531	0.84
554_F	571_L	0.530	0.84
121_A	162_I	0.529	0.84
231_A	241_L	0.529	0.84
128_I	169_L	0.529	0.84
189_I	386_N	0.529	0.84
123_A	149_T	0.528	0.84
67_G	70_L	0.528	0.84
103_V	453_Q	0.528	0.84
156_G	196_W	0.528	0.84
650_F	658_K	0.528	0.84
295_D	299_A	0.527	0.84
363_N	366_E	0.527	0.84
438_V	445_V	0.526	0.84
164_H	380_A	0.526	0.84
608_R	625_L	0.525	0.84
628_A	659_A	0.525	0.84
124_V	170_A	0.524	0.84
485_T	615_I	0.524	0.84
282_A	300_G	0.523	0.83
134_A	143_D	0.523	0.83
633_T	640_P	0.522	0.83
381_D	385_S	0.521	0.83
552_L	568_Y	0.521	0.83
217_D	223_S	0.521	0.83
108_G	113_T	0.520	0.83
224_I	245_T	0.520	0.83
423_L	451_M	0.520	0.83
633_T	641_A	0.519	0.83
206_E	211_H	0.517	0.83
164_H	413_G	0.516	0.83
620_Y	624_G	0.516	0.83
459_Y	516_L	0.516	0.83
193_V	196_W	0.515	0.83
490_T	587_D	0.515	0.83
563_L	656_V	0.514	0.82
503_W	516_L	0.514	0.82
392_G	404_Y	0.514	0.82
491_W	516_L	0.514	0.82
476_V	517_I	0.514	0.82
456_V	460_T	0.514	0.82
106_T	113_T	0.513	0.82
569_E	572_T	0.513	0.82
551_E	605_V	0.512	0.82
118_Q	412_F	0.512	0.82
95_S	101_P	0.511	0.82
634_T	644_L	0.511	0.82
99_G	103_V	0.511	0.82
439_E	481_S	0.511	0.82
158_M	164_H	0.511	0.82
501_V	537_A	0.510	0.82
142_H	313_A	0.510	0.82
532_Q	540_G	0.509	0.82
456_V	509_R	0.508	0.82
364_A	368_F	0.507	0.82
446_R	458_V	0.507	0.82
75_L	78_T	0.506	0.81
145_V	329_M	0.506	0.81
354_K	642_E	0.503	0.81
259_D	384_P	0.502	0.81
600_V	604_A	0.502	0.81
480_A	616_A	0.502	0.81
612_E	616_A	0.501	0.81
438_V	484_V	0.501	0.81
366_E	404_Y	0.501	0.81
313_A	318_Y	0.500	0.81

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2r8oA	2	0.991	100	0.214	Contact Map
1r9jA	2	0.9698	100	0.225	Contact Map
3komA	2	0.9819	100	0.226	Contact Map
3uk1A	2	0.9879	100	0.229	Contact Map
1itzA	2	0.9804	100	0.233	Contact Map
3m49A	2	0.9849	100	0.238	Contact Map
3rimA	2	0.9834	100	0.239	Contact Map
4c7vA	2	0.9804	100	0.244	Contact Map
2e6kA	2	0.9668	100	0.25	Contact Map
1gpuA	2	0.9729	100	0.252	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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