GREMLIN Database
LPXK - Tetraacyldisaccharide 4'-kinase
UniProt: P27300 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11409
Length: 328 (304)
Sequences: 2275 (1802)
Seq/√Len: 103.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
44_A131_V3.2681.00
265_Q271_D3.1851.00
126_V129_D3.0141.00
124_S129_D2.7471.00
83_S110_P2.7321.00
56_A176_L2.6891.00
80_G134_I2.6381.00
124_S130_A2.6031.00
126_V154_R2.5471.00
69_V145_V2.5211.00
69_V81_V2.5191.00
51_V65_V2.4751.00
81_V113_I2.4611.00
131_V144_I2.3431.00
64_V195_I2.3201.00
77_I142_Q2.3181.00
64_V163_V2.3061.00
116_R286_E2.2981.00
286_E304_P2.2371.00
233_V259_V2.2341.00
82_V130_A2.2291.00
66_V113_I2.2171.00
65_V145_V2.1951.00
115_Q293_R2.1891.00
97_L106_A2.1561.00
45_P135_L2.1501.00
162_V188_L2.0981.00
122_A133_A2.0851.00
51_V68_L2.0181.00
68_L145_V1.9851.00
161_I193_A1.9801.00
82_V131_V1.9461.00
133_A137_Q1.9171.00
164_I170_F1.9131.00
234_A244_F1.9061.00
131_V155_L1.9031.00
210_L305_V1.8871.00
157_R160_E1.8681.00
41_A156_A1.8541.00
234_A245_F1.8241.00
17_L21_W1.8181.00
106_A111_V1.8121.00
31_R153_Y1.7981.00
67_W71_Q1.7951.00
242_P246_A1.7951.00
211_L308_Q1.7761.00
79_V142_Q1.7311.00
217_N220_T1.7271.00
66_V117_T1.7181.00
183_E187_R1.7161.00
134_I141_V1.6951.00
261_L265_Q1.6871.00
261_L267_L1.6861.00
95_L101_T1.6821.00
236_A245_F1.6811.00
245_F260_P1.6551.00
24_G175_W1.6541.00
80_G141_V1.6361.00
162_V191_V1.6271.00
261_L271_D1.6251.00
43_R156_A1.6121.00
122_A134_I1.6121.00
284_M292_C1.6121.00
150_L191_V1.6061.00
33_C38_L1.5941.00
170_F185_A1.5911.00
72_L143_I1.5851.00
69_V119_A1.5561.00
82_V144_I1.5501.00
101_T106_A1.5491.00
102_T105_Q1.5441.00
165_D168_R1.5421.00
152_H157_R1.5241.00
50_V160_E1.4771.00
42_W132_K1.4771.00
168_R240_H1.4751.00
31_R190_S1.4731.00
42_W128_S1.4641.00
163_V197_N1.4631.00
88_G125_P1.4631.00
46_V135_L1.4551.00
44_A135_L1.4531.00
269_H273_S1.4391.00
33_C39_K1.4381.00
174_W178_A1.4381.00
66_V116_R1.4321.00
65_V81_V1.4121.00
34_Y154_R1.3961.00
43_R158_D1.3931.00
246_A249_K1.3821.00
231_H254_Q1.3811.00
267_L291_K1.3711.00
96_L122_A1.3691.00
234_A248_L1.3600.99
132_K136_A1.3570.99
213_G306_D1.3380.99
231_H256_E1.3380.99
29_A38_L1.3360.99
73_Q79_V1.3350.99
150_L160_E1.3210.99
114_Y121_V1.3160.99
268_N271_D1.2960.99
88_G123_V1.2750.99
44_A128_S1.2670.99
35_K153_Y1.2430.99
32_L36_L1.2410.99
50_V157_R1.2270.99
169_R205_E1.2230.99
265_Q268_N1.2200.99
70_E306_D1.2160.99
233_V257_K1.2150.99
51_V145_V1.2140.99
215_A303_L1.2080.99
101_T105_Q1.2070.99
90_A93_Y1.1990.99
231_H280_Q1.1800.99
247_T303_L1.1750.98
55_T59_N1.1740.98
187_R190_S1.1640.98
135_L140_D1.1540.98
80_G122_A1.1520.98
197_N307_A1.1500.98
215_A283_V1.1460.98
62_T113_I1.1450.98
70_E116_R1.1450.98
62_T112_L1.1430.98
208_M309_L1.1370.98
54_L187_R1.1370.98
20_S178_A1.1370.98
27_S175_W1.1300.98
89_K104_A1.1250.98
313_E317_L1.1230.98
236_A244_F1.1110.98
212_P247_T1.1110.98
286_E302_Y1.1070.98
27_S184_R1.1040.98
216_V220_T1.1030.98
17_L178_A1.0930.98
55_T164_I1.0920.98
71_Q318_L1.0900.98
34_Y39_K1.0850.97
95_L106_A1.0630.97
216_V302_Y1.0620.97
103_T111_V1.0550.97
75_R318_L1.0550.97
67_W314_P1.0480.97
93_Y125_P1.0470.97
92_S125_P1.0350.97
292_C295_F1.0330.97
98_S101_T1.0330.97
232_V255_P1.0260.96
97_L111_V1.0180.96
232_V253_V1.0170.96
49_V159_V1.0110.96
44_A48_V1.0050.96
30_I39_K1.0050.96
78_R142_Q1.0000.96
236_A241_P0.9940.96
89_K105_Q0.9880.96
54_L170_F0.9840.95
66_V112_L0.9780.95
211_L306_D0.9780.95
67_W309_L0.9770.95
20_S175_W0.9730.95
24_G27_S0.9710.95
134_I144_I0.9690.95
83_S123_V0.9680.95
133_A136_A0.9680.95
175_W184_R0.9670.95
259_V274_A0.9660.95
295_F300_W0.9620.95
259_V275_L0.9580.95
82_V146_T0.9560.95
235_M282_L0.9510.95
79_V143_I0.9480.94
232_V283_V0.9460.94
192_D320_Q0.9460.94
31_R187_R0.9450.94
49_V143_I0.9320.94
23_Y30_I0.9300.94
284_M300_W0.9280.94
159_V193_A0.9220.94
59_N163_V0.9180.93
64_V307_A0.9180.93
34_Y37_K0.9130.93
77_I143_I0.9100.93
42_W45_P0.9000.93
218_L289_A0.8990.93
93_Y124_S0.8980.93
246_A250_M0.8940.93
128_S132_K0.8940.93
90_A125_P0.8890.92
128_S131_V0.8890.92
113_I117_T0.8830.92
218_L302_Y0.8790.92
183_E190_S0.8790.92
79_V141_V0.8780.92
233_V275_L0.8750.92
232_V281_T0.8680.91
164_I194_V0.8630.91
233_V280_Q0.8610.91
25_L29_A0.8610.91
165_D171_G0.8600.91
55_T165_D0.8550.91
72_L145_V0.8510.91
70_E74_Q0.8490.90
23_Y153_Y0.8480.90
88_G95_L0.8470.90
50_V146_T0.8440.90
97_L114_Y0.8410.90
235_M275_L0.8400.90
39_K154_R0.8380.90
166_G196_V0.8380.90
309_L313_E0.8360.90
209_H308_Q0.8340.90
90_A123_V0.8330.90
70_E73_Q0.8310.90
31_R183_E0.8310.90
297_E300_W0.8290.89
29_A33_C0.8280.89
262_A265_Q0.8270.89
69_V117_T0.8260.89
50_V155_L0.8200.89
215_A218_L0.8190.89
66_V81_V0.8190.89
24_G28_G0.8160.89
227_A232_V0.8140.89
24_G184_R0.8120.88
46_V131_V0.8080.88
207_P212_P0.8050.88
18_P22_L0.8030.88
33_C37_K0.8010.88
97_L101_T0.7980.88
54_L188_L0.7980.88
67_W163_V0.7980.88
284_M291_K0.7970.87
167_V240_H0.7970.87
282_L300_W0.7950.87
247_T251_C0.7900.87
160_E187_R0.7850.87
71_Q314_P0.7850.87
44_A155_L0.7830.87
212_P251_C0.7830.87
237_G284_M0.7810.86
275_L282_L0.7790.86
150_L162_V0.7700.86
10_S13_W0.7690.86
22_L26_V0.7640.85
78_R140_D0.7630.85
128_S154_R0.7630.85
66_V70_E0.7630.85
207_P310_S0.7570.85
206_I317_L0.7570.85
170_F188_L0.7550.85
50_V149_G0.7550.85
71_Q75_R0.7540.84
20_S24_G0.7510.84
23_Y27_S0.7500.84
172_N180_P0.7480.84
233_V274_A0.7460.84
150_L190_S0.7450.84
27_S30_I0.7440.84
153_Y157_R0.7430.84
213_G216_V0.7410.83
116_R304_P0.7410.83
227_A253_V0.7400.83
230_E281_T0.7400.83
310_S313_E0.7390.83
237_G267_L0.7390.83
284_M302_Y0.7390.83
73_Q118_D0.7370.83
31_R35_K0.7350.83
88_G239_G0.7320.83
224_C227_A0.7280.82
111_V114_Y0.7270.82
72_L77_I0.7260.82
107_G123_V0.7230.82
195_I208_M0.7190.82
13_W180_P0.7190.82
129_D132_K0.7130.81
122_A141_V0.7110.81
23_Y26_V0.7110.81
97_L100_D0.7050.80
165_D239_G0.7030.80
122_A137_Q0.7000.80
21_W24_G0.6980.80
91_E125_P0.6960.79
103_T106_A0.6960.79
103_T291_K0.6930.79
26_V30_I0.6930.79
270_A273_S0.6930.79
73_Q78_R0.6890.79
236_A248_L0.6880.79
216_V219_R0.6880.79
210_L218_L0.6860.78
90_A95_L0.6860.78
29_A39_K0.6830.78
173_G185_A0.6820.78
239_G267_L0.6780.78
224_C253_V0.6780.78
261_L272_V0.6760.77
21_W174_W0.6740.77
249_K254_Q0.6740.77
296_A300_W0.6740.77
20_S174_W0.6740.77
247_T250_M0.6730.77
93_Y130_A0.6720.77
247_T305_V0.6700.77
71_Q74_Q0.6690.77
164_I185_A0.6680.77
164_I196_V0.6650.76
90_A124_S0.6620.76
116_R302_Y0.6620.76
171_G180_P0.6580.75
27_S153_Y0.6570.75
29_A40_R0.6550.75
28_G186_G0.6530.75
164_I188_L0.6510.75
47_P158_D0.6490.74
213_G217_N0.6460.74
95_L123_V0.6430.74
208_M307_A0.6430.74
222_T225_D0.6420.74
292_C300_W0.6370.73
129_D133_A0.6370.73
272_V292_C0.6350.73
96_L137_Q0.6330.73
222_T226_V0.6320.73
76_G79_V0.6290.72
197_N239_G0.6290.72
197_N243_R0.6290.72
206_I210_L0.6280.72
42_W135_L0.6280.72
267_L271_D0.6260.72
54_L162_V0.6260.72
248_L253_V0.6230.71
215_A304_P0.6220.71
214_Q220_T0.6220.71
28_G32_L0.6190.71
37_K41_A0.6190.71
15_L18_P0.6170.71
59_N197_N0.6140.70
101_T111_V0.6130.70
14_R174_W0.6120.70
215_A219_R0.6100.70
75_R79_V0.6100.70
216_V221_G0.6080.70
256_E259_V0.6070.69
248_L283_V0.6070.69
311_G314_P0.6060.69
238_I241_P0.6060.69
226_V230_E0.6060.69
128_S155_L0.6050.69
23_Y34_Y0.6040.69
131_V135_L0.6030.69
116_R306_D0.6020.69
235_M284_M0.6010.69
51_V161_I0.6010.69
215_A251_C0.5990.68
90_A106_A0.5950.68
245_F249_K0.5950.68
197_N208_M0.5950.68
314_P318_L0.5920.68
272_V282_L0.5880.67
83_S144_I0.5850.67
16_L178_A0.5840.67
65_V113_I0.5830.66
59_N161_I0.5830.66
238_I285_T0.5810.66
50_V150_L0.5790.66
219_R298_E0.5790.66
212_P216_V0.5770.66
112_L116_R0.5760.65
132_K250_M0.5750.65
210_L243_R0.5730.65
90_A105_Q0.5730.65
150_L163_V0.5730.65
272_V300_W0.5710.65
17_L174_W0.5700.65
54_L183_E0.5680.64
266_S271_D0.5650.64
102_T106_A0.5650.64
30_I33_C0.5650.64
13_W178_A0.5650.64
42_W154_R0.5630.64
100_D270_A0.5620.64
27_S183_E0.5620.64
239_G305_V0.5610.63
88_G111_V0.5600.63
108_D127_R0.5580.63
126_V132_K0.5580.63
108_D287_K0.5570.63
96_L99_A0.5570.63
130_A140_D0.5530.62
264_H287_K0.5530.62
56_A175_W0.5520.62
28_G184_R0.5520.62
235_M267_L0.5510.62
32_L35_K0.5510.62
63_P286_E0.5500.62
153_Y160_E0.5490.62
90_A101_T0.5480.62
18_P178_A0.5470.62
49_V72_L0.5450.61
34_Y320_Q0.5440.61
293_R300_W0.5430.61
111_V290_V0.5430.61
67_W318_L0.5410.61
146_T160_E0.5400.61
64_V309_L0.5400.61
29_A32_L0.5400.61
214_Q221_G0.5400.61
10_S14_R0.5400.61
188_L191_V0.5390.60
42_W131_V0.5370.60
120_P141_V0.5340.60
137_Q140_D0.5320.59
213_G218_L0.5320.59
273_S277_S0.5310.59
17_L20_S0.5300.59
112_L119_A0.5300.59
79_V140_D0.5290.59
32_L38_L0.5290.59
68_L103_T0.5280.59
159_V192_D0.5270.59
81_V119_A0.5250.58
124_S133_A0.5230.58
96_L114_Y0.5220.58
55_T170_F0.5200.58
279_G299_N0.5200.58
106_A114_Y0.5190.58
147_D287_K0.5190.58
169_R172_N0.5190.58
91_E95_L0.5190.58
212_P303_L0.5170.57
152_H183_E0.5170.57
10_S178_A0.5160.57
71_Q317_L0.5140.57
49_V161_I0.5130.57
169_R204_G0.5130.57
57_G264_H0.5120.57
191_V194_V0.5110.56
64_V67_W0.5100.56
88_G91_E0.5090.56
215_A220_T0.5080.56
237_G291_K0.5060.56
63_P163_V0.5050.56
26_V29_A0.5050.56
251_C303_L0.5040.55
113_I121_V0.5030.55
217_N301_W0.5030.55
98_S105_Q0.5020.55
82_V168_R0.5010.55
13_W174_W0.5010.55
267_L292_C0.5010.55
249_K319_T0.5000.55
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4ehxA 1 0.9207 100 0.284 Contact Map
4nkrA 2 0.497 98.3 0.912 Contact Map
3fkqA 2 0.7744 97.5 0.928 Contact Map
4dzzA 2 0.6159 97.4 0.928 Contact Map
3q9lA 2 0.7104 97.3 0.93 Contact Map
4pfsA 1 0.6799 97.3 0.93 Contact Map
1xjcA 2 0.4177 97.3 0.931 Contact Map
2ynmA 2 0.7226 97.2 0.931 Contact Map
4rz3A 2 0.6768 97.2 0.932 Contact Map
1g3qA 1 0.689 97.1 0.933 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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