GREMLIN Database
BAX - Protein bax
UniProt: P27297 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11360
Length: 274 (217)
Sequences: 322 (245)
Seq/√Len: 16.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
147_D230_R7.0501.00
64_L176_L4.8931.00
156_T268_R3.8131.00
91_Q94_A3.8031.00
181_C186_C3.3840.99
160_A163_G3.3140.99
73_G76_R3.1340.99
108_Q115_E2.6010.96
253_K257_N2.5830.96
179_M208_A2.4830.95
180_K194_K2.4360.95
238_A242_I2.2320.91
242_I259_L2.2280.91
67_L83_T2.1810.90
122_I146_V2.1470.90
95_I98_E2.1470.90
98_E125_R2.1430.90
122_I256_N2.0190.87
170_A196_Y2.0140.86
95_I126_Y1.9920.86
225_S244_K1.9870.86
101_W118_R1.9220.84
159_A180_K1.9150.83
160_A251_K1.8990.83
243_H260_F1.8930.83
119_L142_L1.8840.82
156_T238_A1.8340.81
91_Q203_K1.8270.80
212_N219_Y1.8160.80
185_R195_G1.8090.80
210_V213_L1.8000.79
127_K215_T1.7770.78
77_K177_F1.7280.76
163_G198_Q1.7250.76
153_M242_I1.7190.76
168_K187_T1.7090.76
173_N188_N1.6970.75
160_A262_M1.6470.73
181_C195_G1.6370.72
91_Q210_V1.6320.72
238_A268_R1.6140.71
175_N186_C1.5930.70
251_K254_S1.5840.70
179_M188_N1.5660.69
189_A195_G1.5640.69
169_L180_K1.5440.68
79_A181_C1.5400.67
239_T263_Y1.5240.67
79_A186_C1.4990.65
179_M202_V1.4970.65
152_S268_R1.4940.65
75_P79_A1.4880.65
126_Y146_V1.4670.64
168_K180_K1.4640.63
156_T263_Y1.4320.62
222_F241_M1.4210.61
169_L196_Y1.3850.59
190_P196_Y1.3730.58
175_N181_C1.3450.57
251_K258_Y1.3390.56
92_N214_N1.3110.55
125_R176_L1.2940.54
152_S238_A1.2890.53
247_G252_G1.2790.53
144_E227_A1.2600.52
142_L213_L1.2470.51
109_G217_P1.2360.50
67_L181_C1.2350.50
169_L173_N1.2350.50
160_A258_Y1.2300.50
78_K82_R1.2120.49
142_L156_T1.2090.49
260_F263_Y1.2020.48
180_K196_Y1.1990.48
68_R115_E1.1990.48
81_L160_A1.1960.48
131_S134_T1.1920.48
77_K266_N1.1830.47
214_N226_R1.1790.47
99_R226_R1.1690.46
187_T194_K1.1630.46
160_A244_K1.1560.46
182_M213_L1.1530.45
190_P194_K1.1500.45
126_Y259_L1.1440.45
67_L186_C1.1370.44
83_T182_M1.1250.44
151_T238_A1.1230.44
188_N205_S1.1170.43
187_T199_F1.1080.43
159_A194_K1.0680.40
87_Y206_V1.0640.40
83_T181_C1.0600.40
122_I154_V1.0440.39
186_C195_G1.0370.39
194_K250_T1.0280.38
76_R197_S1.0270.38
175_N249_S1.0230.38
237_T240_A1.0170.38
244_K262_M1.0090.37
89_T93_A0.9990.37
209_Y241_M0.9990.37
160_A180_K0.9980.37
99_R214_N0.9880.36
163_G246_K0.9860.36
182_M256_N0.9710.35
162_S252_G0.9680.35
263_Y268_R0.9680.35
222_F236_V0.9590.34
88_I247_G0.9500.34
187_T190_P0.9460.34
208_A253_K0.9360.33
115_E201_S0.9360.33
176_L202_V0.9310.33
171_R228_Q0.9230.33
156_T174_N0.9170.32
171_R252_G0.9150.32
94_A207_S0.9100.32
82_R85_M0.9080.32
66_D69_K0.9030.32
166_T252_G0.9000.31
88_I113_P0.8990.31
83_T186_C0.8920.31
147_D214_N0.8780.30
188_N194_K0.8770.30
196_Y244_K0.8700.30
185_R196_Y0.8690.30
172_N267_Q0.8650.30
54_Y57_N0.8640.30
69_K171_R0.8620.29
113_P233_D0.8560.29
98_E211_T0.8550.29
95_I210_V0.8530.29
173_N179_M0.8480.29
84_V262_M0.8460.29
96_T236_V0.8450.29
81_L244_K0.8450.29
174_N268_R0.8440.29
205_S208_A0.8400.28
65_P170_A0.8380.28
88_I136_K0.8370.28
99_R147_D0.8340.28
92_N212_N0.8200.27
105_K118_R0.8160.27
99_R212_N0.8100.27
103_I106_Q0.8090.27
227_A231_K0.8090.27
70_Y79_A0.8060.27
179_M189_A0.8000.27
91_Q207_S0.7970.26
212_N216_H0.7940.26
195_G258_Y0.7910.26
95_I128_V0.7910.26
114_A234_Q0.7900.26
77_K206_V0.7880.26
190_P212_N0.7870.26
189_A194_K0.7850.26
114_A233_D0.7800.26
159_A262_M0.7790.26
81_L195_G0.7780.26
85_M156_T0.7780.26
151_T156_T0.7750.25
169_L194_K0.7670.25
195_G244_K0.7640.25
88_I149_I0.7620.25
149_I222_F0.7610.25
211_T215_T0.7590.25
187_T214_N0.7580.25
102_L208_A0.7540.24
106_Q140_N0.7510.24
65_P149_I0.7500.24
100_N200_S0.7500.24
70_Y73_G0.7470.24
180_K244_K0.7460.24
62_S149_I0.7410.24
117_A121_D0.7400.24
180_K190_P0.7390.24
161_E178_G0.7380.24
128_V176_L0.7350.24
166_T222_F0.7310.23
149_I214_N0.7290.23
112_S254_S0.7290.23
83_T195_G0.7280.23
143_L218_A0.7280.23
67_L79_A0.7270.23
178_G248_Y0.7270.23
91_Q156_T0.7230.23
197_S222_F0.7230.23
92_N99_R0.7190.23
79_A170_A0.7130.23
112_S231_K0.7110.23
189_A251_K0.7090.23
149_I154_V0.7080.22
168_K194_K0.7070.22
77_K223_R0.7070.22
115_E236_V0.7060.22
175_N195_G0.7000.22
152_S173_N0.7000.22
188_N197_S0.6970.22
152_S156_T0.6910.22
95_I238_A0.6880.22
156_T269_L0.6840.22
155_A256_N0.6810.21
100_N107_Y0.6790.21
201_S204_E0.6790.21
158_A230_R0.6770.21
136_K215_T0.6740.21
84_V244_K0.6740.21
201_S261_A0.6730.21
154_V257_N0.6710.21
67_L195_G0.6680.21
154_V206_V0.6670.21
180_K187_T0.6670.21
77_K187_T0.6650.21
180_K189_A0.6610.21
81_L155_A0.6600.21
113_P171_R0.6590.21
193_V205_S0.6580.20
65_P226_R0.6570.20
76_R98_E0.6560.20
169_L187_T0.6560.20
181_C214_N0.6550.20
238_A263_Y0.6500.20
84_V87_Y0.6490.20
127_K243_H0.6480.20
65_P147_D0.6460.20
158_A231_K0.6440.20
185_R251_K0.6440.20
66_D175_N0.6440.20
88_I134_T0.6440.20
180_K258_Y0.6380.20
129_K148_I0.6370.20
156_T163_G0.6340.20
225_S262_M0.6310.19
109_G201_S0.6310.19
185_R244_K0.6270.19
159_A206_V0.6260.19
106_Q134_T0.6260.19
62_S172_N0.6250.19
168_K182_M0.6230.19
108_Q137_I0.6230.19
168_K188_N0.6210.19
91_Q135_R0.6200.19
100_N138_P0.6170.19
155_A162_S0.6170.19
129_K145_R0.6130.19
72_S199_F0.6130.19
170_A181_C0.6080.19
119_L207_S0.6080.19
102_L267_Q0.6040.18
117_A141_T0.6010.18
124_K133_N0.6000.18
87_Y154_V0.5990.18
160_A254_S0.5960.18
125_R207_S0.5940.18
103_I140_N0.5940.18
168_K196_Y0.5930.18
138_P242_I0.5890.18
56_R89_T0.5880.18
73_G200_S0.5870.18
121_D137_I0.5860.18
115_E134_T0.5850.18
135_R138_P0.5850.18
87_Y176_L0.5830.18
173_N190_P0.5810.18
113_P184_G0.5800.18
163_G242_I0.5790.18
81_L177_F0.5730.17
163_G257_N0.5730.17
190_P199_F0.5700.17
130_W136_K0.5690.17
182_M195_G0.5670.17
135_R220_S0.5640.17
149_I170_A0.5630.17
244_K256_N0.5620.17
101_W115_E0.5620.17
160_A175_N0.5610.17
113_P228_Q0.5600.17
122_I204_E0.5590.17
141_T144_E0.5590.17
154_V268_R0.5560.17
64_L247_G0.5560.17
162_S218_A0.5560.17
250_T262_M0.5540.17
82_R246_K0.5520.17
203_K242_I0.5520.17
68_R76_R0.5490.17
160_A195_G0.5480.17
72_S76_R0.5430.16
219_Y251_K0.5430.16
147_D226_R0.5420.16
149_I221_S0.5410.16
96_T148_I0.5400.16
94_A98_E0.5380.16
73_G102_L0.5380.16
156_T213_L0.5360.16
125_R205_S0.5360.16
159_A244_K0.5310.16
157_M178_G0.5300.16
109_G228_Q0.5280.16
135_R213_L0.5280.16
211_T216_H0.5260.16
69_K74_T0.5250.16
59_A261_A0.5230.16
168_K173_N0.5230.16
123_A199_F0.5210.16
254_S258_Y0.5210.16
65_P214_N0.5210.16
218_A265_D0.5190.16
61_S117_A0.5160.16
96_T233_D0.5160.16
112_S220_S0.5150.16
205_S223_R0.5150.16
220_S224_K0.5130.15
58_S101_W0.5130.15
85_M171_R0.5110.15
260_F268_R0.5090.15
188_N199_F0.5090.15
89_T181_C0.5090.15
199_F214_N0.5090.15
74_T128_V0.5080.15
161_E167_S0.5050.15
180_K195_G0.5040.15
112_S154_V0.5040.15
56_R59_A0.5010.15
100_N103_I0.5000.15
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3fi7A 4 0.5766 100 0.737 Contact Map
2zycA 1 0.4781 99.9 0.739 Contact Map
4kt3A 1 0.4672 99.9 0.781 Contact Map
4qdnA 2 0.4161 99.9 0.783 Contact Map
4q2wA 1 0.7956 99.7 0.83 Contact Map
3j04B 1 0.5109 47 0.964 Contact Map
3w6bA 1 0.4781 35.7 0.966 Contact Map
4p0gA 1 0.9051 29.9 0.968 Contact Map
1u7kA 3 0.1934 21.9 0.97 Contact Map
3qrxA 2 0.5182 20.4 0.97 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0089 seconds.