GREMLIN Database
INAA - Protein InaA
UniProt: P27294 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11422
Length: 216 (190)
Sequences: 1268 (873)
Seq/√Len: 63.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
142_K146_S5.5431.00
85_K105_E4.9331.00
141_F154_C4.8941.00
92_V99_R3.5951.00
44_L87_V3.5341.00
140_A169_A3.2361.00
42_K105_E3.1711.00
137_V169_A2.9171.00
75_E79_A2.9041.00
67_V71_A2.5091.00
17_E20_W2.4671.00
45_Y106_D2.1931.00
112_S115_D1.9861.00
51_H55_H1.8721.00
51_H56_S1.8431.00
58_R61_F1.8341.00
79_A147_I1.8311.00
150_Q180_R1.8221.00
73_I83_V1.7851.00
32_S35_Q1.7711.00
159_I194_L1.7661.00
152_G177_S1.7350.99
136_A139_L1.7010.99
162_K168_E1.6790.99
53_L56_S1.6780.99
38_E41_G1.6530.99
43_K106_D1.6400.99
138_A209_V1.6340.99
13_W16_T1.6270.99
208_Q212_Y1.6230.99
107_M170_G1.6150.99
81_V144_M1.6040.99
180_R186_A1.5850.99
144_M171_F1.5260.99
131_Q135_K1.5020.98
183_R186_A1.4970.98
195_E199_E1.4890.98
206_W209_V1.4240.98
69_E73_I1.3870.97
73_I174_L1.3680.97
66_I100_A1.3650.97
69_E102_L1.3610.97
49_M102_L1.3520.97
13_W20_W1.3510.97
65_T175_E1.3340.97
143_K147_I1.3240.96
111_I115_D1.3100.96
20_W26_Y1.3080.96
133_M169_A1.3030.96
205_D208_Q1.3000.96
15_A20_W1.2880.96
162_K170_G1.2860.96
208_Q211_A1.2740.96
15_A19_D1.2730.96
38_E43_K1.2620.95
159_I171_F1.2610.95
203_K207_E1.2580.95
151_H159_I1.2510.95
133_M161_V1.2470.95
153_C158_H1.2350.95
69_E174_L1.2290.95
137_V140_A1.2100.94
175_E193_Q1.2090.94
12_H15_A1.2040.94
57_V60_P1.1960.94
201_I205_D1.1950.94
207_E211_A1.1870.94
68_R178_R1.1830.93
111_I119_Q1.1830.93
83_V89_G1.1600.93
140_A144_M1.1580.93
52_H56_S1.1500.92
14_W17_E1.1420.92
202_P205_D1.1230.92
138_A151_H1.1190.91
138_A212_Y1.1100.91
158_H175_E1.1100.91
49_M158_H1.1060.91
179_R207_E1.0690.89
148_N187_I1.0540.89
164_E168_E1.0410.88
77_E85_K1.0300.88
90_E101_L1.0300.88
130_R205_D1.0260.87
120_H128_E1.0100.87
204_A207_E1.0080.86
155_Y158_H1.0080.86
18_G21_V1.0070.86
74_K78_R1.0010.86
189_H192_R0.9960.86
15_A21_V0.9950.86
134_L156_V0.9920.86
67_V89_G0.9900.85
65_T153_C0.9850.85
14_W18_G0.9820.85
36_C43_K0.9780.85
13_W18_G0.9760.85
34_V102_L0.9650.84
20_W37_V0.9540.83
82_I140_A0.9520.83
201_I209_V0.9490.83
49_M175_E0.9470.83
39_R44_L0.9460.83
155_Y193_Q0.9440.83
72_V177_S0.9410.82
144_M147_I0.9410.82
69_E196_K0.9390.82
154_C159_I0.9290.82
49_M69_E0.9290.82
47_K152_G0.9150.81
204_A208_Q0.9140.81
76_L81_V0.9120.80
88_F153_C0.9110.80
151_H154_C0.9090.80
142_K187_I0.9050.80
76_L149_R0.8990.79
29_N34_V0.8940.79
201_I204_A0.8730.77
158_H193_Q0.8680.77
116_W120_H0.8610.76
48_R101_L0.8580.76
202_P207_E0.8550.76
54_F81_V0.8500.76
199_E203_K0.8370.74
144_M177_S0.8370.74
134_L138_A0.8340.74
107_M110_F0.8190.73
152_G176_K0.8190.73
138_A142_K0.8180.73
52_H175_E0.8160.73
86_I171_F0.8130.72
81_V140_A0.8120.72
148_N183_R0.8120.72
155_Y176_K0.8070.72
149_R174_L0.7980.71
38_E44_L0.7950.71
49_M65_T0.7940.70
69_E155_Y0.7930.70
17_E21_V0.7910.70
184_D188_N0.7910.70
83_V177_S0.7880.70
66_I174_L0.7880.70
150_Q186_A0.7880.70
75_E78_R0.7870.70
31_M51_H0.7870.70
73_I86_I0.7860.70
155_Y175_E0.7860.70
145_H194_L0.7860.70
112_S194_L0.7850.70
37_V103_V0.7840.69
27_R34_V0.7830.69
195_E206_W0.7820.69
82_I168_E0.7800.69
130_R133_M0.7760.69
87_V103_V0.7680.68
30_G196_K0.7680.68
100_A157_R0.7680.68
104_T114_A0.7660.68
54_F61_F0.7630.67
70_V74_K0.7630.67
84_P158_H0.7610.67
80_G147_I0.7580.67
109_G189_H0.7540.66
64_P91_A0.7520.66
103_V140_A0.7460.66
180_R183_R0.7430.65
49_M196_K0.7430.65
113_I116_W0.7430.65
32_S157_R0.7390.65
53_L183_R0.7380.65
136_A140_A0.7370.65
37_V136_A0.7360.65
69_E175_E0.7350.64
40_N85_K0.7340.64
65_T155_Y0.7260.64
31_M35_Q0.7200.63
59_Y164_E0.7180.63
31_M34_V0.7160.62
28_R32_S0.7160.62
45_Y76_L0.7150.62
37_V96_G0.7100.62
49_M157_R0.7080.62
21_V103_V0.7040.61
145_H176_K0.7030.61
70_V86_I0.7010.61
175_E196_K0.7000.61
32_S176_K0.6950.60
51_H65_T0.6940.60
52_H55_H0.6860.59
142_K161_V0.6770.58
32_S175_E0.6700.57
153_C175_E0.6640.57
134_L174_L0.6630.57
36_C128_E0.6610.56
15_A26_Y0.6600.56
30_G53_L0.6600.56
107_M162_K0.6590.56
96_G118_A0.6590.56
200_P204_A0.6580.56
203_K211_A0.6570.56
174_L197_Y0.6560.56
12_H20_W0.6540.56
104_T151_H0.6500.55
155_Y190_D0.6500.55
32_S36_C0.6490.55
89_G155_Y0.6380.54
203_K209_V0.6380.54
153_C173_D0.6330.53
141_F147_I0.6330.53
86_I193_Q0.6310.53
113_I151_H0.6300.53
148_N184_D0.6290.53
38_E135_K0.6270.52
53_L96_G0.6260.52
119_Q136_A0.6260.52
182_R187_I0.6250.52
50_T152_G0.6240.52
49_M193_Q0.6230.52
67_V120_H0.6220.52
14_W19_D0.6220.52
114_A157_R0.6180.51
49_M153_C0.6170.51
140_A171_F0.6150.51
40_N120_H0.6130.51
149_R179_R0.6130.51
66_I73_I0.6120.51
50_T66_I0.6110.51
82_I144_M0.6020.50
114_A156_V0.6000.49
103_V161_V0.5970.49
142_K213_Y0.5950.49
100_A196_K0.5950.49
75_E179_R0.5940.49
57_V61_F0.5900.48
38_E85_K0.5890.48
33_G36_C0.5880.48
34_V157_R0.5880.48
16_T21_V0.5870.48
79_A144_M0.5850.48
108_A162_K0.5820.47
32_S62_G0.5810.47
71_A143_K0.5800.47
144_M189_H0.5800.47
90_E103_V0.5780.47
41_G208_Q0.5700.46
19_D128_E0.5680.46
87_V163_T0.5670.46
119_Q172_L0.5650.45
76_L177_S0.5650.45
27_R33_G0.5640.45
13_W17_E0.5640.45
114_A160_Y0.5620.45
150_Q178_R0.5610.45
45_Y193_Q0.5580.45
94_I97_E0.5570.44
94_I98_W0.5550.44
34_V156_V0.5540.44
200_P203_K0.5520.44
206_W210_K0.5500.44
89_G142_K0.5450.43
74_K77_E0.5440.43
44_L76_L0.5440.43
70_V155_Y0.5420.43
88_F101_L0.5420.43
52_H196_K0.5400.42
28_R104_T0.5380.42
129_V161_V0.5380.42
65_T151_H0.5350.42
118_A204_A0.5350.42
138_A159_I0.5330.42
93_K96_G0.5300.41
109_G180_R0.5300.41
142_K151_H0.5300.41
77_E185_K0.5290.41
160_Y190_D0.5270.41
204_A211_A0.5260.41
19_D26_Y0.5220.40
49_M52_H0.5190.40
73_I102_L0.5170.40
147_I179_R0.5060.39
37_V46_V0.5030.38
110_F160_Y0.5020.38
69_E86_I0.5020.38
138_A195_E0.5000.38
34_V152_G0.5000.38
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4h05A 1 0.8426 99.7 0.666 Contact Map
3csvA 2 0.8194 99.7 0.678 Contact Map
3dxpA 2 0.8519 99.7 0.682 Contact Map
3atsA 1 0.9259 99.7 0.682 Contact Map
3tm0A 1 0.8472 99.7 0.686 Contact Map
4gkhA 8 0.8519 99.7 0.687 Contact Map
4ocvA 1 0.9213 99.6 0.691 Contact Map
3sg8A 2 0.8935 99.6 0.699 Contact Map
1nd4A 2 0.8102 99.6 0.7 Contact Map
3w0oA 1 0.8241 99.6 0.702 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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