GREMLIN Database
NADR - Trifunctional NAD biosynthesis/regulator protein NadR
UniProt: P27278 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11335
Length: 410 (325)
Sequences: 330 (226)
Seq/√Len: 12.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
255_F403_R6.1501.00
390_D393_S4.2221.00
178_S198_D3.7610.99
343_I386_V3.5370.99
290_G293_Q3.4270.98
307_F402_V3.2520.98
76_L127_L3.1860.97
255_F399_V3.0930.97
373_V385_R2.9460.96
67_G91_V2.9310.96
91_V94_L2.9260.96
84_I127_L2.7920.94
81_I131_F2.7600.94
343_I398_C2.6740.93
254_I399_V2.6070.92
310_T315_T2.5940.92
241_S365_R2.5480.91
65_T92_D2.4350.89
320_K371_L2.4050.88
241_S265_R2.3880.88
258_T302_A2.2230.84
291_H308_I2.2110.83
241_S354_D2.1860.83
245_S259_S2.1780.82
185_Q189_H2.1730.82
231_V402_V2.1400.81
179_E208_G2.1260.81
219_W227_K2.1130.80
241_S357_R2.1020.80
265_R354_D2.0440.78
281_Y319_C1.9330.74
252_A257_T1.8880.72
69_V83_L1.8620.71
196_L199_P1.8520.70
257_T307_F1.8390.70
368_F372_L1.8020.68
132_K135_K1.7980.68
233_T299_V1.7830.67
266_D294_Y1.7540.66
241_S315_T1.7490.66
233_T308_I1.7090.64
264_G355_G1.6870.63
162_K406_M1.6870.63
95_H140_H1.6600.62
344_L376_L1.6590.62
201_R206_I1.6510.61
223_P226_V1.6510.61
305_V402_V1.6380.61
265_R315_T1.6040.59
357_R365_R1.5940.58
354_D357_R1.5710.57
295_I339_F1.5570.57
72_K179_E1.5520.56
375_M378_E1.5180.55
262_E357_R1.5160.54
214_N217_R1.5140.54
219_W305_V1.4840.53
248_V307_F1.4830.53
125_R129_Q1.4810.53
210_Q217_R1.4800.53
322_Y358_S1.4780.52
265_R357_R1.4620.52
346_E385_R1.4580.51
347_N369_Q1.4500.51
284_Y372_L1.4430.51
247_L386_V1.4420.51
98_M127_L1.4310.50
198_D205_S1.4270.50
199_P328_P1.4230.50
70_F94_L1.4190.49
254_I403_R1.4170.49
344_L369_Q1.4140.49
74_Y228_P1.4070.49
129_Q300_K1.4000.48
183_A187_M1.3930.48
91_V174_L1.3900.48
257_T304_K1.3810.48
178_S205_S1.3810.48
72_K198_D1.3780.47
257_T303_N1.3720.47
74_Y120_V1.3710.47
80_H212_R1.3710.47
341_L401_L1.3690.47
265_R365_R1.3530.46
249_N259_S1.3250.45
345_L386_V1.3230.45
226_V257_T1.3170.44
72_K207_S1.3170.44
96_I211_I1.3140.44
123_R207_S1.3140.44
293_Q297_F1.3080.44
210_Q218_Y1.3040.44
67_G176_Y1.2790.42
82_Y290_G1.2780.42
64_K92_D1.2720.42
358_S368_F1.2710.42
161_I190_L1.2690.42
234_V305_V1.2640.42
236_I323_E1.2620.41
351_W357_R1.2620.41
308_I312_F1.2610.41
238_G243_G1.2600.41
258_T298_A1.2540.41
255_F259_S1.2520.41
165_M318_F1.2430.41
176_Y260_A1.2360.40
291_H358_S1.2360.40
123_R212_R1.2310.40
155_D159_N1.2220.40
119_T235_A1.2210.39
351_W361_S1.2170.39
264_G268_V1.2150.39
201_R212_R1.2110.39
181_A187_M1.2030.39
177_T322_Y1.2000.38
154_W186_Y1.1920.38
322_Y372_L1.1810.38
240_E354_D1.1750.37
248_V259_S1.1720.37
82_Y197_V1.1710.37
240_E260_A1.1630.37
290_G294_Y1.1570.36
81_I223_P1.1560.36
234_V245_S1.1540.36
141_A386_V1.1500.36
210_Q213_E1.1500.36
159_N380_N1.1460.36
358_S372_L1.1370.35
201_R207_S1.1330.35
374_E400_E1.1300.35
73_F83_L1.1270.35
73_F247_L1.1240.35
384_V401_L1.1210.35
325_R393_S1.1210.35
238_G309_D1.1200.35
243_G309_D1.1200.35
354_D365_R1.1180.35
132_K137_I1.1180.35
210_Q328_P1.1150.34
237_L266_D1.1090.34
314_T345_L1.1070.34
318_F358_S1.1020.34
235_A288_A1.0970.34
86_R197_V1.0950.33
88_C134_Q1.0930.33
370_N390_D1.0920.33
235_A311_D1.0920.33
94_L223_P1.0800.33
263_Y353_A1.0690.32
378_E397_R1.0640.32
72_K177_T1.0610.32
126_W389_E1.0580.32
267_Y287_I1.0560.32
179_E209_A1.0550.32
74_Y279_L1.0500.31
239_G242_S1.0480.31
263_Y376_L1.0460.31
265_R352_V1.0420.31
315_T357_R1.0290.31
317_A368_F1.0260.30
67_G132_K1.0240.30
64_K220_E1.0230.30
215_P396_L1.0210.30
97_I164_F1.0200.30
240_E351_W1.0130.30
387_E397_R1.0110.30
91_V176_Y1.0090.30
150_Y153_G1.0080.30
137_I215_P1.0070.30
197_V205_S1.0040.29
325_R390_D1.0020.29
90_Q195_V0.9990.29
219_W311_D0.9920.29
268_V356_L0.9890.29
245_S321_K0.9800.28
123_R206_I0.9790.28
231_V323_E0.9790.28
288_A361_S0.9780.28
279_L342_V0.9740.28
235_A312_F0.9740.28
89_S249_N0.9730.28
236_I251_L0.9710.28
119_T210_Q0.9690.28
234_V405_M0.9680.28
322_Y368_F0.9660.28
318_F351_W0.9650.28
402_V405_M0.9650.28
74_Y321_K0.9640.28
374_E378_E0.9600.28
81_I130_T0.9580.28
279_L284_Y0.9530.27
255_F260_A0.9530.27
279_L368_F0.9490.27
134_Q206_I0.9460.27
283_D319_C0.9440.27
252_A259_S0.9400.27
82_Y94_L0.9300.26
237_L284_Y0.9240.26
96_I352_V0.9240.26
370_N380_N0.9200.26
253_N395_F0.9150.26
226_V376_L0.9110.26
208_G361_S0.9080.26
288_A291_H0.9080.26
132_K136_N0.9070.25
76_L342_V0.9050.25
94_L383_F0.9040.25
258_T403_R0.8980.25
200_K341_L0.8980.25
241_S264_G0.8970.25
181_A372_L0.8930.25
178_S288_A0.8770.24
211_I248_V0.8690.24
72_K208_G0.8680.24
179_E207_S0.8670.24
393_S397_R0.8640.24
80_H123_R0.8620.24
240_E365_R0.8570.24
181_A353_A0.8570.24
120_V322_Y0.8570.24
67_G405_M0.8550.24
76_L120_V0.8550.24
244_K318_F0.8540.23
248_V384_V0.8530.23
295_I334_I0.8530.23
239_G368_F0.8500.23
239_G264_G0.8490.23
335_D378_E0.8490.23
386_V391_Y0.8480.23
261_W361_S0.8470.23
77_H389_E0.8460.23
179_E194_T0.8450.23
153_G157_W0.8440.23
151_P154_W0.8430.23
309_D365_R0.8420.23
64_K174_L0.8380.23
346_E387_E0.8370.23
163_K230_F0.8330.23
241_S246_T0.8300.23
250_K295_I0.8300.23
241_S309_D0.8270.22
264_G357_R0.8220.22
318_F357_R0.8190.22
267_Y343_I0.8180.22
181_A284_Y0.8140.22
66_I95_H0.8140.22
291_H318_F0.8080.22
244_K314_T0.8050.22
207_S242_S0.8020.22
70_F144_E0.8000.22
347_N387_E0.8000.22
289_L329_F0.8000.22
97_I221_Y0.8000.22
132_K227_K0.7970.21
377_E382_E0.7960.21
67_G287_I0.7920.21
137_I255_F0.7920.21
90_Q176_Y0.7920.21
197_V382_E0.7880.21
256_N343_I0.7870.21
185_Q368_F0.7860.21
122_D229_F0.7820.21
99_G391_Y0.7800.21
137_I349_T0.7760.21
390_D399_V0.7760.21
150_Y237_L0.7740.21
70_F153_G0.7730.21
306_A389_E0.7730.21
240_E355_G0.7700.21
144_E147_M0.7660.20
391_Y395_F0.7650.20
208_G403_R0.7620.20
181_A389_E0.7610.20
236_I386_V0.7600.20
177_T194_T0.7560.20
233_T337_Y0.7540.20
70_F158_S0.7520.20
237_L259_S0.7480.20
219_W402_V0.7470.20
198_D201_R0.7470.20
351_W362_S0.7470.20
161_I244_K0.7460.20
125_R234_V0.7460.20
178_S201_R0.7440.20
126_W226_V0.7430.20
250_K254_I0.7420.20
318_F372_L0.7370.19
181_A242_S0.7360.19
217_R245_S0.7350.19
291_H337_Y0.7340.19
266_D270_S0.7320.19
262_E354_D0.7310.19
375_M379_N0.7300.19
208_G351_W0.7250.19
155_D370_N0.7220.19
133_Y398_C0.7220.19
66_I93_E0.7190.19
194_T353_A0.7180.19
171_Q397_R0.7160.19
221_Y396_L0.7100.19
92_D390_D0.7070.18
82_Y263_Y0.7070.18
97_I147_M0.7060.18
239_G351_W0.7040.18
244_K279_L0.6990.18
245_S303_N0.6980.18
322_Y356_L0.6970.18
240_E356_L0.6950.18
169_G211_I0.6950.18
143_N147_M0.6940.18
392_D396_L0.6940.18
97_I149_P0.6910.18
241_S352_V0.6880.18
377_E403_R0.6870.18
232_R330_V0.6870.18
67_G307_F0.6850.18
130_T330_V0.6840.18
318_F342_V0.6830.18
307_F342_V0.6820.18
173_D299_V0.6820.18
201_R209_A0.6810.18
209_A252_A0.6790.18
94_L387_E0.6750.18
179_E198_D0.6750.18
162_K196_L0.6740.17
234_V361_S0.6710.17
288_A292_A0.6680.17
78_T89_S0.6670.17
147_M283_D0.6660.17
279_L364_D0.6640.17
83_L344_L0.6630.17
178_S204_M0.6620.17
263_Y287_I0.6620.17
74_Y116_Q0.6590.17
207_S212_R0.6580.17
224_T294_Y0.6570.17
126_W264_G0.6570.17
237_L376_L0.6550.17
352_V355_G0.6550.17
176_Y247_L0.6540.17
211_I273_G0.6530.17
348_N389_E0.6520.17
99_G339_F0.6490.17
207_S230_F0.6480.17
234_V390_D0.6460.17
135_K170_I0.6460.17
172_P215_P0.6450.17
156_V384_V0.6430.17
312_F337_Y0.6420.17
262_E309_D0.6400.17
184_P193_E0.6400.17
99_G157_W0.6380.16
322_Y353_A0.6380.16
74_Y117_Q0.6370.16
285_D333_L0.6370.16
345_L351_W0.6360.16
99_G161_I0.6350.16
79_G123_R0.6330.16
351_W386_V0.6330.16
239_G369_Q0.6320.16
222_I239_G0.6300.16
120_V186_Y0.6280.16
246_T365_R0.6270.16
190_L215_P0.6240.16
234_V267_Y0.6240.16
262_E265_R0.6220.16
138_R177_T0.6210.16
219_W398_C0.6210.16
295_I389_E0.6200.16
98_M154_W0.6180.16
173_D233_T0.6180.16
245_S261_W0.6180.16
330_V339_F0.6160.16
180_E393_S0.6150.16
221_Y374_E0.6120.16
163_K400_E0.6110.16
166_A170_I0.6090.16
227_K300_K0.6070.16
76_L284_Y0.6070.16
74_Y118_P0.6030.15
329_F332_A0.6000.15
199_P210_Q0.5990.15
329_F333_L0.5970.15
377_E383_F0.5970.15
97_I267_Y0.5960.15
155_D189_H0.5960.15
293_Q401_L0.5920.15
70_F99_G0.5900.15
309_D354_D0.5900.15
157_W391_Y0.5890.15
244_K345_L0.5880.15
229_F245_S0.5870.15
67_G280_Q0.5870.15
216_F403_R0.5860.15
83_L233_T0.5860.15
74_Y311_D0.5850.15
159_N218_Y0.5850.15
94_L166_A0.5840.15
102_D269_F0.5810.15
77_H207_S0.5800.15
144_E157_W0.5790.15
362_S372_L0.5790.15
263_Y322_Y0.5760.15
178_S197_V0.5760.15
135_K307_F0.5760.15
219_W345_L0.5750.15
226_V310_T0.5740.15
213_E233_T0.5740.15
224_T346_E0.5710.15
67_G257_T0.5710.15
264_G324_G0.5700.15
122_D291_H0.5690.15
287_I302_A0.5680.15
253_N335_D0.5680.15
252_A305_V0.5660.15
402_V406_M0.5650.14
335_D374_E0.5650.14
197_V346_E0.5610.14
144_E400_E0.5600.14
76_L279_L0.5600.14
64_K176_Y0.5590.14
349_T406_M0.5590.14
199_P233_T0.5560.14
204_M234_V0.5530.14
263_Y328_P0.5530.14
352_V357_R0.5530.14
209_A212_R0.5520.14
291_H325_R0.5520.14
202_T387_E0.5520.14
206_I270_S0.5470.14
291_H369_Q0.5430.14
206_I303_N0.5420.14
233_T368_F0.5420.14
211_I395_F0.5420.14
264_G365_R0.5400.14
242_S358_S0.5400.14
98_M247_L0.5380.14
156_V159_N0.5380.14
66_I206_I0.5370.14
204_M343_I0.5370.14
276_E356_L0.5360.14
183_A205_S0.5360.14
356_L372_L0.5350.14
137_I250_K0.5340.14
276_E315_T0.5340.14
351_W356_L0.5340.14
301_Y370_N0.5330.14
76_L318_F0.5320.14
208_G218_Y0.5320.14
178_S195_V0.5320.14
94_L282_S0.5310.14
289_L307_F0.5310.14
206_I212_R0.5300.14
189_H287_I0.5280.14
74_Y244_K0.5270.14
120_V276_E0.5270.14
217_R335_D0.5240.13
137_I396_L0.5230.13
144_E153_G0.5220.13
173_D187_M0.5210.13
77_H247_L0.5210.13
208_G386_V0.5190.13
232_R401_L0.5190.13
227_K345_L0.5180.13
68_V190_L0.5160.13
137_I267_Y0.5150.13
346_E373_V0.5150.13
136_N340_D0.5140.13
281_Y325_R0.5140.13
164_F303_N0.5130.13
69_V178_S0.5130.13
67_G402_V0.5120.13
241_S314_T0.5110.13
152_H155_D0.5110.13
228_P299_V0.5100.13
315_T354_D0.5090.13
284_Y321_K0.5080.13
128_L386_V0.5070.13
143_N146_G0.5060.13
152_H202_T0.5050.13
211_I218_Y0.5050.13
353_A356_L0.5050.13
262_E315_T0.5050.13
202_T218_Y0.5040.13
67_G226_V0.5020.13
257_T306_A0.5020.13
332_A387_E0.5000.13
70_F252_A0.5000.13
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1lw7A 4 0.8195 100 0.665 Contact Map
4x0eA 1 0.3805 99.9 0.842 Contact Map
3h05A 2 0.3732 99.8 0.871 Contact Map
3k9wA 5 0.361 99.7 0.884 Contact Map
1qjcA 4 0.3512 99.7 0.887 Contact Map
4natA 5 0.3488 99.7 0.888 Contact Map
1f9aA 5 0.3902 99.7 0.889 Contact Map
4f3rA 5 0.3317 99.7 0.889 Contact Map
1od6A 5 0.3463 99.7 0.89 Contact Map
3nv7A 4 0.3463 99.6 0.891 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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