GREMLIN Database
ARGK - Probable GTPase ArgK
UniProt: P27254 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11445
Length: 331 (310)
Sequences: 2201 (1386)
Seq/√Len: 78.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
79_I114_A4.7031.00
15_R50_Y4.3211.00
22_L141_L4.0441.00
306_A311_T3.9941.00
13_R18_E3.4241.00
198_V249_I3.2061.00
170_C256_F2.9801.00
86_A142_C2.7971.00
257_K261_T2.7951.00
14_L25_A2.7871.00
88_I138_L2.7441.00
252_A255_D2.6771.00
283_E287_L2.6071.00
75_G87_V2.5081.00
10_S21_T2.4461.00
76_M114_A2.4381.00
79_I116_A2.4201.00
29_V141_L2.3841.00
51_C140_L2.3831.00
170_C196_L2.3451.00
13_R21_T2.3381.00
59_V172_I2.2911.00
139_M152_V2.2851.00
83_L148_D2.2671.00
199_I214_R2.2501.00
17_G84_K2.2471.00
313_S316_T2.2281.00
57_L151_I2.2251.00
65_A176_I2.2241.00
238_C249_I2.1931.00
172_I198_V2.1131.00
72_E110_D2.1041.00
173_S191_M2.0791.00
290_L321_L2.0611.00
214_R237_T2.0151.00
70_F249_I2.0081.00
77_L81_E2.0051.00
55_L257_K1.9981.00
22_L142_C1.9761.00
49_P52_G1.9731.00
86_A147_Y1.9461.00
234_R255_D1.9411.00
75_G117_A1.9061.00
122_V138_L1.8851.00
268_Q271_Q1.8501.00
11_I46_A1.8471.00
76_M110_D1.8471.00
9_E12_R1.8391.00
222_H232_Q1.8311.00
65_A174_L1.8241.00
319_R323_E1.8161.00
172_I249_I1.8091.00
251_H255_D1.8071.00
57_L74_F1.8011.00
314_P318_L1.7821.00
305_L309_N1.7801.00
77_L247_D1.7621.00
70_F174_L1.7611.00
83_L149_V1.7181.00
26_M138_L1.7051.00
176_I179_G1.7051.00
81_E251_H1.7021.00
75_G111_L1.6911.00
54_T143_E1.6601.00
254_I258_T1.6541.00
25_A43_L1.6191.00
152_V168_V1.5901.00
12_R16_Q1.5781.00
81_E254_I1.5761.00
169_D270_R1.5741.00
70_F238_C1.5380.99
258_T262_A1.5340.99
59_V71_L1.5320.99
80_R114_A1.5000.99
84_K116_A1.4820.99
248_E251_H1.4820.99
81_E250_W1.4810.99
76_M79_I1.4740.99
25_A141_L1.4490.99
320_Q323_E1.4340.99
22_L145_A1.4180.99
149_V250_W1.4130.99
303_T317_G1.4020.99
260_L265_R1.3970.99
218_E228_Y1.3940.99
175_Q217_Y1.3660.99
261_T266_L1.3650.99
198_V238_C1.3430.98
302_Q306_A1.3380.98
208_T237_T1.3320.98
177_A207_H1.3070.98
214_R218_E1.3060.98
27_T31_S1.2970.98
78_L85_V1.2950.98
57_L253_I1.2930.98
77_L246_I1.2770.98
178_G204_G1.2750.98
47_I141_L1.2720.98
178_G206_N1.2720.98
302_Q305_L1.2700.98
256_F260_L1.2660.98
101_I186_I1.2450.97
140_L277_W1.2400.97
131_A167_M1.2390.97
191_M217_Y1.2330.97
22_L147_Y1.2200.97
204_G210_V1.2110.97
95_P126_G1.2080.97
306_A320_Q1.2040.97
18_E21_T1.1960.97
206_N209_N1.1940.97
299_Y320_Q1.1840.96
234_R252_A1.1840.96
299_Y302_Q1.1770.96
191_M220_A1.1720.96
282_T318_L1.1690.96
76_M80_R1.1660.96
312_L317_G1.1510.96
236_L252_A1.1480.96
175_Q199_I1.1440.96
318_L322_S1.1430.96
268_Q272_Q1.1430.96
78_L250_W1.1350.96
52_G143_E1.1270.95
279_R304_L1.1260.95
9_E13_R1.1190.95
218_E231_W1.1010.95
231_W256_F1.0940.95
106_T183_L1.0900.94
200_N240_A1.0890.94
59_V74_F1.0870.94
306_A309_N1.0870.94
285_E288_N1.0820.94
11_I15_R1.0690.94
172_I253_I1.0590.94
228_Y231_W1.0580.93
312_L320_Q1.0530.93
20_A23_A1.0520.93
119_I157_V1.0440.93
62_T176_I1.0390.93
47_I51_C1.0320.93
256_F259_A1.0300.93
79_I85_V1.0290.93
306_A312_L1.0230.92
26_M145_A1.0170.92
196_L252_A1.0120.92
130_G160_S1.0050.92
307_V317_G0.9990.91
275_V304_L0.9980.91
11_I43_L0.9920.91
316_T320_Q0.9880.91
60_T178_G0.9860.91
14_L145_A0.9840.91
27_T30_E0.9830.91
14_L141_L0.9730.90
285_E289_H0.9710.90
45_D313_S0.9700.90
44_L47_I0.9700.90
177_A206_N0.9650.90
174_L200_N0.9620.90
122_V132_S0.9580.90
267_Q271_Q0.9570.90
10_S13_R0.9460.89
42_Q46_A0.9450.89
242_E247_D0.9390.89
259_A263_S0.9370.89
97_T238_C0.9240.88
157_V161_E0.9150.87
171_F195_D0.9060.87
42_Q45_D0.9030.87
215_H219_S0.9010.87
317_G322_S0.8990.86
77_L243_K0.8970.86
48_M313_S0.8940.86
110_D113_R0.8940.86
10_S43_L0.8930.86
18_E319_R0.8920.86
124_S157_V0.8910.86
313_S320_Q0.8840.85
128_L160_S0.8820.85
105_K121_P0.8780.85
69_T240_A0.8770.85
178_G216_M0.8740.85
131_A135_A0.8720.85
170_C260_L0.8710.85
126_G129_G0.8650.84
175_Q191_M0.8640.84
245_G248_E0.8610.84
69_T239_S0.8590.84
280_K283_E0.8550.83
136_R167_M0.8530.83
10_S28_L0.8440.83
214_R235_V0.8380.82
124_S160_S0.8360.82
73_A240_A0.8360.82
33_H36_H0.8320.82
109_N191_M0.8300.82
172_I196_L0.8290.82
88_I142_C0.8270.81
24_Q144_A0.8240.81
284_E288_N0.8220.81
305_L308_K0.8200.81
127_H163_E0.8130.80
55_L254_I0.8120.80
47_I52_G0.8100.80
111_L119_I0.8070.80
293_N296_F0.8060.80
9_E267_Q0.8040.80
258_T302_Q0.8030.79
90_V160_S0.7990.79
14_L47_I0.7980.79
118_F147_Y0.7980.79
11_I25_A0.7930.79
228_Y265_R0.7890.78
22_L47_I0.7890.78
270_R273_Q0.7870.78
104_D161_E0.7860.78
124_S165_A0.7860.78
191_M280_K0.7810.78
285_E319_R0.7780.77
80_R243_K0.7770.77
255_D262_A0.7770.77
272_Q275_V0.7770.77
133_Q284_E0.7750.77
52_G146_G0.7750.77
54_T256_F0.7730.77
295_D298_R0.7720.77
12_R268_Q0.7710.77
57_L149_V0.7660.76
300_Y307_V0.7650.76
111_L117_A0.7650.76
128_L135_A0.7640.76
175_Q216_M0.7580.75
93_S124_S0.7550.75
74_F246_I0.7530.75
85_V151_I0.7460.74
227_K230_E0.7460.74
258_T261_T0.7450.74
177_A238_C0.7450.74
135_A167_M0.7400.74
279_R291_F0.7390.74
294_E298_R0.7380.73
191_M197_I0.7370.73
65_A213_A0.7350.73
134_R138_L0.7330.73
79_I115_E0.7310.73
65_A220_A0.7310.73
73_A243_K0.7310.73
182_D186_I0.7300.73
275_V308_K0.7290.73
312_L316_T0.7270.72
272_Q276_E0.7270.72
54_T146_G0.7260.72
110_D243_K0.7240.72
139_M168_V0.7200.72
12_R46_A0.7190.72
251_H267_Q0.7190.72
205_D208_T0.7180.71
77_L80_R0.7170.71
265_R269_V0.7150.71
44_L97_T0.7140.71
210_V317_G0.7080.70
22_L137_E0.7070.70
62_T179_G0.7020.70
177_A213_A0.7010.70
273_Q277_W0.6980.69
136_R277_W0.6980.69
251_H254_I0.6960.69
26_M30_E0.6920.69
303_T306_A0.6910.69
194_A250_W0.6900.68
285_E292_A0.6890.68
45_D316_T0.6880.68
71_L151_I0.6830.68
93_S203_D0.6830.68
19_R23_A0.6820.68
172_I236_L0.6820.68
132_S135_A0.6820.68
79_I117_A0.6820.68
137_E140_L0.6810.67
27_T145_A0.6800.67
30_E122_V0.6800.67
189_G193_V0.6770.67
31_S160_S0.6770.67
296_F321_L0.6760.67
255_D259_A0.6760.67
13_R46_A0.6760.67
24_Q285_E0.6750.67
137_E277_W0.6740.67
196_L214_R0.6700.66
12_R247_D0.6630.65
265_R268_Q0.6630.65
73_A246_I0.6600.65
281_Q284_E0.6590.65
302_Q319_R0.6580.65
293_N307_V0.6560.65
55_L256_F0.6560.65
303_T312_L0.6550.64
48_M51_C0.6540.64
226_R230_E0.6530.64
131_A239_S0.6520.64
238_C246_I0.6490.64
102_L200_N0.6490.64
303_T320_Q0.6480.64
92_P104_D0.6480.64
138_L209_N0.6470.63
28_L31_S0.6430.63
27_T169_D0.6420.63
171_F193_V0.6410.63
234_R256_F0.6400.63
95_P162_T0.6390.62
257_K260_L0.6390.62
190_L220_A0.6360.62
86_A123_P0.6360.62
167_M176_I0.6350.62
257_K266_L0.6350.62
188_K224_L0.6330.62
202_D237_T0.6310.62
173_S290_L0.6310.62
183_L273_Q0.6310.62
97_T272_Q0.6300.61
191_M215_H0.6300.61
55_L253_I0.6280.61
11_I14_L0.6260.61
97_T199_I0.6230.61
286_V290_L0.6220.60
49_P53_N0.6210.60
300_Y303_T0.6210.60
302_Q323_E0.6200.60
62_T190_L0.6190.60
175_Q179_G0.6190.60
317_G320_Q0.6180.60
257_K288_N0.6170.60
196_L253_I0.6160.60
176_I186_I0.6150.60
276_E280_K0.6130.59
244_R248_E0.6120.59
72_E105_K0.6110.59
26_M88_I0.6110.59
88_I139_M0.6100.59
308_K312_L0.6080.59
76_M216_M0.6080.59
105_K174_L0.6080.59
139_M150_V0.6070.59
231_W260_L0.6060.58
274_S304_L0.6060.58
81_E255_D0.6060.58
175_Q188_K0.6040.58
283_E291_F0.6030.58
128_L161_E0.6030.58
267_Q305_L0.6010.58
56_R139_M0.6000.58
260_L269_V0.5990.58
218_E222_H0.5960.57
185_G210_V0.5950.57
121_P188_K0.5940.57
74_F253_I0.5920.57
84_K147_Y0.5910.57
44_L137_E0.5890.56
278_L304_L0.5880.56
162_T193_V0.5850.56
45_D319_R0.5850.56
128_L183_L0.5850.56
115_E227_K0.5840.56
22_L25_A0.5840.56
278_L287_L0.5830.56
23_A90_V0.5810.55
119_I155_V0.5800.55
116_A132_S0.5800.55
71_L75_G0.5800.55
173_S190_L0.5790.55
108_M194_A0.5770.55
11_I50_Y0.5760.55
26_M83_L0.5740.54
176_I204_G0.5730.54
50_Y227_K0.5720.54
129_G155_V0.5700.54
232_Q255_D0.5700.54
194_A197_I0.5690.54
304_L308_K0.5690.54
292_A302_Q0.5680.54
266_L270_R0.5680.54
136_R140_L0.5660.53
101_I182_D0.5650.53
307_V313_S0.5630.53
115_E254_I0.5620.53
27_T160_S0.5610.53
125_S238_C0.5610.53
74_F77_L0.5600.53
29_V82_G0.5600.53
96_V220_A0.5590.52
172_I225_R0.5590.52
11_I35_R0.5580.52
137_E160_S0.5550.52
230_E265_R0.5520.52
154_T164_V0.5510.51
19_R27_T0.5500.51
150_V293_N0.5500.51
47_I140_L0.5490.51
94_S221_L0.5470.51
267_Q309_N0.5460.51
48_M140_L0.5450.51
186_I220_A0.5450.51
209_N241_L0.5450.51
281_Q318_L0.5440.51
16_Q19_R0.5420.50
150_V316_T0.5410.50
22_L273_Q0.5410.50
160_S204_G0.5410.50
175_Q206_N0.5390.50
263_S292_A0.5380.50
70_F133_Q0.5380.50
69_T202_D0.5370.50
95_P124_S0.5360.49
282_T290_L0.5360.49
90_V135_A0.5360.49
179_G185_G0.5350.49
165_A220_A0.5340.49
100_S182_D0.5330.49
176_I206_N0.5330.49
299_Y303_T0.5320.49
152_V288_N0.5310.49
127_H194_A0.5310.49
130_G155_V0.5310.49
90_V136_R0.5300.49
72_E241_L0.5280.48
185_G204_G0.5280.48
305_L312_L0.5260.48
248_E252_A0.5260.48
94_S155_V0.5250.48
176_I185_G0.5250.48
209_N212_I0.5230.48
55_L170_C0.5220.48
47_I54_T0.5220.48
145_A169_D0.5210.48
298_R302_Q0.5210.48
303_T307_V0.5210.48
300_Y304_L0.5200.47
15_R84_K0.5190.47
35_R46_A0.5190.47
199_I224_L0.5150.47
10_S14_L0.5150.47
94_S192_E0.5150.47
23_A26_M0.5150.47
59_V108_M0.5150.47
19_R37_Q0.5130.47
65_A70_F0.5130.47
31_S164_V0.5120.46
255_D288_N0.5120.46
69_T132_S0.5100.46
60_T225_R0.5100.46
148_D245_G0.5100.46
97_T173_S0.5100.46
205_D242_E0.5060.46
20_A95_P0.5060.46
28_L33_H0.5040.45
37_Q174_L0.5040.45
135_A152_V0.5040.45
150_V257_K0.5040.45
127_H137_E0.5030.45
190_L278_L0.5030.45
77_L250_W0.5010.45
253_I291_F0.5000.45
247_D290_L0.5000.45
166_R276_E0.5000.45
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2wwwA 2 0.9063 100 0.49 Contact Map
2qm8A 2 0.9819 100 0.548 Contact Map
2p67A 2 0.9094 100 0.558 Contact Map
3p32A 2 0.9245 100 0.585 Contact Map
4xc8A 2 0.9728 100 0.673 Contact Map
2j69A 1 0.9577 100 0.735 Contact Map
2wsmA 2 0.6193 99.9 0.797 Contact Map
3t34A 2 0.8338 99.9 0.807 Contact Map
4hi0E 2 0.5559 99.9 0.807 Contact Map
2x2eA 2 0.8671 99.9 0.81 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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