GREMLIN Database
AHR - Aldehyde reductase Ahr
UniProt: P27250 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11436
Length: 339 (302)
Sequences: 52858 (36292)
Seq/√Len: 2088.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
316_K319_D2.9501.00
36_D144_I2.8151.00
34_Q70_V2.7431.00
36_D68_R2.6681.00
32_E70_V2.6061.00
31_V135_V2.5601.00
171_R194_E2.5151.00
189_H214_D2.4851.00
143_D146_S2.4811.00
85_Q137_P2.3491.00
86_R138_L2.3351.00
82_Q85_Q2.3211.00
312_F323_H2.3201.00
206_Q210_A2.2831.00
145_E311_L2.1971.00
34_Q68_R2.1871.00
226_K229_A2.1631.00
23_P127_K2.1611.00
34_Q127_K2.1221.00
177_I197_A2.1061.00
310_E323_H2.0831.00
194_E215_K2.0791.00
65_V123_G2.0621.00
167_T170_S2.0611.00
298_R302_R2.0561.00
205_E209_L2.0501.00
8_A19_Y2.0481.00
172_V188_L2.0471.00
80_G132_W2.0321.00
313_P316_K1.9741.00
311_L336_K1.9631.00
29_Q75_A1.9561.00
28_P74_S1.9421.00
162_L191_M1.9341.00
27_R30_D1.9301.00
185_I213_A1.9211.00
141_N301_A1.8941.00
65_V89_I1.8941.00
28_P75_A1.8671.00
86_R144_I1.8551.00
66_I144_I1.8461.00
25_E71_A1.8421.00
322_Q326_D1.8261.00
154_G183_I1.7591.00
224_A227_A1.7591.00
32_E129_R1.7481.00
170_S257_N1.7461.00
173_G198_F1.7461.00
70_V127_K1.7291.00
49_D325_R1.7271.00
206_Q209_L1.7271.00
202_P206_Q1.7241.00
319_D322_Q1.7231.00
173_G232_F1.7221.00
196_T232_F1.7131.00
162_L295_K1.7041.00
312_F320_A1.6881.00
233_D253_T1.6751.00
190_A304_K1.6521.00
138_L144_I1.6361.00
73_G76_A1.6331.00
199_S205_E1.6241.00
319_D323_H1.6101.00
323_H328_K1.6031.00
252_L258_F1.5931.00
175_I248_Y1.5901.00
205_E216_V1.5861.00
218_N221_D1.5861.00
257_N281_S1.5741.00
202_P218_N1.5411.00
81_L137_P1.5331.00
164_H234_L1.5301.00
194_E214_D1.5021.00
207_E210_A1.4961.00
7_Y317_I1.4951.00
72_L83_V1.4861.00
257_N283_S1.4851.00
5_K20_E1.4821.00
30_D131_D1.4781.00
252_L280_R1.4761.00
145_E336_K1.4661.00
81_L85_Q1.4651.00
32_E127_K1.4501.00
138_L147_A1.4501.00
124_F321_I1.4381.00
71_A83_V1.4371.00
26_L129_R1.4361.00
224_A229_A1.4351.00
252_L256_G1.4341.00
86_R140_E1.4211.00
35_V65_V1.4211.00
202_P221_D1.4041.00
30_D129_R1.3761.00
29_Q131_D1.3631.00
5_K126_E1.3621.00
26_L32_E1.3611.00
68_R86_R1.3601.00
185_I197_A1.3501.00
235_I248_Y1.3471.00
48_I321_I1.3331.00
11_E17_E1.3151.00
235_I252_L1.3141.00
318_N322_Q1.3111.00
69_V81_L1.3101.00
5_K315_S1.3091.00
37_Y145_E1.2951.00
171_R196_T1.2771.00
223_Q226_K1.2761.00
31_V81_L1.2731.00
32_E71_A1.2601.00
6_S21_Y1.2581.00
298_R301_A1.2381.00
175_I198_F1.2351.00
68_R144_I1.2261.00
37_Y336_K1.2261.00
7_Y18_V1.2241.00
158_F162_L1.2181.00
184_A236_I1.2061.00
223_Q227_A1.2011.00
190_A299_F1.1931.00
200_S219_S1.1921.00
77_Q80_G1.1911.00
225_L229_A1.1761.00
209_L216_V1.1691.00
166_I193_C1.1611.00
205_E218_N1.1591.00
81_L135_V1.1591.00
36_D86_R1.1391.00
171_R233_D1.1291.00
26_L30_D1.1211.00
202_P205_E1.1191.00
23_P32_E1.1161.00
35_V128_L1.0841.00
166_I170_S1.0831.00
29_Q132_W1.0831.00
164_H259_H1.0741.00
186_K306_A1.0691.00
130_A135_V1.0681.00
70_V83_V1.0661.00
207_E330_R1.0611.00
11_E15_E1.0611.00
295_K298_R1.0561.00
33_V67_G1.0541.00
317_I335_L1.0461.00
197_A213_A1.0451.00
48_I325_R1.0391.00
146_S306_A1.0391.00
7_Y314_M1.0341.00
225_L228_L1.0321.00
209_L215_K1.0291.00
76_A80_G1.0281.00
40_I320_A1.0261.00
250_E274_T1.0231.00
299_F304_K1.0131.00
163_M281_S1.0121.00
170_S233_D1.0111.00
142_I147_A1.0031.00
37_Y144_I0.9991.00
12_A15_E0.9931.00
33_V87_V0.9921.00
196_T215_K0.9921.00
157_V187_L0.9921.00
18_V315_S0.9911.00
224_A228_L0.9901.00
313_P336_K0.9881.00
294_R298_R0.9781.00
12_A57_Y0.9761.00
157_V184_A0.9731.00
36_D66_I0.9721.00
239_V244_D0.9661.00
38_C124_F0.9601.00
323_H333_V0.9571.00
124_F317_I0.9541.00
41_C64_E0.9511.00
200_S205_E0.9461.00
8_A21_Y0.9461.00
41_C63_H0.9401.00
8_A60_V0.9381.00
160_P261_V0.9341.00
72_L76_A0.9321.00
38_C123_G0.9211.00
154_G296_L0.9201.00
37_Y334_V0.9181.00
188_L193_C0.9151.00
174_V184_A0.9131.00
177_I199_S0.9131.00
237_N240_N0.9031.00
196_T217_V0.9021.00
200_S220_R0.9021.00
246_Q250_E0.8991.00
23_P71_A0.8981.00
185_I195_V0.8971.00
322_Q325_R0.8931.00
34_Q126_E0.8881.00
174_V188_L0.8871.00
76_A132_W0.8861.00
29_Q73_G0.8841.00
77_Q132_W0.8831.00
158_F295_K0.8811.00
59_L121_R0.8801.00
25_E32_E0.8781.00
201_N204_K0.8781.00
45_L324_V0.8741.00
177_I208_V0.8721.00
198_F219_S0.8711.00
6_S60_V0.8681.00
274_T278_G0.8671.00
82_Q137_P0.8671.00
175_I235_I0.8631.00
150_L300_A0.8621.00
275_L282_V0.8601.00
187_L296_L0.8601.00
146_S308_T0.8571.00
124_F335_L0.8561.00
222_P227_A0.8541.00
203_A206_Q0.8521.00
182_H207_E0.8521.00
177_I185_I0.8511.00
39_G64_E0.8481.00
199_S216_V0.8481.00
247_P250_E0.8451.00
171_R232_F0.8421.00
324_V333_V0.8411.00
160_P236_I0.8401.00
23_P70_V0.8361.00
173_G251_A0.8341.00
163_M283_S0.8281.00
65_V128_L0.8271.00
21_Y121_R0.8251.00
5_K18_V0.8241.00
162_L292_E0.8171.00
201_N218_N0.8141.00
255_G279_D0.8121.00
197_A208_V0.8121.00
295_K299_F0.8081.00
88_G297_M0.8011.00
204_K330_R0.7971.00
29_Q74_S0.7971.00
223_Q229_A0.7951.00
170_S234_L0.7911.00
7_Y16_L0.7911.00
208_V213_A0.7831.00
7_Y318_N0.7831.00
161_L188_L0.7801.00
312_F316_K0.7791.00
40_I324_V0.7781.00
157_V183_I0.7601.00
40_I124_F0.7571.00
11_E14_G0.7561.00
160_P184_A0.7551.00
27_R129_R0.7541.00
162_L187_L0.7531.00
140_E301_A0.7481.00
172_V193_C0.7471.00
248_Y258_F0.7471.00
187_L299_F0.7471.00
18_V314_M0.7451.00
157_V180_L0.7441.00
222_P229_A0.7441.00
191_M295_K0.7421.00
166_I234_L0.7421.00
72_L82_Q0.7421.00
215_K228_L0.7411.00
275_L280_R0.7401.00
188_L195_V0.7391.00
235_I258_F0.7391.00
89_I130_A0.7361.00
222_P226_K0.7361.00
41_C44_D0.7361.00
87_V135_V0.7351.00
142_I300_A0.7341.00
159_K279_D0.7261.00
41_C152_C0.7231.00
299_F302_R0.7221.00
171_R230_G0.7221.00
323_H326_D0.7211.00
43_S63_H0.7201.00
31_V132_W0.7191.00
26_L71_A0.7191.00
21_Y60_V0.7191.00
310_E333_V0.7171.00
26_L73_G0.7161.00
64_E152_C0.7141.00
195_V214_D0.7141.00
136_I294_R0.7141.00
175_I244_D0.7121.00
299_F303_S0.7121.00
230_G253_T0.7121.00
329_A333_V0.7081.00
271_P274_T0.7051.00
310_E319_D0.7031.00
232_F235_I0.7031.00
275_L284_G0.7001.00
165_H257_N0.6931.00
86_R141_N0.6871.00
136_I293_L0.6851.00
174_V197_A0.6831.00
199_S208_V0.6821.00
123_G128_L0.6821.00
88_G138_L0.6801.00
139_P301_A0.6791.00
238_T261_V0.6751.00
234_L259_H0.6751.00
157_V161_L0.6711.00
246_Q267_P0.6691.00
156_T180_L0.6691.00
158_F296_L0.6641.00
136_I297_M0.6631.00
63_H152_C0.6621.00
205_E208_V0.6621.00
66_I148_G0.6601.00
80_G137_P0.6601.00
193_C234_L0.6601.00
312_F333_V0.6571.00
165_H283_S0.6561.00
210_A306_A0.6561.00
260_T282_V0.6541.00
159_K292_E0.6521.00
297_M301_A0.6501.00
321_I325_R0.6501.00
312_F335_L0.6491.00
158_F299_F0.6471.00
31_V69_V0.6441.00
88_G151_L0.6441.00
143_D147_A0.6421.00
85_Q140_E0.6411.00
41_C153_G0.6411.00
245_W258_F0.6401.00
66_I138_L0.6401.00
232_F251_A0.6381.00
33_V89_I0.6361.00
254_Y278_G0.6321.00
36_D336_K0.6291.00
42_H46_S0.6281.00
153_G179_G0.6281.00
152_C156_T0.6281.00
24_G129_R0.6281.00
293_L297_M0.6251.00
199_S219_S0.6231.00
37_Y311_L0.6231.00
29_Q133_Q0.6221.00
66_I86_R0.6191.00
80_G83_V0.6151.00
37_Y66_I0.6141.00
186_K211_M0.6121.00
189_H195_V0.6111.00
207_E211_M0.6091.00
237_N258_F0.6081.00
185_I211_M0.6071.00
205_E219_S0.6071.00
149_P334_V0.6041.00
207_E308_T0.6041.00
182_H308_T0.6031.00
43_S47_M0.6021.00
222_P247_P0.6021.00
77_Q81_L0.6011.00
246_Q274_T0.6001.00
187_L191_M0.5991.00
198_F217_V0.5981.00
90_G136_I0.5971.00
11_E19_Y0.5951.00
184_A261_V0.5931.00
164_H257_N0.5921.00
235_I251_A0.5901.00
35_V38_C0.5881.00
234_L257_N0.5871.00
241_V244_D0.5861.00
55_S59_L0.5841.00
172_V234_L0.5831.00
246_Q269_S0.5831.00
89_I135_V0.5811.00
165_H281_S0.5801.00
58_P62_G0.5791.00
23_P26_L0.5761.00
24_G127_K0.5761.00
300_A307_P0.5751.00
46_S51_E0.5751.00
199_S218_N0.5741.00
237_N262_G0.5741.00
156_T261_V0.5721.00
42_H178_G0.5691.00
24_G32_E0.5691.00
221_D224_A0.5651.00
26_L75_A0.5651.00
13_G48_I0.5651.00
244_D248_Y0.5641.00
45_L325_R0.5621.00
279_D289_T0.5581.00
62_G124_F0.5561.00
33_V135_V0.5561.00
200_S218_N0.5551.00
153_G183_I0.5551.00
242_S246_Q0.5551.00
300_A305_V0.5541.00
23_P129_R0.5541.00
43_S46_S0.5531.00
72_L85_Q0.5501.00
168_A192_G0.5491.00
185_I208_V0.5491.00
160_P285_S0.5491.00
267_P271_P0.5471.00
149_P307_P0.5461.00
38_C335_L0.5441.00
132_W135_V0.5441.00
323_H329_A0.5431.00
66_I147_A0.5421.00
12_A50_N0.5411.00
35_V123_G0.5411.00
161_L187_L0.5381.00
213_A216_V0.5371.00
41_C332_R0.5361.00
171_R231_Q0.5341.00
173_G235_I0.5341.00
259_H285_S0.5301.00
81_L132_W0.5281.00
189_H213_A0.5271.00
35_V89_I0.5271.00
60_V122_G0.5261.00
16_L321_I0.5251.00
183_I187_L0.5241.00
144_I147_A0.5241.00
303_S306_A0.5241.00
215_K227_A0.5211.00
24_G30_D0.5201.00
231_Q253_T0.5191.00
222_P250_E0.5171.00
9_A16_L0.5171.00
45_L49_D0.5171.00
199_S204_K0.5171.00
56_Q59_L0.5141.00
40_I335_L0.5141.00
72_L81_L0.5131.00
312_F319_D0.5121.00
9_A48_I0.5111.00
33_V65_V0.5111.00
22_D25_E0.5101.00
77_Q82_Q0.5091.00
222_P225_L0.5091.00
47_M52_W0.5091.00
89_I128_L0.5081.00
290_P294_R0.5081.00
138_L142_I0.5081.00
158_F191_M0.5081.00
72_L80_G0.5081.00
225_L232_F0.5061.00
165_H170_S0.5061.00
18_V317_I0.5051.00
26_L29_Q0.5041.00
151_L293_L0.5031.00
186_K305_V0.5021.00
143_D311_L0.5021.00
248_Y252_L0.5001.00
168_A191_M0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1h2bA 4 0.9705 100 0.135 Contact Map
3twoA 2 0.9735 100 0.145 Contact Map
1rjwA 4 0.9823 100 0.146 Contact Map
4oaqA 2 0.9941 100 0.148 Contact Map
2h6eA 4 0.9174 100 0.149 Contact Map
4c4oA 4 0.9705 100 0.15 Contact Map
3s2eA 5 0.9912 100 0.154 Contact Map
1uufA 2 0.9617 100 0.154 Contact Map
4gkvA 4 0.9794 100 0.157 Contact Map
1yqdA 2 0.9941 100 0.159 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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