GREMLIN Database
GLND - Bifunctional uridylyltransferase/uridylyl-removing enzyme
UniProt: P27249 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11411
Length: 890 (830)
Sequences: 1191 (806)
Seq/√Len: 28.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
578_A621_T7.4191.00
517_A527_L5.5221.00
583_T586_R5.3211.00
69_D95_Y4.6861.00
536_A549_V4.6491.00
568_I574_I4.5831.00
301_Y315_D4.5631.00
671_Y683_H4.4141.00
363_L399_Q4.3261.00
817_L860_I4.2281.00
666_R745_D3.9861.00
88_A167_L3.9611.00
268_I272_I3.9271.00
475_V600_A3.7871.00
351_D378_R3.7531.00
526_I554_R3.7471.00
147_E150_L3.7421.00
151_E154_S3.7251.00
819_L831_V3.6961.00
555_Q580_E3.5331.00
146_E181_H3.4861.00
559_M577_F3.4331.00
868_L876_V3.4181.00
165_S175_F3.3691.00
376_I400_L3.3581.00
353_E378_R3.2701.00
90_V175_F3.2361.00
503_S545_E3.2051.00
802_T821_A3.2021.00
527_L531_D3.1211.00
461_D521_G3.1021.00
66_E98_G3.0871.00
722_A832_G3.0531.00
379_M400_L3.0341.00
649_L681_A2.9551.00
450_Q538_L2.9531.00
426_R505_E2.9501.00
197_K200_E2.9101.00
555_Q558_L2.9091.00
439_H455_V2.8721.00
529_A554_R2.8441.00
588_R618_Y2.7951.00
680_L684_A2.7681.00
558_L580_E2.6611.00
272_I312_M2.6500.99
51_F54_G2.5900.99
379_M392_I2.5410.99
532_V536_A2.5150.99
447_Y539_H2.4980.99
218_D221_S2.4720.99
201_Q327_N2.4510.99
92_V141_S2.4310.99
511_A596_A2.4280.99
532_V549_V2.3790.99
472_T476_M2.3710.99
109_L148_C2.3200.99
380_F438_M2.3200.99
559_M614_L2.3160.99
100_L106_V2.2860.98
710_I754_V2.2410.98
531_D535_F2.2170.98
479_L511_A2.1850.98
416_E419_K2.1820.98
536_A541_L2.1780.98
432_R436_L2.1710.98
542_N545_E2.1560.98
72_L89_L2.1490.98
435_L476_M2.1410.98
537_E546_T2.1380.98
726_A829_A2.1280.98
824_Q830_R2.1180.97
303_G308_P2.1130.97
529_A550_A2.1100.97
548_L589_Y2.1040.97
68_I106_V2.1000.97
817_L876_V2.0920.97
317_F460_F2.0880.97
66_E70_Q2.0720.97
533_V550_A2.0530.97
422_L426_R2.0310.97
137_E283_Y2.0140.96
517_A531_D2.0090.96
374_E417_A1.9960.96
280_V291_R1.9680.96
355_Q362_D1.9660.96
101_H270_W1.9490.96
375_A378_R1.9350.96
280_V284_D1.9340.96
215_L462_L1.9290.95
75_L130_L1.9260.95
172_V176_L1.9260.95
376_I379_M1.8940.95
506_L549_V1.8690.95
418_R447_Y1.8580.94
316_Y320_T1.8340.94
445_G452_S1.8200.94
513_F538_L1.8180.94
448_M509_I1.8020.93
365_D371_R1.8020.93
407_L411_L1.7880.93
350_I361_I1.7820.93
407_L443_V1.7820.93
577_F621_T1.7770.93
109_L826_G1.7770.93
261_E568_I1.7740.93
482_F596_A1.7710.93
677_P681_A1.7680.93
357_R362_D1.7660.93
646_A664_W1.7660.93
67_F71_L1.7560.93
733_L754_V1.7530.93
559_M621_T1.7520.92
218_D285_N1.7330.92
167_L172_V1.7270.92
116_L120_Q1.7250.92
303_G307_E1.7240.92
716_D720_L1.7150.92
177_E181_H1.7130.92
353_E375_A1.7120.92
566_R576_Q1.7000.91
584_E622_E1.6980.91
409_Q413_N1.6970.91
379_M396_T1.6870.91
475_V511_A1.6710.91
656_D659_A1.6700.91
381_Y427_H1.6690.91
515_D556_H1.6630.90
167_L175_F1.6580.90
717_R723_A1.6520.90
365_D368_L1.6480.90
299_L312_M1.6300.89
146_E150_L1.6300.89
536_A546_T1.6120.89
802_T806_F1.6030.89
361_I382_T1.5980.88
584_E588_R1.5950.88
724_V752_F1.5920.88
367_T371_R1.5900.88
647_L660_L1.5830.88
874_Q877_H1.5820.88
503_S506_L1.5770.88
683_H751_T1.5760.88
381_Y423_S1.5690.88
518_K528_G1.5670.87
574_I616_E1.5640.87
110_I127_L1.5600.87
713_W747_M1.5590.87
725_C735_V1.5570.87
384_V424_I1.5450.87
114_K150_L1.5440.87
219_I272_I1.5300.86
712_I724_V1.5290.86
378_R382_T1.5290.86
520_R527_L1.5280.86
181_H185_E1.5180.86
407_L412_C1.5070.85
411_L417_A1.4980.85
777_V780_Q1.4940.85
363_L369_F1.4900.85
450_Q513_F1.4880.85
193_F197_K1.4860.84
517_A550_A1.4830.84
533_V546_T1.4810.84
490_R599_C1.4800.84
716_D748_A1.4770.84
381_Y385_H1.4760.84
710_I728_L1.4760.84
376_I443_V1.4720.84
144_T230_H1.4700.84
212_S470_E1.4700.84
517_A520_R1.4630.84
454_I621_T1.4630.84
602_N605_L1.4540.83
199_E203_Q1.4490.83
61_I101_H1.4450.83
588_R622_E1.4430.83
215_L846_R1.4400.83
515_D518_K1.4390.82
629_M632_T1.4380.82
862_T872_L1.4370.82
518_K556_H1.4360.82
877_H881_T1.4360.82
350_I382_T1.4310.82
509_I513_F1.4210.82
361_I383_M1.4150.81
716_D750_D1.4110.81
874_Q878_Q1.4070.81
806_F873_Q1.4050.81
171_D176_L1.4030.81
111_L174_L1.4020.81
461_D522_G1.3990.81
60_L64_R1.3990.81
647_L661_H1.3970.81
85_A122_Q1.3950.80
716_D742_T1.3950.80
450_Q517_A1.3870.80
72_L108_L1.3870.80
511_A601_T1.3840.80
515_D524_H1.3840.80
408_Q411_L1.3830.80
524_H556_H1.3820.80
806_F817_L1.3790.80
559_M581_V1.3780.80
279_V295_V1.3750.79
258_E398_R1.3720.79
151_E158_V1.3710.79
837_D879_R1.3700.79
459_Q613_L1.3670.79
93_G107_D1.3610.79
702_Q705_R1.3580.79
584_E626_R1.3570.79
508_F671_Y1.3530.78
475_V478_K1.3480.78
498_W508_F1.3480.78
294_S297_Q1.3480.78
356_L390_T1.3410.78
111_L141_S1.3350.77
839_G863_A1.3350.77
72_L106_V1.3320.77
833_K837_D1.3300.77
115_K121_A1.3150.76
465_A604_T1.3120.76
65_T152_G1.3120.76
236_A330_L1.3070.76
840_I860_I1.3060.76
682_W700_S1.3040.76
519_G593_L1.3000.75
740_I748_A1.2990.75
683_H750_D1.2920.75
139_G143_R1.2910.75
659_A688_L1.2890.75
611_Q615_R1.2790.74
505_E545_E1.2770.74
552_L593_L1.2760.74
460_F725_C1.2730.74
143_R148_C1.2710.74
351_D382_T1.2690.74
834_I880_L1.2650.73
108_L138_V1.2600.73
358_G712_I1.2580.73
478_K481_S1.2540.73
552_L609_W1.2480.72
261_E322_R1.2460.72
384_V427_H1.2440.72
530_Q554_R1.2420.72
104_S107_D1.2390.72
93_G105_D1.2350.72
624_Q629_M1.2340.72
520_R531_D1.2330.71
303_G311_R1.2310.71
698_L771_R1.2290.71
422_L541_L1.2290.71
75_L683_H1.2280.71
462_L852_E1.2280.71
64_R278_L1.2270.71
524_H849_T1.2270.71
71_L106_V1.2240.71
87_L526_I1.2240.71
76_W89_L1.2150.70
110_I842_L1.2140.70
376_I406_H1.2140.70
680_L771_R1.2140.70
776_Q781_S1.2100.70
432_R477_L1.2090.70
824_Q827_L1.2030.70
403_A406_H1.2020.69
712_I877_H1.1990.69
533_V547_Q1.1990.69
291_R295_V1.1980.69
385_H427_H1.1980.69
359_T390_T1.1940.69
276_L291_R1.1890.69
535_F539_H1.1840.68
93_G104_S1.1800.68
396_T699_L1.1770.68
372_Q375_A1.1760.68
808_P867_A1.1740.68
838_L879_R1.1680.67
736_H755_L1.1680.67
518_K524_H1.1650.67
493_L497_V1.1640.67
514_H556_H1.1630.67
91_A96_G1.1610.67
376_I399_Q1.1590.67
88_A281_S1.1560.66
558_L562_T1.1540.66
73_Q168_L1.1540.66
560_S598_I1.1530.66
361_I379_M1.1510.66
621_T625_L1.1510.66
418_R538_L1.1470.66
244_S308_P1.1430.66
483_A504_T1.1410.65
235_V331_L1.1350.65
432_R480_E1.1330.65
406_H451_W1.1320.65
575_K579_E1.1310.65
175_F854_V1.1300.65
349_P364_R1.1280.64
840_I876_V1.1240.64
280_V303_G1.1220.64
321_R439_H1.1220.64
215_L797_H1.1220.64
86_D113_R1.1210.64
459_Q607_N1.1190.64
548_L646_A1.1190.64
372_Q378_R1.1190.64
464_H515_D1.1180.64
464_H556_H1.1150.64
140_H825_P1.1150.64
313_M317_F1.1150.64
470_E610_K1.1130.63
751_T841_S1.1120.63
497_V592_C1.1120.63
397_L441_H1.1110.63
382_T517_A1.1080.63
200_E564_Q1.1050.63
163_I425_L1.1040.63
271_R315_D1.1040.63
90_V165_S1.1030.63
208_Y735_V1.1020.63
244_S247_E1.0980.62
634_D854_V1.0980.62
231_T235_V1.0980.62
415_P419_K1.0940.62
376_I403_A1.0930.62
197_K564_Q1.0930.62
445_G455_V1.0900.62
871_E874_Q1.0900.62
624_Q631_N1.0890.62
103_L281_S1.0880.62
565_R608_S1.0850.61
521_G527_L1.0850.61
469_D594_T1.0850.61
472_T600_A1.0840.61
573_V844_G1.0840.61
860_I865_R1.0820.61
125_G129_T1.0800.61
566_R818_E1.0770.61
517_A573_V1.0740.61
65_T98_G1.0730.61
483_A498_W1.0720.60
64_R124_V1.0720.60
193_F200_E1.0700.60
443_V559_M1.0680.60
147_E769_V1.0640.60
270_W615_R1.0620.60
61_I215_L1.0600.60
400_L403_A1.0570.59
279_V294_S1.0570.59
209_H214_N1.0570.59
114_K121_A1.0560.59
64_R68_I1.0500.59
448_M734_S1.0480.59
233_Q237_R1.0480.59
348_R356_L1.0460.59
173_A176_L1.0460.59
271_R275_A1.0420.58
327_N331_L1.0410.58
626_R629_M1.0400.58
520_R523_D1.0400.58
384_V400_L1.0380.58
361_I429_G1.0370.58
572_E576_Q1.0370.58
168_L359_T1.0360.58
167_L259_R1.0340.58
152_G187_F1.0340.58
450_Q531_D1.0330.58
289_F458_M1.0320.57
65_T168_L1.0300.57
618_Y643_Q1.0290.57
516_I520_R1.0250.57
472_T475_V1.0250.57
740_I750_D1.0250.57
102_P278_L1.0220.57
499_P712_I1.0220.57
810_H816_F1.0210.57
519_G613_L1.0200.57
313_M467_T1.0190.56
583_T630_Q1.0160.56
117_P120_Q1.0160.56
862_T866_R1.0140.56
280_V868_L1.0120.56
328_Q440_R1.0060.56
412_C451_W1.0060.56
164_E248_M1.0050.55
859_I867_A1.0040.55
138_V231_T1.0030.55
203_Q658_E1.0020.55
422_L505_E1.0010.55
73_Q734_S1.0000.55
430_A480_E0.9930.55
82_S122_Q0.9920.54
500_R588_R0.9920.54
149_M182_I0.9920.54
450_Q509_I0.9910.54
566_R859_I0.9900.54
99_E230_H0.9900.54
96_G105_D0.9890.54
643_Q647_L0.9880.54
127_L130_L0.9880.54
207_R218_D0.9870.54
265_C323_V0.9870.54
237_R249_V0.9840.54
448_M512_L0.9840.54
494_C595_V0.9830.54
459_Q593_L0.9830.54
153_L574_I0.9810.54
225_G316_Y0.9800.54
400_L443_V0.9800.54
421_F447_Y0.9780.53
719_Y770_I0.9770.53
578_A625_L0.9770.53
516_I524_H0.9720.53
309_V460_F0.9710.53
97_R105_D0.9710.53
828_L856_D0.9710.53
481_S490_R0.9700.53
61_I270_W0.9690.53
459_Q516_I0.9670.53
284_D739_Q0.9660.52
470_E474_R0.9640.52
318_R442_S0.9630.52
505_E672_F0.9630.52
482_F494_C0.9630.52
827_L854_V0.9620.52
532_V551_W0.9610.52
392_I396_T0.9600.52
190_S238_R0.9600.52
124_V454_I0.9590.52
106_V486_E0.9560.52
147_E625_L0.9540.52
214_N829_A0.9490.51
309_V312_M0.9460.51
773_G777_V0.9450.51
601_T672_F0.9430.51
173_A574_I0.9420.51
514_H518_K0.9400.50
563_A848_T0.9400.50
679_Q709_E0.9400.50
162_L178_L0.9380.50
125_G219_I0.9340.50
425_L431_V0.9320.50
239_H334_F0.9310.50
286_R853_R0.9290.50
591_V614_L0.9290.50
275_A298_R0.9280.50
162_L285_N0.9280.50
122_Q126_E0.9280.50
800_V852_E0.9270.49
376_I840_I0.9250.49
144_T857_L0.9220.49
94_G97_R0.9210.49
476_M508_F0.9200.49
533_V537_E0.9190.49
259_R263_N0.9180.49
212_S324_S0.9170.49
516_I525_S0.9170.49
203_Q206_Q0.9150.49
450_Q534_H0.9130.48
523_D581_V0.9130.48
463_F601_T0.9130.48
481_S495_V0.9120.48
461_D527_L0.9100.48
458_M737_D0.9090.48
463_F475_V0.9090.48
568_I751_T0.9060.48
611_Q848_T0.9060.48
515_D528_G0.9060.48
177_E180_K0.9060.48
754_V792_P0.9060.48
445_G451_W0.9050.48
802_T884_L0.9040.48
528_G556_H0.9030.48
380_F798_F0.9030.48
876_V880_L0.9030.48
640_R643_Q0.8990.47
464_H518_K0.8980.47
771_R775_E0.8970.47
301_Y308_P0.8950.47
316_Y369_F0.8950.47
316_Y467_T0.8940.47
165_S178_L0.8930.47
85_A119_D0.8910.47
114_K117_P0.8910.47
481_S486_E0.8900.47
624_Q630_Q0.8900.47
361_I371_R0.8900.47
179_Q574_I0.8890.47
516_I535_F0.8890.47
408_Q412_C0.8880.46
804_V880_L0.8880.46
476_M558_L0.8870.46
472_T529_A0.8850.46
131_L138_V0.8840.46
157_T197_K0.8800.46
717_R781_S0.8790.46
362_D396_T0.8780.46
134_V305_G0.8770.46
750_D852_E0.8750.45
448_M754_V0.8750.45
514_H524_H0.8720.45
299_L416_E0.8720.45
92_V109_L0.8710.45
445_G453_H0.8710.45
427_H806_F0.8700.45
572_E882_E0.8700.45
218_D280_V0.8670.45
501_L600_A0.8660.45
103_L509_I0.8650.45
468_V560_S0.8650.45
682_W698_L0.8630.45
237_R323_V0.8620.45
80_G114_K0.8620.45
269_L559_M0.8620.45
575_K624_Q0.8610.44
88_A153_L0.8590.44
362_D393_Y0.8590.44
235_V242_A0.8550.44
573_V607_N0.8550.44
641_H645_Q0.8540.44
306_N457_Q0.8530.44
420_L423_S0.8530.44
608_S704_T0.8530.44
135_K473_I0.8500.44
150_L154_S0.8500.44
746_G801_E0.8500.44
317_F467_T0.8490.44
675_H679_Q0.8490.44
820_I853_R0.8470.43
215_L852_E0.8470.43
56_S62_E0.8450.43
601_T855_E0.8450.43
121_A125_G0.8440.43
287_L568_I0.8430.43
464_H524_H0.8400.43
137_E235_V0.8390.43
505_E511_A0.8370.43
435_L451_W0.8360.43
377_L420_L0.8360.43
96_G107_D0.8320.42
515_D557_L0.8320.42
808_P815_S0.8320.42
85_A115_K0.8310.42
164_E458_M0.8310.42
611_Q865_R0.8300.42
667_C743_T0.8290.42
317_F551_W0.8240.42
351_D354_F0.8240.42
683_H884_L0.8200.41
576_Q874_Q0.8180.41
878_Q882_E0.8180.41
284_D291_R0.8180.41
230_H847_I0.8170.41
117_P121_A0.8160.41
232_L248_M0.8160.41
329_M334_F0.8160.41
677_P751_T0.8150.41
475_V497_V0.8150.41
591_V876_V0.8150.41
568_I766_R0.8150.41
301_Y319_V0.8140.41
338_I860_I0.8140.41
837_D871_E0.8140.41
720_L804_V0.8140.41
290_D563_A0.8120.41
560_S564_Q0.8120.41
131_L449_P0.8120.41
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414_I417_A0.5300.22
286_R522_G0.5300.22
200_E326_L0.5300.22
73_Q365_D0.5300.22
354_F373_P0.5300.22
197_K462_L0.5290.22
751_T854_V0.5290.22
502_P585_N0.5290.22
55_I59_Q0.5290.22
790_R795_L0.5290.22
363_L368_L0.5290.22
249_V825_P0.5280.22
147_E430_A0.5280.22
99_E164_E0.5280.22
520_R525_S0.5270.22
89_L530_Q0.5270.22
775_E779_T0.5270.22
281_S640_R0.5270.22
387_S867_A0.5270.22
653_D660_L0.5260.22
128_L586_R0.5260.22
357_R395_T0.5250.22
475_V601_T0.5250.22
158_V361_I0.5250.22
149_M185_E0.5250.22
230_H630_Q0.5250.22
65_T345_E0.5250.22
454_I468_V0.5240.22
115_K302_S0.5240.22
219_I356_L0.5240.22
783_W786_P0.5240.22
746_G871_E0.5220.22
190_S755_L0.5220.22
106_V138_V0.5220.22
430_A443_V0.5220.22
493_L884_L0.5210.22
99_E710_I0.5210.22
87_L776_Q0.5210.22
624_Q665_S0.5210.22
502_P838_L0.5200.22
349_P691_D0.5200.22
70_Q73_Q0.5190.22
599_C723_A0.5190.22
417_A460_F0.5190.22
391_G517_A0.5190.22
648_A868_L0.5180.22
702_Q709_E0.5180.22
325_E457_Q0.5170.22
70_Q110_I0.5170.22
197_K598_I0.5170.22
363_L821_A0.5170.22
330_L425_L0.5170.22
794_K869_N0.5170.22
232_L393_Y0.5170.22
284_D713_W0.5160.22
154_S346_K0.5160.22
84_I361_I0.5160.22
782_S788_P0.5160.22
442_S845_A0.5160.22
786_P789_R0.5150.22
143_R606_W0.5150.22
721_F752_F0.5140.22
772_F775_E0.5140.22
314_K457_Q0.5140.22
314_K751_T0.5140.22
638_R642_H0.5130.22
724_V741_F0.5130.22
99_E522_G0.5120.22
591_V595_V0.5120.22
154_S740_I0.5110.21
648_A779_T0.5110.21
313_M456_G0.5110.21
108_L379_M0.5110.21
475_V796_R0.5090.21
850_I853_R0.5090.21
152_G678_N0.5080.21
64_R318_R0.5080.21
80_G122_Q0.5080.21
135_K400_L0.5080.21
113_R334_F0.5070.21
602_N688_L0.5070.21
674_R751_T0.5070.21
490_R804_V0.5060.21
732_N736_H0.5060.21
165_S317_F0.5050.21
63_A425_L0.5050.21
573_V855_E0.5040.21
290_D607_N0.5040.21
108_L131_L0.5030.21
140_H586_R0.5030.21
829_A853_R0.5030.21
110_I219_I0.5030.21
549_V626_R0.5020.21
208_Y592_C0.5020.21
694_K870_N0.5020.21
138_V232_L0.5010.21
522_G721_F0.5010.21
98_G202_N0.5000.21
110_I718_P0.5000.21
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1v4aA 1 0.3618 100 0.818 Contact Map
3wfpA 2 0.4494 100 0.838 Contact Map
3wfrE 1 0.4506 100 0.838 Contact Map
3wfsC 1 0.4416 100 0.84 Contact Map
3k7dA 2 0.3449 100 0.854 Contact Map
3wfoA 1 0.4494 100 0.858 Contact Map
4wbyA 1 0.3966 100 0.89 Contact Map
3aqlA 2 0.4247 100 0.901 Contact Map
3h38A 1 0.4607 100 0.905 Contact Map
1miwA 2 0.4225 99.9 0.916 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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