GREMLIN Database
GCST - Aminomethyltransferase
UniProt: P27248 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11442
Length: 364 (348)
Sequences: 6997 (4595)
Seq/√Len: 246.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
151_N154_A3.7171.00
10_Q209_R3.6971.00
285_V323_Y3.2541.00
297_P308_H3.1561.00
245_S273_Q3.1281.00
44_A155_K3.1031.00
56_D108_F2.9691.00
339_I346_E2.6911.00
272_V276_H2.6771.00
298_V328_A2.6031.00
8_Y12_T2.5921.00
12_T18_M2.5561.00
43_D151_N2.5201.00
38_H42_T2.4851.00
284_L326_A2.4741.00
143_S204_A2.4711.00
61_R64_E2.3871.00
337_T348_P2.3401.00
58_R108_F2.2531.00
45_G219_C2.2241.00
287_T350_K2.2201.00
13_L209_R2.1781.00
341_Q346_E2.1241.00
40_V45_G2.1231.00
285_V350_K2.0941.00
67_R73_D2.0731.00
238_Q294_N2.0671.00
295_E311_I2.0571.00
69_L125_I2.0431.00
299_R346_E2.0331.00
341_Q344_N2.0131.00
80_S103_Y2.0081.00
9_E13_L1.9851.00
339_I348_P1.9851.00
318_S321_L1.9671.00
263_D267_R1.9551.00
337_T350_K1.9541.00
9_E12_T1.9511.00
39_A43_D1.8741.00
338_A349_V1.8721.00
158_T214_A1.8381.00
267_R271_E1.8301.00
10_Q14_C1.8131.00
200_P203_K1.8091.00
309_E334_I1.8031.00
4_Q25_M1.7961.00
55_V122_L1.7911.00
63_R109_F1.7301.00
39_A217_K1.7301.00
203_K206_D1.7251.00
9_E205_A1.7241.00
10_Q13_L1.7001.00
105_T108_F1.6921.00
56_D137_T1.6721.00
312_I326_A1.6591.00
307_Q331_P1.6511.00
268_E271_E1.6351.00
38_H320_T1.6301.00
11_H30_Y1.6091.00
166_Q170_G1.6031.00
122_L126_T1.5851.00
4_Q8_Y1.5791.00
124_W128_H1.5631.00
58_R137_T1.5551.00
155_K216_V1.5461.00
205_A209_R1.5441.00
282_V330_V1.5401.00
199_L207_F1.5301.00
297_P341_Q1.5121.00
61_R133_G1.5071.00
63_R103_Y1.5051.00
60_S133_G1.4901.00
176_G181_D1.4861.00
83_A100_I1.4851.00
208_W218_P1.4801.00
299_R308_H1.4641.00
14_C218_P1.4641.00
55_V113_V1.4641.00
340_V349_V1.4481.00
178_Q210_A1.4321.00
168_V171_M1.4211.00
37_H226_T1.4181.00
162_D165_R1.4181.00
87_G254_T1.4151.00
46_M212_V1.4121.00
46_M145_I1.4111.00
6_P143_S1.4101.00
248_A279_E1.4091.00
210_A213_E1.4051.00
299_R341_Q1.4051.00
71_A89_L1.4051.00
143_S201_N1.4001.00
70_L86_S1.3931.00
69_L128_H1.3901.00
104_F108_F1.3891.00
167_A170_G1.3881.00
70_L101_V1.3881.00
123_S127_Q1.3871.00
284_L328_A1.3831.00
43_D217_K1.3821.00
58_R135_E1.3751.00
129_A136_I1.3551.00
90_N242_E1.3451.00
327_L354_P1.3431.00
180_G203_K1.3311.00
247_L257_W1.3301.00
147_V156_A1.3191.00
16_A26_M1.3171.00
56_D138_V1.3111.00
159_L211_L1.2991.00
7_L145_I1.2931.00
229_L316_T1.2931.00
331_P334_I1.2911.00
63_R75_A1.2881.00
10_Q205_A1.2881.00
57_L111_L1.2821.00
177_V182_L1.2801.00
317_F322_G1.2761.00
263_D268_E1.2761.00
87_G251_M1.2571.00
154_A157_A1.2531.00
19_V28_L1.2471.00
74_V101_V1.2421.00
62_T109_F1.2411.00
244_I329_R1.2401.00
298_V340_V1.2391.00
249_A329_R1.2261.00
80_S106_E1.2221.00
87_G95_V1.2121.00
111_L125_I1.2081.00
137_T141_D1.2031.00
103_Y106_E1.1991.00
67_R75_A1.1951.00
247_L270_L1.1841.00
284_L349_V1.1811.00
8_Y25_M1.1791.00
336_E351_V1.1781.00
247_L278_T1.1671.00
268_E272_V1.1641.00
306_N346_E1.1561.00
287_T348_P1.1541.00
80_S105_T1.1531.00
120_K242_E1.1471.00
206_D210_A1.1381.00
229_L314_S1.1331.00
248_A273_Q1.1311.00
175_F184_I1.1231.00
330_V338_A1.1221.00
228_R314_S1.1161.00
274_R277_G1.1111.00
199_L204_A1.1061.00
153_Q193_A1.0981.00
38_H322_G1.0951.00
138_V142_L1.0921.00
119_E123_S1.0911.00
241_D244_I1.0901.00
4_Q9_E1.0881.00
44_A216_V1.0851.00
166_Q169_E1.0771.00
262_R267_R1.0751.00
65_F125_I1.0721.00
32_S35_D1.0701.00
88_M125_I1.0691.00
124_W265_I1.0681.00
128_H265_I1.0661.00
65_F134_I1.0591.00
269_A273_Q1.0541.00
160_F163_A1.0531.00
299_R306_N1.0511.00
257_W274_R1.0471.00
285_V352_T1.0391.00
103_Y109_F1.0371.00
101_V109_F1.0341.00
117_T120_K1.0321.00
63_R74_V1.0301.00
73_D76_K1.0251.00
180_G206_D1.0251.00
57_L125_I1.0221.00
252_G274_R1.0201.00
122_L136_I1.0181.00
8_Y18_M1.0131.00
167_A171_M1.0121.00
56_D110_R1.0091.00
355_V358_R1.0051.00
95_V240_M1.0031.00
286_M349_V1.0031.00
68_Y265_I1.0021.00
292_L296_L1.0021.00
32_S217_K1.0001.00
57_L62_T0.9961.00
53_T118_R0.9891.00
284_L340_V0.9871.00
68_Y132_F0.9871.00
271_E275_E0.9851.00
234_N240_M0.9821.00
101_V111_L0.9791.00
153_Q195_Y0.9761.00
299_R339_I0.9751.00
129_A132_F0.9691.00
342_I347_M0.9681.00
209_R213_E0.9671.00
148_Q194_G0.9651.00
199_L203_K0.9641.00
338_A351_V0.9621.00
61_R132_F0.9591.00
102_Y173_P0.9571.00
168_V174_F0.9571.00
147_V155_K0.9561.00
66_L109_F0.9491.00
309_E338_A0.9381.00
308_H311_I0.9381.00
11_H27_P0.9361.00
280_K332_E0.9341.00
46_M208_W0.9341.00
78_T82_K0.9311.00
287_T337_T0.9291.00
335_G338_A0.9271.00
104_F183_F0.9221.00
145_I208_W0.9191.00
138_V141_D0.9181.00
72_N86_S0.9171.00
304_Q339_I0.9151.00
49_V146_A0.9151.00
7_L204_A0.9151.00
57_L136_I0.9141.00
6_P201_N0.9071.00
259_P262_R0.9071.00
257_W264_F0.9061.00
335_G350_K0.9061.00
245_S248_A0.9051.00
54_I142_L0.9031.00
144_M198_A0.9031.00
210_A214_A0.8981.00
76_K84_L0.8961.00
91_A265_I0.8951.00
161_N176_G0.8931.00
72_N256_A0.8901.00
180_G207_F0.8871.00
18_M25_M0.8801.00
95_V249_A0.8791.00
31_G35_D0.8781.00
155_K214_A0.8781.00
247_L252_G0.8740.99
130_E133_G0.8670.99
304_Q307_Q0.8660.99
5_T8_Y0.8650.99
60_S107_D0.8640.99
304_Q309_E0.8620.99
24_W118_R0.8610.99
90_N96_I0.8600.99
244_I279_E0.8600.99
85_Y98_D0.8540.99
14_C209_R0.8450.99
318_S325_I0.8450.99
288_E348_P0.8440.99
70_L88_M0.8390.99
37_H227_L0.8390.99
126_T129_A0.8380.99
39_A219_C0.8370.99
160_F177_V0.8290.99
68_Y263_D0.8190.99
86_S101_V0.8190.99
335_G351_V0.8150.99
96_I120_K0.8130.99
88_M99_L0.8130.99
46_M147_V0.8110.99
65_F132_F0.8090.99
71_A255_I0.8060.99
35_D38_H0.8060.99
29_H33_Q0.8050.99
66_L74_V0.8030.99
288_E347_M0.8030.99
70_L74_V0.7960.99
257_W271_E0.7940.99
257_W267_R0.7920.99
143_S199_L0.7890.99
272_V275_E0.7880.99
278_T332_E0.7800.99
184_I195_Y0.7790.99
71_A87_G0.7770.99
273_Q278_T0.7770.99
152_A193_A0.7760.99
304_Q334_I0.7720.99
14_C30_Y0.7700.99
63_R67_R0.7700.99
176_G179_A0.7690.99
174_F181_D0.7680.99
86_S99_L0.7620.99
12_T25_M0.7600.99
297_P311_I0.7560.99
330_V351_V0.7540.98
178_Q182_L0.7540.98
14_C208_W0.7530.98
245_S269_A0.7510.98
89_L270_L0.7500.98
83_A102_Y0.7450.98
69_L124_W0.7430.98
178_Q206_D0.7430.98
13_L205_A0.7410.98
219_C223_A0.7410.98
35_D217_K0.7370.98
206_D209_R0.7340.98
34_I38_H0.7330.98
264_F271_E0.7310.98
82_K170_G0.7310.98
154_A158_T0.7300.98
124_W127_Q0.7290.98
17_R29_H0.7290.98
298_V338_A0.7280.98
241_D311_I0.7250.98
65_F129_A0.7240.98
54_I198_A0.7200.98
212_V216_V0.7190.98
250_N280_K0.7190.98
247_L255_I0.7170.98
37_H320_T0.7160.98
10_Q212_V0.7150.98
125_I136_I0.7140.98
284_L338_A0.7120.98
72_N84_L0.7120.98
212_V218_P0.7110.98
354_P357_V0.7110.98
270_L273_Q0.7090.98
292_L324_S0.7090.98
55_V125_I0.7080.98
186_T193_A0.7050.98
41_R230_E0.7040.98
52_M112_V0.7030.98
40_V219_C0.7020.98
61_R130_E0.7020.98
164_Q167_A0.7010.98
286_M324_S0.6980.98
58_R107_D0.6960.97
104_F110_R0.6950.97
142_L200_P0.6950.97
156_A195_Y0.6940.97
184_I197_I0.6940.97
67_R259_P0.6920.97
162_D167_A0.6920.97
10_Q208_W0.6880.97
147_V197_I0.6860.97
182_L197_I0.6850.97
71_A254_T0.6850.97
54_I144_M0.6840.97
292_L340_V0.6820.97
113_V121_D0.6820.97
66_L70_L0.6800.97
273_Q277_G0.6780.97
96_I124_W0.6780.97
264_F270_L0.6770.97
293_R296_L0.6760.97
14_C212_V0.6760.97
169_E173_P0.6740.97
123_S126_T0.6730.97
317_F324_S0.6710.97
283_G356_F0.6700.97
279_E331_P0.6700.97
226_T316_T0.6690.97
353_K359_N0.6690.97
41_R227_L0.6680.97
55_V136_I0.6650.97
102_Y185_A0.6640.97
145_I204_A0.6630.97
96_I242_E0.6620.97
40_V227_L0.6620.97
91_A128_H0.6590.96
141_D200_P0.6550.96
239_E281_L0.6540.96
147_V216_V0.6530.96
67_R262_R0.6510.96
88_M121_D0.6510.96
57_L65_F0.6500.96
46_M216_V0.6470.96
66_L111_L0.6450.96
190_T194_G0.6450.96
16_A28_L0.6450.96
73_D256_A0.6430.96
110_R142_L0.6410.96
99_L111_L0.6400.96
283_G354_P0.6400.96
47_F219_C0.6380.96
229_L325_I0.6350.96
49_V144_M0.6350.96
95_V239_E0.6340.96
180_G200_P0.6340.96
236_Y240_M0.6340.96
163_A166_Q0.6320.96
292_L349_V0.6290.95
129_A134_I0.6260.95
70_L84_L0.6240.95
65_F68_Y0.6210.95
90_N94_G0.6200.95
281_L327_L0.6180.95
197_I211_L0.6180.95
64_E68_Y0.6170.95
296_L340_V0.6160.95
247_L274_R0.6160.95
53_T113_V0.6140.95
163_A168_V0.6120.95
165_R170_G0.6100.95
171_M174_F0.6070.94
232_G354_P0.6070.94
11_H18_M0.6060.94
246_P270_L0.6040.94
43_D216_V0.6040.94
226_T318_S0.6040.94
65_F130_E0.6040.94
50_S143_S0.6030.94
139_R142_L0.6030.94
339_I347_M0.6010.94
157_A164_Q0.6000.94
77_L82_K0.5990.94
56_D104_F0.5970.94
282_V351_V0.5960.94
279_E311_I0.5960.94
160_F178_Q0.5950.94
240_M244_I0.5940.94
318_S323_Y0.5940.94
51_H221_L0.5910.94
257_W270_L0.5890.94
41_R320_T0.5880.94
92_S243_T0.5850.93
285_V325_I0.5850.93
77_L84_L0.5840.93
341_Q345_R0.5830.93
16_A19_V0.5830.93
269_A272_V0.5820.93
315_G324_S0.5820.93
57_L66_L0.5800.93
153_Q164_Q0.5790.93
69_L265_I0.5780.93
304_Q338_A0.5770.93
189_Y235_L0.5760.93
182_L199_L0.5760.93
355_V359_N0.5750.93
110_R198_A0.5740.93
241_D279_E0.5720.93
7_L11_H0.5710.93
64_E75_A0.5710.93
239_E244_I0.5700.92
185_A198_A0.5690.92
186_T195_Y0.5680.92
4_Q12_T0.5680.92
54_I139_R0.5680.92
342_I345_R0.5680.92
118_R140_D0.5680.92
69_L88_M0.5680.92
74_V77_L0.5670.92
255_I264_F0.5660.92
247_L273_Q0.5640.92
88_M124_W0.5610.92
220_G223_A0.5610.92
234_N239_E0.5600.92
85_Y187_T0.5590.92
148_Q190_T0.5580.92
277_G332_E0.5560.92
30_Y218_P0.5550.91
92_S269_A0.5540.91
70_L99_L0.5530.91
159_L210_A0.5530.91
155_K158_T0.5520.91
20_D25_M0.5520.91
113_V122_L0.5510.91
240_M249_A0.5510.91
151_N216_V0.5500.91
103_Y108_F0.5490.91
11_H14_C0.5490.91
232_G283_G0.5480.91
225_D235_L0.5470.91
89_L95_V0.5470.91
289_K324_S0.5460.91
304_Q336_E0.5460.91
102_Y112_V0.5450.91
157_A161_N0.5450.91
92_S242_E0.5450.91
43_D155_K0.5430.91
312_I315_G0.5430.91
252_G280_K0.5420.90
281_L329_R0.5380.90
9_E25_M0.5380.90
271_E274_R0.5370.90
120_K123_S0.5360.90
177_V210_A0.5360.90
51_H115_S0.5350.90
246_P255_I0.5340.90
18_M26_M0.5330.90
118_R122_L0.5330.90
61_R129_A0.5320.90
272_V277_G0.5320.90
165_R168_V0.5320.90
61_R134_I0.5320.90
201_N204_A0.5320.90
36_E220_G0.5270.89
66_L125_I0.5270.89
31_G217_K0.5270.89
259_P267_R0.5260.89
286_M340_V0.5260.89
64_E67_R0.5240.89
114_N225_D0.5240.89
117_T242_E0.5220.89
62_T103_Y0.5200.89
282_V336_E0.5170.88
83_A187_T0.5170.88
313_T329_R0.5170.88
304_Q337_T0.5160.88
165_R169_E0.5130.88
309_E331_P0.5130.88
228_R239_E0.5110.88
193_A231_A0.5100.88
177_V180_G0.5090.88
51_H235_L0.5090.88
112_V196_E0.5080.87
52_M224_R0.5070.87
230_E318_S0.5070.87
85_Y254_T0.5060.87
152_A155_K0.5050.87
37_H319_P0.5040.87
298_V349_V0.5040.87
5_T145_I0.5030.87
178_Q181_D0.5020.87
46_M211_L0.5010.87
234_N253_W0.5000.87
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1vloA 1 0.9698 100 0.131 Contact Map
1yx2A 1 0.9588 100 0.137 Contact Map
3girA 1 0.9643 100 0.137 Contact Map
2gagA 1 0.978 100 0.143 Contact Map
1wosA 1 0.9643 100 0.152 Contact Map
4pabA 1 0.9753 100 0.155 Contact Map
1pj5A 3 0.9698 100 0.162 Contact Map
1v5vA 2 0.9725 100 0.162 Contact Map
1wsrA 2 0.9753 100 0.167 Contact Map
3tfiA 2 0.9423 100 0.187 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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