GCST - ECOLI - GREMLIN Contacts

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GCST - Aminomethyltransferase

UniProt:	P27248	Sequences: MAQQTPLYEQHTLCGARMVDFHGWMMPLHYGSQIDEHHAVRTDAGMFDVSHMTIVDLRGSRTREFLRYLLANDVAKLTKSGKALYSGMLNASGGVIDDLIVYYFTEDFFRLVVNSATREKDLSWITQHAEPFGIEITVRDDLSMIAVQGPNAQAKAATLFNDAQRQAVEGMKPFFGVQAGDLFIATTGYTGEAGYEIALPNEKAADFWRALVEAGVKPCGLGARDTLRLEAGMNLYGQEMDETISPLAANMGWTIAWEPADRDFIGREALEVQREHGTEKLVGLVMTEKGVLRNELPVRFTDAQGNQHEGIITSGTFSPTLGYSIALARVPEGIGETAIVQIRNREMPVKVTKPVFVRNGKAVA	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG11442
Length:	364 (348)
Sequences:	6997 (4595)
Seq/√Len:	246.3

ECOLI - GCST YGFZ
BACSU - GCST
HALSA - GCST Q9HM98
SULSO - Q97ZI7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
151_N	154_A	3.717	1.00
10_Q	209_R	3.697	1.00
285_V	323_Y	3.254	1.00
297_P	308_H	3.156	1.00
245_S	273_Q	3.128	1.00
44_A	155_K	3.103	1.00
56_D	108_F	2.969	1.00
339_I	346_E	2.691	1.00
272_V	276_H	2.677	1.00
298_V	328_A	2.603	1.00
8_Y	12_T	2.592	1.00
12_T	18_M	2.556	1.00
43_D	151_N	2.520	1.00
38_H	42_T	2.485	1.00
284_L	326_A	2.474	1.00
143_S	204_A	2.471	1.00
61_R	64_E	2.387	1.00
337_T	348_P	2.340	1.00
58_R	108_F	2.253	1.00
45_G	219_C	2.224	1.00
287_T	350_K	2.220	1.00
13_L	209_R	2.178	1.00
341_Q	346_E	2.124	1.00
40_V	45_G	2.123	1.00
285_V	350_K	2.094	1.00
67_R	73_D	2.073	1.00
238_Q	294_N	2.067	1.00
295_E	311_I	2.057	1.00
69_L	125_I	2.043	1.00
299_R	346_E	2.033	1.00
341_Q	344_N	2.013	1.00
80_S	103_Y	2.008	1.00
9_E	13_L	1.985	1.00
339_I	348_P	1.985	1.00
318_S	321_L	1.967	1.00
263_D	267_R	1.955	1.00
337_T	350_K	1.954	1.00
9_E	12_T	1.951	1.00
39_A	43_D	1.874	1.00
338_A	349_V	1.872	1.00
158_T	214_A	1.838	1.00
267_R	271_E	1.830	1.00
10_Q	14_C	1.813	1.00
200_P	203_K	1.809	1.00
309_E	334_I	1.803	1.00
4_Q	25_M	1.796	1.00
55_V	122_L	1.791	1.00
63_R	109_F	1.730	1.00
39_A	217_K	1.730	1.00
203_K	206_D	1.725	1.00
9_E	205_A	1.724	1.00
10_Q	13_L	1.700	1.00
105_T	108_F	1.692	1.00
56_D	137_T	1.672	1.00
312_I	326_A	1.659	1.00
307_Q	331_P	1.651	1.00
268_E	271_E	1.635	1.00
38_H	320_T	1.630	1.00
11_H	30_Y	1.609	1.00
166_Q	170_G	1.603	1.00
122_L	126_T	1.585	1.00
4_Q	8_Y	1.579	1.00
124_W	128_H	1.563	1.00
58_R	137_T	1.555	1.00
155_K	216_V	1.546	1.00
205_A	209_R	1.544	1.00
282_V	330_V	1.540	1.00
199_L	207_F	1.530	1.00
297_P	341_Q	1.512	1.00
61_R	133_G	1.507	1.00
63_R	103_Y	1.505	1.00
60_S	133_G	1.490	1.00
176_G	181_D	1.486	1.00
83_A	100_I	1.485	1.00
208_W	218_P	1.480	1.00
299_R	308_H	1.464	1.00
14_C	218_P	1.464	1.00
55_V	113_V	1.464	1.00
340_V	349_V	1.448	1.00
178_Q	210_A	1.432	1.00
168_V	171_M	1.421	1.00
37_H	226_T	1.418	1.00
162_D	165_R	1.418	1.00
87_G	254_T	1.415	1.00
46_M	212_V	1.412	1.00
46_M	145_I	1.411	1.00
6_P	143_S	1.410	1.00
248_A	279_E	1.409	1.00
210_A	213_E	1.405	1.00
299_R	341_Q	1.405	1.00
71_A	89_L	1.405	1.00
143_S	201_N	1.400	1.00
70_L	86_S	1.393	1.00
69_L	128_H	1.390	1.00
104_F	108_F	1.389	1.00
167_A	170_G	1.388	1.00
70_L	101_V	1.388	1.00
123_S	127_Q	1.387	1.00
284_L	328_A	1.383	1.00
43_D	217_K	1.382	1.00
58_R	135_E	1.375	1.00
129_A	136_I	1.355	1.00
90_N	242_E	1.345	1.00
327_L	354_P	1.343	1.00
180_G	203_K	1.331	1.00
247_L	257_W	1.330	1.00
147_V	156_A	1.319	1.00
16_A	26_M	1.317	1.00
56_D	138_V	1.311	1.00
159_L	211_L	1.299	1.00
7_L	145_I	1.293	1.00
229_L	316_T	1.293	1.00
331_P	334_I	1.291	1.00
63_R	75_A	1.288	1.00
10_Q	205_A	1.288	1.00
57_L	111_L	1.282	1.00
177_V	182_L	1.280	1.00
317_F	322_G	1.276	1.00
263_D	268_E	1.276	1.00
87_G	251_M	1.257	1.00
154_A	157_A	1.253	1.00
19_V	28_L	1.247	1.00
74_V	101_V	1.242	1.00
62_T	109_F	1.241	1.00
244_I	329_R	1.240	1.00
298_V	340_V	1.239	1.00
249_A	329_R	1.226	1.00
80_S	106_E	1.222	1.00
87_G	95_V	1.212	1.00
111_L	125_I	1.208	1.00
137_T	141_D	1.203	1.00
103_Y	106_E	1.199	1.00
67_R	75_A	1.195	1.00
247_L	270_L	1.184	1.00
284_L	349_V	1.181	1.00
8_Y	25_M	1.179	1.00
336_E	351_V	1.178	1.00
247_L	278_T	1.167	1.00
268_E	272_V	1.164	1.00
306_N	346_E	1.156	1.00
287_T	348_P	1.154	1.00
80_S	105_T	1.153	1.00
120_K	242_E	1.147	1.00
206_D	210_A	1.138	1.00
229_L	314_S	1.133	1.00
248_A	273_Q	1.131	1.00
175_F	184_I	1.123	1.00
330_V	338_A	1.122	1.00
228_R	314_S	1.116	1.00
274_R	277_G	1.111	1.00
199_L	204_A	1.106	1.00
153_Q	193_A	1.098	1.00
38_H	322_G	1.095	1.00
138_V	142_L	1.092	1.00
119_E	123_S	1.091	1.00
241_D	244_I	1.090	1.00
4_Q	9_E	1.088	1.00
44_A	216_V	1.085	1.00
166_Q	169_E	1.077	1.00
262_R	267_R	1.075	1.00
65_F	125_I	1.072	1.00
32_S	35_D	1.070	1.00
88_M	125_I	1.069	1.00
124_W	265_I	1.068	1.00
128_H	265_I	1.066	1.00
65_F	134_I	1.059	1.00
269_A	273_Q	1.054	1.00
160_F	163_A	1.053	1.00
299_R	306_N	1.051	1.00
257_W	274_R	1.047	1.00
285_V	352_T	1.039	1.00
103_Y	109_F	1.037	1.00
101_V	109_F	1.034	1.00
117_T	120_K	1.032	1.00
63_R	74_V	1.030	1.00
73_D	76_K	1.025	1.00
180_G	206_D	1.025	1.00
57_L	125_I	1.022	1.00
252_G	274_R	1.020	1.00
122_L	136_I	1.018	1.00
8_Y	18_M	1.013	1.00
167_A	171_M	1.012	1.00
56_D	110_R	1.009	1.00
355_V	358_R	1.005	1.00
95_V	240_M	1.003	1.00
286_M	349_V	1.003	1.00
68_Y	265_I	1.002	1.00
292_L	296_L	1.002	1.00
32_S	217_K	1.000	1.00
57_L	62_T	0.996	1.00
53_T	118_R	0.989	1.00
284_L	340_V	0.987	1.00
68_Y	132_F	0.987	1.00
271_E	275_E	0.985	1.00
234_N	240_M	0.982	1.00
101_V	111_L	0.979	1.00
153_Q	195_Y	0.976	1.00
299_R	339_I	0.975	1.00
129_A	132_F	0.969	1.00
342_I	347_M	0.968	1.00
209_R	213_E	0.967	1.00
148_Q	194_G	0.965	1.00
199_L	203_K	0.964	1.00
338_A	351_V	0.962	1.00
61_R	132_F	0.959	1.00
102_Y	173_P	0.957	1.00
168_V	174_F	0.957	1.00
147_V	155_K	0.956	1.00
66_L	109_F	0.949	1.00
309_E	338_A	0.938	1.00
308_H	311_I	0.938	1.00
11_H	27_P	0.936	1.00
280_K	332_E	0.934	1.00
46_M	208_W	0.934	1.00
78_T	82_K	0.931	1.00
287_T	337_T	0.929	1.00
335_G	338_A	0.927	1.00
104_F	183_F	0.922	1.00
145_I	208_W	0.919	1.00
138_V	141_D	0.918	1.00
72_N	86_S	0.917	1.00
304_Q	339_I	0.915	1.00
49_V	146_A	0.915	1.00
7_L	204_A	0.915	1.00
57_L	136_I	0.914	1.00
6_P	201_N	0.907	1.00
259_P	262_R	0.907	1.00
257_W	264_F	0.906	1.00
335_G	350_K	0.906	1.00
245_S	248_A	0.905	1.00
54_I	142_L	0.903	1.00
144_M	198_A	0.903	1.00
210_A	214_A	0.898	1.00
76_K	84_L	0.896	1.00
91_A	265_I	0.895	1.00
161_N	176_G	0.893	1.00
72_N	256_A	0.890	1.00
180_G	207_F	0.887	1.00
18_M	25_M	0.880	1.00
95_V	249_A	0.879	1.00
31_G	35_D	0.878	1.00
155_K	214_A	0.878	1.00
247_L	252_G	0.874	0.99
130_E	133_G	0.867	0.99
304_Q	307_Q	0.866	0.99
5_T	8_Y	0.865	0.99
60_S	107_D	0.864	0.99
304_Q	309_E	0.862	0.99
24_W	118_R	0.861	0.99
90_N	96_I	0.860	0.99
244_I	279_E	0.860	0.99
85_Y	98_D	0.854	0.99
14_C	209_R	0.845	0.99
318_S	325_I	0.845	0.99
288_E	348_P	0.844	0.99
70_L	88_M	0.839	0.99
37_H	227_L	0.839	0.99
126_T	129_A	0.838	0.99
39_A	219_C	0.837	0.99
160_F	177_V	0.829	0.99
68_Y	263_D	0.819	0.99
86_S	101_V	0.819	0.99
335_G	351_V	0.815	0.99
96_I	120_K	0.813	0.99
88_M	99_L	0.813	0.99
46_M	147_V	0.811	0.99
65_F	132_F	0.809	0.99
71_A	255_I	0.806	0.99
35_D	38_H	0.806	0.99
29_H	33_Q	0.805	0.99
66_L	74_V	0.803	0.99
288_E	347_M	0.803	0.99
70_L	74_V	0.796	0.99
257_W	271_E	0.794	0.99
257_W	267_R	0.792	0.99
143_S	199_L	0.789	0.99
272_V	275_E	0.788	0.99
278_T	332_E	0.780	0.99
184_I	195_Y	0.779	0.99
71_A	87_G	0.777	0.99
273_Q	278_T	0.777	0.99
152_A	193_A	0.776	0.99
304_Q	334_I	0.772	0.99
14_C	30_Y	0.770	0.99
63_R	67_R	0.770	0.99
176_G	179_A	0.769	0.99
174_F	181_D	0.768	0.99
86_S	99_L	0.762	0.99
12_T	25_M	0.760	0.99
297_P	311_I	0.756	0.99
330_V	351_V	0.754	0.98
178_Q	182_L	0.754	0.98
14_C	208_W	0.753	0.98
245_S	269_A	0.751	0.98
89_L	270_L	0.750	0.98
83_A	102_Y	0.745	0.98
69_L	124_W	0.743	0.98
178_Q	206_D	0.743	0.98
13_L	205_A	0.741	0.98
219_C	223_A	0.741	0.98
35_D	217_K	0.737	0.98
206_D	209_R	0.734	0.98
34_I	38_H	0.733	0.98
264_F	271_E	0.731	0.98
82_K	170_G	0.731	0.98
154_A	158_T	0.730	0.98
124_W	127_Q	0.729	0.98
17_R	29_H	0.729	0.98
298_V	338_A	0.728	0.98
241_D	311_I	0.725	0.98
65_F	129_A	0.724	0.98
54_I	198_A	0.720	0.98
212_V	216_V	0.719	0.98
250_N	280_K	0.719	0.98
247_L	255_I	0.717	0.98
37_H	320_T	0.716	0.98
10_Q	212_V	0.715	0.98
125_I	136_I	0.714	0.98
284_L	338_A	0.712	0.98
72_N	84_L	0.712	0.98
212_V	218_P	0.711	0.98
354_P	357_V	0.711	0.98
270_L	273_Q	0.709	0.98
292_L	324_S	0.709	0.98
55_V	125_I	0.708	0.98
186_T	193_A	0.705	0.98
41_R	230_E	0.704	0.98
52_M	112_V	0.703	0.98
40_V	219_C	0.702	0.98
61_R	130_E	0.702	0.98
164_Q	167_A	0.701	0.98
286_M	324_S	0.698	0.98
58_R	107_D	0.696	0.97
104_F	110_R	0.695	0.97
142_L	200_P	0.695	0.97
156_A	195_Y	0.694	0.97
184_I	197_I	0.694	0.97
67_R	259_P	0.692	0.97
162_D	167_A	0.692	0.97
10_Q	208_W	0.688	0.97
147_V	197_I	0.686	0.97
182_L	197_I	0.685	0.97
71_A	254_T	0.685	0.97
54_I	144_M	0.684	0.97
292_L	340_V	0.682	0.97
113_V	121_D	0.682	0.97
66_L	70_L	0.680	0.97
273_Q	277_G	0.678	0.97
96_I	124_W	0.678	0.97
264_F	270_L	0.677	0.97
293_R	296_L	0.676	0.97
14_C	212_V	0.676	0.97
169_E	173_P	0.674	0.97
123_S	126_T	0.673	0.97
317_F	324_S	0.671	0.97
283_G	356_F	0.670	0.97
279_E	331_P	0.670	0.97
226_T	316_T	0.669	0.97
353_K	359_N	0.669	0.97
41_R	227_L	0.668	0.97
55_V	136_I	0.665	0.97
102_Y	185_A	0.664	0.97
145_I	204_A	0.663	0.97
96_I	242_E	0.662	0.97
40_V	227_L	0.662	0.97
91_A	128_H	0.659	0.96
141_D	200_P	0.655	0.96
239_E	281_L	0.654	0.96
147_V	216_V	0.653	0.96
67_R	262_R	0.651	0.96
88_M	121_D	0.651	0.96
57_L	65_F	0.650	0.96
46_M	216_V	0.647	0.96
66_L	111_L	0.645	0.96
190_T	194_G	0.645	0.96
16_A	28_L	0.645	0.96
73_D	256_A	0.643	0.96
110_R	142_L	0.641	0.96
99_L	111_L	0.640	0.96
283_G	354_P	0.640	0.96
47_F	219_C	0.638	0.96
229_L	325_I	0.635	0.96
49_V	144_M	0.635	0.96
95_V	239_E	0.634	0.96
180_G	200_P	0.634	0.96
236_Y	240_M	0.634	0.96
163_A	166_Q	0.632	0.96
292_L	349_V	0.629	0.95
129_A	134_I	0.626	0.95
70_L	84_L	0.624	0.95
65_F	68_Y	0.621	0.95
90_N	94_G	0.620	0.95
281_L	327_L	0.618	0.95
197_I	211_L	0.618	0.95
64_E	68_Y	0.617	0.95
296_L	340_V	0.616	0.95
247_L	274_R	0.616	0.95
53_T	113_V	0.614	0.95
163_A	168_V	0.612	0.95
165_R	170_G	0.610	0.95
171_M	174_F	0.607	0.94
232_G	354_P	0.607	0.94
11_H	18_M	0.606	0.94
246_P	270_L	0.604	0.94
43_D	216_V	0.604	0.94
226_T	318_S	0.604	0.94
65_F	130_E	0.604	0.94
50_S	143_S	0.603	0.94
139_R	142_L	0.603	0.94
339_I	347_M	0.601	0.94
157_A	164_Q	0.600	0.94
77_L	82_K	0.599	0.94
56_D	104_F	0.597	0.94
282_V	351_V	0.596	0.94
279_E	311_I	0.596	0.94
160_F	178_Q	0.595	0.94
240_M	244_I	0.594	0.94
318_S	323_Y	0.594	0.94
51_H	221_L	0.591	0.94
257_W	270_L	0.589	0.94
41_R	320_T	0.588	0.94
92_S	243_T	0.585	0.93
285_V	325_I	0.585	0.93
77_L	84_L	0.584	0.93
341_Q	345_R	0.583	0.93
16_A	19_V	0.583	0.93
269_A	272_V	0.582	0.93
315_G	324_S	0.582	0.93
57_L	66_L	0.580	0.93
153_Q	164_Q	0.579	0.93
69_L	265_I	0.578	0.93
304_Q	338_A	0.577	0.93
189_Y	235_L	0.576	0.93
182_L	199_L	0.576	0.93
355_V	359_N	0.575	0.93
110_R	198_A	0.574	0.93
241_D	279_E	0.572	0.93
7_L	11_H	0.571	0.93
64_E	75_A	0.571	0.93
239_E	244_I	0.570	0.92
185_A	198_A	0.569	0.92
186_T	195_Y	0.568	0.92
4_Q	12_T	0.568	0.92
54_I	139_R	0.568	0.92
342_I	345_R	0.568	0.92
118_R	140_D	0.568	0.92
69_L	88_M	0.568	0.92
74_V	77_L	0.567	0.92
255_I	264_F	0.566	0.92
247_L	273_Q	0.564	0.92
88_M	124_W	0.561	0.92
220_G	223_A	0.561	0.92
234_N	239_E	0.560	0.92
85_Y	187_T	0.559	0.92
148_Q	190_T	0.558	0.92
277_G	332_E	0.556	0.92
30_Y	218_P	0.555	0.91
92_S	269_A	0.554	0.91
70_L	99_L	0.553	0.91
159_L	210_A	0.553	0.91
155_K	158_T	0.552	0.91
20_D	25_M	0.552	0.91
113_V	122_L	0.551	0.91
240_M	249_A	0.551	0.91
151_N	216_V	0.550	0.91
103_Y	108_F	0.549	0.91
11_H	14_C	0.549	0.91
232_G	283_G	0.548	0.91
225_D	235_L	0.547	0.91
89_L	95_V	0.547	0.91
289_K	324_S	0.546	0.91
304_Q	336_E	0.546	0.91
102_Y	112_V	0.545	0.91
157_A	161_N	0.545	0.91
92_S	242_E	0.545	0.91
43_D	155_K	0.543	0.91
312_I	315_G	0.543	0.91
252_G	280_K	0.542	0.90
281_L	329_R	0.538	0.90
9_E	25_M	0.538	0.90
271_E	274_R	0.537	0.90
120_K	123_S	0.536	0.90
177_V	210_A	0.536	0.90
51_H	115_S	0.535	0.90
246_P	255_I	0.534	0.90
18_M	26_M	0.533	0.90
118_R	122_L	0.533	0.90
61_R	129_A	0.532	0.90
272_V	277_G	0.532	0.90
165_R	168_V	0.532	0.90
61_R	134_I	0.532	0.90
201_N	204_A	0.532	0.90
36_E	220_G	0.527	0.89
66_L	125_I	0.527	0.89
31_G	217_K	0.527	0.89
259_P	267_R	0.526	0.89
286_M	340_V	0.526	0.89
64_E	67_R	0.524	0.89
114_N	225_D	0.524	0.89
117_T	242_E	0.522	0.89
62_T	103_Y	0.520	0.89
282_V	336_E	0.517	0.88
83_A	187_T	0.517	0.88
313_T	329_R	0.517	0.88
304_Q	337_T	0.516	0.88
165_R	169_E	0.513	0.88
309_E	331_P	0.513	0.88
228_R	239_E	0.511	0.88
193_A	231_A	0.510	0.88
177_V	180_G	0.509	0.88
51_H	235_L	0.509	0.88
112_V	196_E	0.508	0.87
52_M	224_R	0.507	0.87
230_E	318_S	0.507	0.87
85_Y	254_T	0.506	0.87
152_A	155_K	0.505	0.87
37_H	319_P	0.504	0.87
298_V	349_V	0.504	0.87
5_T	145_I	0.503	0.87
178_Q	181_D	0.502	0.87
46_M	211_L	0.501	0.87
234_N	253_W	0.500	0.87

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1vloA	1	0.9698	100	0.131	Contact Map
1yx2A	1	0.9588	100	0.137	Contact Map
3girA	1	0.9643	100	0.137	Contact Map
2gagA	1	0.978	100	0.143	Contact Map
1wosA	1	0.9643	100	0.152	Contact Map
4pabA	1	0.9753	100	0.155	Contact Map
1pj5A	3	0.9698	100	0.162	Contact Map
1v5vA	2	0.9725	100	0.162	Contact Map
1wsrA	2	0.9753	100	0.167	Contact Map
3tfiA	2	0.9423	100	0.187	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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