PLSX - ECOLI - GREMLIN Contacts

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PLSX - Phosphate acyltransferase

UniProt:	P27247	Sequences: MTRLTLALDVMGGDFGPSVTVPAALQALNSNSQLTLLLVGNSDAITPLLAKADFEQRSRLQIIPAQSVIASDARPSQAIRASRGSSMRVALELVKEGRAQACVSAGNTGALMGLAKLLLKPLEGIERPALVTVLPHQQKGKTVVLDLGANVDCDSTMLVQFAIMGSVLAEEVVEIPNPRVALLNIGEEEVKGLDSIRDASAVLKTIPSINYIGYLEANELLTGKTDVLVCDGFTGNVTLKTMEGVVRMFLSLLKSQGEGKKRSWWLLLLKRWLQKSLTRRFSHLNPDQYNGACLLGLRGTVIKSHGAANQRAFAVAIEQAVQAVQRQVPQRIAARLESVYPAGFELLDGGKSGTLR	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG11437
Length:	356 (328)
Sequences:	2576 (1659)
Seq/√Len:	91.6

ECOLI - PLSX
BACSU - PLSX

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
42_S	46_T	5.330	1.00
327_Q	330_Q	4.904	1.00
66_Q	84_G	3.708	1.00
90_A	102_C	3.146	1.00
189_E	204_K	2.969	1.00
287_D	309_N	2.903	1.00
35_T	61_Q	2.866	1.00
42_S	64_P	2.793	1.00
8_L	24_A	2.760	1.00
30_S	314_A	2.757	1.00
41_N	44_A	2.757	1.00
94_V	99_A	2.716	1.00
45_I	62_I	2.641	1.00
159_V	206_I	2.633	1.00
41_N	64_P	2.568	1.00
39_V	93_L	2.535	1.00
19_V	22_P	2.391	1.00
92_E	96_E	2.364	1.00
37_L	99_A	2.336	1.00
28_L	59_R	2.279	1.00
70_A	73_A	2.183	1.00
200_S	211_Y	2.171	1.00
321_V	325_Q	2.158	1.00
84_G	89_V	2.064	1.00
230_C	234_T	2.049	1.00
211_Y	214_Y	2.007	1.00
193_L	196_I	1.944	1.00
212_I	225_T	1.922	1.00
5_T	35_T	1.920	1.00
166_S	180_V	1.878	1.00
27_A	317_I	1.872	1.00
181_A	215_L	1.872	1.00
183_L	238_T	1.867	1.00
298_R	333_A	1.839	1.00
206_I	209_I	1.833	1.00
7_A	99_A	1.815	1.00
26_Q	314_A	1.790	1.00
169_A	173_V	1.789	1.00
126_E	156_T	1.781	1.00
153_C	161_F	1.762	1.00
170_E	176_P	1.752	1.00
87_M	111_L	1.738	1.00
166_S	170_E	1.728	1.00
24_A	36_L	1.713	1.00
27_A	34_L	1.710	1.00
265_W	275_K	1.704	1.00
46_T	62_I	1.700	1.00
215_L	225_T	1.675	1.00
194_D	198_D	1.662	1.00
189_E	200_S	1.655	1.00
63_I	98_R	1.653	1.00
18_S	22_P	1.645	1.00
171_E	331_R	1.644	1.00
151_V	185_I	1.635	1.00
165_G	227_V	1.621	1.00
219_E	224_K	1.609	1.00
65_A	89_V	1.605	1.00
39_V	65_A	1.590	1.00
130_L	303_K	1.584	1.00
258_E	267_L	1.582	1.00
5_T	100_Q	1.580	1.00
61_Q	98_R	1.579	1.00
142_T	228_L	1.571	1.00
37_L	63_I	1.567	1.00
201_A	205_T	1.566	1.00
67_S	84_G	1.563	1.00
48_L	51_K	1.558	1.00
19_V	310_Q	1.537	1.00
177_N	210_N	1.524	1.00
136_H	142_T	1.523	1.00
30_S	318_E	1.516	1.00
31_N	321_V	1.512	1.00
10_V	38_L	1.495	1.00
115_A	301_V	1.491	1.00
278_T	281_F	1.484	1.00
103_V	320_A	1.482	1.00
288_Q	311_R	1.477	1.00
242_M	245_V	1.470	1.00
220_L	238_T	1.470	1.00
159_V	202_V	1.467	1.00
260_K	266_L	1.464	1.00
269_L	272_W	1.455	1.00
152_D	193_L	1.450	0.99
111_L	301_V	1.447	0.99
89_V	92_E	1.441	0.99
234_T	237_V	1.425	0.99
221_L	242_M	1.414	0.99
7_A	90_A	1.410	0.99
144_V	147_L	1.399	0.99
162_A	203_L	1.397	0.99
93_L	98_R	1.395	0.99
179_R	212_I	1.374	0.99
41_N	65_A	1.372	0.99
18_S	48_L	1.365	0.99
91_L	114_L	1.364	0.99
154_D	157_M	1.362	0.99
261_K	267_L	1.354	0.99
37_L	93_L	1.351	0.99
44_A	47_P	1.337	0.99
134_L	144_V	1.334	0.99
255_S	283_H	1.322	0.99
143_V	169_A	1.305	0.99
304_S	316_A	1.290	0.99
198_D	201_A	1.286	0.99
31_N	318_E	1.283	0.99
116_K	121_P	1.269	0.99
291_G	302_I	1.268	0.99
183_L	228_L	1.262	0.99
88_R	118_L	1.258	0.99
16_G	19_V	1.256	0.99
7_A	94_V	1.249	0.98
108_T	130_L	1.244	0.98
67_S	82_S	1.240	0.98
33_Q	321_V	1.239	0.98
195_S	199_A	1.239	0.98
39_V	89_V	1.232	0.98
111_L	303_K	1.229	0.98
257_G	270_K	1.217	0.98
34_L	321_V	1.212	0.98
304_S	313_F	1.208	0.98
175_I	179_R	1.207	0.98
5_T	37_L	1.198	0.98
143_V	173_V	1.194	0.98
136_H	223_G	1.193	0.98
166_S	209_I	1.188	0.98
28_L	60_L	1.185	0.98
257_G	273_L	1.184	0.98
10_V	45_I	1.183	0.98
200_S	214_Y	1.179	0.98
126_E	157_M	1.168	0.98
282_S	288_Q	1.165	0.98
91_L	119_L	1.161	0.98
132_T	147_L	1.151	0.97
22_P	310_Q	1.145	0.97
20_T	313_F	1.142	0.97
256_Q	279_R	1.126	0.97
287_D	311_R	1.122	0.97
92_E	118_L	1.122	0.97
266_L	276_S	1.121	0.97
159_V	163_I	1.114	0.97
131_V	143_V	1.108	0.97
180_V	209_I	1.106	0.97
46_T	57_R	1.101	0.97
37_L	61_Q	1.098	0.97
28_L	36_L	1.092	0.96
253_L	280_R	1.077	0.96
219_E	222_T	1.074	0.96
155_S	198_D	1.064	0.96
33_Q	325_Q	1.064	0.96
335_R	338_S	1.063	0.96
218_N	286_P	1.057	0.96
274_Q	278_T	1.050	0.96
47_P	62_I	1.043	0.95
126_E	160_Q	1.039	0.95
169_A	227_V	1.036	0.95
41_N	66_Q	1.032	0.95
257_G	266_L	1.025	0.95
105_A	313_F	1.020	0.95
212_I	224_K	1.017	0.95
268_L	272_W	1.016	0.95
119_L	299_G	1.014	0.95
293_C	323_A	1.013	0.95
304_S	308_A	1.006	0.94
330_Q	333_A	1.006	0.94
155_S	199_A	1.006	0.94
267_L	274_Q	1.004	0.94
203_L	209_I	1.002	0.94
254_K	258_E	0.997	0.94
23_A	313_F	0.996	0.94
265_W	276_S	0.995	0.94
26_Q	310_Q	0.993	0.94
290_N	304_S	0.991	0.94
145_L	165_G	0.986	0.94
225_T	228_L	0.985	0.94
77_Q	81_A	0.974	0.93
5_T	99_A	0.972	0.93
302_I	320_A	0.972	0.93
169_A	175_I	0.967	0.93
8_L	36_L	0.965	0.93
70_A	82_S	0.961	0.93
182_L	214_Y	0.959	0.93
158_L	199_A	0.956	0.93
190_V	197_R	0.956	0.93
181_A	212_I	0.954	0.93
308_A	312_A	0.952	0.93
24_A	38_L	0.952	0.93
315_V	318_E	0.946	0.92
93_L	99_A	0.942	0.92
221_L	241_T	0.941	0.92
16_G	22_P	0.938	0.92
23_A	310_Q	0.938	0.92
215_L	228_L	0.937	0.92
167_V	171_E	0.937	0.92
21_V	25_L	0.937	0.92
46_T	50_A	0.937	0.92
91_L	102_C	0.936	0.92
69_I	85_S	0.936	0.92
159_V	203_L	0.932	0.92
247_R	286_P	0.927	0.92
181_A	225_T	0.918	0.91
252_L	283_H	0.916	0.91
97_G	299_G	0.914	0.91
6_L	9_D	0.912	0.91
89_V	93_L	0.910	0.91
73_A	82_S	0.902	0.90
252_L	256_Q	0.901	0.90
170_E	335_R	0.900	0.90
129_A	145_L	0.899	0.90
122_L	329_P	0.894	0.90
44_A	48_L	0.894	0.90
133_V	173_V	0.892	0.90
10_V	21_V	0.890	0.90
256_Q	259_G	0.889	0.90
144_V	238_T	0.888	0.90
48_L	52_A	0.888	0.90
95_K	120_K	0.887	0.90
69_I	78_A	0.887	0.90
85_S	88_R	0.882	0.89
261_K	265_W	0.881	0.89
16_G	20_T	0.880	0.89
63_I	93_L	0.880	0.89
314_A	318_E	0.879	0.89
155_S	202_V	0.878	0.89
25_L	52_A	0.877	0.89
113_G	117_L	0.874	0.89
88_R	114_L	0.874	0.89
22_P	26_Q	0.873	0.89
200_S	204_K	0.873	0.89
241_T	245_V	0.872	0.89
286_P	307_A	0.868	0.89
87_M	107_N	0.867	0.89
273_L	276_S	0.863	0.88
159_V	162_A	0.861	0.88
114_L	118_L	0.857	0.88
102_C	111_L	0.855	0.88
82_S	85_S	0.854	0.88
88_R	92_E	0.852	0.88
151_V	234_T	0.852	0.88
87_M	303_K	0.852	0.88
269_L	276_S	0.851	0.88
271_R	274_Q	0.849	0.88
138_Q	251_S	0.847	0.87
26_Q	29_N	0.845	0.87
119_L	301_V	0.844	0.87
39_V	63_I	0.844	0.87
327_Q	331_R	0.843	0.87
332_I	336_L	0.843	0.87
257_G	277_L	0.842	0.87
334_A	337_E	0.833	0.87
270_K	274_Q	0.833	0.87
159_V	199_A	0.832	0.86
256_Q	283_H	0.831	0.86
238_T	241_T	0.831	0.86
73_A	78_A	0.827	0.86
13_G	16_G	0.819	0.86
19_V	309_N	0.818	0.86
258_E	270_K	0.815	0.85
199_A	203_L	0.812	0.85
21_V	49_L	0.801	0.84
103_V	316_A	0.800	0.84
103_V	302_I	0.799	0.84
187_E	303_K	0.798	0.84
217_A	241_T	0.797	0.84
133_V	143_V	0.796	0.84
331_R	334_A	0.795	0.84
260_K	267_L	0.793	0.84
94_V	299_G	0.786	0.83
167_V	335_R	0.786	0.83
104_S	111_L	0.784	0.83
69_I	88_R	0.777	0.82
221_L	245_V	0.771	0.82
8_L	103_V	0.766	0.82
142_T	220_L	0.766	0.82
43_D	47_P	0.763	0.81
21_V	48_L	0.756	0.81
37_L	98_R	0.755	0.81
256_Q	276_S	0.753	0.80
20_T	24_A	0.751	0.80
64_P	89_V	0.750	0.80
184_N	303_K	0.749	0.80
112_M	130_L	0.748	0.80
66_Q	89_V	0.746	0.80
120_K	298_R	0.745	0.80
290_N	308_A	0.744	0.80
25_L	60_L	0.743	0.80
133_V	169_A	0.741	0.79
36_L	60_L	0.740	0.79
266_L	272_W	0.734	0.79
26_Q	30_S	0.734	0.79
174_E	322_Q	0.733	0.79
79_I	88_R	0.730	0.78
101_A	320_A	0.730	0.78
249_F	253_L	0.726	0.78
94_V	97_G	0.721	0.77
187_E	217_A	0.721	0.77
218_N	307_A	0.719	0.77
13_G	20_T	0.719	0.77
285_N	311_R	0.719	0.77
270_K	277_L	0.717	0.77
234_T	238_T	0.716	0.77
156_T	198_D	0.713	0.77
45_I	49_L	0.710	0.76
44_A	64_P	0.706	0.76
166_S	210_N	0.703	0.76
266_L	273_L	0.701	0.75
179_R	227_V	0.701	0.75
269_L	274_Q	0.701	0.75
25_L	49_L	0.700	0.75
49_L	62_I	0.700	0.75
300_T	323_A	0.699	0.75
134_L	142_T	0.695	0.75
131_V	295_L	0.693	0.75
261_K	268_L	0.692	0.75
116_K	120_K	0.692	0.75
10_V	36_L	0.691	0.74
157_M	161_F	0.690	0.74
184_N	196_I	0.690	0.74
4_L	324_V	0.690	0.74
153_C	231_D	0.688	0.74
265_W	269_L	0.688	0.74
75_P	109_G	0.687	0.74
152_D	196_I	0.686	0.74
91_L	115_A	0.686	0.74
166_S	227_V	0.684	0.74
185_I	237_V	0.683	0.74
312_A	315_V	0.681	0.73
112_M	153_C	0.678	0.73
32_S	59_R	0.675	0.73
79_I	114_L	0.671	0.72
10_V	13_G	0.665	0.72
73_A	107_N	0.664	0.72
87_M	102_C	0.663	0.71
257_G	276_S	0.663	0.71
21_V	24_A	0.662	0.71
47_P	51_K	0.658	0.71
152_D	194_D	0.657	0.71
252_L	280_R	0.654	0.70
164_M	332_I	0.653	0.70
21_V	44_A	0.648	0.70
161_F	185_I	0.648	0.70
258_E	274_Q	0.648	0.70
75_P	78_A	0.648	0.70
259_G	266_L	0.647	0.70
45_I	48_L	0.646	0.69
5_T	98_R	0.642	0.69
140_G	175_I	0.639	0.69
268_L	271_R	0.637	0.68
179_R	226_D	0.635	0.68
266_L	269_L	0.634	0.68
156_T	160_Q	0.631	0.68
119_L	297_L	0.631	0.68
193_L	234_T	0.627	0.67
139_K	179_R	0.626	0.67
179_R	219_E	0.625	0.67
147_L	286_P	0.624	0.67
67_S	83_R	0.624	0.67
215_L	224_K	0.624	0.67
330_Q	334_A	0.622	0.67
65_A	68_V	0.621	0.66
15_F	20_T	0.621	0.66
257_G	269_L	0.619	0.66
112_M	150_N	0.619	0.66
26_Q	311_R	0.619	0.66
297_L	303_K	0.617	0.66
308_A	313_F	0.616	0.66
82_S	88_R	0.616	0.66
101_A	324_V	0.614	0.66
179_R	225_T	0.614	0.66
13_G	17_P	0.611	0.65
82_S	114_L	0.610	0.65
112_M	128_P	0.609	0.65
181_A	219_E	0.609	0.65
87_M	91_L	0.601	0.64
202_V	206_I	0.599	0.64
111_L	184_N	0.598	0.63
302_I	323_A	0.596	0.63
28_L	58_S	0.593	0.63
323_A	328_V	0.591	0.63
257_G	260_K	0.590	0.62
172_V	328_V	0.589	0.62
150_N	161_F	0.588	0.62
272_W	275_K	0.586	0.62
125_I	160_Q	0.586	0.62
254_K	267_L	0.585	0.62
258_E	265_W	0.584	0.62
179_R	224_K	0.584	0.62
270_K	273_L	0.584	0.62
247_R	254_K	0.581	0.61
28_L	34_L	0.580	0.61
114_L	290_N	0.579	0.61
76_S	80_R	0.579	0.61
91_L	118_L	0.573	0.60
22_P	52_A	0.571	0.60
74_R	77_Q	0.571	0.60
8_L	20_T	0.571	0.60
138_Q	222_T	0.569	0.60
309_N	312_A	0.569	0.60
318_E	321_V	0.569	0.60
286_P	312_A	0.567	0.59
288_Q	315_V	0.566	0.59
138_Q	248_M	0.565	0.59
75_P	107_N	0.562	0.59
310_Q	314_A	0.562	0.59
237_V	241_T	0.561	0.59
28_L	32_S	0.561	0.59
184_N	307_A	0.561	0.59
16_G	105_A	0.560	0.58
38_L	60_L	0.559	0.58
251_S	255_S	0.558	0.58
253_L	257_G	0.558	0.58
25_L	54_F	0.557	0.58
117_L	120_K	0.555	0.58
167_V	170_E	0.554	0.58
48_L	62_I	0.554	0.58
266_L	270_K	0.554	0.58
297_L	300_T	0.553	0.58
311_R	315_V	0.552	0.57
115_A	119_L	0.551	0.57
129_A	161_F	0.550	0.57
42_S	66_Q	0.550	0.57
252_L	255_S	0.549	0.57
21_V	60_L	0.549	0.57
163_I	206_I	0.544	0.56
108_T	111_L	0.543	0.56
328_V	332_I	0.543	0.56
4_L	108_T	0.542	0.56
7_A	102_C	0.542	0.56
318_E	322_Q	0.542	0.56
265_W	272_W	0.542	0.56
71_S	217_A	0.542	0.56
297_L	308_A	0.541	0.56
6_L	101_A	0.540	0.56
76_S	115_A	0.540	0.56
31_N	325_Q	0.539	0.56
39_V	90_A	0.538	0.55
183_L	217_A	0.538	0.55
47_P	50_A	0.537	0.55
51_K	58_S	0.536	0.55
50_A	53_D	0.536	0.55
150_N	153_C	0.536	0.55
256_Q	277_L	0.535	0.55
29_N	59_R	0.535	0.55
91_L	94_V	0.535	0.55
322_Q	325_Q	0.534	0.55
8_L	317_I	0.533	0.55
46_T	51_K	0.533	0.55
155_S	159_V	0.532	0.55
167_V	332_I	0.531	0.55
53_D	57_R	0.530	0.54
71_S	187_E	0.527	0.54
222_T	248_M	0.526	0.54
54_F	57_R	0.526	0.54
175_I	178_P	0.524	0.54
138_Q	223_G	0.524	0.54
33_Q	59_R	0.523	0.53
100_Q	324_V	0.522	0.53
250_L	281_F	0.522	0.53
43_D	46_T	0.522	0.53
43_D	66_Q	0.521	0.53
103_V	313_F	0.520	0.53
246_V	250_L	0.519	0.53
230_C	245_V	0.519	0.53
218_N	222_T	0.518	0.53
180_V	224_K	0.517	0.53
68_V	71_S	0.517	0.53
312_A	316_A	0.517	0.53
122_L	336_L	0.517	0.53
169_A	226_D	0.516	0.52
201_A	204_K	0.516	0.52
76_S	214_Y	0.516	0.52
42_S	62_I	0.516	0.52
71_S	107_N	0.514	0.52
103_V	304_S	0.514	0.52
31_N	125_I	0.511	0.52
7_A	299_G	0.509	0.51
315_V	319_Q	0.508	0.51
28_L	57_R	0.508	0.51
333_A	337_E	0.507	0.51
69_I	114_L	0.507	0.51
48_L	140_G	0.507	0.51
78_A	113_G	0.505	0.51
130_L	147_L	0.505	0.51
180_V	227_V	0.505	0.51
167_V	336_L	0.504	0.51
18_S	51_K	0.504	0.51
326_R	336_L	0.504	0.51
246_V	249_F	0.503	0.51
320_A	324_V	0.502	0.51
49_L	54_F	0.502	0.51
266_L	279_R	0.501	0.50
179_R	210_N	0.500	0.50
153_C	158_L	0.500	0.50

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1u7nA	2	0.8961	100	0.379	Contact Map
1vi1A	2	0.9213	100	0.383	Contact Map
1vmiA	2	0.7753	100	0.594	Contact Map
2af4C	2	0.7893	100	0.599	Contact Map
1td9A	3	0.7781	100	0.617	Contact Map
1r5jA	4	0.7865	100	0.621	Contact Map
4e4rA	2	0.7781	100	0.633	Contact Map
3uf6A	2	0.7079	100	0.637	Contact Map
1ycoA	2	0.6994	100	0.647	Contact Map
3lxyA	2	0.7921	100	0.7	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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