GREMLIN Database
PLSX - Phosphate acyltransferase
UniProt: P27247 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11437
Length: 356 (328)
Sequences: 2576 (1659)
Seq/√Len: 91.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
42_S46_T5.3301.00
327_Q330_Q4.9041.00
66_Q84_G3.7081.00
90_A102_C3.1461.00
189_E204_K2.9691.00
287_D309_N2.9031.00
35_T61_Q2.8661.00
42_S64_P2.7931.00
8_L24_A2.7601.00
30_S314_A2.7571.00
41_N44_A2.7571.00
94_V99_A2.7161.00
45_I62_I2.6411.00
159_V206_I2.6331.00
41_N64_P2.5681.00
39_V93_L2.5351.00
19_V22_P2.3911.00
92_E96_E2.3641.00
37_L99_A2.3361.00
28_L59_R2.2791.00
70_A73_A2.1831.00
200_S211_Y2.1711.00
321_V325_Q2.1581.00
84_G89_V2.0641.00
230_C234_T2.0491.00
211_Y214_Y2.0071.00
193_L196_I1.9441.00
212_I225_T1.9221.00
5_T35_T1.9201.00
166_S180_V1.8781.00
27_A317_I1.8721.00
181_A215_L1.8721.00
183_L238_T1.8671.00
298_R333_A1.8391.00
206_I209_I1.8331.00
7_A99_A1.8151.00
26_Q314_A1.7901.00
169_A173_V1.7891.00
126_E156_T1.7811.00
153_C161_F1.7621.00
170_E176_P1.7521.00
87_M111_L1.7381.00
166_S170_E1.7281.00
24_A36_L1.7131.00
27_A34_L1.7101.00
265_W275_K1.7041.00
46_T62_I1.7001.00
215_L225_T1.6751.00
194_D198_D1.6621.00
189_E200_S1.6551.00
63_I98_R1.6531.00
18_S22_P1.6451.00
171_E331_R1.6441.00
151_V185_I1.6351.00
165_G227_V1.6211.00
219_E224_K1.6091.00
65_A89_V1.6051.00
39_V65_A1.5901.00
130_L303_K1.5841.00
258_E267_L1.5821.00
5_T100_Q1.5801.00
61_Q98_R1.5791.00
142_T228_L1.5711.00
37_L63_I1.5671.00
201_A205_T1.5661.00
67_S84_G1.5631.00
48_L51_K1.5581.00
19_V310_Q1.5371.00
177_N210_N1.5241.00
136_H142_T1.5231.00
30_S318_E1.5161.00
31_N321_V1.5121.00
10_V38_L1.4951.00
115_A301_V1.4911.00
278_T281_F1.4841.00
103_V320_A1.4821.00
288_Q311_R1.4771.00
242_M245_V1.4701.00
220_L238_T1.4701.00
159_V202_V1.4671.00
260_K266_L1.4641.00
269_L272_W1.4551.00
152_D193_L1.4500.99
111_L301_V1.4470.99
89_V92_E1.4410.99
234_T237_V1.4250.99
221_L242_M1.4140.99
7_A90_A1.4100.99
144_V147_L1.3990.99
162_A203_L1.3970.99
93_L98_R1.3950.99
179_R212_I1.3740.99
41_N65_A1.3720.99
18_S48_L1.3650.99
91_L114_L1.3640.99
154_D157_M1.3620.99
261_K267_L1.3540.99
37_L93_L1.3510.99
44_A47_P1.3370.99
134_L144_V1.3340.99
255_S283_H1.3220.99
143_V169_A1.3050.99
304_S316_A1.2900.99
198_D201_A1.2860.99
31_N318_E1.2830.99
116_K121_P1.2690.99
291_G302_I1.2680.99
183_L228_L1.2620.99
88_R118_L1.2580.99
16_G19_V1.2560.99
7_A94_V1.2490.98
108_T130_L1.2440.98
67_S82_S1.2400.98
33_Q321_V1.2390.98
195_S199_A1.2390.98
39_V89_V1.2320.98
111_L303_K1.2290.98
257_G270_K1.2170.98
34_L321_V1.2120.98
304_S313_F1.2080.98
175_I179_R1.2070.98
5_T37_L1.1980.98
143_V173_V1.1940.98
136_H223_G1.1930.98
166_S209_I1.1880.98
28_L60_L1.1850.98
257_G273_L1.1840.98
10_V45_I1.1830.98
200_S214_Y1.1790.98
126_E157_M1.1680.98
282_S288_Q1.1650.98
91_L119_L1.1610.98
132_T147_L1.1510.97
22_P310_Q1.1450.97
20_T313_F1.1420.97
256_Q279_R1.1260.97
287_D311_R1.1220.97
92_E118_L1.1220.97
266_L276_S1.1210.97
159_V163_I1.1140.97
131_V143_V1.1080.97
180_V209_I1.1060.97
46_T57_R1.1010.97
37_L61_Q1.0980.97
28_L36_L1.0920.96
253_L280_R1.0770.96
219_E222_T1.0740.96
155_S198_D1.0640.96
33_Q325_Q1.0640.96
335_R338_S1.0630.96
218_N286_P1.0570.96
274_Q278_T1.0500.96
47_P62_I1.0430.95
126_E160_Q1.0390.95
169_A227_V1.0360.95
41_N66_Q1.0320.95
257_G266_L1.0250.95
105_A313_F1.0200.95
212_I224_K1.0170.95
268_L272_W1.0160.95
119_L299_G1.0140.95
293_C323_A1.0130.95
304_S308_A1.0060.94
330_Q333_A1.0060.94
155_S199_A1.0060.94
267_L274_Q1.0040.94
203_L209_I1.0020.94
254_K258_E0.9970.94
23_A313_F0.9960.94
265_W276_S0.9950.94
26_Q310_Q0.9930.94
290_N304_S0.9910.94
145_L165_G0.9860.94
225_T228_L0.9850.94
77_Q81_A0.9740.93
5_T99_A0.9720.93
302_I320_A0.9720.93
169_A175_I0.9670.93
8_L36_L0.9650.93
70_A82_S0.9610.93
182_L214_Y0.9590.93
158_L199_A0.9560.93
190_V197_R0.9560.93
181_A212_I0.9540.93
308_A312_A0.9520.93
24_A38_L0.9520.93
315_V318_E0.9460.92
93_L99_A0.9420.92
221_L241_T0.9410.92
16_G22_P0.9380.92
23_A310_Q0.9380.92
215_L228_L0.9370.92
167_V171_E0.9370.92
21_V25_L0.9370.92
46_T50_A0.9370.92
91_L102_C0.9360.92
69_I85_S0.9360.92
159_V203_L0.9320.92
247_R286_P0.9270.92
181_A225_T0.9180.91
252_L283_H0.9160.91
97_G299_G0.9140.91
6_L9_D0.9120.91
89_V93_L0.9100.91
73_A82_S0.9020.90
252_L256_Q0.9010.90
170_E335_R0.9000.90
129_A145_L0.8990.90
122_L329_P0.8940.90
44_A48_L0.8940.90
133_V173_V0.8920.90
10_V21_V0.8900.90
256_Q259_G0.8890.90
144_V238_T0.8880.90
48_L52_A0.8880.90
95_K120_K0.8870.90
69_I78_A0.8870.90
85_S88_R0.8820.89
261_K265_W0.8810.89
16_G20_T0.8800.89
63_I93_L0.8800.89
314_A318_E0.8790.89
155_S202_V0.8780.89
25_L52_A0.8770.89
113_G117_L0.8740.89
88_R114_L0.8740.89
22_P26_Q0.8730.89
200_S204_K0.8730.89
241_T245_V0.8720.89
286_P307_A0.8680.89
87_M107_N0.8670.89
273_L276_S0.8630.88
159_V162_A0.8610.88
114_L118_L0.8570.88
102_C111_L0.8550.88
82_S85_S0.8540.88
88_R92_E0.8520.88
151_V234_T0.8520.88
87_M303_K0.8520.88
269_L276_S0.8510.88
271_R274_Q0.8490.88
138_Q251_S0.8470.87
26_Q29_N0.8450.87
119_L301_V0.8440.87
39_V63_I0.8440.87
327_Q331_R0.8430.87
332_I336_L0.8430.87
257_G277_L0.8420.87
334_A337_E0.8330.87
270_K274_Q0.8330.87
159_V199_A0.8320.86
256_Q283_H0.8310.86
238_T241_T0.8310.86
73_A78_A0.8270.86
13_G16_G0.8190.86
19_V309_N0.8180.86
258_E270_K0.8150.85
199_A203_L0.8120.85
21_V49_L0.8010.84
103_V316_A0.8000.84
103_V302_I0.7990.84
187_E303_K0.7980.84
217_A241_T0.7970.84
133_V143_V0.7960.84
331_R334_A0.7950.84
260_K267_L0.7930.84
94_V299_G0.7860.83
167_V335_R0.7860.83
104_S111_L0.7840.83
69_I88_R0.7770.82
221_L245_V0.7710.82
8_L103_V0.7660.82
142_T220_L0.7660.82
43_D47_P0.7630.81
21_V48_L0.7560.81
37_L98_R0.7550.81
256_Q276_S0.7530.80
20_T24_A0.7510.80
64_P89_V0.7500.80
184_N303_K0.7490.80
112_M130_L0.7480.80
66_Q89_V0.7460.80
120_K298_R0.7450.80
290_N308_A0.7440.80
25_L60_L0.7430.80
133_V169_A0.7410.79
36_L60_L0.7400.79
266_L272_W0.7340.79
26_Q30_S0.7340.79
174_E322_Q0.7330.79
79_I88_R0.7300.78
101_A320_A0.7300.78
249_F253_L0.7260.78
94_V97_G0.7210.77
187_E217_A0.7210.77
218_N307_A0.7190.77
13_G20_T0.7190.77
285_N311_R0.7190.77
270_K277_L0.7170.77
234_T238_T0.7160.77
156_T198_D0.7130.77
45_I49_L0.7100.76
44_A64_P0.7060.76
166_S210_N0.7030.76
266_L273_L0.7010.75
179_R227_V0.7010.75
269_L274_Q0.7010.75
25_L49_L0.7000.75
49_L62_I0.7000.75
300_T323_A0.6990.75
134_L142_T0.6950.75
131_V295_L0.6930.75
261_K268_L0.6920.75
116_K120_K0.6920.75
10_V36_L0.6910.74
157_M161_F0.6900.74
184_N196_I0.6900.74
4_L324_V0.6900.74
153_C231_D0.6880.74
265_W269_L0.6880.74
75_P109_G0.6870.74
152_D196_I0.6860.74
91_L115_A0.6860.74
166_S227_V0.6840.74
185_I237_V0.6830.74
312_A315_V0.6810.73
112_M153_C0.6780.73
32_S59_R0.6750.73
79_I114_L0.6710.72
10_V13_G0.6650.72
73_A107_N0.6640.72
87_M102_C0.6630.71
257_G276_S0.6630.71
21_V24_A0.6620.71
47_P51_K0.6580.71
152_D194_D0.6570.71
252_L280_R0.6540.70
164_M332_I0.6530.70
21_V44_A0.6480.70
161_F185_I0.6480.70
258_E274_Q0.6480.70
75_P78_A0.6480.70
259_G266_L0.6470.70
45_I48_L0.6460.69
5_T98_R0.6420.69
140_G175_I0.6390.69
268_L271_R0.6370.68
179_R226_D0.6350.68
266_L269_L0.6340.68
156_T160_Q0.6310.68
119_L297_L0.6310.68
193_L234_T0.6270.67
139_K179_R0.6260.67
179_R219_E0.6250.67
147_L286_P0.6240.67
67_S83_R0.6240.67
215_L224_K0.6240.67
330_Q334_A0.6220.67
65_A68_V0.6210.66
15_F20_T0.6210.66
257_G269_L0.6190.66
112_M150_N0.6190.66
26_Q311_R0.6190.66
297_L303_K0.6170.66
308_A313_F0.6160.66
82_S88_R0.6160.66
101_A324_V0.6140.66
179_R225_T0.6140.66
13_G17_P0.6110.65
82_S114_L0.6100.65
112_M128_P0.6090.65
181_A219_E0.6090.65
87_M91_L0.6010.64
202_V206_I0.5990.64
111_L184_N0.5980.63
302_I323_A0.5960.63
28_L58_S0.5930.63
323_A328_V0.5910.63
257_G260_K0.5900.62
172_V328_V0.5890.62
150_N161_F0.5880.62
272_W275_K0.5860.62
125_I160_Q0.5860.62
254_K267_L0.5850.62
258_E265_W0.5840.62
179_R224_K0.5840.62
270_K273_L0.5840.62
247_R254_K0.5810.61
28_L34_L0.5800.61
114_L290_N0.5790.61
76_S80_R0.5790.61
91_L118_L0.5730.60
22_P52_A0.5710.60
74_R77_Q0.5710.60
8_L20_T0.5710.60
138_Q222_T0.5690.60
309_N312_A0.5690.60
318_E321_V0.5690.60
286_P312_A0.5670.59
288_Q315_V0.5660.59
138_Q248_M0.5650.59
75_P107_N0.5620.59
310_Q314_A0.5620.59
237_V241_T0.5610.59
28_L32_S0.5610.59
184_N307_A0.5610.59
16_G105_A0.5600.58
38_L60_L0.5590.58
251_S255_S0.5580.58
253_L257_G0.5580.58
25_L54_F0.5570.58
117_L120_K0.5550.58
167_V170_E0.5540.58
48_L62_I0.5540.58
266_L270_K0.5540.58
297_L300_T0.5530.58
311_R315_V0.5520.57
115_A119_L0.5510.57
129_A161_F0.5500.57
42_S66_Q0.5500.57
252_L255_S0.5490.57
21_V60_L0.5490.57
163_I206_I0.5440.56
108_T111_L0.5430.56
328_V332_I0.5430.56
4_L108_T0.5420.56
7_A102_C0.5420.56
318_E322_Q0.5420.56
265_W272_W0.5420.56
71_S217_A0.5420.56
297_L308_A0.5410.56
6_L101_A0.5400.56
76_S115_A0.5400.56
31_N325_Q0.5390.56
39_V90_A0.5380.55
183_L217_A0.5380.55
47_P50_A0.5370.55
51_K58_S0.5360.55
50_A53_D0.5360.55
150_N153_C0.5360.55
256_Q277_L0.5350.55
29_N59_R0.5350.55
91_L94_V0.5350.55
322_Q325_Q0.5340.55
8_L317_I0.5330.55
46_T51_K0.5330.55
155_S159_V0.5320.55
167_V332_I0.5310.55
53_D57_R0.5300.54
71_S187_E0.5270.54
222_T248_M0.5260.54
54_F57_R0.5260.54
175_I178_P0.5240.54
138_Q223_G0.5240.54
33_Q59_R0.5230.53
100_Q324_V0.5220.53
250_L281_F0.5220.53
43_D46_T0.5220.53
43_D66_Q0.5210.53
103_V313_F0.5200.53
246_V250_L0.5190.53
230_C245_V0.5190.53
218_N222_T0.5180.53
180_V224_K0.5170.53
68_V71_S0.5170.53
312_A316_A0.5170.53
122_L336_L0.5170.53
169_A226_D0.5160.52
201_A204_K0.5160.52
76_S214_Y0.5160.52
42_S62_I0.5160.52
71_S107_N0.5140.52
103_V304_S0.5140.52
31_N125_I0.5110.52
7_A299_G0.5090.51
315_V319_Q0.5080.51
28_L57_R0.5080.51
333_A337_E0.5070.51
69_I114_L0.5070.51
48_L140_G0.5070.51
78_A113_G0.5050.51
130_L147_L0.5050.51
180_V227_V0.5050.51
167_V336_L0.5040.51
18_S51_K0.5040.51
326_R336_L0.5040.51
246_V249_F0.5030.51
320_A324_V0.5020.51
49_L54_F0.5020.51
266_L279_R0.5010.50
179_R210_N0.5000.50
153_C158_L0.5000.50
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1u7nA 2 0.8961 100 0.379 Contact Map
1vi1A 2 0.9213 100 0.383 Contact Map
1vmiA 2 0.7753 100 0.594 Contact Map
2af4C 2 0.7893 100 0.599 Contact Map
1td9A 3 0.7781 100 0.617 Contact Map
1r5jA 4 0.7865 100 0.621 Contact Map
4e4rA 2 0.7781 100 0.633 Contact Map
3uf6A 2 0.7079 100 0.637 Contact Map
1ycoA 2 0.6994 100 0.647 Contact Map
3lxyA 2 0.7921 100 0.7 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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