GREMLIN Database
MARR - Multiple antibiotic resistance protein MarR
UniProt: P27245 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11435
Length: 144 (129)
Sequences: 21519 (15855)
Seq/√Len: 1395.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
54_C99_K3.1851.00
87_L99_K3.0211.00
131_E141_K2.8371.00
89_N97_L2.5541.00
85_E99_K2.5301.00
56_T95_G2.4771.00
128_T131_E2.3631.00
134_T137_Y2.2331.00
50_R108_C2.0661.00
134_T138_L2.0451.00
88_P96_V2.0201.00
56_T59_E1.9431.00
54_C97_L1.9311.00
42_Q81_K1.9071.00
127_L138_L1.8751.00
89_N95_G1.7431.00
131_E134_T1.7361.00
50_R100_L1.7221.00
103_G107_I1.5801.00
42_Q77_R1.5761.00
82_G103_G1.5741.00
52_A63_V1.5451.00
57_P75_L1.5301.00
54_C87_L1.5291.00
17_L140_K1.5151.00
107_I110_Q1.4971.00
39_T42_Q1.4931.00
103_G106_A1.4911.00
79_V86_R1.4651.00
76_D80_C1.4621.00
131_E137_Y1.4601.00
135_L138_L1.4491.00
75_L98_V1.4461.00
50_R105_A1.3811.00
45_V74_M1.3741.00
48_S63_V1.3181.00
17_L136_E1.2721.00
36_L110_Q1.2711.00
36_L115_V1.2671.00
106_A110_Q1.2591.00
59_E62_K1.2411.00
57_P96_V1.2371.00
32_Y115_V1.2111.00
116_G120_H1.2061.00
76_D93_K1.2051.00
58_V68_L1.1921.00
32_Y118_D1.1671.00
66_V70_A1.1551.00
138_L141_K1.1181.00
58_V62_K1.1171.00
67_D70_A1.1051.00
30_N34_S1.1011.00
45_V71_L1.0991.00
120_H123_L1.0781.00
130_D134_T1.0691.00
83_W107_I1.0611.00
57_P98_V1.0591.00
35_P115_V1.0441.00
100_L104_G1.0381.00
32_Y122_E1.0371.00
72_T76_D1.0201.00
136_E140_K1.0111.00
115_V118_D1.0111.00
132_V136_E1.0051.00
19_H22_N0.9991.00
137_Y141_K0.9881.00
102_T105_A0.9881.00
69_G72_T0.9801.00
86_R96_V0.9701.00
57_P71_L0.9691.00
76_D79_V0.9681.00
53_A105_A0.9671.00
105_A109_E0.9651.00
81_K107_I0.9581.00
50_R109_E0.9571.00
52_A55_I0.9511.00
81_K103_G0.9451.00
55_I59_E0.9391.00
41_A74_M0.9391.00
55_I63_V0.9291.00
131_E138_L0.9291.00
70_A73_R0.9171.00
36_L111_C0.9161.00
87_L97_L0.9041.00
102_T106_A0.9021.00
88_P93_K0.8981.00
37_D81_K0.8931.00
66_V71_L0.8851.00
57_P68_L0.8821.00
59_E63_V0.8821.00
21_V139_L0.8731.00
118_D121_Q0.8681.00
85_E101_T0.8651.00
28_L119_L0.8641.00
67_D73_R0.8641.00
75_L84_V0.8611.00
22_N26_D0.8511.00
49_I84_V0.8451.00
83_W103_G0.8441.00
14_L136_E0.8421.00
18_I22_N0.8421.00
129_A133_A0.8401.00
43_F111_C0.8321.00
118_D122_E0.8281.00
46_L108_C0.8211.00
89_N92_D0.8141.00
100_L105_A0.8071.00
110_Q115_V0.7951.00
52_A59_E0.7941.00
90_P97_L0.7921.00
73_R76_D0.7851.00
50_R112_H0.7841.00
92_D95_G0.7841.00
73_R77_R0.7831.00
30_N40_A0.7821.00
44_K64_L0.7751.00
32_Y35_P0.7721.00
48_S64_L0.7691.00
75_L79_V0.7671.00
19_H23_Q0.7651.00
79_V85_E0.7641.00
113_Q118_D0.7601.00
28_L122_E0.7511.00
124_T132_V0.7431.00
48_S55_I0.7361.00
41_A70_A0.7291.00
122_E125_K0.7281.00
130_D133_A0.7281.00
128_T132_V0.7261.00
106_A109_E0.7211.00
45_V60_L0.7201.00
23_Q27_R0.7161.00
49_I100_L0.7101.00
45_V64_L0.7091.00
113_Q117_Q0.7001.00
133_A136_E0.6991.00
77_R80_C0.6961.00
18_I21_V0.6961.00
57_P72_T0.6941.00
78_L83_W0.6891.00
48_S60_L0.6871.00
61_K71_L0.6811.00
32_Y119_L0.6791.00
133_A137_Y0.6751.00
43_F116_G0.6741.00
21_V142_V0.6711.00
49_I55_I0.6701.00
117_Q121_Q0.6671.00
76_D86_R0.6661.00
42_Q74_M0.6601.00
17_L20_M0.6591.00
116_G119_L0.6561.00
110_Q113_Q0.6541.00
48_S52_A0.6471.00
79_V84_V0.6461.00
47_C51_C0.6421.00
26_D30_N0.6401.00
127_L142_V0.6351.00
128_T141_K0.6291.00
61_K68_L0.6271.00
119_L122_E0.6261.00
43_F108_C0.6251.00
77_R81_K0.6221.00
71_L75_L0.6171.00
127_L132_V0.6141.00
53_A99_K0.6121.00
47_C112_H0.6031.00
20_M24_K0.6001.00
29_L116_G0.5951.00
124_T128_T0.5881.00
60_L98_V0.5861.00
44_K48_S0.5761.00
112_H117_Q0.5721.00
28_L31_E0.5681.00
109_E113_Q0.5671.00
108_C112_H0.5631.00
57_P95_G0.5601.00
29_L32_Y0.5571.00
46_L50_R0.5501.00
87_L90_P0.5421.00
24_K28_L0.5421.00
82_G85_E0.5291.00
27_R31_E0.5261.00
31_E34_S0.5201.00
109_E112_H0.5191.00
47_C108_C0.5151.00
40_A44_K0.5151.00
41_A66_V0.5121.00
127_L141_K0.5121.00
122_E126_N0.5101.00
134_T141_K0.5081.00
38_I107_I0.5061.00
58_V61_K0.5061.00
23_Q26_D0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3cdhA 4 0.9236 99.9 0.254 Contact Map
3cjnA 2 0.9375 99.9 0.256 Contact Map
1z91A 2 0.9306 99.9 0.261 Contact Map
3u2rA 4 0.9236 99.9 0.265 Contact Map
4rguA 4 0.9444 99.9 0.267 Contact Map
3deuA 2 0.875 99.9 0.267 Contact Map
3e6mA 2 0.9931 99.9 0.268 Contact Map
2nnnA 2 0.9306 99.9 0.269 Contact Map
3oopA 2 0.9444 99.9 0.271 Contact Map
3bj6A 2 0.9722 99.9 0.273 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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