GREMLIN Database
WAAU - Lipopolysaccharide 1,2-N-acetylglucosaminetransferase
UniProt: P27242 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11423
Length: 357 (296)
Sequences: 5488 (4417)
Seq/√Len: 256.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
73_T116_F4.1221.00
212_I280_S3.9711.00
235_E345_T3.3731.00
42_S71_K3.2311.00
282_F348_V2.9641.00
92_E114_L2.9461.00
213_I233_Y2.9151.00
239_H349_K2.9111.00
66_Y91_F2.7011.00
228_Q341_T2.6331.00
254_L258_P2.5591.00
71_K91_F2.5571.00
291_V303_A2.5071.00
327_I350_R2.4561.00
269_E272_Y2.4031.00
43_C70_V2.3351.00
55_L84_L2.2781.00
166_E174_E2.2591.00
212_I277_T2.2591.00
225_T228_Q2.2401.00
212_I248_T2.1851.00
229_I286_V2.1831.00
198_E278_K2.1681.00
232_I345_T2.1461.00
71_K92_E2.1461.00
232_I284_I2.1421.00
142_Y156_F2.1171.00
273_T290_L2.1131.00
202_K279_Y2.0561.00
200_K272_Y2.0311.00
208_T244_R1.9641.00
224_L344_L1.9571.00
209_R281_D1.9491.00
285_S291_V1.9221.00
210_I279_Y1.8991.00
81_G85_S1.8921.00
211_V236_V1.8881.00
73_T91_F1.8811.00
226_F259_I1.8791.00
342_E346_N1.8521.00
235_E342_E1.8491.00
240_F243_Y1.7561.00
224_L228_Q1.7481.00
61_I122_P1.7321.00
44_L75_L1.7281.00
237_K261_E1.6941.00
42_S73_T1.6781.00
174_E177_K1.6591.00
284_I348_V1.6591.00
45_I62_Y1.6471.00
105_L109_K1.6461.00
235_E239_H1.6411.00
247_F257_I1.6301.00
340_D343_T1.6261.00
274_V293_I1.6171.00
197_V271_I1.5981.00
211_V243_Y1.5981.00
73_T94_C1.5941.00
257_I265_L1.5921.00
210_I281_D1.5841.00
78_R97_E1.5691.00
58_L122_P1.5691.00
210_I280_S1.5631.00
42_S114_L1.5421.00
211_V282_F1.5311.00
249_G266_P1.5201.00
334_Y338_D1.5181.00
228_Q231_V1.5091.00
82_E85_S1.5051.00
331_S343_T1.5051.00
73_T92_E1.4971.00
224_L229_I1.4961.00
347_S350_R1.4911.00
263_E266_P1.4581.00
210_I246_I1.4411.00
63_R190_D1.4301.00
283_V299_K1.4291.00
194_P197_V1.4071.00
231_V234_Q1.4021.00
327_I347_S1.3781.00
136_S143_I1.3671.00
176_L182_E1.3651.00
217_G223_R1.3521.00
119_V135_L1.3501.00
309_R317_L1.3471.00
204_F272_Y1.3451.00
214_N288_T1.3341.00
225_T337_K1.3331.00
277_T297_Y1.3211.00
209_R243_Y1.3201.00
73_T114_L1.3071.00
214_N285_S1.3051.00
230_K234_Q1.2931.00
248_T273_T1.2771.00
283_V294_A1.2601.00
66_Y72_I1.2401.00
118_I144_L1.2381.00
63_R67_S1.2331.00
197_V272_Y1.2231.00
47_H50_N1.2141.00
43_C72_I1.2061.00
235_E238_T1.2001.00
255_L259_I1.1931.00
210_I244_R1.1921.00
61_I176_L1.1891.00
222_C287_D1.1891.00
188_N298_H1.1871.00
231_V235_E1.1861.00
257_I263_E1.1851.00
255_L258_P1.1801.00
224_L232_I1.1691.00
63_R89_N1.1641.00
74_L84_L1.1621.00
215_P247_F1.1581.00
44_L116_F1.1561.00
212_I276_L1.1521.00
62_Y74_L1.1471.00
343_T346_N1.1441.00
234_Q238_T1.1401.00
57_V319_W1.1351.00
304_F339_I1.1301.00
343_T347_S1.1231.00
231_V341_T1.1211.00
195_V199_D1.1141.00
345_T349_K1.1141.00
81_G95_I1.1011.00
81_G93_F1.0971.00
235_E341_T1.0961.00
244_R262_I1.0871.00
319_W322_N1.0831.00
43_C118_I1.0821.00
156_F159_P1.0641.00
86_N271_I1.0621.00
285_S303_A1.0581.00
66_Y70_V1.0451.00
170_T322_N1.0441.00
233_Y247_F1.0421.00
282_F302_L1.0401.00
277_T299_K1.0381.00
323_H326_S1.0321.00
222_C308_S1.0281.00
55_L80_G1.0281.00
140_D143_I1.0281.00
302_L351_L1.0261.00
223_R286_V1.0231.00
51_K218_A1.0231.00
236_V348_V1.0221.00
64_E67_S1.0221.00
236_V345_T1.0191.00
201_I275_A1.0161.00
119_V140_D1.0151.00
223_R256_T1.0091.00
302_L347_S1.0071.00
231_V342_E1.0041.00
336_V339_I1.0001.00
64_E68_K0.9981.00
232_I235_E0.9941.00
224_L341_T0.9871.00
232_I341_T0.9851.00
248_T280_S0.9851.00
68_K182_E0.9821.00
82_E271_I0.9771.00
239_H345_T0.9771.00
169_S322_N0.9771.00
214_N283_V0.9761.00
227_E337_K0.9741.00
249_G263_E0.9721.00
310_T330_V0.9701.00
41_K117_D0.9691.00
46_I75_L0.9591.00
59_S87_N0.9491.00
85_S271_I0.9481.00
166_E170_T0.9461.00
200_K204_F0.9451.00
258_P263_E0.9441.00
143_I155_S0.9431.00
108_C112_R0.9381.00
304_F344_L0.9351.00
302_L348_V0.9351.00
118_I142_Y0.9301.00
74_L90_I0.9271.00
55_L74_L0.9241.00
342_E345_T0.9211.00
121_D131_H0.9201.00
221_I335_T0.9171.00
56_I293_I0.9131.00
200_K203_E0.9081.00
213_I284_I0.9071.00
274_V297_Y0.9021.00
216_L253_D0.9011.00
246_I276_L0.9011.00
109_K113_D0.9001.00
228_Q340_D0.8971.00
210_I243_Y0.8951.00
243_Y281_D0.8931.00
52_L80_G0.8891.00
211_V284_I0.8861.00
237_K245_I0.8841.00
154_Y157_Y0.8841.00
199_D203_E0.8731.00
254_L267_F0.8721.00
284_I302_L0.8721.00
167_H320_S0.8631.00
230_K233_Y0.8631.00
339_I343_T0.8570.99
88_K192_H0.8510.99
66_Y89_N0.8480.99
263_E267_F0.8450.99
216_L223_R0.8430.99
214_N248_T0.8410.99
227_E259_I0.8410.99
167_H322_N0.8400.99
240_F245_I0.8390.99
41_K69_G0.8380.99
78_R81_G0.8370.99
277_T283_V0.8370.99
52_L270_F0.8300.99
76_T93_F0.8210.99
108_C137_S0.8190.99
168_M171_R0.8130.99
229_I233_Y0.8110.99
278_K299_K0.8040.99
64_E173_I0.8010.99
212_I283_V0.7990.99
333_T338_D0.7970.99
188_N324_H0.7930.99
106_T109_K0.7900.99
235_E349_K0.7890.99
102_L106_T0.7870.99
268_D276_L0.7800.99
341_T345_T0.7790.99
66_Y69_G0.7780.99
287_D305_Y0.7740.99
148_H151_K0.7720.99
291_V305_Y0.7700.99
193_L201_I0.7660.99
236_V240_F0.7580.99
217_G286_V0.7570.99
219_K307_N0.7570.99
251_P254_L0.7520.99
224_L340_D0.7490.99
62_Y89_N0.7480.99
47_H55_L0.7450.99
42_S117_D0.7440.99
264_T268_D0.7430.99
119_V138_L0.7410.99
291_V301_T0.7400.99
65_L70_V0.7400.99
47_H51_K0.7380.98
135_L143_I0.7360.98
219_K222_C0.7350.98
330_V333_T0.7320.98
53_G292_H0.7320.98
147_D159_P0.7320.98
306_P336_V0.7270.98
275_A278_K0.7250.98
321_P328_Q0.7240.98
250_L253_D0.7240.98
42_S116_F0.7230.98
226_F230_K0.7230.98
70_V117_D0.7230.98
60_S173_I0.7230.98
278_K297_Y0.7210.98
306_P335_T0.7190.98
194_P271_I0.7190.98
135_L138_L0.7180.98
331_S338_D0.7180.98
228_Q337_K0.7150.98
145_G148_H0.7120.98
216_L256_T0.7120.98
44_L119_V0.7040.98
92_E110_H0.7030.98
216_L286_V0.7000.98
158_H161_D0.7000.98
211_V245_I0.6990.98
59_S296_A0.6990.98
268_D272_Y0.6950.98
146_F175_I0.6940.98
50_N123_F0.6910.98
234_Q237_K0.6890.98
170_T174_E0.6850.98
45_I65_L0.6830.98
51_K123_F0.6810.97
139_K143_I0.6790.97
59_S189_Y0.6780.97
195_V198_E0.6760.97
253_D256_T0.6750.97
346_N349_K0.6730.97
346_N350_R0.6690.97
177_K183_G0.6690.97
56_I274_V0.6660.97
184_K187_T0.6650.97
111_L138_L0.6640.97
89_N190_D0.6620.97
327_I351_L0.6590.97
256_T259_I0.6580.97
100_G103_E0.6550.97
216_L250_L0.6550.97
348_V351_L0.6550.97
224_L304_F0.6540.97
56_I296_A0.6520.97
281_D300_P0.6490.97
240_F349_K0.6490.97
46_I119_V0.6460.97
329_I339_I0.6450.96
249_G265_L0.6450.96
248_T290_L0.6450.96
51_K55_L0.6440.96
232_I348_V0.6430.96
228_Q232_I0.6430.96
280_S299_K0.6400.96
345_T348_V0.6400.96
91_F114_L0.6370.96
135_L140_D0.6370.96
53_G289_A0.6360.96
86_N275_A0.6340.96
120_L179_I0.6340.96
77_N80_G0.6320.96
302_L327_I0.6320.96
277_T293_I0.6310.96
198_E279_Y0.6300.96
254_L263_E0.6290.96
133_L137_S0.6260.96
167_H170_T0.6250.96
236_V243_Y0.6180.96
71_K116_F0.6140.95
302_L344_L0.6130.95
49_N123_F0.6090.95
207_D244_R0.6090.95
103_E106_T0.6080.95
50_N80_G0.6070.95
63_R186_S0.6050.95
214_N290_L0.6040.95
223_R229_I0.6040.95
87_N192_H0.6030.95
47_H58_L0.6020.95
121_D125_T0.6000.95
51_K57_V0.6000.95
105_L113_D0.6000.95
214_N319_W0.5990.95
334_Y337_K0.5950.95
168_M318_I0.5940.94
193_L198_E0.5940.94
275_A279_Y0.5940.94
125_T130_K0.5910.94
152_R156_F0.5900.94
94_C114_L0.5880.94
307_N335_T0.5880.94
190_D193_L0.5880.94
46_I135_L0.5880.94
117_D141_S0.5850.94
265_L268_D0.5840.94
304_F329_I0.5840.94
307_N336_V0.5830.94
54_D222_C0.5810.94
200_K269_E0.5790.94
55_L76_T0.5790.94
121_D124_E0.5780.94
328_Q332_P0.5770.94
51_K288_T0.5760.94
135_L139_K0.5760.94
201_I276_L0.5750.93
152_R155_S0.5750.93
277_T290_L0.5730.93
174_E178_H0.5720.93
87_N90_I0.5720.93
347_S351_L0.5710.93
199_D202_K0.5690.93
144_L158_H0.5680.93
62_Y90_I0.5670.93
50_N218_A0.5670.93
49_N175_I0.5670.93
90_I93_F0.5640.93
132_S145_G0.5630.93
122_P175_I0.5620.93
308_S336_V0.5610.93
161_D165_K0.5600.93
78_R95_I0.5590.93
264_T267_F0.5580.92
105_L112_R0.5580.92
234_Q260_L0.5570.92
110_H113_D0.5550.92
57_V169_S0.5550.92
301_T326_S0.5530.92
213_I245_I0.5510.92
112_R139_K0.5510.92
45_I120_L0.5510.92
123_F318_I0.5510.92
283_V301_T0.5500.92
205_I279_Y0.5470.92
144_L179_I0.5470.92
304_F335_T0.5470.92
201_I204_F0.5470.92
209_R244_R0.5450.92
67_S195_V0.5430.91
53_G222_C0.5430.91
205_I210_I0.5420.91
91_F116_F0.5420.91
213_I229_I0.5420.91
301_T323_H0.5410.91
50_N121_D0.5400.91
121_D135_L0.5390.91
198_E275_A0.5390.91
105_L137_S0.5380.91
295_A322_N0.5370.91
106_T110_H0.5350.91
280_S283_V0.5350.91
65_L120_L0.5320.91
138_L143_I0.5320.91
239_H243_Y0.5320.91
123_F319_W0.5290.90
198_E202_K0.5280.90
65_L72_I0.5240.90
51_K219_K0.5240.90
268_D273_T0.5220.90
70_V118_I0.5220.90
42_S70_V0.5200.90
246_I262_I0.5190.89
310_T317_L0.5180.89
120_L144_L0.5170.89
327_I330_V0.5160.89
67_S188_N0.5160.89
109_K112_R0.5160.89
67_S185_F0.5150.89
166_E171_R0.5140.89
262_I267_F0.5130.89
301_T305_Y0.5130.89
248_T277_T0.5130.89
283_V291_V0.5120.89
237_K260_L0.5120.89
213_I232_I0.5110.89
49_N288_T0.5100.89
67_S186_S0.5100.89
52_L293_I0.5090.89
107_L110_H0.5080.88
168_M222_C0.5070.88
153_Y159_P0.5050.88
224_L286_V0.5040.88
123_F171_R0.5040.88
249_G264_T0.5030.88
75_L111_L0.5030.88
170_T187_T0.5010.88
86_N194_P0.5000.88
168_M319_W0.5000.88
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2gt1A 1 0.8403 100 0.342 Contact Map
3tovA 1 0.8655 100 0.359 Contact Map
1pswA 1 0.8459 100 0.369 Contact Map
4rapA 3 0.8403 100 0.519 Contact Map
3ot5A 2 0.8263 99.2 0.812 Contact Map
4nesA 2 0.8151 99.1 0.818 Contact Map
4fkzA 2 0.8319 99.1 0.822 Contact Map
4rifA 2 0.8179 99.1 0.824 Contact Map
4hwgA 5 0.8179 99 0.831 Contact Map
1v4vA 2 0.8263 98.9 0.834 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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