GREMLIN Database
RFAB - Lipopolysaccharide 1,6-galactosyltransferase
UniProt: P27127 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11351
Length: 359 (334)
Sequences: 56816 (48698)
Seq/√Len: 2664.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
182_I256_V4.6001.00
210_K237_V3.5251.00
134_Y157_N3.1221.00
220_F224_Q3.0901.00
259_L275_A3.0901.00
180_T212_H3.0311.00
212_H239_Y2.7691.00
204_Q313_V2.7491.00
89_I351_I2.7391.00
183_Y195_V2.6151.00
200_D226_Y2.5661.00
334_S337_E2.5521.00
178_T210_K2.5491.00
206_K235_R2.4471.00
143_K147_I2.1911.00
179_A320_I2.1171.00
35_E85_P2.1111.00
194_R197_D2.0961.00
212_H237_V2.0871.00
200_D309_I2.0861.00
179_A257_S2.0691.00
219_D222_K2.0601.00
226_Y230_L2.0331.00
180_T210_K2.0291.00
315_L318_K2.0061.00
4_A85_P2.0041.00
286_D292_A1.9931.00
214_L252_D1.9681.00
180_T255_K1.9391.00
32_I348_H1.9261.00
322_G325_H1.9161.00
181_F258_A1.8581.00
318_K322_G1.8441.00
216_D220_F1.8431.00
202_L211_L1.8391.00
89_I115_W1.8261.00
302_H315_L1.7931.00
204_Q310_A1.7901.00
295_I301_G1.7681.00
279_G332_P1.7481.00
203_S230_L1.7461.00
194_R264_S1.7391.00
296_Q299_V1.7311.00
134_Y350_V1.7191.00
342_K346_R1.7111.00
140_S143_K1.6771.00
198_L211_L1.6701.00
318_K325_H1.6691.00
259_L280_I1.6551.00
296_Q300_N1.6491.00
157_N353_S1.6431.00
143_K158_V1.6391.00
348_H352_I1.6241.00
162_P340_Q1.6241.00
305_Q311_G1.6181.00
300_N334_S1.6131.00
30_Q345_D1.6031.00
30_Q348_H1.5991.00
137_A156_I1.5941.00
140_S293_D1.5841.00
286_D305_Q1.5821.00
114_S132_A1.5571.00
228_R233_D1.5321.00
202_L209_W1.5201.00
26_T344_Y1.5191.00
296_Q334_S1.5061.00
311_G315_L1.5041.00
302_H318_K1.4991.00
35_E83_Y1.4961.00
317_N321_A1.4911.00
198_L260_L1.4861.00
184_V249_V1.4831.00
140_S158_V1.4781.00
143_K156_I1.4751.00
26_T341_S1.4751.00
35_E60_S1.4701.00
197_D264_S1.4681.00
214_L239_Y1.4651.00
308_D311_G1.4571.00
188_K192_Q1.4541.00
192_Q265_F1.4371.00
21_R25_T1.4331.00
196_K226_Y1.4331.00
197_D309_I1.4321.00
205_A317_N1.4261.00
26_T29_Q1.4251.00
284_S291_P1.4181.00
322_G326_I1.4131.00
212_H252_D1.4071.00
256_V280_I1.3951.00
180_T257_S1.3931.00
242_Q248_L1.3911.00
212_H256_V1.3751.00
299_V330_K1.3741.00
250_Q278_W1.3491.00
243_Q248_L1.3471.00
137_A143_K1.3451.00
323_E326_I1.3311.00
136_L350_V1.3201.00
147_I153_E1.3191.00
242_Q252_D1.3191.00
195_V213_V1.3181.00
309_I313_V1.3151.00
214_L242_Q1.3061.00
325_H328_H1.3051.00
304_Y315_L1.3021.00
204_Q309_I1.3011.00
183_Y198_L1.2991.00
4_A37_F1.2951.00
90_C112_V1.2701.00
201_G312_F1.2631.00
254_E278_W1.2541.00
346_R349_K1.2431.00
333_A336_D1.2401.00
182_I214_L1.2361.00
187_M213_V1.2331.00
136_L347_L1.2301.00
226_Y229_E1.2261.00
181_F260_L1.2171.00
203_S207_G1.2161.00
248_L251_Q1.2141.00
311_G314_T1.2111.00
239_Y242_Q1.2051.00
342_K345_D1.2011.00
5_F27_F1.2001.00
5_F91_I1.1931.00
330_K333_A1.1861.00
268_F273_L1.1851.00
181_F316_L1.1781.00
134_Y353_S1.1731.00
79_W83_Y1.1621.00
197_D200_D1.1491.00
264_S307_G1.1481.00
313_V317_N1.1461.00
19_V270_M1.1411.00
279_G329_E1.1361.00
339_Y342_K1.1361.00
179_A258_A1.1341.00
167_D250_Q1.1221.00
216_D241_W1.1221.00
225_A229_E1.1161.00
175_E178_T1.1151.00
179_A209_W1.1131.00
196_K200_D1.1121.00
140_S144_Q1.1111.00
35_E58_S1.1081.00
261_L272_L1.1061.00
144_Q147_I1.1051.00
340_Q343_Y1.1001.00
285_A304_Y1.0991.00
197_D285_A1.0971.00
272_L291_P1.0971.00
304_Y312_F1.0911.00
253_I278_W1.0901.00
180_T256_V1.0841.00
249_V253_I1.0801.00
289_S292_A1.0791.00
343_Y346_R1.0761.00
26_T30_Q1.0541.00
297_P315_L1.0531.00
138_I142_I1.0471.00
28_R31_H1.0461.00
224_Q228_R1.0421.00
261_L271_T1.0411.00
263_S266_E1.0381.00
221_E224_Q1.0371.00
212_H255_K1.0341.00
200_D230_L1.0331.00
290_G293_D1.0321.00
244_Y249_V1.0261.00
197_D307_G1.0251.00
250_Q254_E1.0191.00
181_F202_L1.0171.00
138_I161_N1.0161.00
137_A146_M1.0121.00
221_E225_A1.0091.00
262_T312_F1.0041.00
22_D25_T1.0031.00
5_F24_I0.9991.00
182_I252_D0.9951.00
157_N350_V0.9891.00
22_D340_Q0.9891.00
272_L284_S0.9891.00
179_A208_N0.9881.00
117_H270_M0.9871.00
178_T208_N0.9851.00
165_T339_Y0.9831.00
276_L282_C0.9831.00
168_S173_P0.9811.00
137_A142_I0.9811.00
239_Y252_D0.9801.00
259_L271_T0.9791.00
302_H319_Y0.9771.00
343_Y347_L0.9721.00
198_L262_T0.9711.00
314_T318_K0.9661.00
14_G17_E0.9621.00
284_S303_L0.9611.00
196_K222_K0.9591.00
184_V253_I0.9581.00
269_P291_P0.9561.00
91_I117_H0.9501.00
227_G238_W0.9501.00
184_V214_L0.9451.00
202_L235_R0.9441.00
74_H78_K0.9341.00
209_W320_I0.9331.00
345_D349_K0.9301.00
112_V132_A0.9281.00
90_C114_S0.9271.00
186_R192_Q0.9241.00
161_N270_M0.9191.00
197_D312_F0.9171.00
196_K264_S0.9121.00
138_I267_G0.9101.00
323_E327_E0.9091.00
18_T22_D0.9051.00
275_A280_I0.9051.00
162_P343_Y0.9041.00
164_E167_D0.9021.00
199_L227_G0.9011.00
145_Q148_N0.8981.00
188_K218_S0.8931.00
183_Y213_V0.8921.00
272_L282_C0.8911.00
204_Q207_G0.8911.00
132_A135_H0.8911.00
329_E333_A0.8891.00
24_I36_M0.8881.00
283_I304_Y0.8651.00
266_E269_P0.8641.00
205_A313_V0.8641.00
19_V117_H0.8631.00
284_S295_I0.8601.00
24_I28_R0.8591.00
210_K235_R0.8591.00
222_K225_A0.8581.00
205_A320_I0.8581.00
200_D203_S0.8561.00
345_D348_H0.8541.00
196_K219_D0.8541.00
261_L291_P0.8531.00
244_Y250_Q0.8501.00
193_K266_E0.8481.00
227_G232_I0.8471.00
287_C291_P0.8421.00
201_G313_V0.8401.00
113_F136_L0.8391.00
205_A209_W0.8391.00
253_I280_I0.8381.00
258_A319_Y0.8331.00
144_Q148_N0.8311.00
205_A316_L0.8301.00
183_Y262_T0.8281.00
222_K226_Y0.8281.00
35_E39_F0.8241.00
276_L331_I0.8221.00
147_I156_I0.8211.00
200_D204_Q0.8211.00
77_S107_G0.8181.00
141_G144_Q0.8171.00
203_S206_K0.8131.00
281_P319_Y0.8111.00
77_S81_Q0.8101.00
159_I350_V0.8101.00
193_K271_T0.8091.00
283_I315_L0.8071.00
157_N346_R0.8041.00
297_P300_N0.8021.00
272_L294_I0.8021.00
332_P335_I0.8001.00
176_G179_A0.8001.00
276_L300_N0.7961.00
22_D164_E0.7951.00
168_S278_W0.7911.00
20_I91_I0.7911.00
302_H325_H0.7871.00
252_D255_K0.7841.00
113_F134_Y0.7841.00
331_I334_S0.7821.00
251_Q255_K0.7811.00
136_L159_I0.7791.00
340_Q344_Y0.7791.00
74_H77_S0.7751.00
182_I253_I0.7741.00
111_P133_D0.7741.00
183_Y211_L0.7711.00
141_G145_Q0.7691.00
201_G309_I0.7671.00
260_L316_L0.7661.00
295_I303_L0.7621.00
349_K353_S0.7621.00
339_Y343_Y0.7611.00
276_L334_S0.7601.00
184_V259_L0.7591.00
227_G236_I0.7581.00
191_G196_K0.7571.00
225_A228_R0.7531.00
89_I347_L0.7501.00
286_D303_L0.7491.00
251_Q254_E0.7471.00
118_F192_Q0.7471.00
19_V115_W0.7461.00
19_V161_N0.7441.00
305_Q308_D0.7421.00
117_H138_I0.7411.00
5_F34_S0.7381.00
203_S232_I0.7351.00
123_K126_A0.7341.00
334_S338_F0.7341.00
14_G186_R0.7341.00
227_G230_L0.7331.00
300_N331_I0.7321.00
314_T317_N0.7281.00
22_D26_T0.7281.00
160_F346_R0.7271.00
191_G219_D0.7251.00
258_A316_L0.7241.00
310_A314_T0.7221.00
329_E332_P0.7211.00
341_S345_D0.7211.00
269_P272_L0.7191.00
324_I328_H0.7181.00
310_A313_V0.7151.00
193_K263_S0.7141.00
30_Q341_S0.7111.00
183_Y259_L0.7061.00
319_Y326_I0.7051.00
7_G20_I0.7041.00
330_K334_S0.7031.00
91_I115_W0.7031.00
243_Q247_E0.7011.00
292_A303_L0.7011.00
347_L351_I0.6991.00
78_K82_E0.6991.00
185_G195_V0.6981.00
191_G264_S0.6981.00
219_D223_C0.6961.00
18_T21_R0.6951.00
159_I347_L0.6931.00
30_Q344_Y0.6931.00
181_F209_W0.6901.00
318_K321_A0.6891.00
350_V353_S0.6881.00
285_A306_P0.6831.00
90_C96_C0.6791.00
138_I270_M0.6791.00
61_N64_L0.6771.00
108_I111_P0.6741.00
206_K209_W0.6741.00
7_G16_M0.6741.00
185_G193_K0.6741.00
113_F351_I0.6701.00
165_T277_S0.6701.00
157_N160_F0.6681.00
160_F293_D0.6661.00
181_F320_I0.6631.00
107_G110_M0.6601.00
49_W53_I0.6591.00
285_A312_F0.6591.00
28_R34_S0.6581.00
187_M220_F0.6541.00
283_I319_Y0.6521.00
224_Q238_W0.6521.00
50_L54_K0.6521.00
87_I113_F0.6511.00
188_K191_G0.6491.00
349_K352_I0.6481.00
127_E131_C0.6481.00
175_E210_K0.6481.00
261_L269_P0.6481.00
268_F338_F0.6461.00
295_I300_N0.6431.00
179_A182_I0.6431.00
252_D256_V0.6421.00
85_P110_M0.6401.00
273_L338_F0.6371.00
242_Q249_V0.6371.00
297_P302_H0.6351.00
174_E178_T0.6301.00
195_V219_D0.6301.00
56_S60_S0.6281.00
24_I34_S0.6281.00
28_R32_I0.6271.00
337_E342_K0.6271.00
208_N235_R0.6261.00
259_L282_C0.6231.00
99_A103_R0.6221.00
19_V347_L0.6221.00
159_I346_R0.6201.00
260_L312_F0.6201.00
115_W347_L0.6191.00
180_T252_D0.6171.00
9_A17_E0.6161.00
202_L205_A0.6161.00
201_G205_A0.6101.00
197_D201_G0.6091.00
344_Y348_H0.6091.00
25_T29_Q0.6091.00
142_I145_Q0.6091.00
199_L236_I0.6081.00
201_G316_L0.6081.00
331_I335_I0.6041.00
194_R307_G0.6041.00
258_A283_I0.6041.00
123_K127_E0.6041.00
160_F338_F0.5991.00
253_I271_T0.5991.00
23_V347_L0.5971.00
87_I351_I0.5961.00
187_M195_V0.5961.00
88_V110_M0.5951.00
29_Q341_S0.5921.00
194_R262_T0.5921.00
96_C99_A0.5911.00
92_D95_S0.5891.00
141_G292_A0.5871.00
90_C99_A0.5841.00
262_T285_A0.5831.00
164_E340_Q0.5791.00
304_Y311_G0.5791.00
137_A158_V0.5781.00
22_D270_M0.5761.00
281_P326_I0.5721.00
18_T244_Y0.5721.00
47_K51_E0.5721.00
194_R285_A0.5721.00
26_T340_Q0.5711.00
174_E180_T0.5701.00
276_L335_I0.5691.00
32_I352_I0.5691.00
165_T335_I0.5661.00
4_A35_E0.5641.00
112_V133_D0.5641.00
182_I259_L0.5631.00
257_S326_I0.5601.00
139_S142_I0.5601.00
5_F89_I0.5591.00
140_S160_F0.5581.00
211_L236_I0.5581.00
227_G233_D0.5571.00
253_I259_L0.5551.00
117_H161_N0.5551.00
275_A282_C0.5551.00
202_L206_K0.5531.00
182_I280_I0.5521.00
198_L202_L0.5511.00
179_A323_E0.5501.00
87_I90_C0.5501.00
119_S122_H0.5501.00
182_I212_H0.5481.00
81_Q108_I0.5471.00
298_D318_K0.5471.00
134_Y138_I0.5471.00
79_W82_E0.5451.00
283_I316_L0.5451.00
263_S267_G0.5451.00
199_L223_C0.5431.00
25_T28_R0.5431.00
143_K153_E0.5421.00
16_M92_D0.5411.00
115_W136_L0.5411.00
19_V23_V0.5401.00
5_F351_I0.5401.00
19_V91_I0.5401.00
13_F241_W0.5401.00
174_E255_K0.5401.00
31_H34_S0.5391.00
286_D306_P0.5391.00
142_I267_G0.5381.00
273_L294_I0.5381.00
100_A103_R0.5371.00
116_P142_I0.5351.00
269_P273_L0.5341.00
23_V26_T0.5321.00
203_S229_E0.5321.00
322_G327_E0.5261.00
253_I275_A0.5251.00
214_L249_V0.5251.00
201_G260_L0.5211.00
271_T275_A0.5201.00
300_N330_K0.5171.00
160_F268_F0.5141.00
147_I155_T0.5141.00
10_V21_R0.5141.00
160_F343_Y0.5141.00
28_R56_S0.5131.00
203_S226_Y0.5101.00
324_I327_E0.5091.00
47_K50_L0.5091.00
68_R72_H0.5091.00
224_Q227_G0.5071.00
215_G240_G0.5071.00
141_G293_D0.5061.00
58_S61_N0.5051.00
263_S269_P0.5031.00
287_C292_A0.5021.00
186_R193_K0.5021.00
196_K223_C0.5011.00
118_F121_D0.5001.00
147_I150_G0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2r60A 1 0.9749 100 0.14 Contact Map
3c48A 2 0.9582 100 0.156 Contact Map
4n9wA 1 0.9164 100 0.164 Contact Map
1rzuA 1 0.9749 100 0.172 Contact Map
2qzsA 1 0.961 100 0.185 Contact Map
2jjmA 4 0.9276 100 0.186 Contact Map
3froA 3 0.9721 100 0.193 Contact Map
3oy2A 2 0.9526 100 0.198 Contact Map
4hlnA 1 0.9694 100 0.204 Contact Map
2x6qA 1 0.9387 100 0.211 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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