GREMLIN Database
RHAT - L-rhamnose-proton symporter
UniProt: P27125 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11313
Length: 344 (332)
Sequences: 269 (169)
Seq/√Len: 9.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
150_I330_V9.2011.00
143_V337_I8.2901.00
189_S193_N5.4381.00
90_Y303_G4.1830.99
255_I259_V3.7280.97
214_L277_A3.3330.95
153_R157_L3.2870.94
171_L175_L3.1520.93
189_S220_I3.0950.92
57_L214_L2.9680.91
112_I141_V2.7940.88
75_P78_L2.7400.87
29_V262_S2.6710.85
83_W224_G2.6240.84
240_K319_R2.4890.81
61_F64_Y2.4470.79
47_I225_A2.4350.79
112_I145_L2.4080.78
69_S201_A2.2870.74
105_I267_L2.2370.73
247_D250_L2.1940.71
36_T236_L2.1810.71
234_I238_K2.1650.70
12_H295_H2.1590.70
60_N63_A2.1080.68
290_I342_M2.0940.68
161_K317_G2.0710.67
242_L246_A2.0200.65
77_F226_I1.9440.61
21_C306_V1.9280.61
311_K314_N1.8930.59
240_K332_I1.7870.55
237_A242_L1.7780.54
162_M316_A1.7640.54
103_I303_G1.7630.54
28_K177_L1.7460.53
196_K200_E1.7440.53
107_I239_V1.7300.52
41_G45_S1.7280.52
206_G209_P1.6830.50
112_I149_G1.6790.50
30_K319_R1.6720.50
195_A216_S1.6490.49
203_A206_G1.6430.48
113_V137_T1.6400.48
115_T302_C1.6380.48
59_P202_A1.6360.48
13_L302_C1.6330.48
115_T270_Y1.6320.48
184_F215_P1.6300.48
99_M109_I1.6100.47
20_A270_Y1.6070.47
35_E83_W1.5770.45
43_I225_A1.5770.45
305_I318_R1.5740.45
225_A229_L1.5720.45
71_S120_I1.5540.44
126_D130_S1.5540.44
270_Y302_C1.5480.44
94_M103_I1.5450.44
134_G138_L1.5160.43
43_I63_A1.5070.42
70_L260_L1.5060.42
252_K318_R1.4990.42
62_W67_S1.4910.42
228_N269_W1.4800.41
94_M303_G1.4800.41
305_I333_V1.4750.41
266_G279_G1.4730.41
192_M220_I1.4680.41
241_D330_V1.4580.40
142_L146_I1.4560.40
21_C88_I1.4530.40
67_S201_A1.4520.40
110_T113_V1.4390.40
90_Y207_V1.4270.39
65_Y198_M1.4240.39
13_L298_F1.4210.39
78_L148_V1.4140.39
48_I204_A1.4120.38
319_R322_T1.4030.38
99_M209_P1.3970.38
246_A260_L1.3940.38
183_I311_K1.3910.38
106_A115_T1.3880.37
90_Y103_I1.3770.37
199_H213_A1.3730.37
37_M261_L1.3720.37
258_N273_F1.3530.36
48_I318_R1.3420.36
48_I229_L1.3330.35
51_W93_T1.3280.35
137_T190_F1.3260.35
52_A162_M1.3210.35
231_F300_V1.3180.35
69_S179_V1.2980.34
172_K303_G1.2950.34
117_M308_L1.2930.34
92_L97_L1.2890.33
39_S233_F1.2850.33
133_G206_G1.2570.32
9_I234_I1.2530.32
158_K339_G1.2510.32
16_A49_L1.2220.31
186_A298_F1.2170.31
109_I235_R1.2100.30
108_G174_G1.1850.29
89_N299_Y1.1830.29
199_H277_A1.1820.29
36_T283_I1.1800.29
40_V236_L1.1800.29
115_T324_L1.1710.29
20_A302_C1.1710.29
229_L233_F1.1680.29
74_L257_H1.1560.28
189_S297_S1.1560.28
87_N227_I1.1540.28
57_L277_A1.1530.28
70_L204_A1.1490.28
282_R303_G1.1480.28
99_M103_I1.1390.28
72_T77_F1.1370.28
249_S319_R1.1320.28
42_G224_G1.1290.27
46_W274_F1.1290.27
27_K113_V1.1290.27
183_I315_N1.1280.27
123_G206_G1.1270.27
192_M217_Y1.1100.27
147_G232_C1.1090.27
203_A208_D1.1080.27
180_M184_F1.1070.27
179_V234_I1.1040.27
175_L202_A1.1030.27
71_S116_L1.1000.26
93_T103_I1.0990.26
189_S211_Y1.0870.26
191_A306_V1.0840.26
246_A319_R1.0710.25
278_W300_V1.0680.25
47_I328_C1.0620.25
52_A316_A1.0600.25
197_P200_E1.0560.25
10_F105_I1.0390.24
63_A142_L1.0370.24
176_V233_F1.0340.24
51_W303_G1.0300.24
46_W272_Q1.0270.24
58_L175_L1.0250.24
180_M331_I1.0250.24
146_I333_V1.0160.24
60_N326_L1.0150.24
151_V303_G1.0130.24
85_I180_M1.0110.24
308_L324_L1.0100.23
42_G46_W1.0080.23
137_T157_L1.0070.23
113_V117_M1.0060.23
158_K316_A1.0030.23
181_C277_A0.9970.23
218_V221_M0.9940.23
60_N209_P0.9910.23
188_M192_M0.9880.23
69_S142_L0.9860.23
5_I216_S0.9790.23
10_F337_I0.9770.22
105_I176_V0.9740.22
200_E332_I0.9730.22
149_G162_M0.9690.22
151_V215_P0.9670.22
30_K240_K0.9670.22
46_W296_M0.9660.22
35_E327_G0.9600.22
297_S310_L0.9580.22
93_T123_G0.9550.22
114_G182_G0.9540.22
10_F66_S0.9530.22
164_I326_L0.9530.22
200_E204_A0.9510.22
74_L149_G0.9490.22
201_A337_I0.9390.21
166_A323_V0.9390.21
55_A160_R0.9390.21
90_Y268_M0.9390.21
139_L176_V0.9350.21
204_A234_I0.9350.21
142_L326_L0.9320.21
315_N334_A0.9290.21
144_A297_S0.9250.21
185_S334_A0.9220.21
218_V338_V0.9130.21
122_N193_N0.9110.20
266_G269_W0.9090.20
161_K316_A0.9090.20
228_N327_G0.9080.20
123_G189_S0.9060.20
74_L78_L0.9030.20
316_A321_V0.9030.20
105_I220_I0.9020.20
39_S48_I0.8980.20
102_G258_N0.8950.20
107_I191_A0.8870.20
278_W281_A0.8840.20
198_M219_V0.8840.20
203_A212_V0.8830.20
23_Y232_C0.8820.20
218_V308_L0.8820.20
56_L200_E0.8720.19
42_G188_M0.8700.19
120_I169_F0.8690.19
7_M139_L0.8640.19
139_L260_L0.8620.19
70_L78_L0.8590.19
280_H288_D0.8580.19
23_Y272_Q0.8570.19
69_S196_K0.8550.19
178_A327_G0.8530.19
49_L263_T0.8510.19
167_E171_L0.8460.19
145_L203_A0.8430.19
92_L102_G0.8420.19
202_A218_V0.8390.19
171_L315_N0.8370.18
67_S200_E0.8340.18
117_M322_T0.8330.18
250_L253_S0.8330.18
127_V252_K0.8320.18
34_W269_W0.8250.18
294_L298_F0.8250.18
27_K219_V0.8240.18
41_G181_C0.8230.18
298_F331_I0.8190.18
324_L330_V0.8150.18
142_L333_V0.8150.18
186_A190_F0.8150.18
146_I318_R0.8140.18
67_S71_S0.8140.18
177_L186_A0.8110.18
43_I260_L0.8040.18
189_S289_Y0.8020.18
139_L196_K0.7980.17
45_S265_G0.7970.17
117_M201_A0.7970.17
42_G102_G0.7930.17
25_P195_A0.7930.17
260_L264_L0.7900.17
14_I291_S0.7860.17
67_S139_L0.7840.17
23_Y273_F0.7800.17
32_W273_F0.7790.17
6_T326_L0.7740.17
29_V177_L0.7720.17
109_I179_V0.7720.17
52_A318_R0.7700.17
113_V316_A0.7700.17
145_L190_F0.7660.17
62_W66_S0.7650.17
79_F229_L0.7630.17
93_T295_H0.7630.17
74_L121_I0.7630.17
240_K257_H0.7610.17
74_L201_A0.7600.16
94_M97_L0.7590.16
122_N319_R0.7590.16
120_I194_A0.7570.16
148_V236_L0.7560.16
146_I149_G0.7530.16
15_G273_F0.7490.16
159_E171_L0.7460.16
240_K329_V0.7450.16
69_S219_V0.7430.16
293_M335_A0.7420.16
261_L310_L0.7410.16
93_T119_P0.7400.16
241_D305_I0.7400.16
160_R250_L0.7390.16
293_M334_A0.7380.16
63_A329_V0.7370.16
136_M139_L0.7360.16
189_S214_L0.7350.16
261_L308_L0.7340.16
60_N321_V0.7310.16
111_L141_V0.7310.16
283_I336_N0.7290.16
118_T284_P0.7260.16
112_I268_M0.7250.16
104_G152_T0.7220.16
59_P207_V0.7210.16
20_A49_L0.7190.16
16_A295_H0.7160.15
40_V219_V0.7160.15
48_I67_S0.7150.15
83_W228_N0.7140.15
15_G46_W0.7140.15
58_L161_K0.7030.15
137_T171_L0.7020.15
5_I104_G0.6980.15
49_L219_V0.6970.15
288_D291_S0.6950.15
69_S193_N0.6910.15
43_I128_L0.6900.15
105_I207_V0.6890.15
75_P121_I0.6880.15
46_W273_F0.6880.15
12_H279_G0.6850.15
186_A236_L0.6850.15
46_W227_I0.6850.15
179_V268_M0.6850.15
104_G289_Y0.6820.15
327_G339_G0.6800.15
262_S316_A0.6790.15
65_Y69_S0.6780.15
16_A299_Y0.6780.15
45_S131_T0.6770.15
97_L102_G0.6770.15
49_L267_L0.6750.15
77_F142_L0.6720.14
66_S139_L0.6710.14
139_L179_V0.6700.14
97_L232_C0.6690.14
160_R318_R0.6690.14
10_F63_A0.6680.14
19_A231_F0.6670.14
30_K261_L0.6670.14
64_Y219_V0.6620.14
27_K328_C0.6600.14
104_G320_P0.6600.14
159_E197_P0.6590.14
17_A298_F0.6580.14
82_M165_K0.6550.14
166_A303_G0.6540.14
45_S93_T0.6530.14
218_V282_R0.6520.14
11_W221_M0.6510.14
88_I231_F0.6490.14
76_V238_K0.6470.14
335_A341_G0.6470.14
160_R238_K0.6470.14
56_L203_A0.6470.14
105_I325_S0.6460.14
120_I241_D0.6460.14
129_I301_L0.6450.14
80_G269_W0.6450.14
117_M132_E0.6430.14
56_L139_L0.6400.14
175_L325_S0.6380.14
7_M317_G0.6370.14
118_T292_W0.6370.14
15_G272_Q0.6370.14
109_I167_E0.6360.14
167_E319_R0.6320.14
221_M334_A0.6300.14
236_L242_L0.6290.14
19_A300_V0.6270.14
176_V332_I0.6260.13
85_I175_L0.6250.13
159_E276_Y0.6240.13
32_W296_M0.6240.13
68_F337_I0.6240.13
37_M137_T0.6240.13
189_S324_L0.6240.13
129_I183_I0.6240.13
10_F267_L0.6230.13
23_Y46_W0.6220.13
106_A141_V0.6210.13
35_E239_V0.6200.13
15_G95_R0.6200.13
77_F81_A0.6190.13
66_S70_L0.6180.13
78_L237_A0.6180.13
99_M241_D0.6170.13
119_P289_Y0.6130.13
6_T240_K0.6120.13
103_I206_G0.6120.13
110_T150_I0.6110.13
151_V214_L0.6100.13
32_W272_Q0.6040.13
80_G266_G0.6040.13
256_I329_V0.6040.13
18_S268_M0.6030.13
139_L142_L0.6020.13
60_N201_A0.5990.13
6_T230_G0.5990.13
63_A67_S0.5980.13
95_R296_M0.5980.13
127_V200_E0.5970.13
140_G313_W0.5970.13
16_A278_W0.5970.13
93_T106_A0.5960.13
151_V184_F0.5950.13
189_S304_G0.5940.13
81_A131_T0.5930.13
22_F41_G0.5930.13
14_I322_T0.5930.13
70_L322_T0.5930.13
14_I17_A0.5920.13
60_N252_K0.5910.13
146_I164_I0.5880.13
14_I240_K0.5880.13
73_R311_K0.5870.13
24_A58_L0.5860.13
19_A275_F0.5860.13
306_V334_A0.5850.13
169_F272_Q0.5840.13
106_A110_T0.5840.13
326_L332_I0.5840.13
141_V175_L0.5810.13
217_Y293_M0.5800.13
210_L292_W0.5790.13
160_R332_I0.5780.13
111_L192_M0.5780.13
60_N74_L0.5770.13
10_F256_I0.5770.13
34_W228_N0.5770.13
118_T254_L0.5740.12
30_K143_V0.5730.12
318_R337_I0.5730.12
82_M87_N0.5720.12
23_Y29_V0.5680.12
5_I284_P0.5670.12
135_R143_V0.5670.12
252_K322_T0.5660.12
41_G279_G0.5660.12
131_T319_R0.5630.12
204_A216_S0.5620.12
132_E135_R0.5610.12
100_S131_T0.5600.12
25_P102_G0.5600.12
10_F139_L0.5590.12
46_W169_F0.5590.12
139_L333_V0.5570.12
25_P258_N0.5550.12
279_G303_G0.5540.12
116_L146_I0.5540.12
12_H19_A0.5540.12
15_G92_L0.5530.12
274_F296_M0.5510.12
32_W97_L0.5510.12
26_F109_I0.5500.12
196_K212_V0.5490.12
161_K262_S0.5480.12
164_I176_V0.5480.12
256_I305_I0.5470.12
276_Y292_W0.5460.12
94_M181_C0.5450.12
29_V116_L0.5440.12
268_M337_I0.5430.12
126_D149_G0.5430.12
202_A277_A0.5410.12
20_A53_I0.5410.12
183_I303_G0.5400.12
56_L326_L0.5390.12
270_Y274_F0.5380.12
31_K240_K0.5350.12
100_S262_S0.5350.12
236_L241_D0.5350.12
276_Y284_P0.5340.12
90_Y112_I0.5320.12
272_Q296_M0.5320.12
191_A220_I0.5320.12
274_F291_S0.5280.12
63_A66_S0.5280.12
47_I283_I0.5280.12
272_Q295_H0.5280.12
100_S107_I0.5270.12
5_I289_Y0.5260.12
6_T130_S0.5250.12
234_I246_A0.5250.12
137_T170_N0.5240.12
64_Y104_G0.5240.12
88_I334_A0.5230.12
126_D167_E0.5210.11
293_M297_S0.5190.11
247_D337_I0.5170.11
78_L170_N0.5150.11
127_V260_L0.5150.11
113_V163_G0.5140.11
164_I204_A0.5130.11
42_G97_L0.5120.11
17_A248_F0.5120.11
115_T215_P0.5100.11
175_L326_L0.5090.11
25_P32_W0.5080.11
15_G169_F0.5080.11
112_I175_L0.5070.11
233_F242_L0.5070.11
201_A204_A0.5070.11
180_M231_F0.5070.11
22_F181_C0.5050.11
9_I141_V0.5040.11
107_I113_V0.5040.11
45_S228_N0.5030.11
210_L278_W0.5030.11
201_A336_N0.5020.11
112_I203_A0.5010.11
94_M99_M0.5010.11
10_F333_V0.5000.11
240_K246_A0.5000.11
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2i68A 2 0.2267 92.3 0.955 Contact Map
3b5dA 2 0.2965 89.9 0.958 Contact Map
3wdoA 1 0.8314 85.5 0.961 Contact Map
2cfqA 1 0.8314 83.7 0.962 Contact Map
3o7qA 1 0.843 70.3 0.966 Contact Map
4tphA 2 0.7965 68.5 0.967 Contact Map
4xnjA 1 0.843 62.9 0.968 Contact Map
4m64A 1 0.8372 61.7 0.968 Contact Map
1pw4A 1 0.8314 60.4 0.968 Contact Map
4q65A 1 0.7878 38.8 0.972 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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