GREMLIN Database
CYNR - HTH-type transcriptional regulator CynR
UniProt: P27111 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11421
Length: 299 (284)
Sequences: 79809 (58246)
Seq/√Len: 3456.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
70_R74_E3.7061.00
15_H24_A3.4801.00
158_I287_L2.7471.00
96_A141_L2.5481.00
67_Y81_A2.5141.00
11_A24_A2.3901.00
231_I238_T2.3081.00
159_P162_T2.2741.00
248_H251_L2.2701.00
162_T264_T2.2571.00
92_S123_Q2.2531.00
173_H189_E2.2451.00
164_S242_A2.2091.00
159_P264_T2.1991.00
45_V60_A2.1351.00
92_S121_T2.1321.00
8_Y35_Q2.1091.00
20_R23_S2.1081.00
162_T262_E2.0631.00
112_D285_M2.0451.00
10_L69_S2.0361.00
182_A185_R2.0291.00
14_E69_S2.0231.00
67_Y74_E2.0151.00
10_L14_E1.9961.00
94_R123_Q1.9951.00
10_L65_R1.9841.00
166_A242_A1.9681.00
11_A14_E1.9571.00
11_A15_H1.9471.00
13_A57_L1.9141.00
8_Y32_L1.9131.00
71_A75_L1.8931.00
192_V236_L1.8821.00
65_R69_S1.8461.00
18_F36_I1.7791.00
49_D56_R1.7461.00
190_K218_V1.7441.00
64_W78_G1.7351.00
135_M140_E1.7261.00
63_V81_A1.7081.00
157_A266_V1.6951.00
13_A65_R1.6691.00
132_I144_G1.6671.00
169_V254_I1.6101.00
15_H20_R1.6091.00
113_F282_F1.5891.00
14_E24_A1.5861.00
156_E271_K1.5731.00
10_L68_A1.5721.00
134_D138_R1.5491.00
9_F65_R1.5431.00
5_H35_Q1.5421.00
67_Y70_R1.5121.00
8_Y27_V1.5081.00
17_S20_R1.5041.00
178_H185_R1.5031.00
5_H38_Q1.4971.00
158_I269_R1.4941.00
5_H42_S1.4881.00
113_F120_I1.4871.00
88_L119_S1.4831.00
28_S31_A1.4821.00
19_T29_Q1.4791.00
127_M131_K1.4701.00
201_R205_D1.4611.00
46_P49_D1.4521.00
11_A25_L1.4461.00
59_D62_E1.4321.00
283_L287_L1.4281.00
146_A268_L1.4231.00
103_S225_S1.4151.00
67_Y77_A1.4121.00
156_E269_R1.4091.00
10_L72_L1.4021.00
275_Q279_A1.3821.00
71_A78_G1.3781.00
148_A266_V1.3701.00
90_R119_S1.3651.00
269_R283_L1.3531.00
94_R125_Q1.3521.00
51_S56_R1.3471.00
281_A284_H1.3411.00
163_E243_A1.3261.00
135_M141_L1.3241.00
116_R285_M1.3221.00
64_W79_K1.3221.00
74_E77_A1.3171.00
267_L283_L1.3131.00
112_D116_R1.3071.00
137_C154_E1.2971.00
232_R250_G1.2781.00
227_V238_T1.2771.00
169_V237_S1.2761.00
143_V279_A1.2711.00
255_S258_P1.2701.00
66_Q70_R1.2651.00
171_Q250_G1.2641.00
189_E237_S1.2621.00
143_V267_L1.2621.00
42_S79_K1.2581.00
114_Y218_V1.2561.00
67_Y78_G1.2441.00
3_S75_L1.2431.00
232_R247_Q1.2311.00
114_Y190_K1.2161.00
229_E232_R1.2141.00
171_Q252_K1.2121.00
159_P266_V1.2111.00
63_V66_Q1.1971.00
9_F48_F1.1941.00
111_A115_A1.1931.00
27_V31_A1.1921.00
34_Q38_Q1.1691.00
37_R41_E1.1691.00
62_E66_Q1.1681.00
242_A246_T1.1611.00
111_A233_R1.1571.00
9_F13_A1.1541.00
180_Q257_A1.1521.00
174_P189_E1.1431.00
157_A268_L1.1391.00
34_Q37_R1.1261.00
123_Q220_E1.1201.00
208_C213_L1.1061.00
63_V67_Y1.1031.00
117_Y281_A1.1021.00
228_L247_Q1.1001.00
9_F47_L1.0921.00
70_R77_A1.0911.00
6_I68_A1.0901.00
33_S37_R1.0811.00
112_D115_A1.0811.00
284_H287_L1.0801.00
102_T126_E1.0771.00
136_L144_G1.0771.00
18_F55_I1.0751.00
190_K216_Q1.0701.00
192_V227_V1.0691.00
113_F285_M1.0681.00
11_A21_A1.0671.00
181_V185_R1.0671.00
93_L282_F1.0641.00
108_P233_R1.0621.00
158_I283_L1.0521.00
71_A74_E1.0501.00
12_V21_A1.0501.00
166_A253_A1.0451.00
270_R273_S1.0401.00
280_K284_H1.0381.00
221_A227_V1.0341.00
35_Q38_Q1.0331.00
127_M135_M1.0321.00
109_L286_A1.0321.00
170_A234_T1.0281.00
228_L232_R1.0281.00
4_R7_N1.0231.00
229_E233_R1.0221.00
7_N76_G1.0181.00
168_V245_A1.0171.00
137_C152_S1.0111.00
79_K83_H1.0101.00
164_S262_E1.0041.00
57_L61_G0.9951.00
64_W68_A0.9721.00
167_L237_S0.9681.00
13_A48_F0.9661.00
166_A255_S0.9611.00
76_G80_R0.9601.00
73_Q77_A0.9601.00
27_V32_L0.9601.00
125_Q135_M0.9581.00
285_M288_D0.9571.00
113_F117_Y0.9561.00
8_Y25_L0.9561.00
76_G79_K0.9551.00
193_L217_V0.9471.00
168_V253_A0.9471.00
221_A230_L0.9431.00
202_E206_H0.9411.00
12_V18_F0.9401.00
169_V173_H0.9401.00
9_F57_L0.9321.00
202_E205_D0.9321.00
96_A146_A0.9261.00
38_Q41_E0.9211.00
21_A32_L0.9181.00
135_M138_R0.9181.00
276_T279_A0.9131.00
116_R288_D0.9111.00
164_S255_S0.9111.00
109_L285_M0.9091.00
9_F39_L0.9041.00
20_R24_A0.8951.00
45_V82_I0.8861.00
48_F55_I0.8791.00
121_T216_Q0.8731.00
70_R73_Q0.8681.00
99_P223_S0.8661.00
148_A264_T0.8641.00
66_Q69_S0.8621.00
169_V174_P0.8611.00
16_G56_R0.8611.00
13_A61_G0.8581.00
131_K134_D0.8561.00
177_V190_K0.8551.00
173_H176_A0.8501.00
141_L144_G0.8481.00
190_K217_V0.8481.00
173_H190_K0.8461.00
120_I278_A0.8451.00
19_T23_S0.8351.00
182_A257_A0.8331.00
251_L257_A0.8261.00
185_R188_D0.8251.00
174_P179_E0.8251.00
25_L32_L0.8221.00
242_A255_S0.8171.00
155_L268_L0.8151.00
95_I143_V0.8141.00
96_A144_G0.8141.00
175_L189_E0.8141.00
51_S54_T0.8141.00
156_E159_P0.8121.00
91_G278_A0.8121.00
75_L79_K0.8081.00
111_A235_S0.8071.00
125_Q141_L0.8051.00
60_A82_I0.8001.00
154_E271_K0.7991.00
284_H288_D0.7991.00
74_E78_G0.7921.00
29_Q33_S0.7891.00
133_E137_C0.7881.00
63_V85_V0.7881.00
13_A16_G0.7881.00
246_T249_D0.7871.00
207_Y211_A0.7861.00
9_F64_W0.7851.00
168_V238_T0.7841.00
4_R35_Q0.7841.00
275_Q280_K0.7831.00
60_A63_V0.7821.00
3_S72_L0.7801.00
77_A81_A0.7781.00
75_L78_G0.7761.00
16_G62_E0.7751.00
14_E65_R0.7751.00
184_S187_H0.7741.00
37_R46_P0.7741.00
191_L215_P0.7721.00
16_G54_T0.7691.00
114_Y235_S0.7691.00
12_V48_F0.7671.00
204_I208_C0.7641.00
91_G120_I0.7621.00
164_S260_L0.7601.00
170_A235_S0.7591.00
277_A281_A0.7591.00
12_V36_I0.7581.00
247_Q251_L0.7551.00
15_H21_A0.7541.00
96_A132_I0.7491.00
247_Q250_G0.7471.00
7_N11_A0.7431.00
143_V282_F0.7401.00
5_H8_Y0.7381.00
172_H176_A0.7381.00
230_L235_S0.7371.00
83_H86_A0.7291.00
78_G82_I0.7281.00
60_A85_V0.7261.00
18_F32_L0.7251.00
168_V240_L0.7251.00
89_T117_Y0.7241.00
68_A71_A0.7231.00
116_R281_A0.7201.00
97_V102_T0.7191.00
12_V32_L0.7161.00
251_L255_S0.7141.00
49_D58_T0.7131.00
242_A253_A0.7111.00
113_F281_A0.7111.00
137_C155_L0.7091.00
69_S73_Q0.7031.00
170_A173_H0.7031.00
223_S226_A0.7001.00
206_H210_K0.6951.00
187_H213_L0.6931.00
201_R220_E0.6901.00
31_A35_Q0.6901.00
273_S276_T0.6871.00
62_E65_R0.6871.00
131_K135_M0.6861.00
56_R62_E0.6861.00
206_H209_E0.6851.00
207_Y210_K0.6841.00
173_H177_V0.6831.00
241_P244_I0.6821.00
57_L62_E0.6811.00
60_A64_W0.6801.00
139_D270_R0.6791.00
94_R141_L0.6791.00
195_S220_E0.6791.00
169_V175_L0.6771.00
247_Q252_K0.6691.00
281_A285_M0.6681.00
142_D279_A0.6681.00
49_D54_T0.6661.00
94_R142_D0.6641.00
59_D63_V0.6611.00
252_K255_S0.6571.00
184_S211_A0.6531.00
205_D209_E0.6501.00
194_L227_V0.6501.00
7_N10_L0.6501.00
103_S229_E0.6491.00
40_E45_V0.6491.00
172_H234_T0.6491.00
127_M132_I0.6481.00
112_D288_D0.6471.00
172_H175_L0.6421.00
203_Q207_Y0.6401.00
219_I230_L0.6401.00
64_W82_I0.6401.00
188_D216_Q0.6371.00
73_Q76_G0.6281.00
77_A80_R0.6271.00
232_R252_K0.6261.00
137_C140_E0.6251.00
40_E50_R0.6241.00
97_V106_I0.6241.00
191_L237_S0.6231.00
67_Y71_A0.6201.00
121_T220_E0.6201.00
23_S26_H0.6191.00
179_E254_I0.6171.00
202_E207_Y0.6161.00
248_H253_A0.6161.00
36_I40_E0.6121.00
68_A72_L0.6111.00
203_Q206_H0.6101.00
167_L239_L0.6091.00
251_L256_L0.6071.00
204_I207_Y0.6041.00
4_R38_Q0.6021.00
126_E222_N0.6021.00
12_V17_S0.6011.00
93_L278_A0.5991.00
195_S222_N0.5991.00
143_V283_L0.5951.00
208_C215_P0.5951.00
201_R207_Y0.5941.00
108_P111_A0.5941.00
167_L186_L0.5941.00
176_A252_K0.5921.00
21_A25_L0.5911.00
232_R248_H0.5861.00
145_I286_A0.5841.00
277_A280_K0.5841.00
99_P128_S0.5841.00
90_R121_T0.5841.00
80_R84_D0.5811.00
63_V82_I0.5771.00
106_I109_L0.5761.00
93_L143_V0.5711.00
31_A34_Q0.5691.00
282_F286_A0.5641.00
126_E223_S0.5641.00
7_N72_L0.5641.00
43_L64_W0.5631.00
18_F54_T0.5631.00
147_F263_R0.5621.00
30_P34_Q0.5621.00
175_L178_H0.5581.00
221_A226_A0.5551.00
251_L254_I0.5541.00
9_F61_G0.5541.00
134_D137_C0.5521.00
43_L82_I0.5521.00
4_R8_Y0.5521.00
134_D140_E0.5501.00
45_V49_D0.5481.00
227_V231_I0.5471.00
161_L265_A0.5461.00
175_L181_V0.5441.00
57_L65_R0.5431.00
72_L76_G0.5431.00
108_P112_D0.5421.00
48_F57_L0.5411.00
167_L191_L0.5411.00
28_S34_Q0.5411.00
165_L239_L0.5361.00
230_L236_L0.5361.00
269_R280_K0.5351.00
173_H237_S0.5321.00
117_Y120_I0.5301.00
201_R204_I0.5291.00
163_E263_R0.5291.00
156_E272_N0.5241.00
169_V252_K0.5241.00
101_F105_F0.5221.00
96_A125_Q0.5201.00
171_Q249_D0.5191.00
18_F29_Q0.5181.00
148_A157_A0.5181.00
196_A220_E0.5181.00
205_D208_C0.5171.00
136_L155_L0.5171.00
174_P178_H0.5171.00
8_Y36_I0.5151.00
43_L46_P0.5131.00
66_Q81_A0.5101.00
91_G119_S0.5091.00
110_M122_L0.5081.00
13_A62_E0.5081.00
96_A127_M0.5051.00
180_Q185_R0.5031.00
115_A176_A0.5021.00
240_L245_A0.5021.00
72_L75_L0.5011.00
103_S223_S0.5011.00
182_A258_P0.5011.00
80_R83_H0.5011.00
224_I241_P0.5001.00
8_Y21_A0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1ixcA 4 0.9732 100 0.081 Contact Map
1al3A 1 0.7157 100 0.086 Contact Map
1uthA 2 0.7492 100 0.088 Contact Map
2h98A 2 0.699 100 0.09 Contact Map
4x6gA 4 1 100 0.09 Contact Map
2esnA 3 0.9699 100 0.091 Contact Map
2h9bA 2 0.699 100 0.094 Contact Map
3fzvA 4 0.9498 100 0.095 Contact Map
3fxqA 3 0.9666 100 0.099 Contact Map
3szpA 3 0.9599 100 0.119 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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