GREMLIN Database
PLSC - 1-acyl-sn-glycerol-3-phosphate acyltransferase
UniProt: P26647 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11377
Length: 245 (198)
Sequences: 11275 (7906)
Seq/√Len: 561.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
56_R199_E3.8261.00
60_D202_P3.5891.00
56_R197_I3.4281.00
54_E197_I3.3031.00
96_K117_D3.1711.00
178_C201_L3.1431.00
54_E195_L2.9381.00
222_R226_E2.8601.00
228_K231_E2.7141.00
57_K60_D2.5621.00
52_K195_L2.4121.00
220_H224_I2.2901.00
177_V200_M2.0751.00
132_V136_K2.0571.00
99_L115_L2.0441.00
173_P205_D2.0261.00
180_S197_I1.9921.00
96_K100_W1.9871.00
226_E230_A1.9791.00
90_T143_W1.9731.00
67_A141_S1.9311.00
216_E220_H1.9221.00
67_A175_I1.9041.00
178_C225_M1.8431.00
65_G173_P1.8341.00
106_Q110_L1.8301.00
132_V169_A1.8221.00
99_L109_W1.7381.00
180_S199_E1.7311.00
132_V170_A1.7261.00
223_S227_Q1.7201.00
69_Y141_S1.6801.00
37_T41_M1.6661.00
91_V140_I1.6481.00
209_Y220_H1.6291.00
69_Y175_I1.6291.00
176_P201_L1.6021.00
214_V218_A1.5821.00
70_I163_A1.5531.00
219_A223_S1.5501.00
201_L228_K1.5241.00
105_G109_W1.5081.00
224_I227_Q1.4821.00
213_Q216_E1.4681.00
82_A177_V1.4651.00
126_G130_E1.4581.00
130_E134_H1.4531.00
165_H169_A1.4481.00
94_G98_L1.4461.00
120_N123_K1.4441.00
218_A222_R1.4351.00
85_I200_M1.4271.00
131_V166_A1.4191.00
159_F222_R1.4051.00
219_A222_R1.3991.00
71_A177_V1.3841.00
133_N138_R1.3691.00
199_E228_K1.3671.00
135_F172_V1.3321.00
224_I228_K1.3251.00
95_K149_T1.2961.00
178_C229_I1.2771.00
130_E133_N1.2641.00
134_H140_I1.2501.00
205_D208_Q1.2471.00
215_R219_A1.2361.00
125_H129_A1.2361.00
40_H44_R1.2351.00
67_A173_P1.1881.00
97_S118_R1.1871.00
175_I203_P1.1861.00
178_C228_K1.1861.00
95_K118_R1.1841.00
95_K98_L1.1811.00
93_V116_I1.1801.00
227_Q231_E1.1651.00
74_Q183_S1.1531.00
71_A82_A1.1501.00
94_G99_L1.1441.00
161_T165_H1.1181.00
71_A145_F1.1141.00
69_Y86_V1.1131.00
93_V114_L1.1071.00
106_Q109_W1.1031.00
55_C200_M1.0901.00
91_V134_H1.0791.00
151_S157_L1.0781.00
206_V209_Y1.0451.00
199_E231_E1.0381.00
123_K126_G1.0341.00
94_G113_N1.0301.00
70_I221_C1.0101.00
43_G47_P1.0091.00
82_A145_F1.0081.00
101_I104_F1.0031.00
205_D209_Y0.9891.00
220_H223_S0.9871.00
221_C224_I0.9851.00
118_R149_T0.9711.00
159_F226_E0.9701.00
176_P203_P0.9661.00
53_V81_T0.9661.00
131_V142_I0.9611.00
122_T126_G0.9541.00
217_L221_C0.9511.00
36_A40_H0.9511.00
112_G140_I0.9451.00
151_S154_R0.9401.00
92_T143_W0.9401.00
223_S226_E0.9391.00
173_P203_P0.9391.00
133_N136_K0.9331.00
102_P105_G0.9291.00
215_R218_A0.9261.00
117_D120_N0.9251.00
55_C58_P0.9231.00
40_H43_G0.9211.00
211_K214_V0.8991.00
129_A132_V0.8981.00
134_H138_R0.8951.00
159_F225_M0.8891.00
85_I198_V0.8891.00
98_L108_Y0.8891.00
167_A174_I0.8891.00
68_I163_A0.8741.00
226_E229_I0.8721.00
62_E65_G0.8711.00
221_C225_M0.8671.00
114_L142_I0.8581.00
126_G129_A0.8511.00
156_L229_I0.8511.00
66_N139_R0.8461.00
165_H168_I0.8441.00
201_L224_I0.8411.00
71_A143_W0.8371.00
218_A221_C0.8331.00
227_Q230_A0.8321.00
164_F221_C0.8271.00
129_A133_N0.8251.00
153_G157_L0.8221.00
66_N172_V0.8181.00
74_Q182_T0.8151.00
65_G205_D0.8041.00
34_H38_F0.8031.00
164_F218_A0.8031.00
86_V200_M0.8011.00
41_M44_R0.7991.00
114_L127_T0.7981.00
32_P35_V0.7981.00
116_I124_A0.7941.00
222_R228_K0.7941.00
214_V217_L0.7891.00
132_V166_A0.7881.00
185_K194_G0.7851.00
42_F46_A0.7841.00
44_R48_L0.7831.00
36_A39_G0.7791.00
95_K150_R0.7791.00
134_H142_I0.7771.00
135_F166_A0.7771.00
61_A200_M0.7761.00
156_L226_E0.7751.00
104_F108_Y0.7631.00
79_M94_G0.7531.00
33_K36_A0.7531.00
38_F42_F0.7441.00
43_G46_A0.7421.00
114_L134_H0.7421.00
100_W109_W0.7401.00
69_Y177_V0.7391.00
74_Q150_R0.7381.00
76_N79_M0.7311.00
43_G84_N0.7241.00
93_V144_M0.7241.00
79_M83_S0.7221.00
87_Q90_T0.7211.00
129_A169_A0.7191.00
82_A179_V0.7181.00
88_P141_S0.7161.00
37_T40_H0.7121.00
53_V84_N0.7071.00
39_G43_G0.7061.00
148_G162_G0.7021.00
101_I105_G0.6961.00
168_I209_Y0.6961.00
52_K193_N0.6941.00
109_W115_L0.6891.00
35_V38_F0.6871.00
212_D216_E0.6861.00
96_K99_L0.6861.00
78_D179_V0.6851.00
38_F41_M0.6851.00
114_L131_V0.6841.00
94_G108_Y0.6841.00
161_T218_A0.6811.00
81_T196_V0.6791.00
93_V127_T0.6781.00
161_T215_R0.6771.00
181_T185_K0.6771.00
171_G206_V0.6751.00
57_K200_M0.6741.00
65_G88_P0.6741.00
173_P206_V0.6731.00
220_H227_Q0.6731.00
222_R229_I0.6721.00
32_P36_A0.6721.00
144_M166_A0.6711.00
65_G141_S0.6711.00
179_V182_T0.6671.00
163_A174_I0.6611.00
187_N190_R0.6611.00
201_L225_M0.6601.00
147_E156_L0.6601.00
64_Y67_A0.6601.00
136_K170_A0.6601.00
84_N87_Q0.6541.00
206_V217_L0.6531.00
150_R154_R0.6451.00
168_I214_V0.6441.00
222_R225_M0.6431.00
37_T46_A0.6371.00
213_Q218_A0.6371.00
156_L159_F0.6361.00
171_G207_S0.6341.00
186_I189_N0.6301.00
181_T184_N0.6301.00
62_E88_P0.6271.00
177_V198_V0.6251.00
156_L222_R0.6221.00
68_I167_A0.6201.00
212_D220_H0.6151.00
108_Y113_N0.6131.00
32_P39_G0.6101.00
128_I132_V0.6091.00
72_N159_F0.6081.00
83_S92_T0.6081.00
159_F229_I0.6051.00
60_D200_M0.5981.00
163_A167_A0.5971.00
202_P224_I0.5951.00
58_P62_E0.5921.00
214_V221_C0.5921.00
211_K215_R0.5911.00
99_L108_Y0.5871.00
225_M228_K0.5781.00
79_M92_T0.5781.00
83_S113_N0.5761.00
121_R124_A0.5730.99
98_L104_F0.5700.99
50_G193_N0.5700.99
39_G87_Q0.5680.99
121_R125_H0.5680.99
61_A175_I0.5660.99
149_T157_L0.5640.99
72_N156_L0.5640.99
164_F217_L0.5640.99
76_N186_I0.5630.99
74_Q151_S0.5630.99
66_N141_S0.5620.99
184_N194_G0.5580.99
55_C85_I0.5540.99
167_A170_A0.5530.99
112_G134_H0.5530.99
108_Y115_L0.5520.99
127_T131_V0.5500.99
122_T125_H0.5450.99
204_I209_Y0.5420.99
93_V131_V0.5420.99
208_Q220_H0.5410.99
44_R47_P0.5400.99
128_I166_A0.5390.99
145_F179_V0.5390.99
86_V90_T0.5370.99
70_I159_F0.5320.99
90_T141_S0.5300.99
214_V222_R0.5290.99
224_I231_E0.5270.99
76_N98_L0.5270.99
68_I166_A0.5250.99
46_A51_L0.5250.99
58_P202_P0.5230.99
167_A206_V0.5230.99
79_M145_F0.5220.99
72_N147_E0.5190.99
41_M45_L0.5180.99
204_I220_H0.5180.99
55_C198_V0.5150.99
164_F168_I0.5140.99
75_N182_T0.5120.99
213_Q217_L0.5080.99
35_V42_F0.5050.99
45_L48_L0.5050.99
91_V112_G0.5040.99
152_R155_G0.5030.99
37_T43_G0.5030.99
62_E67_A0.5020.99
194_G197_I0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1iuqA 1 0.9714 100 0.371 Contact Map
1fyxA 2 0.5796 37.7 0.936 Contact Map
1kvnA 1 0.3592 32.3 0.938 Contact Map
4lqcA 2 0.5388 28 0.94 Contact Map
4om7A 2 0.5551 24.2 0.942 Contact Map
2j67A 2 0.5714 21.6 0.943 Contact Map
2xwsA 2 0.449 16.8 0.946 Contact Map
3h16A 2 0.5592 16.3 0.946 Contact Map
1jidA 1 0.3837 14.4 0.947 Contact Map
3jrnA 1 0.5306 13.5 0.948 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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