GREMLIN Database
ACUI - Probable acrylyl-CoA reductase AcuI
UniProt: P26646 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11315
Length: 324 (296)
Sequences: 52822 (36038)
Seq/√Len: 2094.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
302_E305_N2.9931.00
35_H118_A2.9231.00
33_D70_R2.8351.00
35_H68_T2.7801.00
7_E18_Q2.7521.00
31_T70_R2.7031.00
30_V109_L2.6211.00
149_E173_Q2.5621.00
117_D120_K2.5481.00
168_H193_S2.5291.00
298_I309_A2.4381.00
82_E112_M2.4311.00
81_Q111_A2.4261.00
78_H81_Q2.4031.00
33_D68_T2.2751.00
22_E101_Q2.2411.00
296_K309_A2.1941.00
119_R297_E2.1881.00
33_D101_Q2.1781.00
65_F97_G2.1581.00
173_Q194_R2.1251.00
7_E16_S2.1161.00
184_H188_K2.1101.00
150_I167_L2.1091.00
76_R106_G2.0971.00
284_A288_E2.0861.00
5_L18_Q2.0751.00
26_P29_D2.0591.00
299_S302_E2.0521.00
164_V192_A1.9931.00
27_E74_D1.9791.00
185_E189_S1.9721.00
66_A118_A1.9471.00
115_G287_P1.9061.00
82_E118_A1.9001.00
308_E312_N1.8901.00
24_R71_T1.8671.00
144_R148_G1.8641.00
128_G162_T1.8641.00
148_G236_C1.8371.00
31_T103_R1.8051.00
151_V177_V1.7981.00
175_V212_W1.7971.00
151_V212_W1.7841.00
70_R101_Q1.7811.00
48_T311_I1.7761.00
181_E185_E1.7701.00
305_N308_E1.7591.00
169_K290_F1.7231.00
185_E188_K1.7231.00
298_I306_F1.7171.00
213_A232_N1.6811.00
236_C261_R1.6751.00
178_S184_H1.6731.00
112_M118_A1.6721.00
309_A314_Q1.6571.00
184_H195_V1.6471.00
305_N309_A1.6461.00
65_F85_L1.6311.00
153_T227_V1.6211.00
186_Y189_S1.6201.00
204_S207_L1.5971.00
181_E197_P1.5941.00
197_P200_E1.5821.00
231_M237_V1.5781.00
173_Q193_S1.5581.00
72_S79_A1.5571.00
25_L103_R1.5451.00
77_F111_A1.5431.00
4_L303_A1.5401.00
231_M260_V1.5361.00
29_D105_K1.5241.00
141_A214_G1.5161.00
236_C263_Q1.5161.00
98_L307_A1.5151.00
71_T79_A1.4971.00
112_M121_A1.4921.00
31_T101_Q1.4731.00
164_V176_A1.4681.00
34_V65_F1.4661.00
77_F81_Q1.4631.00
231_M235_G1.4501.00
179_G198_R1.4491.00
181_E200_E1.4351.00
25_L31_T1.4341.00
68_T82_E1.4281.00
82_E114_Q1.4121.00
28_G105_K1.3981.00
29_D103_R1.3931.00
36_W119_R1.3831.00
47_I307_A1.3801.00
215_A227_V1.3711.00
215_A231_M1.3701.00
304_P308_E1.3411.00
69_V77_F1.3341.00
204_S208_E1.3311.00
156_S176_A1.3171.00
149_E175_V1.3101.00
30_V77_F1.3081.00
295_A309_A1.3051.00
31_T71_T1.2991.00
68_T118_A1.2821.00
153_T177_V1.2721.00
4_L17_V1.2611.00
163_A216_I1.2591.00
284_A287_P1.2461.00
169_K285_D1.2461.00
139_E281_R1.2211.00
143_V172_Y1.2191.00
25_L29_D1.1761.00
22_E31_T1.1741.00
35_H82_E1.1741.00
77_F109_L1.1731.00
188_K195_V1.1651.00
156_S178_S1.1641.00
139_E278_A1.1621.00
149_E213_A1.1591.00
205_R208_E1.1531.00
28_G106_G1.1521.00
184_H197_P1.1401.00
181_E184_H1.1401.00
165_A292_T1.1331.00
28_G74_D1.1091.00
180_R197_P1.1011.00
176_A192_A1.0981.00
34_V102_A1.0971.00
104_V109_L1.0971.00
276_A280_Q1.0961.00
32_V67_G1.0911.00
8_Q14_L1.0891.00
70_R79_A1.0871.00
47_I311_I1.0841.00
281_R284_A1.0731.00
229_A254_P1.0731.00
120_K292_T1.0651.00
148_G213_A1.0611.00
194_R207_L1.0611.00
4_L300_L1.0601.00
188_K194_R1.0501.00
133_L278_A1.0421.00
36_W118_A1.0401.00
17_V301_S1.0381.00
39_L306_F1.0361.00
179_G199_D1.0301.00
219_V223_V1.0281.00
186_Y316_Q1.0261.00
285_D290_F1.0251.00
131_A166_L1.0231.00
141_A238_A1.0191.00
37_S98_L1.0141.00
32_V83_V1.0131.00
35_H66_A1.0121.00
175_V194_R1.0111.00
131_A163_A1.0061.00
40_N64_D1.0051.00
140_D261_R0.9951.00
280_Q284_A0.9941.00
40_N63_I0.9921.00
303_A321_V0.9861.00
5_L20_L0.9801.00
217_D220_G0.9781.00
134_C240_C0.9771.00
179_G184_H0.9551.00
98_L303_A0.9541.00
167_L172_Y0.9501.00
309_A319_T0.9471.00
116_L121_A0.9451.00
22_E71_T0.9451.00
28_G73_E0.9431.00
128_G282_L0.9331.00
37_S97_G0.9321.00
164_V174_V0.9311.00
152_V163_A0.9241.00
308_E311_I0.9201.00
5_L60_I0.9181.00
175_V196_L0.9101.00
161_S186_Y0.9091.00
33_D100_E0.9071.00
152_V167_L0.9061.00
132_M281_R0.9031.00
44_A310_I0.9021.00
166_L282_L0.9011.00
225_A229_A0.9011.00
72_S75_P0.8971.00
36_W320_L0.8961.00
177_V198_R0.8951.00
153_T215_A0.8911.00
65_F102_A0.8901.00
78_H111_A0.8801.00
254_P258_R0.8791.00
143_V148_G0.8791.00
208_E211_V0.8761.00
38_S64_D0.8751.00
178_S195_V0.8741.00
124_I286_L0.8721.00
151_V230_Q0.8711.00
134_C216_I0.8701.00
24_R31_T0.8701.00
183_T316_Q0.8701.00
226_K229_A0.8691.00
149_E212_W0.8681.00
4_L15_A0.8571.00
189_S292_T0.8561.00
22_E70_R0.8541.00
255_F262_L0.8541.00
114_Q287_P0.8531.00
176_A187_L0.8511.00
234_G259_N0.8491.00
98_L321_V0.8481.00
182_S185_E0.8431.00
84_L283_V0.8401.00
144_R147_D0.8381.00
59_M95_W0.8311.00
20_L95_W0.8301.00
281_R285_D0.8301.00
148_G214_G0.8271.00
180_R183_T0.8221.00
25_L73_E0.8211.00
156_S187_L0.8151.00
26_P103_R0.8141.00
40_N43_D0.8131.00
135_V167_L0.8131.00
187_L192_A0.8111.00
75_P106_G0.8101.00
166_L285_D0.8051.00
251_T254_P0.8051.00
129_F278_A0.8021.00
134_C163_A0.8011.00
39_L310_I0.8011.00
277_Q281_R0.7981.00
4_L304_P0.7971.00
310_I319_T0.7881.00
131_A162_T0.7881.00
131_A159_V0.7881.00
7_E14_L0.7761.00
140_D263_Q0.7751.00
72_S78_H0.7701.00
298_I302_E0.7671.00
30_V106_G0.7661.00
150_I172_Y0.7661.00
25_L71_T0.7651.00
143_V214_G0.7641.00
227_V237_V0.7591.00
17_V300_L0.7571.00
42_K63_I0.7561.00
83_V109_L0.7561.00
167_L174_V0.7501.00
39_L98_L0.7481.00
174_V193_S0.7481.00
64_D126_T0.7481.00
215_A237_V0.7451.00
40_N126_T0.7451.00
277_Q280_Q0.7441.00
285_D288_E0.7441.00
116_L286_L0.7391.00
6_L14_L0.7351.00
85_L104_V0.7301.00
170_L281_R0.7301.00
25_L28_G0.7271.00
142_G236_C0.7261.00
218_T240_C0.7241.00
66_A122_M0.7221.00
13_T308_E0.7201.00
20_L60_I0.7171.00
296_K305_N0.7171.00
203_E226_K0.7141.00
84_L112_M0.7141.00
152_V176_A0.7131.00
110_V280_Q0.7131.00
309_A312_N0.7121.00
149_E210_Q0.7091.00
212_W215_A0.7091.00
239_A262_L0.7071.00
113_P287_P0.7061.00
117_D121_A0.7051.00
133_L259_N0.7041.00
178_S187_L0.7031.00
214_G238_A0.7031.00
285_D289_S0.6991.00
142_G263_Q0.6981.00
132_M282_L0.6971.00
315_I319_T0.6961.00
153_T223_V0.6961.00
196_L201_F0.6961.00
255_F260_V0.6951.00
36_W297_E0.6941.00
202_A226_K0.6931.00
131_A135_V0.6921.00
255_F264_G0.6901.00
97_G102_A0.6861.00
210_Q232_N0.6801.00
166_L170_L0.6801.00
63_I126_T0.6791.00
184_H187_L0.6791.00
130_T159_V0.6771.00
296_K319_T0.6761.00
298_I321_V0.6731.00
72_S81_Q0.6721.00
233_Y258_R0.6721.00
23_S103_R0.6721.00
204_S212_W0.6701.00
84_L125_G0.6681.00
76_R276_A0.6671.00
224_L237_V0.6651.00
110_V283_V0.6631.00
82_E115_G0.6631.00
142_G261_R0.6631.00
126_T130_T0.6621.00
132_M285_D0.6621.00
172_Y214_G0.6621.00
26_P73_E0.6601.00
110_V279_W0.6591.00
307_A311_I0.6591.00
40_N127_A0.6581.00
41_Y45_L0.6571.00
127_A158_G0.6561.00
212_W230_Q0.6541.00
66_A112_M0.6541.00
283_V287_P0.6511.00
28_G107_D0.6491.00
8_Q16_S0.6461.00
298_I319_T0.6431.00
30_V69_V0.6421.00
197_P202_A0.6421.00
168_H174_V0.6411.00
76_R111_A0.6371.00
34_V37_S0.6351.00
294_A297_E0.6331.00
51_G55_R0.6331.00
222_K225_A0.6271.00
66_A82_E0.6271.00
118_A121_A0.6261.00
81_Q114_Q0.6251.00
217_D237_V0.6221.00
42_K46_A0.6221.00
139_E170_L0.6201.00
51_G54_I0.6201.00
36_W66_A0.6191.00
123_I320_L0.6181.00
163_A240_C0.6151.00
225_A254_P0.6151.00
186_Y190_L0.6141.00
132_M278_A0.6131.00
164_V190_L0.6121.00
76_R79_A0.6121.00
184_H198_R0.6121.00
164_V187_L0.6091.00
156_S164_V0.6081.00
178_S198_R0.6071.00
32_V85_L0.6071.00
23_S31_T0.6061.00
127_A162_T0.6051.00
223_V227_V0.6041.00
141_A236_C0.6011.00
214_G236_C0.6001.00
130_T240_C0.6001.00
27_E73_E0.5991.00
215_A230_Q0.5961.00
91_G95_W0.5961.00
23_S101_Q0.5951.00
175_V207_L0.5941.00
200_E203_E0.5911.00
177_V196_L0.5911.00
165_A190_L0.5901.00
199_D202_A0.5891.00
150_I214_G0.5861.00
45_L50_K0.5851.00
225_A247_T0.5851.00
75_P78_H0.5851.00
222_K226_K0.5841.00
259_N269_M0.5821.00
110_V276_A0.5791.00
41_Y157_G0.5781.00
22_E25_L0.5751.00
106_G109_L0.5741.00
42_K45_L0.5731.00
62_G98_L0.5721.00
32_V109_L0.5711.00
44_A311_I0.5681.00
135_V166_L0.5661.00
134_C265_V0.5661.00
72_S77_F0.5651.00
139_E142_G0.5631.00
66_A121_A0.5621.00
123_I293_Q0.5601.00
178_S197_P0.5561.00
162_T166_L0.5551.00
286_L293_Q0.5551.00
132_M170_L0.5551.00
178_S183_T0.5541.00
151_V215_A0.5541.00
52_K55_R0.5511.00
77_F106_G0.5491.00
22_E103_R0.5481.00
225_A249_P0.5481.00
58_P62_G0.5451.00
309_A315_I0.5441.00
217_D241_G0.5441.00
117_D297_E0.5431.00
34_V97_G0.5431.00
168_H192_A0.5431.00
85_L109_L0.5411.00
15_A307_A0.5401.00
8_Q13_T0.5391.00
286_L291_Y0.5381.00
156_S183_T0.5381.00
14_L47_I0.5341.00
56_N59_M0.5341.00
162_T291_Y0.5331.00
40_N318_R0.5331.00
179_G197_P0.5321.00
37_S321_V0.5311.00
85_L91_G0.5301.00
14_L304_P0.5291.00
187_L195_V0.5231.00
192_A195_V0.5221.00
17_V303_A0.5211.00
13_T47_I0.5211.00
238_A265_V0.5201.00
23_S29_D0.5191.00
32_V65_F0.5191.00
188_K192_A0.5181.00
162_T165_A0.5171.00
139_E277_Q0.5171.00
105_K108_W0.5151.00
205_R211_V0.5151.00
6_L47_I0.5151.00
289_S292_T0.5151.00
38_S122_M0.5151.00
161_S190_L0.5151.00
204_S230_Q0.5141.00
46_A51_G0.5111.00
298_I305_N0.5101.00
44_A48_T0.5081.00
21_D24_R0.5071.00
206_P209_K0.5051.00
112_M116_L0.5041.00
182_S314_Q0.5031.00
75_P81_Q0.5021.00
64_D318_R0.5021.00
149_E211_V0.5011.00
20_L100_E0.5011.00
232_N235_G0.5001.00
125_G279_W0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3nx4A 2 0.9969 100 0.128 Contact Map
4jxkA 2 0.9938 100 0.162 Contact Map
1tt7A 5 0.9938 100 0.175 Contact Map
4j6fA 2 0.966 100 0.179 Contact Map
4gi2A 2 0.9784 100 0.179 Contact Map
1xa0A 2 0.9877 100 0.182 Contact Map
1rjwA 4 0.9568 100 0.184 Contact Map
3uogA 4 0.9599 100 0.189 Contact Map
4oaqA 2 0.9599 100 0.19 Contact Map
1zsyA 2 0.9722 100 0.192 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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