ACUI - ECOLI - GREMLIN Contacts

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ACUI - Probable acrylyl-CoA reductase AcuI

UniProt:	P26646	Sequences: MQALLLEQQDGKTLASVQTLDESRLPEGDVTVDVHWSSLNYKDALAITGKGKIIRNFPMIPGIDFAGTVRTSEDPRFHAGQEVLLTGWGVGENHWGGLAEQARVKGDWLVAMPQGLDARKAMIIGTAGFTAMLCVMALEDAGVRPQDGEIVVTGASGGVGSTAVALLHKLGYQVVAVSGRESTHEYLKSLGASRVLPRDEFAESRPLEKQVWAGAIDTVGDKVLAKVLAQMNYGGCVAACGLAGGFTLPTTVMPFILRNVRLQGVDSVMTPPERRAQAWQRLVADLPESFYTQAAKEISLSEAPNFAEAIINNQIQGRTLVKVN	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG11315
Length:	324 (296)
Sequences:	52822 (36038)
Seq/√Len:	2094.7

ECOLI - ACUI YAHK CURA AHR QOR1 YBDR YGGP ADHP RSPB YPHC FRMA YDJL TDH IDND YJJN YDJJ YCJQ GATD
BACSU - YHFP YOGA ADHA BDHA ADHB YFMJ YJMD DHSO YYCR TDH
HALSA - Q9HP38 Q9HR85 Q9HMB6 Q9HQS8 GLCDH
SULSO - Q7LXK1 Q97YT7 Q97VW0 ADH Q97ZV3 Q97VV5 Q97V32 GLCD2 Q97YM2 Q97XR4 Q97WA1 GLCD1 Q97W06 Q97TZ4 Q97UW5 GLCD3 Q97VB8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
302_E	305_N	2.993	1.00
35_H	118_A	2.923	1.00
33_D	70_R	2.835	1.00
35_H	68_T	2.780	1.00
7_E	18_Q	2.752	1.00
31_T	70_R	2.703	1.00
30_V	109_L	2.621	1.00
149_E	173_Q	2.562	1.00
117_D	120_K	2.548	1.00
168_H	193_S	2.529	1.00
298_I	309_A	2.438	1.00
82_E	112_M	2.431	1.00
81_Q	111_A	2.426	1.00
78_H	81_Q	2.403	1.00
33_D	68_T	2.275	1.00
22_E	101_Q	2.241	1.00
296_K	309_A	2.194	1.00
119_R	297_E	2.188	1.00
33_D	101_Q	2.178	1.00
65_F	97_G	2.158	1.00
173_Q	194_R	2.125	1.00
7_E	16_S	2.116	1.00
184_H	188_K	2.110	1.00
150_I	167_L	2.109	1.00
76_R	106_G	2.097	1.00
284_A	288_E	2.086	1.00
5_L	18_Q	2.075	1.00
26_P	29_D	2.059	1.00
299_S	302_E	2.052	1.00
164_V	192_A	1.993	1.00
27_E	74_D	1.979	1.00
185_E	189_S	1.972	1.00
66_A	118_A	1.947	1.00
115_G	287_P	1.906	1.00
82_E	118_A	1.900	1.00
308_E	312_N	1.890	1.00
24_R	71_T	1.867	1.00
144_R	148_G	1.864	1.00
128_G	162_T	1.864	1.00
148_G	236_C	1.837	1.00
31_T	103_R	1.805	1.00
151_V	177_V	1.798	1.00
175_V	212_W	1.797	1.00
151_V	212_W	1.784	1.00
70_R	101_Q	1.781	1.00
48_T	311_I	1.776	1.00
181_E	185_E	1.770	1.00
305_N	308_E	1.759	1.00
169_K	290_F	1.723	1.00
185_E	188_K	1.723	1.00
298_I	306_F	1.717	1.00
213_A	232_N	1.681	1.00
236_C	261_R	1.675	1.00
178_S	184_H	1.673	1.00
112_M	118_A	1.672	1.00
309_A	314_Q	1.657	1.00
184_H	195_V	1.647	1.00
305_N	309_A	1.646	1.00
65_F	85_L	1.631	1.00
153_T	227_V	1.621	1.00
186_Y	189_S	1.620	1.00
204_S	207_L	1.597	1.00
181_E	197_P	1.594	1.00
197_P	200_E	1.582	1.00
231_M	237_V	1.578	1.00
173_Q	193_S	1.558	1.00
72_S	79_A	1.557	1.00
25_L	103_R	1.545	1.00
77_F	111_A	1.543	1.00
4_L	303_A	1.540	1.00
231_M	260_V	1.536	1.00
29_D	105_K	1.524	1.00
141_A	214_G	1.516	1.00
236_C	263_Q	1.516	1.00
98_L	307_A	1.515	1.00
71_T	79_A	1.497	1.00
112_M	121_A	1.492	1.00
31_T	101_Q	1.473	1.00
164_V	176_A	1.468	1.00
34_V	65_F	1.466	1.00
77_F	81_Q	1.463	1.00
231_M	235_G	1.450	1.00
179_G	198_R	1.449	1.00
181_E	200_E	1.435	1.00
25_L	31_T	1.434	1.00
68_T	82_E	1.428	1.00
82_E	114_Q	1.412	1.00
28_G	105_K	1.398	1.00
29_D	103_R	1.393	1.00
36_W	119_R	1.383	1.00
47_I	307_A	1.380	1.00
215_A	227_V	1.371	1.00
215_A	231_M	1.370	1.00
304_P	308_E	1.341	1.00
69_V	77_F	1.334	1.00
204_S	208_E	1.331	1.00
156_S	176_A	1.317	1.00
149_E	175_V	1.310	1.00
30_V	77_F	1.308	1.00
295_A	309_A	1.305	1.00
31_T	71_T	1.299	1.00
68_T	118_A	1.282	1.00
153_T	177_V	1.272	1.00
4_L	17_V	1.261	1.00
163_A	216_I	1.259	1.00
284_A	287_P	1.246	1.00
169_K	285_D	1.246	1.00
139_E	281_R	1.221	1.00
143_V	172_Y	1.219	1.00
25_L	29_D	1.176	1.00
22_E	31_T	1.174	1.00
35_H	82_E	1.174	1.00
77_F	109_L	1.173	1.00
188_K	195_V	1.165	1.00
156_S	178_S	1.164	1.00
139_E	278_A	1.162	1.00
149_E	213_A	1.159	1.00
205_R	208_E	1.153	1.00
28_G	106_G	1.152	1.00
184_H	197_P	1.140	1.00
181_E	184_H	1.140	1.00
165_A	292_T	1.133	1.00
28_G	74_D	1.109	1.00
180_R	197_P	1.101	1.00
176_A	192_A	1.098	1.00
34_V	102_A	1.097	1.00
104_V	109_L	1.097	1.00
276_A	280_Q	1.096	1.00
32_V	67_G	1.091	1.00
8_Q	14_L	1.089	1.00
70_R	79_A	1.087	1.00
47_I	311_I	1.084	1.00
281_R	284_A	1.073	1.00
229_A	254_P	1.073	1.00
120_K	292_T	1.065	1.00
148_G	213_A	1.061	1.00
194_R	207_L	1.061	1.00
4_L	300_L	1.060	1.00
188_K	194_R	1.050	1.00
133_L	278_A	1.042	1.00
36_W	118_A	1.040	1.00
17_V	301_S	1.038	1.00
39_L	306_F	1.036	1.00
179_G	199_D	1.030	1.00
219_V	223_V	1.028	1.00
186_Y	316_Q	1.026	1.00
285_D	290_F	1.025	1.00
131_A	166_L	1.023	1.00
141_A	238_A	1.019	1.00
37_S	98_L	1.014	1.00
32_V	83_V	1.013	1.00
35_H	66_A	1.012	1.00
175_V	194_R	1.011	1.00
131_A	163_A	1.006	1.00
40_N	64_D	1.005	1.00
140_D	261_R	0.995	1.00
280_Q	284_A	0.994	1.00
40_N	63_I	0.992	1.00
303_A	321_V	0.986	1.00
5_L	20_L	0.980	1.00
217_D	220_G	0.978	1.00
134_C	240_C	0.977	1.00
179_G	184_H	0.955	1.00
98_L	303_A	0.954	1.00
167_L	172_Y	0.950	1.00
309_A	319_T	0.947	1.00
116_L	121_A	0.945	1.00
22_E	71_T	0.945	1.00
28_G	73_E	0.943	1.00
128_G	282_L	0.933	1.00
37_S	97_G	0.932	1.00
164_V	174_V	0.931	1.00
152_V	163_A	0.924	1.00
308_E	311_I	0.920	1.00
5_L	60_I	0.918	1.00
175_V	196_L	0.910	1.00
161_S	186_Y	0.909	1.00
33_D	100_E	0.907	1.00
152_V	167_L	0.906	1.00
132_M	281_R	0.903	1.00
44_A	310_I	0.902	1.00
166_L	282_L	0.901	1.00
225_A	229_A	0.901	1.00
72_S	75_P	0.897	1.00
36_W	320_L	0.896	1.00
177_V	198_R	0.895	1.00
153_T	215_A	0.891	1.00
65_F	102_A	0.890	1.00
78_H	111_A	0.880	1.00
254_P	258_R	0.879	1.00
143_V	148_G	0.879	1.00
208_E	211_V	0.876	1.00
38_S	64_D	0.875	1.00
178_S	195_V	0.874	1.00
124_I	286_L	0.872	1.00
151_V	230_Q	0.871	1.00
134_C	216_I	0.870	1.00
24_R	31_T	0.870	1.00
183_T	316_Q	0.870	1.00
226_K	229_A	0.869	1.00
149_E	212_W	0.868	1.00
4_L	15_A	0.857	1.00
189_S	292_T	0.856	1.00
22_E	70_R	0.854	1.00
255_F	262_L	0.854	1.00
114_Q	287_P	0.853	1.00
176_A	187_L	0.851	1.00
234_G	259_N	0.849	1.00
98_L	321_V	0.848	1.00
182_S	185_E	0.843	1.00
84_L	283_V	0.840	1.00
144_R	147_D	0.838	1.00
59_M	95_W	0.831	1.00
20_L	95_W	0.830	1.00
281_R	285_D	0.830	1.00
148_G	214_G	0.827	1.00
180_R	183_T	0.822	1.00
25_L	73_E	0.821	1.00
156_S	187_L	0.815	1.00
26_P	103_R	0.814	1.00
40_N	43_D	0.813	1.00
135_V	167_L	0.813	1.00
187_L	192_A	0.811	1.00
75_P	106_G	0.810	1.00
166_L	285_D	0.805	1.00
251_T	254_P	0.805	1.00
129_F	278_A	0.802	1.00
134_C	163_A	0.801	1.00
39_L	310_I	0.801	1.00
277_Q	281_R	0.798	1.00
4_L	304_P	0.797	1.00
310_I	319_T	0.788	1.00
131_A	162_T	0.788	1.00
131_A	159_V	0.788	1.00
7_E	14_L	0.776	1.00
140_D	263_Q	0.775	1.00
72_S	78_H	0.770	1.00
298_I	302_E	0.767	1.00
30_V	106_G	0.766	1.00
150_I	172_Y	0.766	1.00
25_L	71_T	0.765	1.00
143_V	214_G	0.764	1.00
227_V	237_V	0.759	1.00
17_V	300_L	0.757	1.00
42_K	63_I	0.756	1.00
83_V	109_L	0.756	1.00
167_L	174_V	0.750	1.00
39_L	98_L	0.748	1.00
174_V	193_S	0.748	1.00
64_D	126_T	0.748	1.00
215_A	237_V	0.745	1.00
40_N	126_T	0.745	1.00
277_Q	280_Q	0.744	1.00
285_D	288_E	0.744	1.00
116_L	286_L	0.739	1.00
6_L	14_L	0.735	1.00
85_L	104_V	0.730	1.00
170_L	281_R	0.730	1.00
25_L	28_G	0.727	1.00
142_G	236_C	0.726	1.00
218_T	240_C	0.724	1.00
66_A	122_M	0.722	1.00
13_T	308_E	0.720	1.00
20_L	60_I	0.717	1.00
296_K	305_N	0.717	1.00
203_E	226_K	0.714	1.00
84_L	112_M	0.714	1.00
152_V	176_A	0.713	1.00
110_V	280_Q	0.713	1.00
309_A	312_N	0.712	1.00
149_E	210_Q	0.709	1.00
212_W	215_A	0.709	1.00
239_A	262_L	0.707	1.00
113_P	287_P	0.706	1.00
117_D	121_A	0.705	1.00
133_L	259_N	0.704	1.00
178_S	187_L	0.703	1.00
214_G	238_A	0.703	1.00
285_D	289_S	0.699	1.00
142_G	263_Q	0.698	1.00
132_M	282_L	0.697	1.00
315_I	319_T	0.696	1.00
153_T	223_V	0.696	1.00
196_L	201_F	0.696	1.00
255_F	260_V	0.695	1.00
36_W	297_E	0.694	1.00
202_A	226_K	0.693	1.00
131_A	135_V	0.692	1.00
255_F	264_G	0.690	1.00
97_G	102_A	0.686	1.00
210_Q	232_N	0.680	1.00
166_L	170_L	0.680	1.00
63_I	126_T	0.679	1.00
184_H	187_L	0.679	1.00
130_T	159_V	0.677	1.00
296_K	319_T	0.676	1.00
298_I	321_V	0.673	1.00
72_S	81_Q	0.672	1.00
233_Y	258_R	0.672	1.00
23_S	103_R	0.672	1.00
204_S	212_W	0.670	1.00
84_L	125_G	0.668	1.00
76_R	276_A	0.667	1.00
224_L	237_V	0.665	1.00
110_V	283_V	0.663	1.00
82_E	115_G	0.663	1.00
142_G	261_R	0.663	1.00
126_T	130_T	0.662	1.00
132_M	285_D	0.662	1.00
172_Y	214_G	0.662	1.00
26_P	73_E	0.660	1.00
110_V	279_W	0.659	1.00
307_A	311_I	0.659	1.00
40_N	127_A	0.658	1.00
41_Y	45_L	0.657	1.00
127_A	158_G	0.656	1.00
212_W	230_Q	0.654	1.00
66_A	112_M	0.654	1.00
283_V	287_P	0.651	1.00
28_G	107_D	0.649	1.00
8_Q	16_S	0.646	1.00
298_I	319_T	0.643	1.00
30_V	69_V	0.642	1.00
197_P	202_A	0.642	1.00
168_H	174_V	0.641	1.00
76_R	111_A	0.637	1.00
34_V	37_S	0.635	1.00
294_A	297_E	0.633	1.00
51_G	55_R	0.633	1.00
222_K	225_A	0.627	1.00
66_A	82_E	0.627	1.00
118_A	121_A	0.626	1.00
81_Q	114_Q	0.625	1.00
217_D	237_V	0.622	1.00
42_K	46_A	0.622	1.00
139_E	170_L	0.620	1.00
51_G	54_I	0.620	1.00
36_W	66_A	0.619	1.00
123_I	320_L	0.618	1.00
163_A	240_C	0.615	1.00
225_A	254_P	0.615	1.00
186_Y	190_L	0.614	1.00
132_M	278_A	0.613	1.00
164_V	190_L	0.612	1.00
76_R	79_A	0.612	1.00
184_H	198_R	0.612	1.00
164_V	187_L	0.609	1.00
156_S	164_V	0.608	1.00
178_S	198_R	0.607	1.00
32_V	85_L	0.607	1.00
23_S	31_T	0.606	1.00
127_A	162_T	0.605	1.00
223_V	227_V	0.604	1.00
141_A	236_C	0.601	1.00
214_G	236_C	0.600	1.00
130_T	240_C	0.600	1.00
27_E	73_E	0.599	1.00
215_A	230_Q	0.596	1.00
91_G	95_W	0.596	1.00
23_S	101_Q	0.595	1.00
175_V	207_L	0.594	1.00
200_E	203_E	0.591	1.00
177_V	196_L	0.591	1.00
165_A	190_L	0.590	1.00
199_D	202_A	0.589	1.00
150_I	214_G	0.586	1.00
45_L	50_K	0.585	1.00
225_A	247_T	0.585	1.00
75_P	78_H	0.585	1.00
222_K	226_K	0.584	1.00
259_N	269_M	0.582	1.00
110_V	276_A	0.579	1.00
41_Y	157_G	0.578	1.00
22_E	25_L	0.575	1.00
106_G	109_L	0.574	1.00
42_K	45_L	0.573	1.00
62_G	98_L	0.572	1.00
32_V	109_L	0.571	1.00
44_A	311_I	0.568	1.00
135_V	166_L	0.566	1.00
134_C	265_V	0.566	1.00
72_S	77_F	0.565	1.00
139_E	142_G	0.563	1.00
66_A	121_A	0.562	1.00
123_I	293_Q	0.560	1.00
178_S	197_P	0.556	1.00
162_T	166_L	0.555	1.00
286_L	293_Q	0.555	1.00
132_M	170_L	0.555	1.00
178_S	183_T	0.554	1.00
151_V	215_A	0.554	1.00
52_K	55_R	0.551	1.00
77_F	106_G	0.549	1.00
22_E	103_R	0.548	1.00
225_A	249_P	0.548	1.00
58_P	62_G	0.545	1.00
309_A	315_I	0.544	1.00
217_D	241_G	0.544	1.00
117_D	297_E	0.543	1.00
34_V	97_G	0.543	1.00
168_H	192_A	0.543	1.00
85_L	109_L	0.541	1.00
15_A	307_A	0.540	1.00
8_Q	13_T	0.539	1.00
286_L	291_Y	0.538	1.00
156_S	183_T	0.538	1.00
14_L	47_I	0.534	1.00
56_N	59_M	0.534	1.00
162_T	291_Y	0.533	1.00
40_N	318_R	0.533	1.00
179_G	197_P	0.532	1.00
37_S	321_V	0.531	1.00
85_L	91_G	0.530	1.00
14_L	304_P	0.529	1.00
187_L	195_V	0.523	1.00
192_A	195_V	0.522	1.00
17_V	303_A	0.521	1.00
13_T	47_I	0.521	1.00
238_A	265_V	0.520	1.00
23_S	29_D	0.519	1.00
32_V	65_F	0.519	1.00
188_K	192_A	0.518	1.00
162_T	165_A	0.517	1.00
139_E	277_Q	0.517	1.00
105_K	108_W	0.515	1.00
205_R	211_V	0.515	1.00
6_L	47_I	0.515	1.00
289_S	292_T	0.515	1.00
38_S	122_M	0.515	1.00
161_S	190_L	0.515	1.00
204_S	230_Q	0.514	1.00
46_A	51_G	0.511	1.00
298_I	305_N	0.510	1.00
44_A	48_T	0.508	1.00
21_D	24_R	0.507	1.00
206_P	209_K	0.505	1.00
112_M	116_L	0.504	1.00
182_S	314_Q	0.503	1.00
75_P	81_Q	0.502	1.00
64_D	318_R	0.502	1.00
149_E	211_V	0.501	1.00
20_L	100_E	0.501	1.00
232_N	235_G	0.500	1.00
125_G	279_W	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3nx4A	2	0.9969	100	0.128	Contact Map
4jxkA	2	0.9938	100	0.162	Contact Map
1tt7A	5	0.9938	100	0.175	Contact Map
4j6fA	2	0.966	100	0.179	Contact Map
4gi2A	2	0.9784	100	0.179	Contact Map
1xa0A	2	0.9877	100	0.182	Contact Map
1rjwA	4	0.9568	100	0.184	Contact Map
3uogA	4	0.9599	100	0.189	Contact Map
4oaqA	2	0.9599	100	0.19	Contact Map
1zsyA	2	0.9722	100	0.192	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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