MAO1 - ECOLI - GREMLIN Contacts

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MAO1 - NAD-dependent malic enzyme

UniProt:	P26616	Sequences: MEPKTKKQRSLYIPYAGPVLLEFPLLNKGSAFSMEERRNFNLLGLLPEVVETIEEQAERAWIQYQGFKTEIDKHIYLRNIQDTNETLFYRLVNNHLDEMMPVIYTPTVGAACERFSEIYRRSRGVFISYQNRHNMDDILQNVPNHNIKVIVVTDGERILGLGDQGIGGMGIPIGKLSLYTACGGISPAYTLPVVLDVGTNNQQLLNDPLYMGWRNPRITDDEYYEFVDEFIQAVKQRWPDVLLQFEDFAQKNAMPLLNRYRNEICSFNDDIQGTAAVTVGTLIAASRAAGGQLSEKKIVFLGAGSAGCGIAEMIISQTQREGLSEEAARQKVFMVDRFGLLTDKMPNLLPFQTKLVQKRENLSDWDTDSDVLSLLDVVRNVKPDILIGVSGQTGLFTEEIIREMHKHCPRPIVMPLSNPTSRVEATPQDIIAWTEGNALVATGSPFNPVVWKDKIYPIAQCNNAFIFPGIGLGVIASGASRITDEMLMSASETLAQYSPLVLNGEGMVLPELKDIQKVSRAIAFAVGKMAQQQGVAVKTSAEALQQAIDDNFWQAEYRDYRRTSI	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG10948
Length:	565 (537)
Sequences:	1486 (838)
Seq/√Len:	36.1

ECOLI - MAO1
BACSU - MAO2 MAO3 MAO1 MAO4
SULSO - Q97UX2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
398_E	402_R	8.635	1.00
202_Q	206_N	6.031	1.00
221_D	225_E	4.263	1.00
136_D	236_Q	4.091	1.00
64_Y	99_M	4.045	1.00
485_E	533_Q	4.041	1.00
312_E	355_L	4.028	1.00
92_V	103_I	4.016	1.00
148_K	189_Y	3.961	1.00
405_H	434_T	3.800	1.00
483_T	535_V	3.662	1.00
152_V	230_F	3.661	1.00
224_Y	255_P	3.585	1.00
401_I	433_W	3.336	1.00
428_Q	432_A	3.250	1.00
299_V	377_V	3.231	1.00
373_S	376_D	3.188	1.00
90_R	94_N	3.161	1.00
343_D	358_K	3.061	1.00
133_H	229_E	3.031	1.00
110_A	114_R	2.954	1.00
405_H	437_N	2.903	1.00
261_R	484_D	2.901	1.00
200_N	219_T	2.879	1.00
435_E	452_K	2.864	1.00
195_L	227_V	2.856	1.00
375_L	399_E	2.758	1.00
228_D	263_E	2.728	1.00
202_Q	216_P	2.718	1.00
379_R	403_E	2.710	1.00
60_A	91_L	2.652	1.00
402_R	435_E	2.598	1.00
245_F	266_S	2.594	1.00
425_A	430_I	2.585	1.00
231_I	264_I	2.565	1.00
403_E	407_H	2.502	1.00
324_S	327_A	2.436	1.00
67_F	72_D	2.399	1.00
524_F	548_I	2.399	1.00
520_R	549_D	2.379	1.00
28_K	36_E	2.378	1.00
474_V	482_I	2.375	1.00
483_T	533_Q	2.340	1.00
529_M	533_Q	2.333	0.99
403_E	406_K	2.331	0.99
500_L	504_G	2.289	0.99
230_F	234_V	2.229	0.99
375_L	400_I	2.206	0.99
529_M	532_Q	2.182	0.99
140_Q	237_R	2.171	0.99
275_A	313_M	2.163	0.99
65_Q	98_E	2.132	0.99
337_R	352_Q	2.112	0.99
301_L	395_L	2.080	0.99
431_I	451_W	2.073	0.99
404_M	413_V	2.062	0.99
38_R	43_L	2.016	0.99
70_E	73_K	2.010	0.98
95_H	98_E	1.994	0.98
323_L	331_K	1.966	0.98
85_E	123_R	1.962	0.98
252_N	255_P	1.928	0.98
292_Q	295_E	1.911	0.98
409_P	437_N	1.905	0.98
469_G	473_G	1.904	0.98
61_W	95_H	1.899	0.98
69_T	72_D	1.883	0.98
228_D	259_R	1.883	0.98
466_I	470_I	1.876	0.98
401_I	413_V	1.874	0.98
52_T	55_E	1.855	0.97
426_T	429_D	1.854	0.97
486_M	530_A	1.849	0.97
53_I	90_R	1.847	0.97
127_I	135_M	1.837	0.97
129_Y	218_I	1.813	0.97
439_L	508_V	1.811	0.97
310_I	389_V	1.791	0.97
282_L	314_I	1.786	0.97
546_Q	550_D	1.774	0.97
282_L	385_I	1.765	0.96
130_Q	213_W	1.753	0.96
105_T	444_S	1.742	0.96
228_D	232_Q	1.734	0.96
348_L	356_V	1.731	0.96
378_V	400_I	1.728	0.96
301_L	392_Q	1.697	0.96
545_Q	549_D	1.695	0.96
240_D	478_G	1.672	0.95
57_A	90_R	1.669	0.95
265_C	474_V	1.653	0.95
205_L	216_P	1.626	0.94
325_E	329_R	1.625	0.94
450_V	455_I	1.619	0.94
327_A	331_K	1.610	0.94
231_I	243_L	1.599	0.94
150_I	234_V	1.588	0.94
375_L	379_R	1.577	0.93
540_S	543_A	1.577	0.93
296_K	384_D	1.577	0.93
294_S	321_E	1.575	0.93
514_D	517_K	1.567	0.93
224_Y	252_N	1.566	0.93
201_N	204_L	1.558	0.93
382_K	407_H	1.557	0.93
299_V	381_V	1.551	0.93
135_M	226_F	1.550	0.93
299_V	335_V	1.549	0.93
157_R	161_L	1.545	0.93
320_R	492_E	1.543	0.93
398_E	433_W	1.539	0.93
281_T	509_L	1.531	0.92
156_E	252_N	1.526	0.92
61_W	65_Q	1.525	0.92
156_E	200_N	1.521	0.92
57_A	94_N	1.512	0.92
129_Y	226_F	1.507	0.92
152_V	234_V	1.505	0.92
315_I	329_R	1.498	0.92
97_D	513_K	1.497	0.91
543_A	546_Q	1.493	0.91
231_I	245_F	1.493	0.91
528_K	532_Q	1.484	0.91
117_E	207_D	1.464	0.91
193_V	230_F	1.446	0.90
227_V	256_L	1.445	0.90
243_L	264_I	1.442	0.90
483_T	529_M	1.442	0.90
524_F	545_Q	1.436	0.90
401_I	434_T	1.434	0.90
51_E	59_R	1.432	0.90
156_E	249_A	1.423	0.89
450_V	453_D	1.410	0.89
483_T	486_M	1.402	0.89
520_R	545_Q	1.402	0.89
129_Y	213_W	1.398	0.88
64_Y	102_V	1.398	0.88
43_L	131_N	1.393	0.88
476_A	527_G	1.384	0.88
53_I	86_T	1.378	0.88
215_N	218_I	1.369	0.87
473_G	477_S	1.368	0.87
332_V	357_Q	1.367	0.87
338_F	352_Q	1.366	0.87
398_E	435_E	1.364	0.87
61_W	99_M	1.361	0.87
413_V	430_I	1.358	0.87
427_P	440_V	1.357	0.87
473_G	479_A	1.353	0.87
379_R	399_E	1.339	0.86
461_C	509_L	1.335	0.86
451_W	456_Y	1.333	0.86
431_I	458_I	1.332	0.86
473_G	530_A	1.331	0.86
130_Q	215_N	1.326	0.86
298_I	318_T	1.325	0.86
30_S	211_M	1.324	0.85
149_V	471_G	1.318	0.85
391_G	395_L	1.310	0.85
285_A	412_I	1.307	0.85
193_V	226_F	1.300	0.84
528_K	541_A	1.295	0.84
169_M	194_V	1.278	0.83
61_W	98_E	1.276	0.83
300_F	311_A	1.274	0.83
473_G	526_V	1.270	0.83
477_S	527_G	1.256	0.82
132_R	222_E	1.256	0.82
341_L	352_Q	1.246	0.82
357_Q	381_V	1.245	0.82
529_M	535_V	1.243	0.82
375_L	403_E	1.242	0.82
282_L	298_I	1.239	0.81
429_D	432_A	1.236	0.81
425_A	440_V	1.235	0.81
105_T	109_G	1.232	0.81
435_E	451_W	1.229	0.81
479_A	486_M	1.224	0.81
318_T	323_L	1.214	0.80
112_C	161_L	1.214	0.80
242_L	482_I	1.212	0.80
61_W	91_L	1.207	0.80
221_D	224_Y	1.197	0.79
153_T	194_V	1.194	0.79
84_N	557_Y	1.193	0.79
124_G	169_M	1.191	0.79
235_K	264_I	1.188	0.79
337_R	341_L	1.180	0.78
402_R	437_N	1.179	0.78
277_V	494_L	1.175	0.78
401_I	430_I	1.172	0.78
78_R	88_F	1.171	0.78
20_L	40_F	1.167	0.77
431_I	456_Y	1.161	0.77
109_G	467_F	1.143	0.76
132_R	229_E	1.137	0.75
297_K	384_D	1.137	0.75
60_A	76_Y	1.135	0.75
35_E	39_N	1.132	0.75
521_A	545_Q	1.127	0.75
281_T	414_M	1.125	0.75
17_G	20_L	1.125	0.75
80_I	108_V	1.122	0.74
394_G	429_D	1.118	0.74
195_L	226_F	1.116	0.74
110_A	113_E	1.112	0.74
112_C	158_I	1.107	0.73
382_K	406_K	1.107	0.73
333_F	381_V	1.101	0.73
81_Q	123_R	1.098	0.73
330_Q	358_K	1.098	0.73
335_V	374_L	1.094	0.73
297_K	381_V	1.087	0.72
93_N	516_Q	1.086	0.72
185_I	472_L	1.083	0.72
136_D	237_R	1.079	0.71
219_T	252_N	1.069	0.71
136_D	229_E	1.066	0.71
254_M	352_Q	1.063	0.70
277_V	522_I	1.061	0.70
132_R	225_E	1.060	0.70
105_T	467_F	1.059	0.70
71_I	118_I	1.052	0.70
135_M	139_L	1.047	0.69
496_Q	525_A	1.046	0.69
115_F	173_I	1.044	0.69
448_P	457_P	1.044	0.69
318_T	331_K	1.044	0.69
431_I	436_G	1.042	0.69
185_I	475_I	1.035	0.68
335_V	377_V	1.034	0.68
400_I	403_E	1.032	0.68
312_E	354_K	1.031	0.68
49_V	214_R	1.031	0.68
344_K	359_R	1.028	0.68
374_L	386_L	1.026	0.68
341_L	356_V	1.019	0.67
235_K	243_L	1.011	0.66
82_D	121_R	1.010	0.66
539_T	542_E	1.009	0.66
489_S	525_A	1.006	0.66
112_C	157_R	1.006	0.66
233_A	237_R	1.004	0.66
425_A	442_T	1.004	0.66
520_R	552_F	1.002	0.66
499_P	503_N	1.002	0.66
228_D	260_Y	1.001	0.66
319_Q	325_E	1.001	0.66
376_D	379_R	1.001	0.66
234_V	241_V	1.000	0.66
112_C	170_G	0.995	0.65
262_N	481_R	0.990	0.65
327_A	330_Q	0.989	0.65
161_L	164_Q	0.989	0.65
182_C	389_V	0.987	0.65
127_I	139_L	0.985	0.64
81_Q	85_E	0.980	0.64
27_N	32_F	0.977	0.64
20_L	42_L	0.971	0.63
520_R	524_F	0.971	0.63
315_I	319_Q	0.965	0.63
15_Y	20_L	0.965	0.63
232_Q	263_E	0.963	0.63
249_A	305_S	0.960	0.62
376_D	380_N	0.959	0.62
49_V	55_E	0.958	0.62
155_G	194_V	0.957	0.62
91_L	99_M	0.953	0.62
250_Q	305_S	0.950	0.62
28_K	558_R	0.943	0.61
68_K	72_D	0.938	0.61
494_L	522_I	0.936	0.60
183_G	249_A	0.935	0.60
399_E	403_E	0.935	0.60
54_E	452_K	0.932	0.60
108_V	174_G	0.923	0.59
46_L	50_V	0.921	0.59
65_Q	95_H	0.921	0.59
129_Y	135_M	0.921	0.59
318_T	322_G	0.919	0.59
281_T	459_A	0.919	0.59
343_D	356_V	0.919	0.59
478_G	538_K	0.915	0.59
200_N	216_P	0.910	0.58
105_T	277_V	0.909	0.58
174_G	181_A	0.909	0.58
308_C	334_M	0.908	0.58
288_A	410_R	0.907	0.58
343_D	359_R	0.906	0.58
78_R	81_Q	0.906	0.58
146_N	189_Y	0.906	0.58
31_A	557_Y	0.905	0.58
512_L	522_I	0.904	0.58
470_I	487_L	0.902	0.57
79_N	83_T	0.901	0.57
478_G	537_V	0.900	0.57
75_I	120_R	0.897	0.57
326_E	330_Q	0.895	0.57
205_L	214_R	0.894	0.57
493_T	521_A	0.891	0.57
516_Q	552_F	0.890	0.56
110_A	421_S	0.889	0.56
434_T	518_V	0.888	0.56
149_V	179_Y	0.886	0.56
82_D	123_R	0.883	0.56
278_T	341_L	0.881	0.56
105_T	446_F	0.880	0.56
398_E	434_T	0.878	0.55
442_T	458_I	0.878	0.55
295_E	327_A	0.877	0.55
156_E	219_T	0.877	0.55
402_R	434_T	0.872	0.55
466_I	494_L	0.869	0.55
332_V	377_V	0.869	0.55
430_I	440_V	0.865	0.54
476_A	547_A	0.864	0.54
345_M	352_Q	0.863	0.54
501_V	504_G	0.861	0.54
151_V	244_Q	0.859	0.54
67_F	75_I	0.859	0.54
202_Q	205_L	0.857	0.54
157_R	170_G	0.850	0.53
200_N	203_Q	0.849	0.53
372_L	377_V	0.848	0.53
293_L	318_T	0.848	0.53
108_V	169_M	0.847	0.53
127_I	138_I	0.847	0.53
136_D	140_Q	0.846	0.53
186_S	189_Y	0.846	0.53
481_R	535_V	0.844	0.52
15_Y	23_F	0.843	0.52
333_F	357_Q	0.843	0.52
80_I	83_T	0.842	0.52
425_A	553_W	0.841	0.52
338_F	341_L	0.840	0.52
135_M	229_E	0.839	0.52
131_N	134_N	0.835	0.52
112_C	465_F	0.834	0.52
427_P	442_T	0.834	0.52
117_E	209_L	0.830	0.51
29_G	121_R	0.830	0.51
383_P	404_M	0.827	0.51
291_G	296_K	0.826	0.51
116_S	205_L	0.822	0.51
377_V	381_V	0.819	0.50
540_S	544_L	0.818	0.50
174_G	179_Y	0.817	0.50
531_Q	541_A	0.816	0.50
294_S	323_L	0.814	0.50
405_H	408_C	0.812	0.50
157_R	465_F	0.811	0.50
420_T	445_P	0.811	0.50
75_I	118_I	0.805	0.49
227_V	266_S	0.803	0.49
193_V	234_V	0.803	0.49
69_T	110_A	0.802	0.49
316_S	325_E	0.800	0.49
51_E	83_T	0.798	0.48
139_L	237_R	0.798	0.48
299_V	400_I	0.789	0.48
166_I	227_V	0.787	0.48
317_Q	321_E	0.785	0.47
113_E	421_S	0.783	0.47
288_A	439_L	0.782	0.47
254_M	355_L	0.781	0.47
301_L	374_L	0.780	0.47
497_Y	521_A	0.778	0.47
398_E	432_A	0.777	0.47
485_E	529_M	0.775	0.46
416_L	446_F	0.771	0.46
59_R	441_A	0.770	0.46
249_A	252_N	0.769	0.46
546_Q	549_D	0.768	0.46
245_F	264_I	0.768	0.46
225_E	399_E	0.767	0.46
62_I	65_Q	0.766	0.46
398_E	401_I	0.765	0.46
393_T	397_T	0.765	0.46
297_K	383_P	0.765	0.46
415_P	433_W	0.765	0.46
122_S	414_M	0.765	0.46
156_E	389_V	0.763	0.45
174_G	460_Q	0.763	0.45
32_F	36_E	0.761	0.45
75_I	522_I	0.760	0.45
173_I	319_Q	0.757	0.45
423_V	446_F	0.756	0.45
254_M	351_F	0.756	0.45
337_R	391_G	0.755	0.45
112_C	275_A	0.753	0.45
157_R	172_P	0.752	0.44
412_I	441_A	0.749	0.44
476_A	551_N	0.747	0.44
194_V	341_L	0.746	0.44
544_L	548_I	0.746	0.44
74_H	313_M	0.746	0.44
287_R	496_Q	0.745	0.44
300_F	387_I	0.745	0.44
51_E	76_Y	0.745	0.44
250_Q	352_Q	0.744	0.44
136_D	233_A	0.744	0.44
527_G	531_Q	0.744	0.44
30_S	555_A	0.741	0.44
371_V	377_V	0.739	0.43
166_I	211_M	0.737	0.43
161_L	170_G	0.735	0.43
199_T	205_L	0.735	0.43
254_M	271_I	0.729	0.43
499_P	502_L	0.729	0.43
282_L	414_M	0.728	0.42
383_P	407_H	0.727	0.42
42_L	46_L	0.726	0.42
298_I	314_I	0.726	0.42
73_K	98_E	0.725	0.42
430_I	442_T	0.725	0.42
420_T	448_P	0.724	0.42
43_L	134_N	0.724	0.42
397_T	400_I	0.722	0.42
319_Q	546_Q	0.720	0.42
390_S	395_L	0.720	0.42
530_A	535_V	0.720	0.42
108_V	161_L	0.719	0.42
239_P	555_A	0.717	0.41
319_Q	323_L	0.717	0.41
515_I	522_I	0.717	0.41
307_G	508_V	0.717	0.41
299_V	357_Q	0.716	0.41
389_V	465_F	0.714	0.41
321_E	492_E	0.712	0.41
129_Y	132_R	0.712	0.41
265_C	275_A	0.711	0.41
286_S	291_G	0.711	0.41
62_I	117_E	0.710	0.41
497_Y	514_D	0.705	0.40
342_T	359_R	0.705	0.40
156_E	223_Y	0.705	0.40
97_D	511_E	0.704	0.40
33_S	36_E	0.704	0.40
218_I	226_F	0.703	0.40
316_S	319_Q	0.702	0.40
242_L	265_C	0.701	0.40
493_T	497_Y	0.701	0.40
67_F	76_Y	0.701	0.40
57_A	91_L	0.699	0.40
45_L	141_N	0.698	0.40
278_T	461_C	0.697	0.40
479_A	482_I	0.696	0.40
85_E	275_A	0.695	0.40
182_C	512_L	0.695	0.40
178_L	244_Q	0.694	0.40
479_A	526_V	0.694	0.40
31_A	52_T	0.693	0.39
176_L	459_A	0.692	0.39
161_L	465_F	0.692	0.39
111_A	124_G	0.692	0.39
480_S	537_V	0.691	0.39
267_F	445_P	0.690	0.39
112_C	172_P	0.689	0.39
531_Q	536_A	0.687	0.39
245_F	465_F	0.685	0.39
223_Y	249_A	0.684	0.39
518_V	522_I	0.684	0.39
459_A	498_S	0.683	0.39
16_A	41_N	0.683	0.39
513_K	532_Q	0.682	0.39
28_K	32_F	0.681	0.38
472_L	552_F	0.679	0.38
156_E	464_A	0.679	0.38
50_V	438_A	0.678	0.38
492_E	496_Q	0.677	0.38
67_F	464_A	0.676	0.38
350_P	353_T	0.676	0.38
244_Q	461_C	0.676	0.38
73_K	102_V	0.675	0.38
121_R	410_R	0.675	0.38
338_F	345_M	0.675	0.38
30_S	51_E	0.675	0.38
149_V	242_L	0.674	0.38
74_H	275_A	0.673	0.38
515_I	519_S	0.672	0.38
169_M	172_P	0.671	0.38
324_S	330_Q	0.671	0.38
116_S	167_G	0.669	0.37
307_G	389_V	0.668	0.37
337_R	345_M	0.665	0.37
402_R	433_W	0.664	0.37
448_P	455_I	0.664	0.37
220_D	252_N	0.663	0.37
205_L	448_P	0.663	0.37
337_R	392_Q	0.663	0.37
88_F	92_V	0.662	0.37
16_A	20_L	0.661	0.37
301_L	335_V	0.661	0.37
391_G	422_R	0.660	0.37
405_H	435_E	0.659	0.37
90_R	556_E	0.657	0.37
201_N	206_N	0.656	0.36
502_L	514_D	0.654	0.36
464_A	548_I	0.653	0.36
161_L	389_V	0.653	0.36
193_V	227_V	0.653	0.36
352_Q	509_L	0.653	0.36
178_L	266_S	0.652	0.36
446_F	467_F	0.650	0.36
56_Q	87_L	0.650	0.36
459_A	509_L	0.649	0.36
112_C	389_V	0.649	0.36
245_F	256_L	0.648	0.36
254_M	305_S	0.648	0.36
99_M	102_V	0.648	0.36
330_Q	378_V	0.645	0.36
111_A	441_A	0.645	0.36
426_T	440_V	0.645	0.36
282_L	286_S	0.645	0.36
36_E	56_Q	0.645	0.36
267_F	444_S	0.644	0.35
375_L	378_V	0.644	0.35
315_I	356_V	0.643	0.35
547_A	551_N	0.642	0.35
177_S	522_I	0.641	0.35
86_T	307_G	0.641	0.35
465_F	522_I	0.641	0.35
303_A	334_M	0.640	0.35
407_H	434_T	0.640	0.35
222_E	330_Q	0.639	0.35
197_V	223_Y	0.638	0.35
252_N	464_A	0.638	0.35
332_V	384_D	0.636	0.35
393_T	429_D	0.635	0.35
54_E	94_N	0.634	0.35
76_Y	119_Y	0.634	0.35
171_I	418_N	0.634	0.35
205_L	215_N	0.632	0.35
123_R	265_C	0.632	0.35
440_V	449_V	0.631	0.34
105_T	391_G	0.631	0.34
434_T	438_A	0.629	0.34
112_C	155_G	0.627	0.34
182_C	310_I	0.626	0.34
520_R	548_I	0.626	0.34
516_Q	554_Q	0.625	0.34
225_E	229_E	0.624	0.34
108_V	244_Q	0.624	0.34
330_Q	432_A	0.624	0.34
236_Q	402_R	0.624	0.34
382_K	430_I	0.623	0.34
306_A	418_N	0.623	0.34
56_Q	84_N	0.623	0.34
275_A	389_V	0.622	0.34
114_R	117_E	0.622	0.34
281_T	288_A	0.622	0.34
483_T	530_A	0.622	0.34
85_E	120_R	0.621	0.34
479_A	535_V	0.621	0.34
224_Y	227_V	0.620	0.34
222_E	225_E	0.620	0.34
157_R	178_L	0.620	0.34
71_I	75_I	0.619	0.34
528_K	531_Q	0.619	0.34
181_A	461_C	0.618	0.33
170_G	466_I	0.618	0.33
286_S	292_Q	0.617	0.33
425_A	429_D	0.617	0.33
112_C	164_Q	0.616	0.33
250_Q	349_L	0.615	0.33
316_S	329_R	0.615	0.33
278_T	416_L	0.613	0.33
112_C	244_Q	0.612	0.33
53_I	57_A	0.612	0.33
147_I	237_R	0.610	0.33
430_I	553_W	0.610	0.33
135_M	371_V	0.609	0.33
448_P	481_R	0.609	0.33
224_Y	228_D	0.609	0.33
105_T	421_S	0.608	0.33
493_T	522_I	0.607	0.33
105_T	271_I	0.607	0.33
125_V	142_V	0.605	0.32
128_S	226_F	0.604	0.32
114_R	263_E	0.604	0.32
129_Y	548_I	0.604	0.32
313_M	487_L	0.604	0.32
373_S	400_I	0.603	0.32
384_D	408_C	0.603	0.32
17_G	73_K	0.601	0.32
157_R	389_V	0.600	0.32
423_V	426_T	0.600	0.32
30_S	80_I	0.599	0.32
398_E	429_D	0.598	0.32
203_Q	378_V	0.597	0.32
190_T	244_Q	0.597	0.32
403_E	408_C	0.597	0.32
137_D	454_K	0.597	0.32
149_V	178_L	0.597	0.32
23_F	26_L	0.596	0.32
245_F	375_L	0.595	0.32
70_E	110_A	0.595	0.32
67_F	79_N	0.595	0.32
112_C	149_V	0.595	0.32
149_V	161_L	0.593	0.32
298_I	385_I	0.593	0.32
391_G	416_L	0.593	0.32
220_D	223_Y	0.593	0.32
152_V	201_N	0.591	0.31
386_L	469_G	0.590	0.31
34_M	38_R	0.590	0.31
373_S	377_V	0.590	0.31
166_I	487_L	0.589	0.31
89_Y	413_V	0.589	0.31
115_F	177_S	0.588	0.31
21_L	46_L	0.588	0.31
249_A	464_A	0.588	0.31
156_E	310_I	0.586	0.31
397_T	429_D	0.585	0.31
161_L	172_P	0.585	0.31
178_L	245_F	0.584	0.31
140_Q	214_R	0.584	0.31
115_F	310_I	0.584	0.31
310_I	464_A	0.584	0.31
31_A	56_Q	0.584	0.31
156_E	509_L	0.583	0.31
125_V	133_H	0.583	0.31
245_F	303_A	0.582	0.31
465_F	512_L	0.581	0.31
19_V	23_F	0.581	0.31
301_L	391_G	0.580	0.31
242_L	470_I	0.580	0.31
24_P	27_N	0.579	0.30
142_V	553_W	0.578	0.30
244_Q	465_F	0.578	0.30
245_F	300_F	0.577	0.30
405_H	409_P	0.576	0.30
89_Y	221_D	0.575	0.30
50_V	69_T	0.575	0.30
126_F	148_K	0.575	0.30
469_G	530_A	0.575	0.30
172_P	194_V	0.575	0.30
454_K	505_E	0.575	0.30
109_G	153_T	0.574	0.30
241_V	256_L	0.574	0.30
350_P	390_S	0.573	0.30
382_K	480_S	0.573	0.30
244_Q	267_F	0.572	0.30
128_S	131_N	0.571	0.30
219_T	222_E	0.571	0.30
115_F	279_V	0.571	0.30
152_V	195_L	0.571	0.30
158_I	171_I	0.571	0.30
59_R	209_L	0.569	0.30
279_V	317_Q	0.568	0.30
524_F	528_K	0.568	0.30
88_F	483_T	0.568	0.30
132_R	233_A	0.567	0.30
418_N	445_P	0.566	0.30
415_P	522_I	0.566	0.30
254_M	312_E	0.566	0.30
427_P	446_F	0.565	0.29
403_E	439_L	0.565	0.29
157_R	250_Q	0.565	0.29
312_E	329_R	0.564	0.29
55_E	72_D	0.564	0.29
54_E	517_K	0.564	0.29
88_F	177_S	0.564	0.29
415_P	431_I	0.563	0.29
482_I	526_V	0.563	0.29
324_S	504_G	0.562	0.29
130_Q	222_E	0.562	0.29
503_N	506_G	0.561	0.29
493_T	523_A	0.561	0.29
423_V	430_I	0.560	0.29
37_R	46_L	0.560	0.29
525_A	528_K	0.560	0.29
498_S	503_N	0.559	0.29
425_A	458_I	0.557	0.29
261_R	530_A	0.557	0.29
223_Y	252_N	0.557	0.29
444_S	467_F	0.556	0.29
82_D	120_R	0.556	0.29
86_T	557_Y	0.555	0.29
476_A	548_I	0.555	0.29
531_Q	544_L	0.555	0.29
444_S	519_S	0.554	0.29
58_E	62_I	0.554	0.29
89_Y	173_I	0.554	0.29
327_A	428_Q	0.553	0.29
127_I	137_D	0.553	0.29
59_R	297_K	0.553	0.29
330_Q	357_Q	0.552	0.29
259_R	299_V	0.552	0.29
174_G	461_C	0.549	0.28
124_G	446_F	0.547	0.28
195_L	291_G	0.546	0.28
378_V	428_Q	0.545	0.28
176_L	190_T	0.545	0.28
64_Y	91_L	0.545	0.28
291_G	384_D	0.544	0.28
493_T	496_Q	0.544	0.28
105_T	267_F	0.544	0.28
245_F	334_M	0.542	0.28
401_I	429_D	0.542	0.28
319_Q	328_A	0.541	0.28
180_T	448_P	0.541	0.28
486_M	533_Q	0.539	0.28
497_Y	518_V	0.539	0.28
494_L	525_A	0.539	0.28
271_I	305_S	0.539	0.28
98_E	473_G	0.539	0.28
200_N	313_M	0.538	0.28
67_F	70_E	0.538	0.28
512_L	519_S	0.538	0.28
474_V	477_S	0.537	0.27
344_K	353_T	0.537	0.27
238_W	288_A	0.536	0.27
134_N	137_D	0.535	0.27
84_N	87_L	0.535	0.27
44_G	141_N	0.535	0.27
250_Q	465_F	0.534	0.27
283_I	492_E	0.534	0.27
148_K	551_N	0.533	0.27
248_F	445_P	0.532	0.27
143_P	229_E	0.532	0.27
418_N	463_N	0.532	0.27
16_A	19_V	0.531	0.27
105_T	418_N	0.530	0.27
51_E	115_F	0.530	0.27
319_Q	322_G	0.529	0.27
517_K	520_R	0.529	0.27
251_K	255_P	0.528	0.27
256_L	465_F	0.527	0.27
24_P	452_K	0.527	0.27
54_E	240_D	0.527	0.27
80_I	142_V	0.527	0.27
338_F	392_Q	0.527	0.27
16_A	40_F	0.526	0.27
133_H	195_L	0.526	0.27
200_N	326_E	0.526	0.27
316_S	484_D	0.525	0.27
114_R	414_M	0.525	0.27
108_V	242_L	0.525	0.27
502_L	505_E	0.522	0.26
116_S	487_L	0.522	0.26
431_I	438_A	0.521	0.26
512_L	515_I	0.521	0.26
23_F	38_R	0.521	0.26
486_M	522_I	0.520	0.26
86_T	238_W	0.520	0.26
96_L	556_E	0.519	0.26
415_P	425_A	0.518	0.26
431_I	449_V	0.518	0.26
225_E	376_D	0.518	0.26
108_V	112_C	0.518	0.26
54_E	58_E	0.518	0.26
416_L	423_V	0.517	0.26
30_S	41_N	0.517	0.26
129_Y	195_L	0.516	0.26
334_M	341_L	0.516	0.26
41_N	146_N	0.515	0.26
113_E	467_F	0.514	0.26
77_L	80_I	0.514	0.26
58_E	208_P	0.514	0.26
94_N	98_E	0.514	0.26
34_M	43_L	0.513	0.26
55_E	214_R	0.513	0.26
376_D	399_E	0.513	0.26
201_N	337_R	0.513	0.26
116_S	470_I	0.512	0.26
489_S	529_M	0.512	0.26
58_E	69_T	0.511	0.26
217_R	223_Y	0.511	0.26
57_A	95_H	0.511	0.26
142_V	229_E	0.511	0.26
534_G	548_I	0.511	0.26
157_R	275_A	0.510	0.26
454_K	506_G	0.510	0.26
298_I	553_W	0.509	0.26
322_G	328_A	0.509	0.26
261_R	414_M	0.509	0.26
80_I	209_L	0.508	0.25
487_L	490_A	0.508	0.25
286_S	289_A	0.508	0.25
159_L	171_I	0.507	0.25
300_F	334_M	0.507	0.25
209_L	525_A	0.506	0.25
275_A	474_V	0.506	0.25
526_V	530_A	0.506	0.25
320_R	485_E	0.505	0.25
290_G	500_L	0.505	0.25
99_M	494_L	0.505	0.25
343_D	353_T	0.504	0.25
423_V	444_S	0.504	0.25
34_M	50_V	0.504	0.25
76_Y	513_K	0.503	0.25
244_Q	250_Q	0.503	0.25
290_G	330_Q	0.502	0.25
142_V	440_V	0.502	0.25
93_N	200_N	0.502	0.25
113_E	167_G	0.502	0.25
223_Y	248_F	0.502	0.25
75_I	215_N	0.501	0.25
353_T	542_E	0.501	0.25
129_Y	197_V	0.500	0.25
336_D	345_M	0.500	0.25
347_N	469_G	0.500	0.25
105_T	445_P	0.500	0.25
83_T	193_V	0.500	0.25
421_S	444_S	0.500	0.25

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1gq2A	6	0.9593	100	0.145	Contact Map
1o0sA	4	0.9841	100	0.146	Contact Map
1pj3A	4	0.9664	100	0.149	Contact Map
3nv9A	2	0.7965	100	0.536	Contact Map
1vl6A	4	0.6354	100	0.608	Contact Map
2a9fA	2	0.669	100	0.66	Contact Map
2dvmA	2	0.7292	100	0.67	Contact Map
4ppmA	2	0.0407	99.3	0.945	Contact Map
1v8bA	4	0.7398	99	0.952	Contact Map
3aoeE	3	0.6549	98.5	0.961	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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