AMY2 - ECOLI - GREMLIN Contacts

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AMY2 - Cytoplasmic alpha-amylase

UniProt:	P26612	Sequences: MRNPTLLQCFHWYYPEGGKLWPELAERADGFNDIGINMVWLPPAYKGASGGYSVGYDSYDLFDLGEFDQKGSIPTKYGDKAQLLAAIDALKRNDIAVLLDVVVNHKMGADEKEAIRVQRVNADDRTQIDEEIIECEGWTRYTFPARAGQYSQFIWDFKCFSGIDHIENPDEDGIFKIVNDYTGEGWNDQVDDELGNFDYLMGENIDFRNHAVTEEIKYWARWVMEQTQCDGFRLDAVKHIPAWFYKEWIEHVQEVAPKPLFIVAEYWSHEVDKLQTYIDQVEGKTMLFDAPLQMKFHEASRMGRDYDMTQIFTGTLVEADPFHAVTLVANHDTQPLQALEAPVEPWFKPLAYALILLRENGVPSVFYPDLYGAHYEDVGGDGQTYPIDMPIIEQLDELILARQRFAHGVQTLFFDHPNCIAFSRSGTDEFPGCVVVMSNGDDGEKTIHLGENYGNKTWRDFLGNRQERVVTDENGEATFFCNGGSVSVWVIEEVI	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG11387
Length:	495 (406)
Sequences:	12912 (8974)
Seq/√Len:	445.4

ECOLI - AMY2 MALZ TREC AMY1 GLGX SUCP YGAQ GLGB
BACSU - BBMA O16G2 O16G3 O16G1 AMY TREC GLGB PULA
SULSO - TREZ Q7LX99

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
29_D	93_N	4.245	1.00
91_K	230_D	4.218	1.00
15_P	27_R	4.172	1.00
89_A	92_R	3.980	1.00
46_K	72_S	3.978	1.00
84_L	226_Q	3.726	1.00
213_T	247_E	3.566	1.00
22_P	85_A	3.561	1.00
89_A	93_N	3.422	1.00
79_D	82_Q	3.414	1.00
132_I	196_N	3.163	1.00
31_F	36_I	3.128	1.00
22_P	25_A	3.065	1.00
25_A	89_A	3.008	1.00
15_P	26_E	3.006	1.00
90_L	97_V	2.897	1.00
25_A	85_A	2.804	1.00
90_L	95_I	2.781	1.00
28_A	93_N	2.769	1.00
46_K	59_Y	2.714	1.00
22_P	82_Q	2.654	1.00
32_N	93_N	2.649	1.00
411_T	423_S	2.554	1.00
329_A	369_D	2.436	1.00
353_A	394_Q	2.428	1.00
423_S	432_G	2.357	1.00
221_R	251_H	2.332	1.00
33_D	396_D	2.303	1.00
393_E	396_D	2.244	1.00
357_L	422_F	2.196	1.00
28_A	90_L	2.178	1.00
352_Y	395_L	2.174	1.00
421_A	436_V	2.166	1.00
4_P	37_N	2.164	1.00
9_C	24_L	2.139	1.00
249_I	253_Q	2.093	1.00
106_K	128_I	2.055	1.00
217_K	247_E	2.009	1.00
221_R	225_E	1.986	1.00
242_A	283_G	1.985	1.00
400_L	404_R	1.981	1.00
85_A	89_A	1.981	1.00
83_L	87_I	1.968	1.00
24_L	41_L	1.965	1.00
22_P	26_E	1.959	1.00
37_N	403_Q	1.951	1.00
215_E	218_Y	1.929	1.00
62_F	218_Y	1.927	1.00
220_A	248_W	1.918	1.00
88_D	92_R	1.901	1.00
198_D	202_G	1.888	1.00
460_D	463_G	1.879	1.00
6_L	38_M	1.873	1.00
224_M	260_L	1.865	1.00
72_S	80_K	1.844	1.00
87_I	97_V	1.840	1.00
106_K	205_I	1.831	1.00
80_K	226_Q	1.830	1.00
425_S	432_G	1.829	1.00
411_T	425_S	1.815	1.00
60_D	72_S	1.792	1.00
80_K	222_W	1.749	1.00
349_P	394_Q	1.742	1.00
418_N	440_G	1.736	1.00
354_L	437_M	1.727	1.00
409_V	425_S	1.718	1.00
39_V	90_L	1.706	1.00
214_E	218_Y	1.682	1.00
350_L	437_M	1.675	1.00
315_T	319_A	1.672	1.00
46_K	75_T	1.664	1.00
103_V	216_I	1.660	1.00
210_H	214_E	1.647	1.00
423_S	434_V	1.639	1.00
111_E	115_I	1.634	1.00
214_E	251_H	1.622	1.00
24_L	86_A	1.611	1.00
83_L	99_L	1.611	1.00
328_V	351_A	1.607	1.00
356_L	399_I	1.605	1.00
221_R	256_A	1.589	1.00
5_T	399_I	1.583	1.00
20_L	23_E	1.581	1.00
345_P	349_P	1.563	1.00
217_K	251_H	1.554	1.00
407_H	426_G	1.553	1.00
316_L	319_A	1.545	1.00
81_A	84_L	1.537	1.00
33_D	392_I	1.527	1.00
62_F	222_W	1.521	1.00
84_L	88_D	1.520	1.00
8_Q	42_P	1.485	1.00
337_Q	348_K	1.467	1.00
125_R	194_L	1.466	1.00
46_K	60_D	1.448	1.00
117_V	191_D	1.444	1.00
307_D	310_Q	1.440	1.00
80_K	84_L	1.440	1.00
246_K	283_G	1.437	1.00
41_L	44_A	1.431	1.00
225_E	256_A	1.428	1.00
188_D	195_G	1.418	1.00
353_A	398_L	1.412	1.00
211_A	214_E	1.409	1.00
81_A	85_A	1.404	1.00
460_D	464_N	1.399	1.00
62_F	219_W	1.382	1.00
115_I	118_Q	1.381	1.00
124_D	127_Q	1.374	1.00
246_K	282_E	1.371	1.00
305_D	311_I	1.368	1.00
183_G	186_W	1.362	1.00
392_I	396_D	1.361	1.00
422_F	435_V	1.357	1.00
382_G	385_Y	1.354	1.00
261_F	286_M	1.338	1.00
44_A	73_I	1.336	1.00
25_A	86_A	1.335	1.00
32_N	95_I	1.331	1.00
315_T	318_E	1.328	1.00
305_D	309_T	1.326	1.00
82_Q	85_A	1.325	1.00
205_I	212_V	1.323	1.00
52_Y	109_A	1.319	1.00
357_L	435_V	1.319	1.00
372_G	391_I	1.311	1.00
127_Q	215_E	1.295	1.00
373_A	386_P	1.285	1.00
108_G	203_E	1.283	1.00
101_V	220_A	1.281	1.00
44_A	99_L	1.279	1.00
309_T	312_F	1.263	1.00
45_Y	99_L	1.262	1.00
114_A	117_V	1.257	1.00
44_A	83_L	1.248	1.00
96_A	230_D	1.248	1.00
215_E	219_W	1.244	1.00
236_A	239_H	1.242	1.00
396_D	400_L	1.232	1.00
18_G	76_K	1.229	1.00
336_L	340_E	1.225	1.00
199_Y	202_G	1.207	1.00
378_V	381_D	1.205	1.00
344_E	347_F	1.178	1.00
98_L	231_G	1.178	1.00
309_T	313_T	1.169	1.00
28_A	89_A	1.167	1.00
397_E	400_L	1.166	1.00
196_N	202_G	1.160	1.00
21_W	73_I	1.156	1.00
416_H	445_K	1.153	1.00
62_F	215_E	1.147	1.00
305_D	312_F	1.141	1.00
4_P	38_M	1.138	1.00
308_M	312_F	1.137	1.00
306_Y	310_Q	1.136	1.00
103_V	234_L	1.124	1.00
128_I	132_I	1.124	1.00
27_R	30_G	1.120	1.00
115_I	122_A	1.118	1.00
393_E	397_E	1.104	1.00
383_Q	386_P	1.088	1.00
329_A	336_L	1.087	1.00
28_A	86_A	1.084	1.00
214_E	217_K	1.075	1.00
98_L	261_F	1.071	1.00
73_I	83_L	1.070	1.00
130_E	133_I	1.068	1.00
119_R	123_D	1.065	1.00
405_F	408_G	1.062	1.00
25_A	82_Q	1.060	1.00
249_I	262_I	1.054	1.00
99_L	229_C	1.046	1.00
183_G	188_D	1.042	1.00
413_F	434_V	1.041	1.00
88_D	91_K	1.038	1.00
184_E	187_N	1.034	1.00
323_H	362_V	1.028	1.00
377_D	381_D	1.026	1.00
127_Q	130_E	1.026	1.00
306_Y	312_F	1.025	1.00
191_D	194_L	1.023	1.00
55_G	77_Y	1.020	1.00
207_F	216_I	1.014	1.00
29_D	89_A	1.014	1.00
185_G	188_D	1.009	1.00
115_I	119_R	1.006	1.00
21_W	83_L	1.005	1.00
197_F	202_G	1.005	1.00
49_S	74_P	1.004	1.00
425_S	428_D	1.003	1.00
85_A	88_D	1.000	1.00
310_Q	314_G	0.998	1.00
304_R	307_D	0.998	1.00
115_I	124_D	0.998	1.00
327_L	330_N	0.996	1.00
122_A	125_R	0.990	1.00
228_Q	257_P	0.990	1.00
29_D	33_D	0.990	1.00
9_C	31_F	0.990	1.00
83_L	229_C	0.988	1.00
426_G	431_P	0.985	1.00
253_Q	285_T	0.980	1.00
308_M	311_I	0.978	1.00
206_D	209_N	0.978	1.00
111_E	114_A	0.970	1.00
349_P	391_I	0.962	1.00
413_F	423_S	0.960	1.00
133_I	137_G	0.960	1.00
350_L	439_N	0.957	1.00
310_Q	313_T	0.953	1.00
21_W	44_A	0.946	1.00
31_F	39_V	0.945	1.00
383_Q	387_I	0.933	1.00
213_T	244_F	0.933	1.00
377_D	380_G	0.932	1.00
195_G	202_G	0.930	1.00
49_S	76_K	0.926	1.00
219_W	222_W	0.918	1.00
273_K	276_T	0.917	1.00
6_L	364_S	0.913	1.00
405_F	433_C	0.911	1.00
276_T	279_D	0.907	1.00
222_W	226_Q	0.905	1.00
428_D	431_P	0.904	1.00
119_R	122_A	0.903	1.00
123_D	211_A	0.902	1.00
220_A	252_V	0.898	1.00
382_G	387_I	0.897	1.00
125_R	130_E	0.897	1.00
288_F	292_L	0.895	1.00
36_I	365_V	0.889	1.00
120_V	124_D	0.888	1.00
289_D	326_T	0.888	1.00
348_K	391_I	0.887	1.00
12_W	76_K	0.885	1.00
103_V	220_A	0.880	1.00
5_T	36_I	0.880	1.00
32_N	94_D	0.879	1.00
263_V	364_S	0.878	1.00
225_E	257_P	0.877	1.00
418_N	442_D	0.871	1.00
120_V	125_R	0.868	1.00
391_I	394_Q	0.865	1.00
357_L	405_F	0.865	1.00
179_N	183_G	0.864	1.00
357_L	398_L	0.864	1.00
106_K	212_V	0.864	1.00
285_T	288_F	0.861	1.00
356_L	363_P	0.856	1.00
114_A	118_Q	0.856	1.00
316_L	320_D	0.851	1.00
109_A	114_A	0.848	1.00
325_V	364_S	0.845	1.00
197_F	200_L	0.844	1.00
48_A	59_Y	0.843	1.00
123_D	128_I	0.841	1.00
384_T	387_I	0.841	1.00
129_D	132_I	0.839	1.00
343_V	346_W	0.839	1.00
133_I	136_E	0.838	1.00
382_G	386_P	0.838	1.00
86_A	97_V	0.837	1.00
45_Y	58_S	0.837	1.00
300_S	354_L	0.835	1.00
128_I	131_E	0.834	1.00
235_D	332_D	0.833	1.00
246_K	250_E	0.832	1.00
214_E	247_E	0.830	1.00
237_V	245_Y	0.829	1.00
240_I	245_Y	0.827	1.00
123_D	127_Q	0.825	1.00
421_A	434_V	0.825	1.00
365_V	395_L	0.821	1.00
418_N	445_K	0.821	1.00
4_P	96_A	0.820	1.00
221_R	255_V	0.820	1.00
36_I	95_I	0.820	1.00
247_E	251_H	0.817	1.00
380_G	383_Q	0.817	1.00
251_H	255_V	0.816	1.00
8_Q	11_H	0.816	1.00
224_M	252_V	0.815	1.00
292_L	296_F	0.814	1.00
213_T	217_K	0.810	1.00
25_A	29_D	0.807	1.00
195_G	198_D	0.806	1.00
235_D	265_E	0.805	1.00
311_I	314_G	0.805	1.00
267_W	333_T	0.804	1.00
192_D	195_G	0.801	1.00
247_E	250_E	0.798	1.00
182_T	186_W	0.797	1.00
217_K	248_W	0.797	1.00
16_E	20_L	0.794	1.00
11_H	24_L	0.793	1.00
233_R	332_D	0.793	1.00
48_A	109_A	0.792	1.00
196_N	199_Y	0.792	1.00
202_G	239_H	0.788	1.00
101_V	234_L	0.788	1.00
118_Q	122_A	0.782	1.00
237_V	240_I	0.781	1.00
121_N	124_D	0.778	1.00
306_Y	309_T	0.775	1.00
46_K	74_P	0.772	1.00
21_W	82_Q	0.772	1.00
38_M	98_L	0.771	1.00
418_N	439_N	0.770	1.00
349_P	390_P	0.770	1.00
183_G	187_N	0.769	1.00
284_K	287_L	0.768	1.00
242_A	246_K	0.762	1.00
317_V	320_D	0.761	1.00
39_V	86_A	0.759	1.00
87_I	229_C	0.757	1.00
194_L	197_F	0.757	1.00
251_H	256_A	0.754	1.00
196_N	200_L	0.751	1.00
11_H	42_P	0.751	1.00
59_Y	109_A	0.749	1.00
354_L	439_N	0.746	1.00
86_A	90_L	0.746	1.00
354_L	358_R	0.746	1.00
126_T	129_D	0.743	1.00
307_D	311_I	0.742	1.00
238_K	266_Y	0.741	1.00
459_R	463_G	0.740	1.00
356_L	398_L	0.738	1.00
127_Q	132_I	0.732	1.00
440_G	445_K	0.730	1.00
450_G	454_G	0.727	1.00
288_F	364_S	0.723	1.00
328_V	336_L	0.722	1.00
263_V	325_V	0.720	1.00
328_V	355_I	0.720	1.00
31_F	95_I	0.719	1.00
19_K	23_E	0.719	1.00
128_I	133_I	0.718	1.00
90_L	93_N	0.717	1.00
304_R	311_I	0.716	1.00
284_K	288_F	0.714	1.00
265_E	332_D	0.712	1.00
275_Q	278_I	0.712	1.00
115_I	123_D	0.711	1.00
279_D	282_E	0.707	1.00
233_R	265_E	0.706	1.00
249_I	285_T	0.706	1.00
298_E	302_M	0.706	1.00
353_A	437_M	0.705	1.00
101_V	232_F	0.705	1.00
197_F	201_M	0.704	1.00
58_S	61_L	0.703	1.00
91_K	96_A	0.703	1.00
346_W	349_P	0.702	1.00
129_D	133_I	0.699	1.00
235_D	331_H	0.698	1.00
173_G	176_K	0.697	1.00
188_D	192_D	0.696	1.00
234_L	284_K	0.695	1.00
134_E	172_D	0.694	1.00
193_E	196_N	0.692	1.00
38_M	261_F	0.690	1.00
118_Q	121_N	0.690	1.00
132_I	137_G	0.689	1.00
288_F	293_Q	0.689	1.00
252_V	260_L	0.689	1.00
352_Y	398_L	0.686	1.00
182_T	185_G	0.685	1.00
433_C	461_F	0.685	1.00
285_T	289_D	0.682	1.00
11_H	41_L	0.682	1.00
298_E	301_R	0.680	1.00
305_D	308_M	0.680	1.00
307_D	312_F	0.677	1.00
313_T	412_L	0.674	1.00
400_L	403_Q	0.674	1.00
105_H	331_H	0.674	1.00
131_E	134_E	0.671	1.00
264_A	284_K	0.670	1.00
124_D	128_I	0.670	1.00
343_V	347_F	0.670	1.00
375_Y	379_G	0.669	1.00
241_P	244_F	0.667	1.00
389_M	393_E	0.666	1.00
304_R	417_P	0.665	1.00
172_D	175_F	0.664	1.00
220_A	232_F	0.663	1.00
306_Y	311_I	0.663	1.00
192_D	196_N	0.661	1.00
30_G	33_D	0.660	1.00
205_I	216_I	0.659	1.00
293_Q	297_H	0.659	1.00
382_G	388_D	0.658	1.00
203_E	206_D	0.657	1.00
123_D	126_T	0.657	1.00
25_A	93_N	0.656	1.00
218_Y	222_W	0.656	1.00
367_Y	385_Y	0.654	1.00
385_Y	388_D	0.653	1.00
412_L	420_I	0.652	1.00
383_Q	388_D	0.652	1.00
173_G	177_I	0.651	1.00
116_R	130_E	0.651	1.00
304_R	308_M	0.651	1.00
198_D	201_M	0.650	1.00
348_K	352_Y	0.650	1.00
371_Y	386_P	0.649	1.00
356_L	365_V	0.649	1.00
196_N	201_M	0.647	0.99
265_E	331_H	0.647	0.99
211_A	215_E	0.647	0.99
218_Y	221_R	0.646	0.99
131_E	135_C	0.646	0.99
119_R	124_D	0.644	0.99
100_D	233_R	0.644	0.99
22_P	79_D	0.643	0.99
122_A	127_Q	0.642	0.99
306_Y	417_P	0.642	0.99
130_E	136_E	0.642	0.99
126_T	130_E	0.642	0.99
410_Q	422_F	0.641	0.99
290_A	327_L	0.640	0.99
184_E	188_D	0.639	0.99
121_N	127_Q	0.638	0.99
56_Y	235_D	0.638	0.99
17_G	384_T	0.638	0.99
36_I	399_I	0.637	0.99
62_F	72_S	0.636	0.99
277_Y	280_Q	0.635	0.99
289_D	293_Q	0.634	0.99
188_D	193_E	0.634	0.99
291_P	295_K	0.634	0.99
61_L	106_K	0.633	0.99
174_I	177_I	0.630	0.99
375_Y	381_D	0.630	0.99
133_I	173_G	0.629	0.99
134_E	137_G	0.629	0.99
91_K	97_V	0.628	0.99
371_Y	392_I	0.625	0.99
275_Q	279_D	0.624	0.99
83_L	86_A	0.622	0.99
292_L	358_R	0.618	0.99
350_L	353_A	0.618	0.99
341_A	347_F	0.618	0.99
188_D	194_L	0.617	0.99
293_Q	296_F	0.616	0.99
120_V	123_D	0.615	0.99
21_W	86_A	0.614	0.99
234_L	237_V	0.612	0.99
295_K	298_E	0.611	0.99
97_V	230_D	0.611	0.99
357_L	437_M	0.611	0.99
73_I	80_K	0.610	0.99
376_E	379_G	0.609	0.99
257_P	260_L	0.608	0.99
286_M	362_V	0.608	0.99
224_M	257_P	0.607	0.99
116_R	119_R	0.606	0.99
250_E	255_V	0.605	0.99
6_L	325_V	0.604	0.99
130_E	135_C	0.604	0.99
238_K	267_W	0.603	0.99
458_W	461_F	0.602	0.99
127_Q	133_I	0.601	0.99
25_A	28_A	0.601	0.99
375_Y	378_V	0.600	0.99
124_D	211_A	0.600	0.99
120_V	132_I	0.600	0.99
447_I	451_E	0.599	0.99
283_G	287_L	0.598	0.99
294_M	298_E	0.598	0.99
33_D	400_L	0.597	0.99
210_H	247_E	0.597	0.99
125_R	128_I	0.596	0.99
52_Y	108_G	0.596	0.99
447_I	450_G	0.596	0.99
104_N	204_N	0.593	0.99
188_D	191_D	0.592	0.99
193_E	197_F	0.591	0.99
38_M	96_A	0.590	0.99
6_L	98_L	0.590	0.99
410_Q	420_I	0.590	0.99
248_W	252_V	0.588	0.99
378_V	382_G	0.587	0.99
291_P	294_M	0.586	0.99
376_E	381_D	0.585	0.99
445_K	448_H	0.584	0.99
315_T	320_D	0.584	0.99
326_T	361_G	0.582	0.99
214_E	221_R	0.581	0.99
278_I	322_F	0.580	0.99
233_R	331_H	0.579	0.99
263_V	288_F	0.578	0.99
101_V	216_I	0.578	0.99
384_T	388_D	0.577	0.99
220_A	234_L	0.577	0.99
236_A	240_I	0.577	0.99
38_M	95_I	0.575	0.99
261_F	362_V	0.575	0.99
83_L	97_V	0.574	0.99
446_T	449_L	0.574	0.99
448_H	451_E	0.572	0.99
242_A	276_T	0.570	0.99
286_M	289_D	0.569	0.99
208_R	244_F	0.569	0.99
12_W	49_S	0.568	0.99
28_A	32_N	0.566	0.99
320_D	359_E	0.564	0.99
53_S	57_D	0.562	0.99
337_Q	340_E	0.560	0.99
303_G	312_F	0.560	0.99
313_T	410_Q	0.559	0.99
30_G	34_I	0.559	0.99
117_V	120_V	0.558	0.99
194_L	198_D	0.558	0.99
245_Y	284_K	0.558	0.99
182_T	187_N	0.557	0.98
194_L	202_G	0.557	0.98
304_R	312_F	0.556	0.98
122_A	130_E	0.555	0.98
112_K	205_I	0.555	0.98
107_M	202_G	0.553	0.98
442_D	445_K	0.553	0.98
181_Y	186_W	0.552	0.98
320_D	409_V	0.550	0.98
216_I	220_A	0.550	0.98
355_I	363_P	0.549	0.98
12_W	18_G	0.548	0.98
330_N	333_T	0.548	0.98
10_F	42_P	0.546	0.98
49_S	54_V	0.546	0.98
103_V	219_W	0.546	0.98
216_I	219_W	0.545	0.98
296_F	300_S	0.544	0.98
312_F	315_T	0.544	0.98
23_E	27_R	0.544	0.98
284_K	292_L	0.543	0.98
26_E	29_D	0.541	0.98
409_V	423_S	0.540	0.98
293_Q	333_T	0.540	0.98
210_H	213_T	0.539	0.98
423_S	426_G	0.539	0.98
326_T	355_I	0.537	0.98
245_Y	249_I	0.537	0.98
135_C	172_D	0.536	0.98
181_Y	184_E	0.536	0.98
313_T	317_V	0.535	0.98
56_Y	233_R	0.535	0.98
249_I	256_A	0.534	0.98
345_P	389_M	0.533	0.98
74_P	77_Y	0.533	0.98
11_H	77_Y	0.533	0.98
136_E	172_D	0.532	0.98
112_K	215_E	0.531	0.98
179_N	182_T	0.531	0.98
455_N	458_W	0.531	0.98
334_Q	338_A	0.530	0.98
191_D	195_G	0.530	0.98
459_R	464_N	0.530	0.98
284_K	289_D	0.529	0.98
334_Q	377_D	0.529	0.98
121_N	125_R	0.528	0.98
345_P	391_I	0.528	0.98
126_T	209_N	0.528	0.98
118_Q	124_D	0.526	0.98
448_H	452_N	0.526	0.98
335_P	338_A	0.526	0.98
303_G	306_Y	0.526	0.98
419_C	445_K	0.524	0.98
305_D	313_T	0.524	0.98
243_W	246_K	0.523	0.98
224_M	258_K	0.522	0.98
287_L	292_L	0.521	0.98
287_L	291_P	0.521	0.98
125_R	191_D	0.520	0.98
58_S	102_V	0.520	0.98
181_Y	187_N	0.520	0.98
6_L	362_V	0.520	0.98
173_G	184_E	0.519	0.98
252_V	262_I	0.517	0.98
336_L	351_A	0.516	0.98
286_M	292_L	0.516	0.98
116_R	194_L	0.516	0.98
399_I	403_Q	0.516	0.98
275_Q	280_Q	0.514	0.97
354_L	420_I	0.514	0.97
87_I	91_K	0.514	0.97
185_G	199_Y	0.514	0.97
221_R	224_M	0.513	0.97
244_F	247_E	0.513	0.97
413_F	421_A	0.512	0.97
438_S	441_D	0.512	0.97
175_F	181_Y	0.511	0.97
244_F	249_I	0.510	0.97
352_Y	356_L	0.510	0.97
287_L	290_A	0.509	0.97
195_G	200_L	0.508	0.97
237_V	266_Y	0.508	0.97
289_D	292_L	0.507	0.97
289_D	294_M	0.507	0.97
47_G	57_D	0.506	0.97
274_L	291_P	0.505	0.97
352_Y	355_I	0.504	0.97
48_A	57_D	0.504	0.97
119_R	194_L	0.503	0.97
124_D	132_I	0.502	0.97
232_F	260_L	0.501	0.97
379_G	384_T	0.500	0.97

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3bh4A	1	0.9636	100	0.243	Contact Map
1wpcA	1	0.9556	100	0.245	Contact Map
4uzuA	1	0.9535	100	0.247	Contact Map
1ud2A	1	0.9515	100	0.248	Contact Map
1wzaA	1	0.8606	100	0.259	Contact Map
4e2oA	1	0.8444	100	0.265	Contact Map
2wc7A	2	0.8263	100	0.268	Contact Map
1ea9C	2	0.8444	100	0.272	Contact Map
4wf7A	2	0.8869	100	0.273	Contact Map
1j0hA	2	0.8465	100	0.273	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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