GREMLIN Database
FLIS - Flagellar protein FliS
UniProt: P26608 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11388
Length: 136 (117)
Sequences: 1695 (1250)
Seq/√Len: 115.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
43_S109_E3.2971.00
70_R86_I3.0681.00
92_M111_V3.0541.00
35_V115_M2.9171.00
95_R107_A2.8581.00
39_L108_V2.8101.00
95_R110_E2.7391.00
54_K103_N2.4311.00
50_N53_G2.3311.00
33_D119_A2.2241.00
47_Q105_V2.2161.00
90_S94_R2.0901.00
55_G59_S2.0701.00
119_A123_K2.0701.00
80_E84_N2.0401.00
74_D77_S1.9921.00
92_M114_L1.9141.00
44_L48_D1.8121.00
36_L112_E1.7561.00
91_Y110_E1.6421.00
25_Q125_S1.5881.00
31_L64_I1.5761.00
95_R98_Q1.5571.00
46_M54_K1.4801.00
75_E82_T1.4681.00
58_L108_V1.4541.00
58_L96_L1.4401.00
92_M115_M1.4231.00
29_T123_K1.4191.00
46_M105_V1.3721.00
79_D82_T1.3581.00
75_E86_I1.3541.00
25_Q126_L1.3181.00
104_D107_A1.2971.00
34_G38_A1.2770.99
65_I92_M1.2750.99
53_G56_V1.2740.99
43_S112_E1.2610.99
43_S105_V1.2250.99
52_Q56_V1.2100.99
35_V61_A1.1890.99
30_M34_G1.1410.99
84_N87_A1.1180.99
75_E83_Q1.1080.98
120_D124_E1.0950.98
39_L112_E1.0930.98
28_V72_S1.0890.98
38_A60_K1.0860.98
41_R57_S1.0800.98
106_S110_E1.0640.98
32_F118_I1.0550.98
121_A124_E1.0530.98
91_Y95_R1.0380.98
110_E114_L1.0350.98
8_Q11_A1.0200.97
118_I121_A1.0080.97
38_A57_S0.9930.97
112_E116_R0.9800.97
51_Q55_G0.9780.97
56_V60_K0.9700.96
68_G72_S0.9630.96
45_F53_G0.9420.96
88_L92_M0.9400.96
95_R111_V0.9340.96
35_V65_I0.9330.96
66_E71_V0.9300.95
102_R107_A0.9290.95
77_S82_T0.9290.95
98_Q107_A0.9250.95
28_V125_S0.9240.95
85_L118_I0.9160.95
40_V112_E0.9070.95
105_V109_E0.9050.95
23_S126_L0.8870.94
91_Y114_L0.8840.94
34_G64_I0.8660.93
45_F50_N0.8550.93
39_L61_A0.8460.93
94_R98_Q0.8340.92
26_Q33_D0.8320.92
58_L100_N0.8250.92
47_Q109_E0.8230.92
60_K63_N0.8170.91
70_R90_S0.8140.91
120_D123_K0.8120.91
43_S47_Q0.8110.91
18_A26_Q0.7930.90
55_G100_N0.7910.90
55_G62_I0.7880.90
46_M103_N0.7870.90
63_N66_E0.7810.89
70_R93_V0.7770.89
37_S41_R0.7730.89
29_T119_A0.7710.89
16_E20_M0.7710.89
42_A58_L0.7660.88
113_A117_N0.7570.88
66_E93_V0.7540.88
88_L114_L0.7450.87
55_G103_N0.7440.87
97_L101_L0.7440.87
57_S60_K0.7370.86
91_Y107_A0.7340.86
30_M64_I0.7280.86
106_S109_E0.7260.86
83_Q87_A0.7060.84
117_N120_D0.7020.84
53_G57_S0.6980.83
75_E81_L0.6970.83
34_G60_K0.6960.83
98_Q102_R0.6960.83
28_V122_W0.6840.82
51_Q103_N0.6820.82
100_N103_N0.6800.82
45_F48_D0.6710.81
59_S63_N0.6680.81
56_V59_S0.6650.80
87_A90_S0.6610.80
36_L40_V0.6610.80
39_L96_L0.6600.80
93_V97_L0.6570.79
27_L68_G0.6550.79
21_S93_V0.6540.79
45_F57_S0.6510.79
5_K8_Q0.6440.78
40_V43_S0.6440.78
16_E68_G0.6410.78
31_L34_G0.6380.77
52_Q55_G0.6310.77
62_I93_V0.6300.77
41_R53_G0.6210.76
61_A96_L0.6150.75
44_L47_Q0.6140.75
66_E70_R0.6130.75
116_R120_D0.6090.74
40_V116_R0.6080.74
59_S62_I0.6080.74
38_A68_G0.6040.74
99_A108_V0.6030.73
109_E113_A0.6000.73
51_Q100_N0.5940.72
35_V64_I0.5910.72
54_K59_S0.5880.72
46_M108_V0.5840.71
38_A41_R0.5830.71
62_I68_G0.5800.70
30_M33_D0.5800.70
76_E82_T0.5790.70
36_L116_R0.5790.70
71_V74_D0.5760.70
75_E79_D0.5700.69
22_A27_L0.5620.68
32_F81_L0.5560.67
51_Q54_K0.5560.67
18_A30_M0.5550.67
7_T17_S0.5460.66
81_L88_L0.5460.66
46_M49_N0.5440.66
28_V33_D0.5420.65
81_L84_N0.5410.65
22_A122_W0.5380.65
88_L118_I0.5330.64
22_A30_M0.5320.64
94_R104_D0.5290.63
124_E127_L0.5230.63
19_V27_L0.5200.62
58_L99_A0.5180.62
49_N116_R0.5180.62
21_S29_T0.5170.62
11_A41_R0.5140.61
65_I96_L0.5140.61
24_Q122_W0.5110.61
33_D120_D0.5090.61
35_V92_M0.5050.60
56_V69_L0.5030.60
28_V126_L0.5000.59
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3iqcA 2 0.875 100 0.155 Contact Map
1vh6A 2 0.7941 100 0.183 Contact Map
4iwbA 1 0.9118 100 0.193 Contact Map
2nrjA 1 0.7868 32.6 0.921 Contact Map
2rklA 2 0.3529 24.1 0.926 Contact Map
3sjrA 2 0.5662 10.4 0.937 Contact Map
2ihr1 1 0.5 7.5 0.941 Contact Map
2za4B 1 0.5809 7.2 0.941 Contact Map
2wpvA 1 0.7279 5.4 0.945 Contact Map
2lt3A 1 0.5809 4.9 0.946 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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