GREMLIN Database
UBIC - Chorismate pyruvate-lyase
UniProt: P26602 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11369
Length: 165 (151)
Sequences: 749 (520)
Seq/√Len: 42.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
53_E75_W3.3481.00
62_P92_R3.3281.00
48_V81_L3.2881.00
131_E142_R3.1901.00
127_R143_S3.1801.00
114_P117_R2.9481.00
35_M89_L2.7731.00
40_E117_R2.7121.00
46_V89_L2.4411.00
55_F97_V2.4041.00
47_S85_G2.2941.00
43_G83_A2.2841.00
58_Q74_Y2.1851.00
83_A88_W2.0470.99
140_G157_L1.9660.99
49_T82_C1.9440.99
22_D25_L1.9280.99
130_I140_G1.9220.99
62_P66_P1.9100.99
82_C87_P1.8900.99
31_L38_R1.8520.98
59_N93_T1.8110.98
47_S82_C1.8050.98
93_T128_D1.7850.98
116_G120_F1.7540.98
92_R155_T1.7250.98
146_R151_P1.7240.98
145_L157_L1.6710.97
99_T147_L1.6510.97
43_G84_D1.6350.97
45_T84_D1.6180.96
100_L107_L1.5790.96
87_P159_L1.5320.95
135_D140_G1.5090.95
99_T151_P1.4310.93
147_L151_P1.3760.91
101_S150_K1.3750.91
86_E161_A1.3530.91
89_L93_T1.3500.91
34_S116_G1.3470.90
88_W104_E1.3400.90
48_V79_I1.3090.89
37_K40_E1.3000.89
25_L139_W1.3000.89
58_Q66_P1.2940.89
127_R130_I1.2670.88
46_V154_L1.2590.87
46_V81_L1.2400.86
115_L154_L1.2360.86
56_V76_L1.2230.86
104_E132_I1.2210.86
46_V79_I1.1880.84
130_I143_S1.1830.84
118_Y130_I1.1780.83
51_I90_A1.1670.83
102_G150_K1.1610.83
118_Y125_L1.1490.82
92_R125_L1.1190.80
28_W93_T1.1140.80
111_G116_G1.1140.80
75_W119_L1.1110.80
127_R145_L1.1100.80
18_I21_L1.0990.79
50_M53_E1.0840.78
51_I80_L1.0680.77
35_M158_F1.0650.77
59_N62_P1.0520.76
40_E46_V1.0340.74
89_L145_L1.0330.74
135_D154_L1.0310.74
127_R140_G1.0290.74
69_P94_V1.0210.74
90_A138_L1.0070.73
104_E125_L1.0070.73
125_L147_L1.0050.72
14_Y79_I0.9940.72
45_T136_A0.9910.71
122_S147_L0.9840.71
132_I139_W0.9830.71
31_L145_L0.9780.70
42_Q84_D0.9570.69
140_G143_S0.9530.68
35_M130_I0.9440.68
124_T150_K0.9390.67
29_L162_S0.9380.67
28_W110_L0.9220.66
75_W107_L0.9210.66
128_D145_L0.9170.65
45_T57_E0.9170.65
83_A131_E0.9160.65
93_T99_T0.9120.65
62_P94_V0.8930.63
36_T119_L0.8920.63
81_L111_G0.8820.62
43_G88_W0.8770.62
17_E20_A0.8720.61
122_S145_L0.8660.61
30_L130_I0.8620.60
38_R138_L0.8620.60
21_L26_L0.8540.60
102_G106_A0.8510.59
13_R20_A0.8370.58
65_L131_E0.8370.58
16_K131_E0.8230.57
92_R121_T0.8220.57
37_K54_G0.8200.57
115_L142_R0.8100.56
50_M112_K0.8070.55
31_L90_A0.8040.55
128_D144_R0.8040.55
91_G155_T0.8000.55
42_Q162_S0.7980.55
136_A152_L0.7790.53
89_L154_L0.7570.51
64_E148_S0.7560.51
100_L116_G0.7520.50
36_T78_E0.7520.50
83_A92_R0.7510.50
99_T130_I0.7490.50
113_T117_R0.7480.50
34_S120_F0.7430.49
92_R133_G0.7400.49
71_E102_G0.7390.49
62_P113_T0.7370.49
83_A120_F0.7370.49
95_V147_L0.7320.48
91_G156_E0.7290.48
117_R121_T0.7190.47
37_K69_P0.7170.47
126_T149_G0.7110.46
33_D38_R0.7080.46
19_P85_G0.7080.46
158_F162_S0.7060.46
130_I154_L0.7010.45
81_L88_W0.7000.45
110_L118_Y0.6990.45
101_S125_L0.6920.45
48_V111_G0.6900.44
33_D154_L0.6900.44
130_I145_L0.6900.44
34_S48_V0.6860.44
75_W115_L0.6760.43
33_D47_S0.6740.43
104_E150_K0.6740.43
35_M156_E0.6700.43
70_K126_T0.6680.42
128_D146_R0.6640.42
66_P145_L0.6630.42
69_P72_S0.6590.41
125_L155_T0.6570.41
115_L133_G0.6570.41
14_Y140_G0.6560.41
142_R153_L0.6560.41
60_E149_G0.6540.41
85_G98_S0.6530.41
81_L116_G0.6520.41
89_L117_R0.6490.41
37_K101_S0.6460.40
35_M118_Y0.6400.40
138_L145_L0.6380.40
64_E70_K0.6350.39
90_A122_S0.6350.39
49_T85_G0.6350.39
140_G153_L0.6290.39
57_E62_P0.6280.39
78_E104_E0.6260.39
16_K98_S0.6250.38
119_L125_L0.6240.38
88_W100_L0.6220.38
27_D37_K0.6210.38
37_K80_L0.6170.38
15_C19_P0.6170.38
54_G102_G0.6150.38
22_D85_G0.6130.37
34_S81_L0.6110.37
30_L52_R0.6090.37
76_L92_R0.6090.37
70_K85_G0.6040.37
63_E74_Y0.6030.36
83_A162_S0.6010.36
141_R156_E0.5990.36
13_R112_K0.5960.36
79_I154_L0.5950.36
98_S161_A0.5910.35
35_M93_T0.5890.35
115_L140_G0.5850.35
93_T133_G0.5840.35
121_T133_G0.5810.35
92_R115_L0.5800.34
104_E147_L0.5780.34
76_L91_G0.5750.34
44_K160_P0.5740.34
56_V62_P0.5720.34
44_K73_R0.5720.34
118_Y143_S0.5710.34
16_K85_G0.5670.33
38_R68_L0.5670.33
18_I101_S0.5650.33
96_P99_T0.5630.33
111_G128_D0.5570.33
88_W99_T0.5560.32
57_E67_L0.5560.32
46_V116_G0.5560.32
75_W78_E0.5530.32
22_D101_S0.5500.32
64_E68_L0.5430.31
45_T87_P0.5410.31
61_I64_E0.5410.31
39_F79_I0.5380.31
22_D51_I0.5370.31
103_P150_K0.5330.31
91_G113_T0.5300.30
77_R141_R0.5230.30
50_M113_T0.5210.30
74_Y147_L0.5200.30
17_E149_G0.5200.30
14_Y31_L0.5170.29
44_K149_G0.5150.29
90_A157_L0.5140.29
65_L88_W0.5130.29
74_Y94_V0.5100.29
24_Q72_S0.5090.29
90_A155_T0.5090.29
35_M155_T0.5080.29
149_G152_L0.5060.28
38_R139_W0.5000.28
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1tt8A 1 0.9939 100 0.198 Contact Map
2nwiA 2 0.8667 100 0.323 Contact Map
3hfiA 2 0.7091 96.2 0.877 Contact Map
2ikkA 2 0.7515 95.9 0.879 Contact Map
2pkhA 5 0.7212 95.7 0.881 Contact Map
2fa1A 2 0.8182 95.3 0.884 Contact Map
3cnvA 4 0.8061 95.3 0.884 Contact Map
2p19A 2 0.7515 95 0.886 Contact Map
3ddvA 3 0.7394 93.9 0.892 Contact Map
2ooiA 2 0.8121 93.3 0.895 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0065 seconds.