GREMLIN Database
APPB - Cytochrome bd-II ubiquinol oxidase subunit 2
UniProt: P26458 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11379
Length: 378 (324)
Sequences: 3272 (1998)
Seq/√Len: 111.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
166_T169_P3.5281.00
34_C181_I3.4091.00
128_L177_L3.1651.00
86_F145_V3.0021.00
359_Y362_W2.9751.00
274_C296_L2.8071.00
343_V347_L2.8071.00
132_V177_L2.6841.00
267_F307_I2.6301.00
333_Q337_S2.6211.00
181_I207_A2.6181.00
132_V173_G2.6121.00
168_F222_L2.5921.00
202_L206_R2.5871.00
45_E199_R2.5671.00
34_C177_L2.5491.00
24_I295_S2.5481.00
205_K283_Y2.4451.00
47_R51_N2.2971.00
107_R120_D2.2491.00
13_L17_V2.2131.00
32_I49_V2.2091.00
178_G214_C2.1881.00
193_V366_T2.1691.00
92_L133_V2.1671.00
286_R289_W2.1381.00
17_V21_V2.1151.00
186_V204_T2.0881.00
204_T282_I2.0801.00
352_L355_L2.0601.00
131_P176_S2.0371.00
19_L71_L2.0161.00
136_I173_G2.0051.00
8_R330_T1.9941.00
174_L178_G1.9931.00
48_I365_M1.9781.00
341_V345_I1.9671.00
124_V128_L1.9241.00
355_L359_Y1.9071.00
139_G172_C1.9071.00
99_F122_G1.8901.00
216_L272_F1.8681.00
178_G210_L1.8661.00
74_A339_M1.8591.00
160_S163_Q1.8571.00
148_A158_L1.8381.00
118_M121_A1.8201.00
170_L174_L1.8061.00
312_F325_T1.8051.00
143_L166_T1.7911.00
49_V188_L1.7911.00
131_P180_V1.7911.00
10_I340_L1.7671.00
43_D116_R1.7651.00
58_E105_D1.7591.00
126_G130_P1.7591.00
281_A293_M1.7421.00
185_G204_T1.7131.00
121_A125_I1.6891.00
197_H287_P1.6801.00
215_F301_V1.6421.00
215_F304_T1.6171.00
273_F277_L1.5941.00
183_Q295_S1.5881.00
50_I104_F1.5331.00
133_V165_L1.5161.00
93_V134_F1.5141.00
35_L185_G1.5131.00
34_C128_L1.5111.00
275_P297_M1.5101.00
174_L214_C1.4901.00
122_G126_G1.4751.00
201_Q205_K1.4751.00
346_F349_I1.4641.00
85_G145_V1.4491.00
274_C300_G1.4481.00
274_C293_M1.4481.00
32_I188_L1.4271.00
15_I70_A1.4221.00
175_L214_C1.4221.00
270_L300_G1.4211.00
337_S341_V1.4201.00
96_S129_V1.4041.00
28_F358_Y1.4021.00
96_S126_G1.4001.00
142_L309_L1.3841.00
48_I196_I1.3741.00
195_V198_L1.3621.00
81_A314_M1.3501.00
46_R120_D1.3431.00
90_M137_A1.3421.00
179_M298_Q1.3421.00
20_V299_F1.3411.00
189_Q197_H1.3271.00
30_M131_P1.3271.00
277_L293_M1.3110.99
32_I53_V1.3100.99
340_L344_L1.3080.99
86_F89_A1.3040.99
45_E367_T1.3000.99
190_L288_G1.2960.99
77_R155_V1.2960.99
117_K121_A1.2870.99
213_L217_L1.2810.99
208_A279_V1.2800.99
44_D367_T1.2790.99
171_L221_W1.2770.99
8_R336_L1.2660.99
208_A278_T1.2600.99
28_F56_H1.2560.99
140_N169_P1.2550.99
220_Y224_V1.2510.99
133_V136_I1.2500.99
223_W255_M1.2420.99
132_V136_I1.2410.99
221_W225_G1.2400.99
104_F119_W1.2400.99
37_P124_V1.2390.99
33_G127_S1.2350.99
209_L213_L1.2320.99
278_T293_M1.2280.99
11_W74_A1.2270.99
91_I95_C1.2170.99
149_F155_V1.2100.99
179_M301_V1.2030.99
18_I21_V1.2020.99
9_F327_W1.1930.99
118_M122_G1.1900.99
114_R118_M1.1890.99
139_G218_A1.1770.99
258_F262_P1.1760.99
21_V351_L1.1750.99
42_N45_E1.1740.99
264_L307_I1.1620.99
86_F140_N1.1480.99
34_C124_V1.1460.99
28_F291_F1.1330.98
48_I51_N1.1260.98
332_S335_T1.1240.98
71_L78_V1.1190.98
78_V82_A1.1140.98
268_P304_T1.1120.98
182_L208_A1.1080.98
212_M275_P1.1070.98
334_L338_I1.1060.98
186_V290_G1.1020.98
333_Q336_L1.0990.98
316_S323_S1.0810.98
176_S180_V1.0770.98
78_V313_V1.0760.98
334_L337_S1.0700.98
267_F300_G1.0660.98
20_V302_I1.0560.98
201_Q285_G1.0500.98
203_A206_R1.0480.97
164_L167_P1.0420.97
68_G83_F1.0410.97
183_Q294_A1.0370.97
89_A136_I1.0340.97
18_I66_L1.0320.97
262_P266_I1.0290.97
81_A147_F1.0290.97
312_F316_S1.0230.97
56_H187_W1.0130.97
189_Q201_Q1.0130.97
264_L267_F1.0130.97
125_I129_V1.0100.97
86_F314_M1.0070.97
42_N367_T1.0000.97
39_V200_S0.9980.97
110_I115_W0.9980.97
312_F323_S0.9910.96
134_F180_V0.9910.96
256_N260_E0.9790.96
145_V314_M0.9760.96
44_D48_I0.9740.96
157_Y163_Q0.9660.96
36_L50_I0.9660.96
182_L186_V0.9650.96
110_I113_A0.9610.96
17_V69_G0.9570.96
48_I192_T0.9500.96
263_V307_I0.9430.95
345_I349_I0.9430.95
223_W265_W0.9410.95
17_V347_L0.9380.95
39_V49_V0.9370.95
186_V294_A0.9330.95
189_Q282_I0.9320.95
140_N164_L0.9320.95
203_A207_A0.9260.95
129_V133_V0.9250.95
68_G79_Y0.9220.95
212_M272_F0.9210.95
12_W16_G0.9210.95
178_G207_A0.9200.95
136_I170_L0.9200.95
305_A309_L0.9180.95
260_E264_L0.9170.95
48_I367_T0.9130.94
47_R108_G0.9130.94
141_L314_M0.9120.94
288_G291_F0.9120.94
108_G116_R0.9060.94
47_R50_I0.9000.94
59_G357_S0.9000.94
36_L124_V0.8990.94
82_A145_V0.8970.94
270_L274_C0.8970.94
281_A289_W0.8920.94
26_D30_M0.8900.94
195_V199_R0.8890.94
178_G211_V0.8890.94
288_G292_L0.8850.93
138_F305_A0.8800.93
182_L204_T0.8780.93
112_D118_M0.8780.93
277_L281_A0.8750.93
132_V170_L0.8700.93
216_L220_Y0.8700.93
122_G125_I0.8690.93
83_F90_M0.8640.93
276_L280_M0.8640.93
128_L132_V0.8600.92
187_W362_W0.8600.92
34_C127_S0.8590.92
11_W339_M0.8570.92
98_F330_T0.8560.92
14_L69_G0.8520.92
197_H201_Q0.8510.92
114_R117_K0.8490.92
182_L278_T0.8470.92
23_M354_T0.8460.92
212_M216_L0.8450.92
198_L202_L0.8440.92
175_L215_F0.8370.91
331_S335_T0.8360.91
190_L291_F0.8350.91
219_G268_P0.8350.91
202_L205_K0.8320.91
84_S87_Y0.8300.91
101_P104_F0.8290.91
18_I69_G0.8240.91
171_L217_L0.8230.91
121_A124_V0.8230.91
93_V133_V0.8230.91
14_L17_V0.8160.90
89_A164_L0.8160.90
325_T328_D0.8150.90
33_G131_P0.8060.90
267_F270_L0.8020.90
51_N54_G0.7970.89
272_F276_L0.7940.89
96_S130_P0.7870.89
26_D191_K0.7860.89
210_L213_L0.7810.88
292_L296_L0.7770.88
131_P134_F0.7760.88
85_G89_A0.7740.88
356_W360_K0.7720.88
23_M134_F0.7710.88
72_F79_Y0.7710.88
212_M279_V0.7710.88
128_L131_P0.7670.87
28_F191_K0.7670.87
267_F271_G0.7670.87
324_L328_D0.7650.87
219_G304_T0.7650.87
185_G203_A0.7650.87
115_W118_M0.7640.87
147_F314_M0.7630.87
35_L188_L0.7610.87
146_P163_Q0.7600.87
280_M284_R0.7570.87
267_F304_T0.7560.87
297_M301_V0.7530.86
299_F303_F0.7490.86
182_L294_A0.7480.86
113_A116_R0.7440.86
30_M101_P0.7440.86
69_G347_L0.7330.85
252_G256_N0.7320.85
198_L201_Q0.7310.85
49_V195_V0.7300.85
338_I342_I0.7270.84
15_I342_I0.7200.84
19_L67_A0.7170.84
324_L329_S0.7170.84
78_V81_A0.7140.83
323_S328_D0.7100.83
20_V24_I0.7070.83
16_G306_G0.7070.83
52_S187_W0.7070.83
209_L279_V0.7040.83
58_E353_Y0.7030.82
101_P304_T0.7000.82
119_W122_G0.6990.82
258_F261_S0.6990.82
51_N108_G0.6980.82
35_L181_I0.6970.82
192_T364_R0.6960.82
57_W79_Y0.6900.81
24_I299_F0.6810.80
14_L347_L0.6810.80
198_L285_G0.6810.80
45_E49_V0.6800.80
278_T294_A0.6780.80
30_M97_L0.6760.80
259_V265_W0.6740.80
92_L129_V0.6730.80
126_G131_P0.6720.80
197_H364_R0.6710.79
188_L200_S0.6700.79
113_A117_K0.6680.79
12_W326_L0.6680.79
40_A49_V0.6670.79
23_M180_V0.6640.79
14_L343_V0.6570.78
276_L279_V0.6560.78
15_I78_V0.6560.78
68_G339_M0.6540.78
287_P290_G0.6520.77
77_R329_S0.6520.77
70_A73_A0.6450.77
29_D32_I0.6440.77
56_H357_S0.6430.76
125_I366_T0.6430.76
20_V295_S0.6430.76
116_R120_D0.6420.76
182_L207_A0.6420.76
103_A122_G0.6400.76
132_V174_L0.6400.76
278_T297_M0.6390.76
185_G189_Q0.6390.76
352_L357_S0.6390.76
347_L351_L0.6350.76
296_L300_G0.6350.76
186_V278_T0.6340.75
41_R199_R0.6340.75
189_Q285_G0.6330.75
8_R333_Q0.6320.75
354_T357_S0.6310.75
188_L192_T0.6300.75
192_T291_F0.6280.75
88_V92_L0.6200.74
92_L95_C0.6190.74
207_A210_L0.6190.74
313_V326_L0.6190.74
213_L273_F0.6180.74
300_G307_I0.6180.74
38_L203_A0.6180.74
269_L273_F0.6180.74
42_N195_V0.6160.73
53_V104_F0.6160.73
340_L343_V0.6130.73
264_L268_P0.6130.73
52_S366_T0.6130.73
206_R209_L0.6120.73
22_F30_M0.6120.73
179_M297_M0.6120.73
49_V110_I0.6120.73
98_F103_A0.6110.73
15_I203_A0.6100.73
50_I108_G0.6100.73
40_A45_E0.6060.72
17_V343_V0.6050.72
23_M302_I0.6050.72
12_W80_A0.6050.72
271_G275_P0.6010.72
186_V282_I0.6000.71
135_G173_G0.5990.71
174_L199_R0.5980.71
49_V196_I0.5980.71
58_E61_Q0.5950.71
109_K354_T0.5950.71
41_R45_E0.5940.71
93_V179_M0.5920.70
281_A286_R0.5910.70
9_F310_F0.5900.70
66_L342_I0.5890.70
147_F316_S0.5890.70
355_L362_W0.5890.70
138_F218_A0.5860.70
303_F307_I0.5860.70
146_P159_G0.5850.70
165_L169_P0.5820.69
147_F155_V0.5810.69
67_A71_L0.5800.69
211_V301_V0.5800.69
199_R202_L0.5790.69
22_F361_M0.5790.69
90_M298_Q0.5780.69
196_I200_S0.5770.68
201_Q287_P0.5770.68
167_P221_W0.5760.68
142_L305_A0.5760.68
341_V344_L0.5750.68
206_R210_L0.5740.68
310_F336_L0.5740.68
66_L70_A0.5730.68
205_K208_A0.5730.68
340_L364_R0.5720.68
123_L127_S0.5700.68
34_C96_S0.5680.67
140_N167_P0.5670.67
43_D108_G0.5670.67
43_D120_D0.5660.67
51_N109_K0.5660.67
68_G165_L0.5650.67
57_W100_R0.5640.67
18_I70_A0.5630.67
81_A155_V0.5620.66
20_V303_F0.5610.66
9_F326_L0.5600.66
275_P279_V0.5600.66
83_F87_Y0.5570.66
13_L344_L0.5560.66
181_I203_A0.5550.66
18_I339_M0.5540.65
33_G100_R0.5510.65
52_S64_L0.5510.65
101_P106_Y0.5500.65
170_L323_S0.5500.65
186_V281_A0.5500.65
42_N213_L0.5490.65
293_M296_L0.5490.65
261_S264_L0.5480.65
27_G60_N0.5470.64
17_V65_I0.5460.64
264_L300_G0.5460.64
68_G90_M0.5450.64
8_R327_W0.5450.64
287_P364_R0.5440.64
212_M264_L0.5440.64
45_E48_I0.5430.64
113_A263_V0.5430.64
181_I185_G0.5420.64
140_N166_T0.5360.63
14_L18_I0.5340.63
43_D46_R0.5340.63
193_V368_E0.5330.62
49_V52_S0.5320.62
270_L280_M0.5310.62
55_A343_V0.5300.62
278_T281_A0.5270.62
55_A97_L0.5270.62
148_A156_E0.5260.61
277_L280_M0.5260.61
68_G353_Y0.5250.61
22_F71_L0.5240.61
46_R107_R0.5240.61
347_L352_L0.5240.61
202_L285_G0.5230.61
182_L211_V0.5230.61
267_F303_F0.5220.61
26_D187_W0.5220.61
83_F339_M0.5220.61
16_G302_I0.5210.61
37_P117_K0.5190.60
312_F315_P0.5180.60
136_I162_W0.5180.60
164_L169_P0.5150.60
279_V293_M0.5150.60
45_E195_V0.5140.60
205_K209_L0.5130.60
192_T197_H0.5110.59
49_V170_L0.5110.59
37_P121_A0.5100.59
139_G363_G0.5100.59
281_A285_G0.5100.59
88_V191_K0.5090.59
330_T336_L0.5090.59
46_R116_R0.5080.59
274_C277_L0.5080.59
263_V266_I0.5080.59
73_A172_C0.5080.59
44_D273_F0.5060.58
131_P141_L0.5050.58
72_F356_W0.5050.58
54_G74_A0.5050.58
60_N63_W0.5040.58
269_L283_Y0.5020.58
44_D365_M0.5020.58
112_D115_W0.5020.58
54_G59_G0.5010.58
217_L221_W0.5000.58
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2mfrA 1 0.1508 37.4 0.969 Contact Map
2m20A 2 0.1217 13.3 0.975 Contact Map
3wdoA 1 0.8148 10.1 0.976 Contact Map
2kncA 1 0.1376 8.5 0.977 Contact Map
3rkoN 1 0.2778 8.2 0.977 Contact Map
2l8sA 1 0.1217 8.1 0.977 Contact Map
3hb3B 1 0.1852 7.3 0.978 Contact Map
2m3eA 1 0.127 6.8 0.978 Contact Map
3rkoM 1 0.2698 6.3 0.978 Contact Map
2mgyA 1 0.4365 5.6 0.979 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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