GREMLIN Database
HPPK - 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
UniProt: P26281 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11374
Length: 159 (148)
Sequences: 4529 (3462)
Seq/√Len: 284.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
39_S131_E3.7151.00
118_D121_N2.9361.00
38_S57_A2.8071.00
81_Q95_L2.4511.00
72_N111_R2.4101.00
6_I97_L2.4081.00
142_E150_T2.3431.00
68_E109_T2.2691.00
25_A80_Q2.2331.00
3_V60_A2.2151.00
74_T97_L2.1091.00
44_P53_D2.0951.00
29_I73_H2.0031.00
100_M119_M1.9971.00
42_R53_D1.9801.00
23_L59_V1.9741.00
41_Y131_E1.9101.00
15_P42_R1.9041.00
68_E111_R1.8881.00
46_L118_D1.8221.00
10_S15_P1.7911.00
3_V62_E1.7481.00
75_Q85_R1.7481.00
5_Y60_A1.7451.00
107_I114_V1.7281.00
108_N113_T1.7271.00
66_A69_E1.6231.00
10_S18_Q1.6141.00
23_L37_V1.5781.00
123_G127_W1.5771.00
14_S17_E1.5711.00
8_I19_V1.5601.00
29_I32_S1.5051.00
15_P18_Q1.5041.00
40_F55_L1.4931.00
48_P88_E1.4871.00
101_L136_L1.4861.00
4_A61_L1.4601.00
36_T60_A1.4481.00
76_R80_Q1.3911.00
25_A81_Q1.3791.00
73_H76_R1.3761.00
143_M146_Q1.3731.00
40_F57_A1.3541.00
17_E21_A1.3431.00
51_Q92_P1.3371.00
48_P54_Y1.3301.00
47_G90_W1.3251.00
120_K147_I1.2961.00
35_L60_A1.2901.00
16_L20_N1.2731.00
20_N40_F1.2501.00
35_L62_E1.2311.00
21_A81_Q1.2041.00
18_Q81_Q1.1991.00
63_T102_F1.1711.00
5_Y133_A1.1601.00
7_A100_M1.1561.00
101_L104_N1.1551.00
33_H62_E1.1271.00
36_T132_I1.1261.00
6_I74_T1.1071.00
4_A70_L1.0781.00
12_L52_P1.0731.00
101_L119_M1.0701.00
85_R94_T1.0511.00
127_W148_L1.0431.00
15_P55_L1.0401.00
27_G34_I1.0311.00
21_A25_A1.0231.00
32_S61_L1.0201.00
6_I61_L1.0131.00
7_A57_A1.0021.00
99_I114_V1.0011.00
130_F148_L1.0011.00
26_L59_V0.9991.00
88_E91_G0.9971.00
34_I61_L0.9951.00
4_A102_F0.9881.00
5_Y101_L0.9781.00
48_P90_W0.9761.00
130_F144_L0.9611.00
51_Q91_G0.9561.00
7_A125_M0.9561.00
89_R118_D0.9561.00
19_V40_F0.9551.00
81_Q94_T0.9491.00
5_Y129_L0.9371.00
37_V59_V0.9351.00
145_R149_H0.9241.00
8_I57_A0.9241.00
133_A136_L0.9151.00
41_Y127_W0.9121.00
32_S73_H0.9061.00
5_Y136_L0.9061.00
142_E146_Q0.9061.00
4_A63_T0.9021.00
8_I59_V0.9001.00
101_L144_L0.8991.00
119_M125_M0.8951.00
25_A28_D0.8831.00
148_L151_R0.8721.00
21_A24_K0.8571.00
120_K138_F0.8501.00
19_V57_A0.8411.00
13_A18_Q0.8341.00
130_F145_R0.8311.00
101_L114_V0.8251.00
125_M128_P0.8241.00
25_A77_I0.8221.00
15_P52_P0.8130.99
37_V57_A0.8090.99
71_L75_Q0.8090.99
68_E107_I0.8070.99
105_E114_V0.8020.99
106_V139_P0.8020.99
126_L148_L0.7930.99
60_A133_A0.7920.99
19_V55_L0.7880.99
135_E145_R0.7860.99
16_L55_L0.7830.99
68_E72_N0.7830.99
88_E92_P0.7790.99
67_P105_E0.7750.99
65_L73_H0.7750.99
86_K91_G0.7720.99
75_Q79_L0.7700.99
60_A132_I0.7620.99
10_S19_V0.7600.99
31_E64_S0.7600.99
146_Q149_H0.7580.99
26_L74_T0.7580.99
70_L102_F0.7550.99
29_I76_R0.7500.99
58_A129_L0.7430.99
50_D92_P0.7420.99
49_Q54_Y0.7280.99
136_L144_L0.7270.99
129_L144_L0.7270.99
16_L40_F0.7120.99
45_P53_D0.7120.99
50_D54_Y0.7090.99
20_N24_K0.7090.99
15_P53_D0.7040.99
18_Q94_T0.6950.98
52_P92_P0.6910.98
5_Y100_M0.6890.98
24_K28_D0.6870.98
137_V143_M0.6860.98
138_F147_I0.6840.98
29_I65_L0.6830.98
71_L112_L0.6800.98
63_T70_L0.6780.98
84_V88_E0.6670.98
58_A100_M0.6630.98
138_F144_L0.6620.98
32_S70_L0.6610.98
79_L85_R0.6440.97
41_Y128_P0.6430.97
65_L69_E0.6430.97
90_W118_D0.6400.97
48_P51_Q0.6260.97
8_I22_A0.6240.97
58_A125_M0.6220.97
25_A29_I0.6210.97
5_Y58_A0.6160.97
22_A77_I0.6150.97
23_L34_I0.6130.97
61_L70_L0.6120.96
142_E147_I0.6090.96
42_R55_L0.6080.96
127_W131_E0.6060.96
82_G94_T0.6040.96
113_T117_Y0.6040.96
45_P51_Q0.6020.96
77_I81_Q0.5990.96
20_N37_V0.5930.96
116_H122_R0.5920.96
100_M125_M0.5920.96
137_V141_G0.5910.96
44_P123_G0.5870.96
43_T127_W0.5810.95
3_V35_L0.5800.95
47_G51_Q0.5780.95
107_I112_L0.5740.95
46_L90_W0.5740.95
75_Q111_R0.5700.95
123_G148_L0.5700.95
46_L123_G0.5700.95
6_I99_I0.5700.95
26_L61_L0.5700.95
69_E72_N0.5690.95
46_L121_N0.5680.95
74_T99_I0.5640.95
73_H77_I0.5620.94
19_V23_L0.5560.94
138_F141_G0.5560.94
119_M126_L0.5560.94
146_Q150_T0.5530.94
134_P145_R0.5510.94
29_I80_Q0.5510.94
126_L147_I0.5510.94
26_L29_I0.5500.94
47_G54_Y0.5490.94
123_G151_R0.5460.94
26_L32_S0.5440.93
76_R79_L0.5310.93
77_I97_L0.5290.92
135_E143_M0.5260.92
34_I37_V0.5220.92
22_A95_L0.5210.92
34_I59_V0.5200.92
138_F142_E0.5170.92
86_K90_W0.5150.91
101_L129_L0.5140.91
126_L144_L0.5130.91
119_M129_L0.5060.91
137_V142_E0.5030.90
102_F114_V0.5030.90
111_R114_V0.5010.90
106_V138_F0.5010.90
101_L139_P0.5000.90
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2qx0A 2 1 100 0.037 Contact Map
1cbkA 2 0.9937 100 0.037 Contact Map
3ip0A 2 0.9937 100 0.052 Contact Map
4cwbA 1 0.9811 100 0.061 Contact Map
2cg8A 4 0.8428 100 0.073 Contact Map
2bmbA 1 0.9371 100 0.085 Contact Map
4pzvA 1 0.9811 100 0.129 Contact Map
3r4vA 1 0.6541 31.6 0.941 Contact Map
2rffA 1 0.6667 23.8 0.944 Contact Map
4lhsA 2 0.7421 21.3 0.945 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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