FEPE - ECOLI - GREMLIN Contacts

Home
GREMLIN
- Submit - Monomer
- Submit - Complex
Contacts
Metagenomics
- Contacts
- Structures
Structures
- List
Old Projects
- Complexes (2014)
- PFAM (2013)

FEPE - Ferric enterobactin transport protein FepE

UniProt:	P26266	Sequences: MSSLNIKQGSDAHFPDYPLASPSNNEIDLLNLISVLWRAKKTVMAVVFAFACAGLLISFILPQKWTSAAVVTPPEPVQWQELEKSFTKLRVLDLDIKIDRTEAFNLFIKKFQSVSLLEEYLRSSPYVMDQLKEAKIDELDLHRAIVALSEKMKAVDDNASKKKDEPSLYTSWTLSFTAPTSEEAQTVLSGYIDYISTLVVKESLENVRNKLEIKTQFEKEKLAQDRIKTKNQLDANIQRLNYSLDIANAAGIKKPVYSNGQAVKDDPDFSISLGADGIERKLEIEKAVTDVAELNGELRNRQYLVEQLTKAHVNDVNFTPFKYQLSPSLPVKKDGPGKAIIVILSALIGGMVACGGVLLRYAMASRKQDAMMADHLV	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG10297
Length:	377 (327)
Sequences:	5364 (4502)
Seq/√Len:	249.0

ECOLI - FEPE WZZE WZZB ETK WZC

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
178_A	184_A	3.980	1.00
54_G	345_S	3.636	1.00
37_W	40_K	3.538	1.00
122_R	148_L	3.433	1.00
185_Q	329_L	3.302	1.00
66_T	334_D	3.231	1.00
189_S	327_P	3.142	1.00
66_T	177_T	2.954	1.00
255_P	258_S	2.942	1.00
69_A	192_I	2.824	1.00
57_I	61_L	2.612	1.00
58_S	341_I	2.487	1.00
28_D	31_N	2.451	1.00
123_S	190_G	2.435	1.00
185_Q	189_S	2.394	1.00
214_K	217_F	2.215	1.00
178_A	183_E	2.205	1.00
107_F	195_I	2.163	1.00
67_S	184_A	2.152	1.00
182_E	186_T	2.139	1.00
225_D	301_R	2.123	1.00
204_L	207_V	2.089	1.00
39_A	360_R	2.089	1.00
290_D	293_E	2.061	1.00
176_F	187_V	2.044	1.00
176_F	188_L	2.039	1.00
50_F	345_S	1.947	1.00
231_N	234_D	1.945	1.00
364_A	368_Q	1.942	1.00
197_T	201_K	1.907	1.00
299_R	302_Q	1.895	1.00
190_G	194_Y	1.889	1.00
118_E	122_R	1.862	1.00
251_G	254_K	1.858	1.00
123_S	194_Y	1.849	1.00
174_L	188_L	1.839	1.00
46_V	50_F	1.819	1.00
125_P	128_M	1.813	1.00
337_G	340_I	1.786	1.00
353_A	357_V	1.774	1.00
222_L	298_L	1.755	1.00
227_I	231_N	1.745	1.00
66_T	175_S	1.739	1.00
64_K	177_T	1.738	1.00
345_S	349_G	1.715	1.00
297_E	301_R	1.701	1.00
269_F	273_L	1.694	1.00
226_R	296_G	1.694	1.00
177_T	335_G	1.693	1.00
219_K	223_A	1.691	1.00
158_N	176_F	1.687	1.00
274_G	277_G	1.677	1.00
309_T	312_H	1.661	1.00
67_S	330_P	1.647	1.00
55_L	342_V	1.639	1.00
58_S	342_V	1.637	1.00
190_G	193_D	1.628	1.00
47_V	350_G	1.596	1.00
51_A	346_A	1.568	1.00
299_R	303_Y	1.552	1.00
261_Q	265_D	1.551	1.00
203_S	207_V	1.529	1.00
302_Q	306_E	1.516	1.00
193_D	197_T	1.511	1.00
301_R	305_V	1.496	1.00
68_A	173_T	1.492	1.00
205_E	209_N	1.490	1.00
349_G	353_A	1.486	1.00
55_L	59_F	1.483	1.00
117_L	155_V	1.478	1.00
119_E	194_Y	1.465	1.00
265_D	268_D	1.460	1.00
243_S	248_N	1.452	1.00
54_G	58_S	1.447	1.00
50_F	349_G	1.430	1.00
220_E	224_Q	1.427	1.00
58_S	345_S	1.419	1.00
264_K	268_D	1.418	1.00
268_D	272_S	1.415	1.00
224_Q	228_K	1.414	1.00
62_P	179_P	1.408	1.00
242_Y	245_D	1.408	1.00
69_A	188_L	1.405	1.00
42_T	46_V	1.393	1.00
251_G	255_P	1.367	1.00
245_D	248_N	1.366	1.00
212_E	216_Q	1.361	1.00
216_Q	219_K	1.355	1.00
114_V	325_L	1.350	1.00
203_S	206_N	1.346	1.00
194_Y	197_T	1.332	1.00
286_K	289_T	1.324	1.00
228_K	297_E	1.319	1.00
115_S	326_S	1.318	1.00
117_L	191_Y	1.314	1.00
301_R	304_L	1.301	1.00
303_Y	306_E	1.294	1.00
272_S	276_D	1.293	1.00
177_T	334_D	1.293	1.00
193_D	326_S	1.288	1.00
119_E	122_R	1.283	1.00
115_S	325_L	1.280	1.00
67_S	185_Q	1.274	1.00
43_V	47_V	1.270	1.00
47_V	51_A	1.270	1.00
118_E	148_L	1.262	1.00
186_T	190_G	1.260	1.00
58_S	61_L	1.246	1.00
40_K	44_M	1.243	1.00
221_K	301_R	1.234	1.00
217_F	221_K	1.232	1.00
206_N	209_N	1.227	1.00
244_L	248_N	1.222	1.00
50_F	54_G	1.213	1.00
202_E	207_V	1.206	1.00
121_L	151_K	1.201	1.00
70_V	325_L	1.194	1.00
63_Q	338_K	1.192	1.00
117_L	187_V	1.189	1.00
301_R	308_L	1.188	1.00
109_K	171_S	1.186	1.00
225_D	228_K	1.177	1.00
222_L	226_R	1.172	1.00
109_K	112_Q	1.166	1.00
39_A	357_V	1.158	1.00
35_V	361_Y	1.154	1.00
118_E	152_M	1.145	1.00
218_E	308_L	1.137	1.00
276_D	279_E	1.137	1.00
291_V	295_N	1.131	1.00
49_A	56_L	1.130	1.00
180_T	183_E	1.124	1.00
189_S	193_D	1.124	1.00
43_V	357_V	1.124	1.00
223_A	227_I	1.120	1.00
123_S	193_D	1.117	1.00
164_D	173_T	1.113	1.00
270_S	273_L	1.110	1.00
246_I	249_A	1.106	1.00
185_Q	327_P	1.105	1.00
117_L	156_D	1.105	1.00
114_V	118_E	1.101	1.00
232_Q	235_A	1.098	1.00
216_Q	220_E	1.094	1.00
119_E	123_S	1.092	1.00
215_T	305_V	1.091	1.00
114_V	328_S	1.090	1.00
51_A	342_V	1.085	1.00
232_Q	236_N	1.083	1.00
229_T	298_L	1.076	1.00
53_A	57_I	1.071	1.00
26_E	29_L	1.069	1.00
64_K	335_G	1.067	1.00
121_L	126_Y	1.060	1.00
188_L	327_P	1.058	1.00
270_S	274_G	1.052	1.00
68_A	175_S	1.051	1.00
300_N	305_V	1.050	1.00
159_A	176_F	1.049	1.00
261_Q	268_D	1.048	1.00
154_A	158_N	1.040	1.00
221_K	297_E	1.039	1.00
162_K	173_T	1.035	1.00
192_I	323_Y	1.034	1.00
70_V	171_S	1.033	1.00
148_L	152_M	1.031	1.00
218_E	301_R	1.030	1.00
70_V	173_T	1.025	1.00
212_E	312_H	1.023	1.00
103_A	107_F	1.017	1.00
47_V	50_F	1.014	1.00
116_L	191_Y	1.012	1.00
159_A	191_Y	1.010	1.00
261_Q	264_K	1.009	1.00
108_I	161_K	1.007	1.00
119_E	198_L	1.002	1.00
106_L	170_T	1.002	1.00
120_Y	191_Y	1.002	1.00
57_I	341_I	1.000	1.00
188_L	192_I	0.998	1.00
58_S	338_K	0.997	1.00
183_E	187_V	0.989	1.00
114_V	152_M	0.988	1.00
43_V	354_C	0.985	1.00
225_D	229_T	0.980	1.00
46_V	356_G	0.970	1.00
121_L	152_M	0.968	1.00
121_L	155_V	0.968	1.00
291_V	294_L	0.959	1.00
46_V	353_A	0.957	1.00
105_N	163_K	0.956	1.00
64_K	179_P	0.953	1.00
155_V	176_F	0.951	1.00
292_A	295_N	0.949	1.00
27_I	32_L	0.948	1.00
120_Y	194_Y	0.947	1.00
171_S	324_Q	0.946	1.00
134_A	141_L	0.941	1.00
356_G	360_R	0.939	1.00
198_L	201_K	0.937	1.00
232_Q	238_Q	0.935	1.00
295_N	299_R	0.932	1.00
109_K	164_D	0.930	1.00
46_V	49_A	0.924	1.00
72_T	106_L	0.918	1.00
120_Y	190_G	0.914	1.00
338_K	342_V	0.912	1.00
253_K	256_V	0.909	1.00
42_T	45_A	0.907	1.00
71_V	192_I	0.904	1.00
63_Q	333_K	0.903	1.00
230_K	233_L	0.902	1.00
225_D	298_L	0.902	1.00
220_E	223_A	0.900	1.00
358_L	362_A	0.900	1.00
54_G	349_G	0.896	1.00
54_G	341_I	0.895	1.00
340_I	344_L	0.894	1.00
271_I	275_A	0.893	1.00
273_L	277_G	0.891	1.00
348_I	355_G	0.888	1.00
153_K	157_D	0.886	1.00
192_I	327_P	0.885	1.00
59_F	342_V	0.883	1.00
226_R	302_Q	0.877	1.00
50_F	352_V	0.870	0.99
51_A	58_S	0.869	0.99
35_V	358_L	0.868	0.99
47_V	346_A	0.867	0.99
153_K	156_D	0.865	0.99
203_S	208_R	0.860	0.99
265_D	269_F	0.860	0.99
260_G	264_K	0.859	0.99
117_L	152_M	0.856	0.99
108_I	112_Q	0.855	0.99
264_K	269_F	0.849	0.99
124_S	190_G	0.844	0.99
184_A	188_L	0.842	0.99
69_A	174_L	0.842	0.99
196_S	199_V	0.842	0.99
47_V	353_A	0.841	0.99
333_K	338_K	0.836	0.99
310_K	314_N	0.833	0.99
221_K	224_Q	0.824	0.99
71_V	111_F	0.821	0.99
38_R	361_Y	0.818	0.99
108_I	172_W	0.816	0.99
268_D	271_I	0.814	0.99
61_L	64_K	0.813	0.99
39_A	361_Y	0.811	0.99
82_L	86_F	0.810	0.99
254_K	258_S	0.809	0.99
262_A	265_D	0.808	0.99
67_S	327_P	0.806	0.99
213_I	217_F	0.806	0.99
256_V	268_D	0.805	0.99
278_I	281_K	0.802	0.99
245_D	249_A	0.801	0.99
259_N	264_K	0.800	0.99
120_Y	187_V	0.799	0.99
59_F	338_K	0.798	0.99
56_L	60_I	0.798	0.99
183_E	186_T	0.797	0.99
269_F	272_S	0.797	0.99
281_K	284_I	0.797	0.99
273_L	276_D	0.793	0.99
33_I	37_W	0.791	0.99
35_V	39_A	0.791	0.99
298_L	302_Q	0.788	0.99
232_Q	289_T	0.787	0.99
155_V	191_Y	0.787	0.99
30_L	34_S	0.786	0.99
182_E	329_L	0.786	0.99
282_L	286_K	0.785	0.99
111_F	195_I	0.784	0.99
181_S	184_A	0.783	0.99
111_F	191_Y	0.779	0.99
218_E	221_K	0.777	0.99
296_G	301_R	0.773	0.99
203_S	209_N	0.770	0.99
300_N	308_L	0.770	0.99
158_N	178_A	0.769	0.99
286_K	291_V	0.767	0.99
82_L	85_S	0.765	0.99
296_G	305_V	0.764	0.99
279_E	283_E	0.760	0.99
39_A	42_T	0.760	0.99
202_E	206_N	0.757	0.99
242_Y	247_A	0.756	0.99
108_I	163_K	0.754	0.99
126_Y	187_V	0.750	0.98
288_V	291_V	0.750	0.98
268_D	275_A	0.745	0.98
286_K	294_L	0.739	0.98
223_A	226_R	0.739	0.98
45_A	52_C	0.738	0.98
256_V	275_A	0.733	0.98
116_L	120_Y	0.729	0.98
218_E	222_L	0.725	0.98
355_G	359_L	0.723	0.98
52_C	56_L	0.722	0.98
67_S	329_L	0.721	0.98
114_V	149_S	0.721	0.98
36_L	354_C	0.721	0.98
261_Q	269_F	0.720	0.98
104_F	107_F	0.720	0.98
338_K	341_I	0.717	0.98
181_S	330_P	0.714	0.98
280_R	283_E	0.709	0.98
195_I	199_V	0.709	0.98
272_S	275_A	0.706	0.98
275_A	279_E	0.704	0.98
67_S	328_S	0.699	0.98
46_V	349_G	0.699	0.98
350_G	353_A	0.696	0.98
111_F	116_L	0.695	0.98
79_W	83_E	0.694	0.98
123_S	197_T	0.693	0.97
153_K	332_K	0.691	0.97
253_K	257_Y	0.689	0.97
129_D	132_K	0.689	0.97
222_L	305_V	0.688	0.97
37_W	41_K	0.687	0.97
332_K	339_A	0.687	0.97
256_V	271_I	0.686	0.97
158_N	177_T	0.686	0.97
42_T	360_R	0.685	0.97
163_K	167_S	0.685	0.97
119_E	201_K	0.682	0.97
121_L	124_S	0.682	0.97
124_S	187_V	0.681	0.97
264_K	273_L	0.680	0.97
211_L	308_L	0.678	0.97
107_F	110_K	0.676	0.97
174_L	192_I	0.676	0.97
152_M	156_D	0.676	0.97
53_A	56_L	0.674	0.97
195_I	321_F	0.674	0.97
64_K	334_D	0.673	0.97
346_A	350_G	0.672	0.97
81_E	84_K	0.672	0.97
277_G	281_K	0.671	0.97
192_I	196_S	0.670	0.97
287_A	290_D	0.669	0.97
242_Y	246_I	0.667	0.97
43_V	50_F	0.667	0.97
160_S	177_T	0.665	0.97
160_S	175_S	0.663	0.97
359_L	363_M	0.662	0.97
250_A	254_K	0.662	0.97
38_R	41_K	0.662	0.97
278_I	282_L	0.662	0.97
110_K	195_I	0.661	0.97
298_L	301_R	0.658	0.97
335_G	338_K	0.657	0.97
300_N	303_Y	0.657	0.97
39_A	364_A	0.656	0.97
159_A	188_L	0.655	0.96
147_A	150_E	0.654	0.96
112_Q	161_K	0.654	0.96
308_L	313_V	0.654	0.96
243_S	247_A	0.654	0.96
51_A	350_G	0.652	0.96
51_A	55_L	0.650	0.96
47_V	349_G	0.648	0.96
72_T	107_F	0.645	0.96
49_A	53_A	0.645	0.96
83_E	86_F	0.644	0.96
121_L	125_P	0.640	0.96
224_Q	227_I	0.638	0.96
248_N	251_G	0.637	0.96
228_K	231_N	0.635	0.96
41_K	45_A	0.634	0.96
189_S	326_S	0.632	0.96
266_D	269_F	0.624	0.95
119_E	197_T	0.623	0.95
186_T	189_S	0.620	0.95
354_C	358_L	0.619	0.95
271_I	289_T	0.619	0.95
264_K	267_P	0.616	0.95
244_L	247_A	0.614	0.95
261_Q	267_P	0.613	0.95
43_V	353_A	0.613	0.95
116_L	194_Y	0.609	0.95
344_L	348_I	0.608	0.95
108_I	195_I	0.608	0.95
222_L	296_G	0.606	0.95
259_N	263_V	0.605	0.95
61_L	341_I	0.603	0.94
107_F	199_V	0.601	0.94
262_A	266_D	0.600	0.94
110_K	198_L	0.600	0.94
110_K	113_S	0.599	0.94
105_N	109_K	0.599	0.94
264_K	271_I	0.598	0.94
276_D	280_R	0.596	0.94
61_L	336_P	0.594	0.94
143_R	146_V	0.592	0.94
261_Q	273_L	0.591	0.94
146_V	151_K	0.591	0.94
341_I	345_S	0.590	0.94
290_D	294_L	0.590	0.94
199_V	320_P	0.585	0.94
161_K	172_W	0.583	0.93
111_F	325_L	0.583	0.93
254_K	257_Y	0.582	0.93
253_K	258_S	0.581	0.93
71_V	174_L	0.581	0.93
303_Y	307_Q	0.580	0.93
341_I	344_L	0.578	0.93
285_E	288_V	0.575	0.93
70_V	109_K	0.574	0.93
280_R	284_I	0.573	0.93
113_S	116_L	0.571	0.93
35_V	357_V	0.570	0.93
189_S	329_L	0.567	0.92
45_A	49_A	0.567	0.92
124_S	186_T	0.567	0.92
27_I	31_N	0.566	0.92
150_E	154_A	0.564	0.92
155_V	187_V	0.564	0.92
296_G	308_L	0.563	0.92
260_G	263_V	0.563	0.92
342_V	346_A	0.562	0.92
278_I	286_K	0.562	0.92
73_P	106_L	0.562	0.92
57_I	60_I	0.561	0.92
182_E	185_Q	0.560	0.92
61_L	335_G	0.560	0.92
285_E	289_T	0.560	0.92
252_I	255_P	0.557	0.92
211_L	310_K	0.556	0.92
302_Q	305_V	0.555	0.92
199_V	321_F	0.551	0.91
289_T	292_A	0.551	0.91
310_K	313_V	0.551	0.91
127_V	148_L	0.550	0.91
252_I	257_Y	0.550	0.91
30_L	37_W	0.550	0.91
32_L	35_V	0.548	0.91
250_A	253_K	0.547	0.91
263_V	266_D	0.546	0.91
149_S	153_K	0.546	0.91
213_I	216_Q	0.546	0.91
346_A	351_M	0.545	0.91
200_V	318_F	0.543	0.91
210_K	309_T	0.543	0.91
339_A	343_I	0.543	0.91
110_K	324_Q	0.539	0.90
116_L	119_E	0.537	0.90
80_Q	83_E	0.537	0.90
335_G	341_I	0.536	0.90
298_L	304_L	0.535	0.90
210_K	214_K	0.534	0.90
350_G	354_C	0.533	0.90
267_P	270_S	0.532	0.90
261_Q	266_D	0.532	0.90
205_E	208_R	0.531	0.90
117_L	120_Y	0.531	0.90
59_F	134_A	0.531	0.90
116_L	198_L	0.530	0.90
274_G	278_I	0.528	0.90
248_N	254_K	0.528	0.90
114_V	156_D	0.526	0.89
289_T	294_L	0.526	0.89
115_S	118_E	0.520	0.89
252_I	256_V	0.519	0.89
162_K	175_S	0.518	0.89
64_K	158_N	0.516	0.88
193_D	196_S	0.516	0.88
330_P	333_K	0.515	0.88
176_F	184_A	0.514	0.88
151_K	154_A	0.513	0.88
57_I	335_G	0.513	0.88
343_I	346_A	0.512	0.88
259_N	262_A	0.511	0.88
39_A	353_A	0.511	0.88
39_A	356_G	0.510	0.88
109_K	169_Y	0.509	0.88
74_P	170_T	0.509	0.88
296_G	302_Q	0.507	0.88
56_L	59_F	0.507	0.88
42_T	357_V	0.506	0.88
269_F	276_D	0.505	0.87
31_N	35_V	0.504	0.87
121_L	148_L	0.502	0.87
111_F	161_K	0.502	0.87
256_V	272_S	0.501	0.87
361_Y	368_Q	0.501	0.87
297_E	308_L	0.500	0.87

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4wl1A	3	0.5862	100	0.406	Contact Map
3b8mA	3	0.6605	99.6	0.74	Contact Map
4e29A	3	0.618	99.4	0.771	Contact Map
3b8oA	3	0.5836	99.4	0.776	Contact Map
4jkvA	2	0.4271	48.2	0.944	Contact Map
2kluA	1	0.1141	40.7	0.947	Contact Map
1fxkC	2	0.2812	26.9	0.951	Contact Map
1rh5B	1	0.1485	24.5	0.952	Contact Map
4w252	1	0.1645	23.8	0.953	Contact Map
2m20A	2	0.1061	22.4	0.953	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0104 seconds.