GREMLIN Database
FEPE - Ferric enterobactin transport protein FepE
UniProt: P26266 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10297
Length: 377 (327)
Sequences: 5364 (4502)
Seq/√Len: 249.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
178_A184_A3.9801.00
54_G345_S3.6361.00
37_W40_K3.5381.00
122_R148_L3.4331.00
185_Q329_L3.3021.00
66_T334_D3.2311.00
189_S327_P3.1421.00
66_T177_T2.9541.00
255_P258_S2.9421.00
69_A192_I2.8241.00
57_I61_L2.6121.00
58_S341_I2.4871.00
28_D31_N2.4511.00
123_S190_G2.4351.00
185_Q189_S2.3941.00
214_K217_F2.2151.00
178_A183_E2.2051.00
107_F195_I2.1631.00
67_S184_A2.1521.00
182_E186_T2.1391.00
225_D301_R2.1231.00
204_L207_V2.0891.00
39_A360_R2.0891.00
290_D293_E2.0611.00
176_F187_V2.0441.00
176_F188_L2.0391.00
50_F345_S1.9471.00
231_N234_D1.9451.00
364_A368_Q1.9421.00
197_T201_K1.9071.00
299_R302_Q1.8951.00
190_G194_Y1.8891.00
118_E122_R1.8621.00
251_G254_K1.8581.00
123_S194_Y1.8491.00
174_L188_L1.8391.00
46_V50_F1.8191.00
125_P128_M1.8131.00
337_G340_I1.7861.00
353_A357_V1.7741.00
222_L298_L1.7551.00
227_I231_N1.7451.00
66_T175_S1.7391.00
64_K177_T1.7381.00
345_S349_G1.7151.00
297_E301_R1.7011.00
269_F273_L1.6941.00
226_R296_G1.6941.00
177_T335_G1.6931.00
219_K223_A1.6911.00
158_N176_F1.6871.00
274_G277_G1.6771.00
309_T312_H1.6611.00
67_S330_P1.6471.00
55_L342_V1.6391.00
58_S342_V1.6371.00
190_G193_D1.6281.00
47_V350_G1.5961.00
51_A346_A1.5681.00
299_R303_Y1.5521.00
261_Q265_D1.5511.00
203_S207_V1.5291.00
302_Q306_E1.5161.00
193_D197_T1.5111.00
301_R305_V1.4961.00
68_A173_T1.4921.00
205_E209_N1.4901.00
349_G353_A1.4861.00
55_L59_F1.4831.00
117_L155_V1.4781.00
119_E194_Y1.4651.00
265_D268_D1.4601.00
243_S248_N1.4521.00
54_G58_S1.4471.00
50_F349_G1.4301.00
220_E224_Q1.4271.00
58_S345_S1.4191.00
264_K268_D1.4181.00
268_D272_S1.4151.00
224_Q228_K1.4141.00
62_P179_P1.4081.00
242_Y245_D1.4081.00
69_A188_L1.4051.00
42_T46_V1.3931.00
251_G255_P1.3671.00
245_D248_N1.3661.00
212_E216_Q1.3611.00
216_Q219_K1.3551.00
114_V325_L1.3501.00
203_S206_N1.3461.00
194_Y197_T1.3321.00
286_K289_T1.3241.00
228_K297_E1.3191.00
115_S326_S1.3181.00
117_L191_Y1.3141.00
301_R304_L1.3011.00
303_Y306_E1.2941.00
272_S276_D1.2931.00
177_T334_D1.2931.00
193_D326_S1.2881.00
119_E122_R1.2831.00
115_S325_L1.2801.00
67_S185_Q1.2741.00
43_V47_V1.2701.00
47_V51_A1.2701.00
118_E148_L1.2621.00
186_T190_G1.2601.00
58_S61_L1.2461.00
40_K44_M1.2431.00
221_K301_R1.2341.00
217_F221_K1.2321.00
206_N209_N1.2271.00
244_L248_N1.2221.00
50_F54_G1.2131.00
202_E207_V1.2061.00
121_L151_K1.2011.00
70_V325_L1.1941.00
63_Q338_K1.1921.00
117_L187_V1.1891.00
301_R308_L1.1881.00
109_K171_S1.1861.00
225_D228_K1.1771.00
222_L226_R1.1721.00
109_K112_Q1.1661.00
39_A357_V1.1581.00
35_V361_Y1.1541.00
118_E152_M1.1451.00
218_E308_L1.1371.00
276_D279_E1.1371.00
291_V295_N1.1311.00
49_A56_L1.1301.00
180_T183_E1.1241.00
189_S193_D1.1241.00
43_V357_V1.1241.00
223_A227_I1.1201.00
123_S193_D1.1171.00
164_D173_T1.1131.00
270_S273_L1.1101.00
246_I249_A1.1061.00
185_Q327_P1.1051.00
117_L156_D1.1051.00
114_V118_E1.1011.00
232_Q235_A1.0981.00
216_Q220_E1.0941.00
119_E123_S1.0921.00
215_T305_V1.0911.00
114_V328_S1.0901.00
51_A342_V1.0851.00
232_Q236_N1.0831.00
229_T298_L1.0761.00
53_A57_I1.0711.00
26_E29_L1.0691.00
64_K335_G1.0671.00
121_L126_Y1.0601.00
188_L327_P1.0581.00
270_S274_G1.0521.00
68_A175_S1.0511.00
300_N305_V1.0501.00
159_A176_F1.0491.00
261_Q268_D1.0481.00
154_A158_N1.0401.00
221_K297_E1.0391.00
162_K173_T1.0351.00
192_I323_Y1.0341.00
70_V171_S1.0331.00
148_L152_M1.0311.00
218_E301_R1.0301.00
70_V173_T1.0251.00
212_E312_H1.0231.00
103_A107_F1.0171.00
47_V50_F1.0141.00
116_L191_Y1.0121.00
159_A191_Y1.0101.00
261_Q264_K1.0091.00
108_I161_K1.0071.00
119_E198_L1.0021.00
106_L170_T1.0021.00
120_Y191_Y1.0021.00
57_I341_I1.0001.00
188_L192_I0.9981.00
58_S338_K0.9971.00
183_E187_V0.9891.00
114_V152_M0.9881.00
43_V354_C0.9851.00
225_D229_T0.9801.00
46_V356_G0.9701.00
121_L152_M0.9681.00
121_L155_V0.9681.00
291_V294_L0.9591.00
46_V353_A0.9571.00
105_N163_K0.9561.00
64_K179_P0.9531.00
155_V176_F0.9511.00
292_A295_N0.9491.00
27_I32_L0.9481.00
120_Y194_Y0.9471.00
171_S324_Q0.9461.00
134_A141_L0.9411.00
356_G360_R0.9391.00
198_L201_K0.9371.00
232_Q238_Q0.9351.00
295_N299_R0.9321.00
109_K164_D0.9301.00
46_V49_A0.9241.00
72_T106_L0.9181.00
120_Y190_G0.9141.00
338_K342_V0.9121.00
253_K256_V0.9091.00
42_T45_A0.9071.00
71_V192_I0.9041.00
63_Q333_K0.9031.00
230_K233_L0.9021.00
225_D298_L0.9021.00
220_E223_A0.9001.00
358_L362_A0.9001.00
54_G349_G0.8961.00
54_G341_I0.8951.00
340_I344_L0.8941.00
271_I275_A0.8931.00
273_L277_G0.8911.00
348_I355_G0.8881.00
153_K157_D0.8861.00
192_I327_P0.8851.00
59_F342_V0.8831.00
226_R302_Q0.8771.00
50_F352_V0.8700.99
51_A58_S0.8690.99
35_V358_L0.8680.99
47_V346_A0.8670.99
153_K156_D0.8650.99
203_S208_R0.8600.99
265_D269_F0.8600.99
260_G264_K0.8590.99
117_L152_M0.8560.99
108_I112_Q0.8550.99
264_K269_F0.8490.99
124_S190_G0.8440.99
184_A188_L0.8420.99
69_A174_L0.8420.99
196_S199_V0.8420.99
47_V353_A0.8410.99
333_K338_K0.8360.99
310_K314_N0.8330.99
221_K224_Q0.8240.99
71_V111_F0.8210.99
38_R361_Y0.8180.99
108_I172_W0.8160.99
268_D271_I0.8140.99
61_L64_K0.8130.99
39_A361_Y0.8110.99
82_L86_F0.8100.99
254_K258_S0.8090.99
262_A265_D0.8080.99
67_S327_P0.8060.99
213_I217_F0.8060.99
256_V268_D0.8050.99
278_I281_K0.8020.99
245_D249_A0.8010.99
259_N264_K0.8000.99
120_Y187_V0.7990.99
59_F338_K0.7980.99
56_L60_I0.7980.99
183_E186_T0.7970.99
269_F272_S0.7970.99
281_K284_I0.7970.99
273_L276_D0.7930.99
33_I37_W0.7910.99
35_V39_A0.7910.99
298_L302_Q0.7880.99
232_Q289_T0.7870.99
155_V191_Y0.7870.99
30_L34_S0.7860.99
182_E329_L0.7860.99
282_L286_K0.7850.99
111_F195_I0.7840.99
181_S184_A0.7830.99
111_F191_Y0.7790.99
218_E221_K0.7770.99
296_G301_R0.7730.99
203_S209_N0.7700.99
300_N308_L0.7700.99
158_N178_A0.7690.99
286_K291_V0.7670.99
82_L85_S0.7650.99
296_G305_V0.7640.99
279_E283_E0.7600.99
39_A42_T0.7600.99
202_E206_N0.7570.99
242_Y247_A0.7560.99
108_I163_K0.7540.99
126_Y187_V0.7500.98
288_V291_V0.7500.98
268_D275_A0.7450.98
286_K294_L0.7390.98
223_A226_R0.7390.98
45_A52_C0.7380.98
256_V275_A0.7330.98
116_L120_Y0.7290.98
218_E222_L0.7250.98
355_G359_L0.7230.98
52_C56_L0.7220.98
67_S329_L0.7210.98
114_V149_S0.7210.98
36_L354_C0.7210.98
261_Q269_F0.7200.98
104_F107_F0.7200.98
338_K341_I0.7170.98
181_S330_P0.7140.98
280_R283_E0.7090.98
195_I199_V0.7090.98
272_S275_A0.7060.98
275_A279_E0.7040.98
67_S328_S0.6990.98
46_V349_G0.6990.98
350_G353_A0.6960.98
111_F116_L0.6950.98
79_W83_E0.6940.98
123_S197_T0.6930.97
153_K332_K0.6910.97
253_K257_Y0.6890.97
129_D132_K0.6890.97
222_L305_V0.6880.97
37_W41_K0.6870.97
332_K339_A0.6870.97
256_V271_I0.6860.97
158_N177_T0.6860.97
42_T360_R0.6850.97
163_K167_S0.6850.97
119_E201_K0.6820.97
121_L124_S0.6820.97
124_S187_V0.6810.97
264_K273_L0.6800.97
211_L308_L0.6780.97
107_F110_K0.6760.97
174_L192_I0.6760.97
152_M156_D0.6760.97
53_A56_L0.6740.97
195_I321_F0.6740.97
64_K334_D0.6730.97
346_A350_G0.6720.97
81_E84_K0.6720.97
277_G281_K0.6710.97
192_I196_S0.6700.97
287_A290_D0.6690.97
242_Y246_I0.6670.97
43_V50_F0.6670.97
160_S177_T0.6650.97
160_S175_S0.6630.97
359_L363_M0.6620.97
250_A254_K0.6620.97
38_R41_K0.6620.97
278_I282_L0.6620.97
110_K195_I0.6610.97
298_L301_R0.6580.97
335_G338_K0.6570.97
300_N303_Y0.6570.97
39_A364_A0.6560.97
159_A188_L0.6550.96
147_A150_E0.6540.96
112_Q161_K0.6540.96
308_L313_V0.6540.96
243_S247_A0.6540.96
51_A350_G0.6520.96
51_A55_L0.6500.96
47_V349_G0.6480.96
72_T107_F0.6450.96
49_A53_A0.6450.96
83_E86_F0.6440.96
121_L125_P0.6400.96
224_Q227_I0.6380.96
248_N251_G0.6370.96
228_K231_N0.6350.96
41_K45_A0.6340.96
189_S326_S0.6320.96
266_D269_F0.6240.95
119_E197_T0.6230.95
186_T189_S0.6200.95
354_C358_L0.6190.95
271_I289_T0.6190.95
264_K267_P0.6160.95
244_L247_A0.6140.95
261_Q267_P0.6130.95
43_V353_A0.6130.95
116_L194_Y0.6090.95
344_L348_I0.6080.95
108_I195_I0.6080.95
222_L296_G0.6060.95
259_N263_V0.6050.95
61_L341_I0.6030.94
107_F199_V0.6010.94
262_A266_D0.6000.94
110_K198_L0.6000.94
110_K113_S0.5990.94
105_N109_K0.5990.94
264_K271_I0.5980.94
276_D280_R0.5960.94
61_L336_P0.5940.94
143_R146_V0.5920.94
261_Q273_L0.5910.94
146_V151_K0.5910.94
341_I345_S0.5900.94
290_D294_L0.5900.94
199_V320_P0.5850.94
161_K172_W0.5830.93
111_F325_L0.5830.93
254_K257_Y0.5820.93
253_K258_S0.5810.93
71_V174_L0.5810.93
303_Y307_Q0.5800.93
341_I344_L0.5780.93
285_E288_V0.5750.93
70_V109_K0.5740.93
280_R284_I0.5730.93
113_S116_L0.5710.93
35_V357_V0.5700.93
189_S329_L0.5670.92
45_A49_A0.5670.92
124_S186_T0.5670.92
27_I31_N0.5660.92
150_E154_A0.5640.92
155_V187_V0.5640.92
296_G308_L0.5630.92
260_G263_V0.5630.92
342_V346_A0.5620.92
278_I286_K0.5620.92
73_P106_L0.5620.92
57_I60_I0.5610.92
182_E185_Q0.5600.92
61_L335_G0.5600.92
285_E289_T0.5600.92
252_I255_P0.5570.92
211_L310_K0.5560.92
302_Q305_V0.5550.92
199_V321_F0.5510.91
289_T292_A0.5510.91
310_K313_V0.5510.91
127_V148_L0.5500.91
252_I257_Y0.5500.91
30_L37_W0.5500.91
32_L35_V0.5480.91
250_A253_K0.5470.91
263_V266_D0.5460.91
149_S153_K0.5460.91
213_I216_Q0.5460.91
346_A351_M0.5450.91
200_V318_F0.5430.91
210_K309_T0.5430.91
339_A343_I0.5430.91
110_K324_Q0.5390.90
116_L119_E0.5370.90
80_Q83_E0.5370.90
335_G341_I0.5360.90
298_L304_L0.5350.90
210_K214_K0.5340.90
350_G354_C0.5330.90
267_P270_S0.5320.90
261_Q266_D0.5320.90
205_E208_R0.5310.90
117_L120_Y0.5310.90
59_F134_A0.5310.90
116_L198_L0.5300.90
274_G278_I0.5280.90
248_N254_K0.5280.90
114_V156_D0.5260.89
289_T294_L0.5260.89
115_S118_E0.5200.89
252_I256_V0.5190.89
162_K175_S0.5180.89
64_K158_N0.5160.88
193_D196_S0.5160.88
330_P333_K0.5150.88
176_F184_A0.5140.88
151_K154_A0.5130.88
57_I335_G0.5130.88
343_I346_A0.5120.88
259_N262_A0.5110.88
39_A353_A0.5110.88
39_A356_G0.5100.88
109_K169_Y0.5090.88
74_P170_T0.5090.88
296_G302_Q0.5070.88
56_L59_F0.5070.88
42_T357_V0.5060.88
269_F276_D0.5050.87
31_N35_V0.5040.87
121_L148_L0.5020.87
111_F161_K0.5020.87
256_V272_S0.5010.87
361_Y368_Q0.5010.87
297_E308_L0.5000.87
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4wl1A 3 0.5862 100 0.406 Contact Map
3b8mA 3 0.6605 99.6 0.74 Contact Map
4e29A 3 0.618 99.4 0.771 Contact Map
3b8oA 3 0.5836 99.4 0.776 Contact Map
4jkvA 2 0.4271 48.2 0.944 Contact Map
2kluA 1 0.1141 40.7 0.947 Contact Map
1fxkC 2 0.2812 26.9 0.951 Contact Map
1rh5B 1 0.1485 24.5 0.952 Contact Map
4w252 1 0.1645 23.8 0.953 Contact Map
2m20A 2 0.1061 22.4 0.953 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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