GREMLIN Database
BGLH - Cryptic outer membrane porin BglH
UniProt: P26218 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11364
Length: 538 (410)
Sequences: 196 (122)
Seq/√Len: 6.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
133_S504_Y4.0990.94
498_R535_E3.9130.93
450_W456_T3.9110.93
165_Q183_M3.8700.93
183_M211_D3.7580.91
454_N486_H3.6070.89
310_L347_L3.4400.87
153_R244_D3.2310.83
456_T484_L3.1280.81
456_T486_H3.0780.80
161_W239_E2.8780.75
305_W349_Q2.7580.72
286_N501_I2.7500.71
253_A258_L2.7140.70
152_G443_V2.6680.69
161_W241_Q2.6670.69
134_G153_R2.6580.69
459_E502_R2.5670.66
276_D299_Y2.5570.66
134_G244_D2.5370.65
132_R244_D2.4150.61
132_R153_R2.3880.60
211_D233_H2.3500.59
505_A528_F2.3100.57
259_E296_D2.2210.54
317_V345_T2.1690.52
244_D459_E2.1340.51
153_R459_E2.0970.50
132_R459_E2.0920.50
195_G210_S2.0920.50
450_W486_H2.0750.49
167_K179_D2.0700.49
348_T358_E2.0650.49
244_D481_K2.0510.48
161_W185_D2.0500.48
145_S158_Y2.0400.48
411_H512_E2.0350.48
130_Y155_G2.0340.47
153_R481_K1.9820.46
244_D502_R1.9380.44
297_L314_G1.9300.44
153_R502_R1.9060.43
414_V506_T1.9040.43
163_D234_G1.8930.43
256_V272_L1.8730.42
153_R157_E1.8670.42
500_E505_A1.8640.41
132_R502_R1.8630.41
198_G530_V1.8370.41
488_F501_I1.8270.40
240_I304_L1.7880.39
218_G226_A1.7770.39
508_I527_Q1.7720.38
157_E481_K1.7710.38
459_E481_K1.7650.38
455_Q489_K1.7620.38
229_W499_P1.7610.38
399_R533_Q1.7570.38
177_R217_K1.7260.37
211_D372_F1.7210.37
132_R157_E1.7190.37
220_L223_A1.7020.36
362_L533_Q1.6970.36
146_W516_D1.6790.35
267_K534_A1.6450.34
481_K502_R1.6430.34
360_S536_I1.6420.34
365_N394_G1.6330.34
218_G316_Y1.6230.33
462_Y501_I1.6090.33
248_Q313_S1.6010.33
445_R459_E1.5930.33
124_G403_Q1.5730.32
122_E491_N1.5590.31
126_S163_D1.5510.31
271_A313_S1.5460.31
173_E263_V1.5460.31
305_W308_A1.5450.31
298_R446_P1.5390.31
463_F479_G1.5310.31
517_G530_V1.5170.30
443_V508_I1.5110.30
231_G257_G1.5060.30
487_T500_E1.5010.30
345_T488_F1.4980.30
157_E244_D1.4950.30
163_D253_A1.4820.29
185_D241_Q1.4760.29
183_M194_T1.4680.29
174_N414_V1.4610.29
459_E533_Q1.4600.29
419_V493_S1.4570.28
239_E535_E1.4460.28
161_W367_S1.4440.28
134_G459_E1.4420.28
367_S412_F1.4370.28
438_E480_Y1.4330.28
337_W340_T1.4290.28
263_V268_I1.4280.28
283_S400_L1.4210.27
343_F532_A1.4120.27
445_R502_R1.4120.27
240_I502_R1.4070.27
323_A471_N1.3980.27
499_P537_W1.3770.26
424_N526_D1.3730.26
445_R535_E1.3670.26
268_I503_F1.3530.26
185_D246_K1.3320.25
261_W270_I1.3250.25
151_L443_V1.3220.25
157_E459_E1.2900.24
343_F474_K1.2870.24
231_G255_G1.2840.24
123_I198_G1.2820.24
286_N327_D1.2810.24
218_G398_V1.2740.23
107_Y110_M1.2710.23
416_N486_H1.2630.23
499_P531_G1.2540.23
185_D239_E1.2520.23
132_R481_K1.2510.23
374_R451_D1.2500.23
479_G508_I1.2500.23
184_M491_N1.2490.23
450_W484_L1.2470.23
531_G537_W1.2460.23
138_A322_S1.2400.23
138_A142_S1.2370.22
284_L332_N1.2360.22
136_G144_K1.2190.22
179_D213_Y1.2180.22
504_Y533_Q1.2120.22
134_G502_R1.2110.22
504_Y510_A1.2090.22
150_S506_T1.2090.22
304_L310_L1.2060.22
128_N484_L1.2040.22
215_T486_H1.2040.22
145_S214_V1.2030.22
134_G481_K1.2000.22
151_L504_Y1.1960.21
152_G439_S1.1940.21
438_E506_T1.1930.21
231_G531_G1.1830.21
239_E496_T1.1830.21
257_G531_G1.1830.21
369_A526_D1.1810.21
302_I357_N1.1800.21
130_Y157_E1.1780.21
229_W257_G1.1710.21
214_V426_I1.1690.21
109_S270_I1.1640.21
114_D117_K1.1620.21
498_R537_W1.1590.21
210_S233_H1.1580.21
372_F421_S1.1500.20
359_F402_S1.1420.20
126_S167_K1.1410.20
111_T115_F1.1400.20
265_P299_Y1.1400.20
218_G230_V1.1350.20
210_S241_Q1.1300.20
310_L357_N1.1250.20
146_W312_V1.1230.20
297_L410_D1.1190.20
133_S411_H1.1190.20
400_L506_T1.1160.20
401_T443_V1.1120.20
410_D440_I1.1100.19
236_P536_I1.1070.19
157_E502_R1.1000.19
176_K420_Y1.0960.19
173_E506_T1.0960.19
397_A421_S1.0950.19
477_E486_H1.0920.19
400_L532_A1.0910.19
196_W222_F1.0860.19
411_H460_L1.0800.19
161_W233_H1.0800.19
154_F235_A1.0760.19
146_W151_L1.0720.19
134_G157_E1.0670.19
443_V527_Q1.0670.19
499_P535_E1.0650.19
150_S377_G1.0600.18
286_N334_Y1.0600.18
243_L417_A1.0480.18
139_S394_G1.0410.18
460_L480_Y1.0370.18
179_D215_T1.0370.18
237_K271_A1.0340.18
310_L345_T1.0330.18
367_S467_N1.0320.18
249_R273_V1.0310.18
405_E449_I1.0300.18
270_I297_L1.0290.18
502_R533_Q1.0200.18
130_Y253_A1.0200.18
174_N352_D1.0110.17
350_K473_N1.0060.17
270_I398_V1.0050.17
174_N354_G1.0020.17
450_W454_N1.0010.17
266_G362_L0.9980.17
394_G462_Y0.9950.17
403_Q417_A0.9880.17
366_N370_S0.9850.17
483_T502_R0.9840.17
444_V496_T0.9830.17
166_L219_F0.9830.17
128_N167_K0.9820.17
174_N410_D0.9820.17
247_T491_N0.9740.17
153_R161_W0.9670.16
261_W289_Q0.9670.16
168_Q172_N0.9640.16
128_N494_M0.9610.16
203_G400_L0.9600.16
199_D269_D0.9600.16
216_T455_Q0.9580.16
229_W498_R0.9570.16
230_V314_G0.9560.16
131_Y453_Y0.9520.16
323_A400_L0.9500.16
137_T338_K0.9490.16
413_I456_T0.9480.16
366_N389_Y0.9470.16
297_L474_K0.9460.16
194_T361_F0.9430.16
243_L403_Q0.9410.16
181_V213_Y0.9400.16
243_L437_F0.9390.16
308_A479_G0.9390.16
241_Q498_R0.9370.16
491_N497_S0.9370.16
196_W262_K0.9340.16
531_G535_E0.9320.16
473_N506_T0.9300.16
172_N175_G0.9240.16
422_F436_D0.9210.16
116_S523_N0.9210.16
245_W399_R0.9210.16
457_G487_T0.9160.16
199_D345_T0.9130.15
145_S530_V0.9130.15
138_A398_V0.9120.15
439_S465_Q0.9120.15
162_F482_T0.9110.15
128_N193_S0.9090.15
462_Y478_S0.9080.15
163_D235_A0.9070.15
271_A311_M0.9030.15
127_Y416_N0.9030.15
184_M482_T0.9000.15
229_W255_G0.9000.15
354_G424_N0.8950.15
130_Y537_W0.8930.15
173_E307_K0.8920.15
188_V209_F0.8900.15
466_Q473_N0.8860.15
259_E298_R0.8850.15
159_S533_Q0.8840.15
408_I413_I0.8830.15
228_F488_F0.8830.15
229_W535_E0.8830.15
445_R533_Q0.8820.15
122_E128_N0.8800.15
405_E415_A0.8790.15
108_S111_T0.8780.15
130_Y231_G0.8770.15
130_Y257_G0.8770.15
152_G463_F0.8730.15
249_R252_A0.8730.15
125_F149_G0.8730.15
338_K341_W0.8700.15
193_S398_V0.8690.15
255_G531_G0.8680.15
339_D422_F0.8670.15
333_G506_T0.8670.15
154_F157_E0.8660.15
258_L427_Y0.8650.15
288_Q444_V0.8650.15
138_A472_S0.8650.15
453_Y468_K0.8640.15
253_A446_P0.8630.15
166_L518_F0.8600.14
124_G315_R0.8590.14
163_D183_M0.8580.14
235_A259_E0.8580.14
207_M518_F0.8580.14
377_G476_N0.8530.14
297_L488_F0.8520.14
241_Q535_E0.8520.14
411_H440_I0.8510.14
189_G289_Q0.8490.14
423_G437_F0.8480.14
250_T298_R0.8480.14
313_S342_M0.8480.14
370_S373_G0.8440.14
361_F516_D0.8440.14
240_I319_A0.8410.14
258_L440_I0.8390.14
227_D272_L0.8390.14
229_W531_G0.8380.14
312_V400_L0.8370.14
155_G537_W0.8350.14
502_R531_G0.8310.14
246_K494_M0.8310.14
388_Y477_E0.8300.14
209_F311_M0.8280.14
164_L448_Y0.8250.14
165_Q211_D0.8250.14
253_A353_K0.8200.14
377_G509_K0.8190.14
413_I449_I0.8180.14
127_Y502_R0.8180.14
474_K523_N0.8160.14
448_Y456_T0.8150.14
253_A323_A0.8110.14
362_L399_R0.8090.14
488_F497_S0.8080.14
314_G393_T0.8070.14
271_A448_Y0.8060.14
154_F459_E0.8020.14
230_V488_F0.8010.13
241_Q367_S0.7970.13
458_V482_T0.7960.13
501_I532_A0.7960.13
213_Y506_T0.7900.13
162_F461_G0.7860.13
415_A449_I0.7850.13
519_T530_V0.7840.13
160_G363_V0.7840.13
233_H340_T0.7790.13
146_W203_G0.7780.13
350_K506_T0.7750.13
264_G483_T0.7740.13
246_K405_E0.7740.13
253_A445_R0.7740.13
371_N525_D0.7720.13
483_T533_Q0.7700.13
253_A270_I0.7670.13
408_I440_I0.7650.13
133_S160_G0.7640.13
261_W533_Q0.7630.13
459_E483_T0.7600.13
152_G508_I0.7590.13
451_D454_N0.7570.13
363_V410_D0.7540.13
160_G504_Y0.7530.13
480_Y507_Y0.7530.13
318_T488_F0.7500.13
424_N435_S0.7490.13
412_F485_F0.7490.13
132_R445_R0.7480.13
174_N336_D0.7420.13
283_S501_I0.7400.13
395_G426_I0.7370.12
228_F372_F0.7340.12
225_E507_Y0.7340.12
188_V212_M0.7340.12
407_Y529_A0.7330.12
369_A390_G0.7320.12
130_Y163_D0.7320.12
354_G371_N0.7300.12
270_I336_D0.7260.12
174_N177_R0.7260.12
195_G367_S0.7250.12
466_Q511_L0.7250.12
272_L532_A0.7240.12
312_V343_F0.7240.12
129_G155_G0.7220.12
107_Y112_L0.7170.12
136_G296_D0.7160.12
247_T345_T0.7150.12
244_D362_L0.7110.12
390_G512_E0.7110.12
235_A249_R0.7100.12
148_I151_L0.7080.12
164_L312_V0.7050.12
165_Q283_S0.7050.12
239_E498_R0.7050.12
323_A478_S0.7030.12
504_Y528_F0.7020.12
353_K466_Q0.7020.12
298_R362_L0.7010.12
313_S344_G0.6990.12
210_S239_E0.6990.12
405_E494_M0.6990.12
168_Q468_K0.6980.12
355_G404_G0.6980.12
177_R272_L0.6970.12
142_S394_G0.6970.12
295_I471_N0.6950.12
369_A467_N0.6950.12
242_M458_V0.6950.12
418_I484_L0.6930.12
257_G499_P0.6900.12
231_G499_P0.6900.12
232_K507_Y0.6900.12
230_V388_Y0.6900.12
344_G443_V0.6880.12
325_E362_L0.6870.12
420_Y534_A0.6870.12
240_I417_A0.6860.12
244_D533_Q0.6860.12
163_D237_K0.6840.12
273_V452_Q0.6840.12
132_R231_G0.6820.12
132_R257_G0.6820.12
259_E446_P0.6800.12
173_E318_T0.6800.12
455_Q500_E0.6780.12
151_L463_F0.6740.12
408_I419_V0.6730.11
114_D118_F0.6730.11
153_R362_L0.6710.11
226_A338_K0.6670.11
140_H256_V0.6650.11
204_E397_A0.6650.11
307_K532_A0.6640.11
512_E532_A0.6640.11
189_G199_D0.6620.11
239_E445_R0.6610.11
293_N463_F0.6600.11
182_V243_L0.6590.11
505_A530_V0.6590.11
427_Y489_K0.6590.11
236_P401_T0.6580.11
411_H518_F0.6580.11
156_N226_A0.6580.11
151_L163_D0.6580.11
258_L336_D0.6580.11
199_D204_E0.6570.11
217_K490_V0.6560.11
312_V453_Y0.6550.11
267_K271_A0.6540.11
130_Y399_R0.6540.11
286_N512_E0.6490.11
523_N532_A0.6490.11
278_D281_D0.6480.11
399_R483_T0.6440.11
176_K423_G0.6430.11
152_G506_T0.6430.11
148_I443_V0.6420.11
502_R537_W0.6410.11
454_N487_T0.6410.11
326_K419_V0.6410.11
459_E531_G0.6400.11
138_A506_T0.6390.11
309_T410_D0.6380.11
139_S398_V0.6360.11
233_H239_E0.6350.11
342_M379_S0.6350.11
326_K444_V0.6340.11
363_V398_V0.6340.11
422_F438_E0.6340.11
140_H534_A0.6330.11
137_T492_T0.6320.11
204_E529_A0.6310.11
195_G368_I0.6290.11
338_K478_S0.6290.11
139_S523_N0.6280.11
474_K532_A0.6270.11
487_T516_D0.6250.11
150_S341_W0.6230.11
398_V448_Y0.6230.11
154_F530_V0.6230.11
304_L369_A0.6220.11
327_D523_N0.6210.11
270_I339_D0.6200.11
362_L502_R0.6190.11
377_G410_D0.6180.11
354_G361_F0.6170.11
335_Y411_H0.6170.11
337_W364_A0.6170.11
140_H268_I0.6160.11
116_S335_Y0.6150.11
263_V448_Y0.6130.11
302_I312_V0.6120.11
301_D309_T0.6120.11
157_E533_Q0.6110.11
313_S346_S0.6100.11
332_N452_Q0.6090.11
340_T486_H0.6080.11
253_A308_A0.6060.11
198_G203_G0.6050.11
274_R293_N0.6050.11
347_L506_T0.6050.11
160_G210_S0.6050.11
115_F376_A0.6050.11
139_S528_F0.6040.11
365_N484_L0.6020.11
154_F533_Q0.6020.11
324_S398_V0.6010.10
321_E350_K0.6010.10
175_G424_N0.6000.10
108_S398_V0.5990.10
395_G423_G0.5980.10
279_D287_K0.5960.10
109_S268_I0.5960.10
150_S511_L0.5950.10
315_R351_F0.5950.10
132_R533_Q0.5940.10
133_S507_Y0.5920.10
278_D283_S0.5920.10
115_F123_I0.5920.10
215_T538_W0.5900.10
274_R338_K0.5870.10
154_F159_S0.5870.10
246_K496_T0.5870.10
152_G168_Q0.5860.10
281_D473_N0.5860.10
220_L493_S0.5850.10
280_Y530_V0.5850.10
132_R362_L0.5850.10
253_A410_D0.5800.10
150_S367_S0.5800.10
414_V418_I0.5780.10
179_D182_V0.5770.10
247_T252_A0.5760.10
306_D422_F0.5760.10
235_A296_D0.5740.10
196_W500_E0.5730.10
249_R375_Y0.5730.10
247_T401_T0.5720.10
117_K411_H0.5720.10
503_F522_D0.5710.10
246_K415_A0.5700.10
364_A395_G0.5700.10
344_G401_T0.5700.10
413_I467_N0.5700.10
274_R320_N0.5680.10
163_D182_V0.5680.10
155_G355_G0.5670.10
258_L494_M0.5670.10
364_A465_Q0.5650.10
186_G207_M0.5630.10
240_I483_T0.5630.10
249_R367_S0.5630.10
414_V438_E0.5610.10
297_L398_V0.5610.10
180_A242_M0.5600.10
116_S494_M0.5600.10
351_F361_F0.5580.10
319_A339_D0.5570.10
160_G195_G0.5560.10
269_D357_N0.5560.10
292_T377_G0.5550.10
440_I534_A0.5540.10
127_Y159_S0.5540.10
204_E227_D0.5520.10
322_S345_T0.5500.10
155_G399_R0.5500.10
151_L407_Y0.5500.10
228_F267_K0.5450.10
400_L440_I0.5420.10
110_M379_S0.5420.10
298_R461_G0.5420.10
175_G404_G0.5410.10
128_N440_I0.5400.10
139_S462_Y0.5400.10
255_G347_L0.5390.10
213_Y313_S0.5380.10
232_K404_G0.5370.10
120_K485_F0.5360.10
293_N299_Y0.5360.10
242_M494_M0.5360.10
214_V530_V0.5340.10
122_E462_Y0.5340.10
299_Y493_S0.5340.10
463_F500_E0.5330.10
358_E374_R0.5330.10
296_D401_T0.5310.10
230_V466_Q0.5290.10
312_V393_T0.5290.10
131_Y492_T0.5290.10
219_F368_I0.5290.10
462_Y509_K0.5290.10
281_D361_F0.5290.10
187_N415_A0.5270.10
249_R488_F0.5260.10
135_W166_L0.5260.10
214_V222_F0.5260.10
453_Y538_W0.5260.10
157_E483_T0.5250.10
357_N402_S0.5250.10
285_Q473_N0.5240.10
252_A514_E0.5220.09
148_I152_G0.5200.09
439_S530_V0.5200.09
246_K449_I0.5200.09
193_S281_D0.5190.09
265_P268_I0.5180.09
238_I376_A0.5160.09
439_S457_G0.5160.09
130_Y531_G0.5160.09
480_Y517_G0.5160.09
115_F227_D0.5100.09
129_G166_L0.5100.09
128_N277_V0.5060.09
217_K410_D0.5050.09
325_E484_L0.5050.09
212_M230_V0.5040.09
108_S442_A0.5030.09
414_V444_V0.5020.09
308_A420_Y0.5020.09
370_S434_H0.5020.09
269_D416_N0.5020.09
299_Y305_W0.5010.09
236_P346_S0.5010.09
444_V460_L0.5000.09
449_I455_Q0.5000.09
270_I509_K0.5000.09
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1af6A 3 0.723 100 0.343 Contact Map
1a0sP 3 0.71 100 0.369 Contact Map
2o4vA 3 0.6468 92.2 0.965 Contact Map
2wjrA 1 0.3717 90.3 0.967 Contact Map
1fxkC 2 0.1301 82.2 0.971 Contact Map
3layA 5 0.1506 80.9 0.971 Contact Map
1zxaA 1 0.052 77.2 0.972 Contact Map
2zfgA 3 0.5985 77.2 0.972 Contact Map
2zdiC 2 0.145 74.2 0.973 Contact Map
4fqeA 1 0.316 74.2 0.973 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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