GREMLIN Database
YDBC - Putative oxidoreductase YdbC
UniProt: P25906 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11309
Length: 286 (252)
Sequences: 32491 (20716)
Seq/√Len: 1305.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
44_E262_R3.0721.00
109_H155_L2.8711.00
73_Y116_G2.7431.00
35_R70_E2.6981.00
230_L276_V2.5931.00
7_T12_S2.4681.00
273_S276_V2.4361.00
39_I74_P2.3691.00
108_V150_M2.3661.00
105_Q149_E2.3431.00
105_Q153_Q2.2891.00
44_E48_L2.2701.00
229_S279_T2.0891.00
39_I70_E2.0071.00
148_A152_Q1.9991.00
6_F15_R1.9911.00
224_S228_A1.9541.00
198_A202_D1.9281.00
119_V157_K1.9271.00
110_D114_N1.9251.00
229_S276_V1.9151.00
244_Q277_L1.9111.00
149_E153_Q1.9091.00
258_V262_R1.8521.00
274_E278_S1.8501.00
225_D279_T1.8141.00
199_L206_Y1.8101.00
101_P149_E1.7801.00
44_E258_V1.7741.00
17_G52_H1.7611.00
232_A270_L1.7381.00
48_L262_R1.7091.00
124_N180_C1.7031.00
245_R281_D1.6921.00
81_I117_L1.6751.00
5_T12_S1.6731.00
170_A174_K1.6671.00
149_E152_Q1.6321.00
45_A50_V1.6151.00
170_A198_A1.6081.00
48_L265_M1.6011.00
66_Q114_N1.5961.00
39_I71_A1.5941.00
240_A270_L1.5891.00
83_T120_L1.5831.00
101_P105_Q1.5811.00
83_T111_N1.5771.00
43_R74_P1.5671.00
85_I123_V1.5591.00
39_I43_R1.5481.00
222_T225_D1.5471.00
44_E47_A1.5421.00
205_A250_L1.5411.00
34_D37_V1.5411.00
11_K158_H1.5381.00
266_A269_K1.5361.00
105_Q109_H1.5291.00
108_V123_V1.5261.00
146_V149_E1.5201.00
233_T263_E1.5201.00
85_I104_L1.5151.00
82_V124_N1.4771.00
20_A53_I1.4721.00
278_S282_G1.4691.00
35_R39_I1.4291.00
43_R75_Y1.4161.00
46_L79_L1.4141.00
106_K110_D1.4091.00
57_D107_A1.4091.00
37_V40_T1.3761.00
197_D201_H1.3721.00
120_L156_V1.3671.00
194_A197_D1.3661.00
124_N207_V1.3521.00
232_A236_Q1.3441.00
109_H113_R1.3391.00
42_L71_A1.3361.00
200_A246_S1.3201.00
158_H179_V1.3171.00
173_R202_D1.3161.00
11_K80_T1.3021.00
262_R266_A1.3001.00
240_A244_Q1.2951.00
183_N206_Y1.2881.00
165_T168_Q1.2871.00
101_P145_T1.2821.00
255_T260_H1.2681.00
43_R47_A1.2631.00
76_S117_L1.2541.00
232_A237_V1.2491.00
105_Q146_V1.2481.00
279_T282_G1.2471.00
173_R198_A1.2451.00
156_V159_I1.2361.00
40_T44_E1.2331.00
141_E175_I1.2311.00
110_D113_R1.2251.00
150_M156_V1.2231.00
69_R116_G1.2221.00
101_P146_V1.2151.00
80_T122_V1.2121.00
255_T261_L1.2071.00
225_D229_S1.1891.00
222_T279_T1.1881.00
115_L120_L1.1771.00
53_I68_I1.1741.00
65_N111_N1.1681.00
166_P198_A1.1661.00
233_T236_Q1.1641.00
185_Y245_R1.1571.00
148_A151_Q1.1551.00
151_Q179_V1.1541.00
224_S234_P1.1291.00
188_A220_S1.1281.00
142_A145_T1.1221.00
122_V180_C1.1201.00
76_S119_V1.1181.00
70_E116_G1.1151.00
170_A201_H1.1121.00
103_E106_K1.1081.00
259_A262_R1.1071.00
196_I200_A1.1061.00
36_H40_T1.1011.00
66_Q70_E1.0961.00
102_A106_K1.0961.00
108_V120_L1.0751.00
226_V237_V1.0741.00
170_A202_D1.0741.00
35_R67_I1.0731.00
9_G179_V1.0721.00
52_H207_V1.0711.00
242_L251_L1.0611.00
100_S103_E1.0611.00
147_L159_I1.0601.00
52_H82_V1.0591.00
41_V261_L1.0481.00
187_I280_L1.0481.00
7_T10_T1.0461.00
109_H153_Q1.0401.00
40_T258_V1.0351.00
43_R71_A1.0341.00
171_E175_I1.0301.00
225_D228_A1.0201.00
125_L147_L1.0191.00
150_M155_L1.0181.00
221_S224_S1.0141.00
221_S225_D1.0131.00
223_L234_P1.0061.00
166_P170_A0.9991.00
51_N80_T0.9951.00
184_E189_H0.9951.00
20_A68_I0.9931.00
236_Q266_A0.9741.00
243_L267_A0.9711.00
161_L178_I0.9691.00
101_P142_A0.9631.00
193_D197_D0.9551.00
65_N114_N0.9541.00
14_N51_N0.9451.00
148_A176_A0.9451.00
180_C207_V0.9431.00
141_E171_E0.9371.00
121_D157_K0.9341.00
130_G168_Q0.9331.00
15_R243_L0.9291.00
187_I238_A0.9291.00
70_E74_P0.9271.00
261_L265_M0.9241.00
150_M153_Q0.9201.00
207_V250_L0.9171.00
200_A248_N0.9161.00
145_T149_E0.9121.00
197_D200_A0.9111.00
236_Q263_E0.9071.00
57_D89_R0.9041.00
66_Q113_R0.9001.00
72_L79_L0.8991.00
105_Q108_V0.8941.00
57_D103_E0.8921.00
14_N50_V0.8911.00
263_E266_A0.8871.00
146_V150_M0.8871.00
15_R268_E0.8751.00
82_V207_V0.8681.00
259_A263_E0.8661.00
40_T43_R0.8661.00
42_L53_I0.8661.00
257_S260_H0.8631.00
278_S281_D0.8621.00
106_K109_H0.8601.00
145_T148_A0.8591.00
226_V230_L0.8531.00
171_E174_K0.8461.00
198_A201_H0.8441.00
244_Q271_H0.8411.00
161_L169_V0.8401.00
275_E279_T0.8351.00
181_V199_L0.8331.00
20_A64_T0.8211.00
148_A159_I0.8191.00
82_V122_V0.8191.00
57_D114_N0.8191.00
275_E278_S0.8161.00
229_S273_S0.8141.00
230_L273_S0.8091.00
169_V204_I0.8071.00
105_Q150_M0.8051.00
239_L267_A0.7991.00
245_R277_L0.7981.00
159_I178_I0.7981.00
190_R281_D0.7971.00
211_P253_P0.7971.00
238_A242_L0.7851.00
18_Y45_A0.7781.00
112_L155_L0.7781.00
44_E261_L0.7731.00
185_Y196_I0.7731.00
151_Q158_H0.7721.00
240_A267_A0.7611.00
166_P195_M0.7481.00
244_Q274_E0.7471.00
163_N209_F0.7461.00
196_I206_Y0.7441.00
57_D110_D0.7431.00
112_L117_L0.7431.00
46_L75_Y0.7341.00
232_A269_K0.7341.00
83_T123_V0.7341.00
127_V163_N0.7311.00
6_F205_A0.7311.00
256_S260_H0.7291.00
173_R177_E0.7241.00
190_R193_D0.7231.00
208_P211_P0.7221.00
48_L266_A0.7211.00
55_T68_I0.7181.00
75_Y78_D0.7141.00
41_V258_V0.7121.00
208_P251_L0.7041.00
17_G253_P0.7031.00
38_A67_I0.7021.00
230_L237_V0.7001.00
104_L143_S0.7001.00
195_M199_L0.6981.00
46_L53_I0.6981.00
144_L176_A0.6971.00
144_L178_I0.6961.00
50_V265_M0.6961.00
108_V155_L0.6961.00
36_H39_I0.6951.00
18_Y23_L0.6921.00
144_L172_A0.6911.00
196_I245_R0.6881.00
5_T51_N0.6861.00
87_A90_G0.6861.00
232_A266_A0.6851.00
166_P194_A0.6841.00
199_L204_I0.6831.00
241_W281_D0.6801.00
144_L159_I0.6781.00
16_L243_L0.6761.00
77_D119_V0.6741.00
205_A249_I0.6721.00
161_L181_V0.6691.00
161_L164_V0.6671.00
192_D197_D0.6651.00
220_S224_S0.6651.00
143_S146_V0.6631.00
107_A110_D0.6631.00
11_K157_K0.6611.00
235_M263_E0.6581.00
111_N123_V0.6571.00
226_V276_V0.6531.00
42_L46_L0.6491.00
124_N160_G0.6481.00
13_V250_L0.6461.00
228_A231_G0.6441.00
58_F86_G0.6441.00
46_L51_N0.6441.00
222_T283_I0.6441.00
227_A237_V0.6421.00
104_L150_M0.6421.00
242_L249_I0.6421.00
51_N78_D0.6411.00
147_L151_Q0.6401.00
272_L277_L0.6401.00
223_L280_L0.6381.00
260_H263_E0.6341.00
21_M210_F0.6331.00
140_I143_S0.6301.00
141_E145_T0.6301.00
48_L261_L0.6301.00
140_I175_I0.6281.00
104_L146_V0.6241.00
173_R176_A0.6231.00
237_V272_L0.6201.00
211_P242_L0.6201.00
37_V258_V0.6171.00
120_L123_V0.6141.00
108_V112_L0.6121.00
276_V279_T0.6101.00
185_Y242_L0.6101.00
161_L172_A0.6051.00
5_T14_N0.6041.00
47_A258_V0.6001.00
23_L38_A0.5981.00
223_L238_A0.5981.00
232_A240_A0.5971.00
89_R103_E0.5951.00
237_V270_L0.5901.00
17_G250_L0.5861.00
170_A173_R0.5851.00
41_V255_T0.5841.00
112_L120_L0.5811.00
54_D182_Q0.5801.00
226_V279_T0.5781.00
151_Q156_V0.5781.00
185_Y206_Y0.5771.00
272_L276_V0.5741.00
227_A234_P0.5731.00
112_L119_V0.5711.00
100_S143_S0.5681.00
17_G252_I0.5671.00
168_Q171_E0.5661.00
236_Q270_L0.5641.00
105_Q155_L0.5641.00
223_L227_A0.5641.00
237_V276_V0.5621.00
227_A230_L0.5621.00
8_L205_A0.5581.00
215_F220_S0.5551.00
112_L118_D0.5551.00
245_R249_I0.5541.00
131_D134_G0.5531.00
123_V156_V0.5501.00
46_L78_D0.5491.00
185_Y249_I0.5491.00
123_V147_L0.5471.00
24_A64_T0.5471.00
13_V52_H0.5451.00
188_A215_F0.5451.00
45_A53_I0.5451.00
167_T170_A0.5441.00
55_T64_T0.5441.00
16_L268_E0.5441.00
185_Y190_R0.5431.00
255_T264_N0.5421.00
87_A127_V0.5421.00
72_L75_Y0.5361.00
46_L71_A0.5361.00
237_V280_L0.5331.00
23_L41_V0.5311.00
42_L68_I0.5301.00
57_D86_G0.5291.00
187_I241_W0.5291.00
85_I107_A0.5281.00
258_V261_L0.5271.00
173_R204_I0.5261.00
226_V283_I0.5221.00
140_I171_E0.5221.00
125_L143_S0.5191.00
208_P248_N0.5181.00
18_Y41_V0.5181.00
140_I168_Q0.5181.00
65_N83_T0.5171.00
70_E73_Y0.5151.00
108_V146_V0.5141.00
230_L270_L0.5131.00
226_V229_S0.5121.00
240_A271_H0.5121.00
52_H80_T0.5081.00
68_I71_A0.5081.00
243_L251_L0.5071.00
56_S59_Y0.5051.00
6_F13_V0.5041.00
124_N162_S0.5011.00
277_L281_D0.5001.00
90_G125_L0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3n2tA 1 0.9685 100 0.115 Contact Map
1pyfA 1 0.9615 100 0.116 Contact Map
3v0sA 1 0.9126 100 0.116 Contact Map
1pz1A 1 0.9615 100 0.12 Contact Map
3eauA 3 0.9545 100 0.128 Contact Map
4xk2A 5 0.9336 100 0.128 Contact Map
4r9oA 5 0.958 100 0.134 Contact Map
3lutA 3 0.951 100 0.14 Contact Map
3erpA 6 0.9545 100 0.142 Contact Map
1ynpA 1 0.9406 100 0.143 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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