GREMLIN Database
LOIP - Metalloprotease LoiP
UniProt: P25894 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11291
Length: 252 (226)
Sequences: 5624 (4051)
Seq/√Len: 269.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
215_E243_R3.8401.00
72_R121_D3.6741.00
77_A91_Y3.6531.00
119_M216_K3.4441.00
123_E216_K3.1441.00
133_G195_Y2.9101.00
95_M113_S2.8561.00
80_L132_M2.7951.00
111_V128_I2.7821.00
126_A210_L2.7171.00
190_A237_E2.6921.00
218_A236_A2.6831.00
227_S237_E2.6011.00
190_A241_H2.4331.00
129_G196_S2.3181.00
90_N108_C2.3101.00
194_D241_H2.2141.00
66_N69_Y2.1271.00
123_E212_T2.1241.00
111_V124_V1.9771.00
137_L195_Y1.9611.00
120_T123_E1.9541.00
212_T215_E1.8591.00
122_N209_G1.8521.00
79_A125_E1.8331.00
23_D26_G1.8111.00
103_A135_V1.8021.00
241_H244_D1.7631.00
143_G188_Q1.6511.00
139_H191_E1.6331.00
196_S200_L1.6331.00
73_L111_V1.6231.00
240_Q243_R1.6211.00
102_F110_R1.6101.00
194_D245_R1.5911.00
69_Y93_V1.5881.00
97_K117_D1.5621.00
41_S44_Q1.5501.00
71_K75_T1.5251.00
136_A199_L1.5151.00
194_D198_D1.5121.00
211_A243_R1.5061.00
208_A246_M1.4961.00
215_E239_A1.4941.00
74_T78_N1.4901.00
46_K50_D1.4731.00
45_V138_G1.4721.00
240_Q244_D1.4541.00
120_T209_G1.4431.00
197_Y242_I1.4311.00
122_N206_S1.4241.00
138_G141_K1.3861.00
98_D112_Y1.3731.00
208_A243_R1.3721.00
237_E240_Q1.3611.00
78_N82_N1.3491.00
198_D245_R1.3291.00
218_A235_S1.3231.00
123_E209_G1.3141.00
187_R190_A1.3101.00
94_Y110_R1.3101.00
50_D54_Q1.3091.00
198_D202_Q1.3081.00
115_L127_V1.2981.00
211_A242_I1.2901.00
126_A209_G1.2891.00
60_A112_Y1.2631.00
72_R76_I1.2441.00
67_S71_K1.2411.00
126_A213_S1.2331.00
211_A246_M1.2251.00
45_V49_S1.2161.00
212_T216_K1.2041.00
56_M94_Y1.2021.00
235_S239_A1.1871.00
53_C57_D1.1761.00
75_T121_D1.1701.00
241_H245_R1.1621.00
158_A161_G1.1551.00
236_A240_Q1.1501.00
149_G153_V1.1501.00
52_A55_E1.1501.00
76_I125_E1.1481.00
55_E59_K1.1401.00
195_Y199_L1.1381.00
133_G137_L1.1031.00
53_C110_R1.1001.00
242_I246_M1.0971.00
53_C92_K1.0941.00
210_L242_I1.0931.00
69_Y72_R1.0891.00
174_N177_E1.0851.00
145_Q149_G1.0831.00
133_G199_L1.0821.00
237_E241_H1.0731.00
215_E219_K1.0711.00
44_Q47_T1.0691.00
234_A237_E1.0661.00
191_E195_Y1.0641.00
113_S117_D1.0631.00
126_A200_L1.0601.00
99_V220_L1.0581.00
77_A81_G1.0531.00
137_L191_E1.0461.00
81_G91_Y1.0411.00
75_T79_A1.0381.00
72_R75_T1.0351.00
209_G212_T1.0341.00
96_A112_Y1.0241.00
178_K182_S1.0241.00
182_S231_D1.0231.00
213_S235_S1.0191.00
183_Q186_Q1.0151.00
22_M25_N1.0151.00
127_V213_S1.0131.00
153_V157_A1.0131.00
70_A74_T1.0131.00
99_V112_Y1.0111.00
99_V118_M1.0091.00
34_A142_K0.9981.00
230_D234_A0.9911.00
105_A140_V0.9861.00
171_Q175_L0.9841.00
56_M60_A0.9821.00
61_T95_M0.9791.00
201_R207_P0.9781.00
122_N205_I0.9731.00
150_T181_N0.9721.00
91_Y109_I0.9701.00
221_E235_S0.9571.00
239_A243_R0.9551.00
119_M123_E0.9501.00
125_E205_I0.9481.00
155_V159_S0.9391.00
70_A93_V0.9251.00
42_D46_K0.9241.00
146_V188_Q0.9221.00
130_H189_E0.9211.00
24_S27_L0.9211.00
185_S188_Q0.9171.00
20_Q24_S0.9161.00
77_A128_I0.9131.00
28_L35_F0.9131.00
206_S209_G0.9121.00
20_Q23_D0.9101.00
174_N178_K0.8931.00
18_G21_N0.8921.00
77_A109_I0.8891.00
80_L199_L0.8881.00
175_L178_K0.8841.00
142_K188_Q0.8791.00
51_Q55_E0.8761.00
133_G136_A0.8751.00
211_A239_A0.8731.00
173_G177_E0.8721.00
214_F235_S0.8651.00
62_I65_A0.8641.00
136_A195_Y0.8511.00
103_A110_R0.8441.00
177_E182_S0.8431.00
219_K222_E0.8370.99
226_S229_F0.8360.99
77_A132_M0.8150.99
49_S104_M0.8120.99
83_N203_R0.8090.99
118_M220_L0.8080.99
218_A239_A0.8070.99
142_K191_E0.8060.99
18_G22_M0.8060.99
224_R235_S0.7990.99
79_A83_N0.7970.99
182_S186_Q0.7970.99
116_M124_V0.7950.99
157_A161_G0.7920.99
111_V116_M0.7900.99
183_Q187_R0.7880.99
92_K108_C0.7870.99
140_V143_G0.7850.99
171_Q174_N0.7820.99
109_I128_I0.7810.99
68_E71_K0.7780.99
208_A212_T0.7770.99
111_V115_L0.7750.99
49_S108_C0.7750.99
89_V136_A0.7750.99
197_Y201_R0.7720.99
214_F242_I0.7700.99
143_G181_N0.7700.99
26_G30_S0.7690.99
38_Y41_S0.7670.99
45_V52_A0.7670.99
79_A205_I0.7640.99
57_D92_K0.7620.99
200_L209_G0.7610.99
97_K113_S0.7600.99
182_S230_D0.7570.99
215_E218_A0.7520.99
73_L76_I0.7500.99
21_N25_N0.7490.99
208_A247_S0.7470.99
47_T50_D0.7470.99
55_E58_S0.7460.99
175_L179_L0.7450.99
76_I124_V0.7430.99
132_M135_V0.7420.99
143_G146_V0.7390.99
84_I199_L0.7370.99
73_L116_M0.7340.99
37_A149_G0.7310.99
173_G176_G0.7290.99
131_E189_E0.7280.99
63_A95_M0.7280.99
169_Q172_L0.7230.99
56_M59_K0.7160.98
197_Y245_R0.7140.98
210_L214_F0.7110.98
42_D45_V0.7070.98
22_M26_G0.7050.98
47_T51_Q0.7040.98
54_Q57_D0.7030.98
126_A214_F0.7020.98
172_L176_G0.7010.98
99_V217_L0.6970.98
81_G89_V0.6950.98
196_S210_L0.6940.98
139_H188_Q0.6940.98
167_L171_Q0.6910.98
57_D62_I0.6910.98
27_L30_S0.6890.98
71_K74_T0.6880.98
155_V158_A0.6880.98
154_R158_A0.6860.98
178_K183_Q0.6850.98
190_A194_D0.6840.98
49_S53_C0.6820.98
29_S34_A0.6810.98
157_A160_A0.6750.98
104_M108_C0.6730.98
17_T20_Q0.6710.98
50_D108_C0.6700.98
168_S172_L0.6690.98
120_T212_T0.6670.98
124_V128_I0.6670.98
92_K110_R0.6650.97
115_L123_E0.6640.97
48_L51_Q0.6610.97
103_A109_I0.6610.97
180_V183_Q0.6600.97
52_A104_M0.6600.97
161_G169_Q0.6590.97
182_S185_S0.6550.97
34_A38_Y0.6540.97
208_A211_A0.6520.97
173_G179_L0.6500.97
36_Q142_K0.6500.97
45_V48_L0.6490.97
49_S106_N0.6480.97
32_A36_Q0.6470.97
214_F217_L0.6460.97
76_I205_I0.6400.97
48_L144_M0.6370.97
62_I92_K0.6370.97
63_A113_S0.6320.97
93_V116_M0.6290.96
117_D123_E0.6290.96
243_R246_M0.6270.96
53_C56_M0.6270.96
23_D27_L0.6260.96
216_K219_K0.6240.96
18_G25_N0.6220.96
180_V184_F0.6200.96
43_A47_T0.6190.96
191_E194_D0.6190.96
23_D28_L0.6180.96
87_Q135_V0.6170.96
89_V132_M0.6130.96
146_V150_T0.6120.96
73_L93_V0.6120.96
96_A114_G0.6080.96
49_S52_A0.6070.96
87_Q107_G0.6060.96
109_I132_M0.6050.96
19_C22_M0.6040.96
79_A82_N0.6010.95
73_L124_V0.5980.95
52_A56_M0.5980.95
139_H142_K0.5970.95
176_G179_L0.5970.95
76_I128_I0.5970.95
81_G86_G0.5950.95
17_T25_N0.5910.95
179_L183_Q0.5870.95
81_G84_I0.5870.95
74_T88_P0.5870.95
107_G135_V0.5820.95
76_I121_D0.5780.94
17_T23_D0.5770.94
53_C108_C0.5730.94
75_T78_N0.5730.94
211_A215_E0.5690.94
227_S234_A0.5670.94
28_L31_G0.5660.94
100_N103_A0.5650.94
63_A70_A0.5640.94
73_L91_Y0.5590.93
54_Q58_S0.5580.93
156_A161_G0.5570.93
18_G23_D0.5560.93
37_A41_S0.5520.93
30_S33_E0.5500.93
63_A67_S0.5460.93
20_Q25_N0.5410.92
197_Y246_M0.5400.92
121_D205_I0.5360.92
154_R161_G0.5330.92
20_Q26_G0.5310.92
63_A69_Y0.5290.91
243_R247_S0.5270.91
48_L52_A0.5270.91
24_S28_L0.5260.91
21_N30_S0.5200.91
156_A159_S0.5200.91
125_E203_R0.5180.91
29_S32_A0.5150.90
141_K145_Q0.5140.90
108_C135_V0.5140.90
76_I80_L0.5130.90
132_M136_A0.5120.90
99_V114_G0.5110.90
25_N30_S0.5100.90
66_N70_A0.5100.90
118_M216_K0.5090.90
178_K229_F0.5090.90
67_S70_A0.5070.90
62_I70_A0.5040.89
100_N112_Y0.5030.89
67_S78_N0.5020.89
125_E206_S0.5010.89
170_S173_G0.5000.89
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3c37A 1 0.8016 100 0.258 Contact Map
4aw6A 2 0.9325 100 0.487 Contact Map
4il3A 1 0.9286 100 0.496 Contact Map
3cqbA 4 0.4048 99.7 0.686 Contact Map
3dteA 2 0.6389 97.3 0.867 Contact Map
4qhjA 2 0.4008 97.3 0.869 Contact Map
4jiuA 1 0.3968 96.4 0.882 Contact Map
4jixA 2 0.4246 96.1 0.886 Contact Map
4iuwA 1 0.9603 76.4 0.925 Contact Map
3zukA 2 0.9524 76.2 0.925 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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